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471 results on '"Hartman, Douglas J."'

2. Genomic Staging of Multifocal Lung Squamous Cell Carcinomas Is Independent of the Comprehensive Morphologic Assessment

Author

Dacic, Sanja, Cao, Xuanye, Bota-Rabassedas, Neus, Sanchez-Espiridion, Beatriz, Berezowska, Sabina, Han, Yuchen, Chung, Jin-Haeng, Beasley, Mary Beth, Dongmei, Lin, Hwang, David, Mino-Kenudson, Mari, Minami, Yuko, Papotti, Mauro, Rekhtman, Natasha, Roden, Anja C., Thunnissen, Erik, Tsao, Ming-Sound, Yatabe, Yasushi, Yoshida, Akihiko, Wang, Linghua, Hartman, Douglas J., Jerome, Jacob A., Kadara, Humam, Chou, Teh-Ying, and Wistuba, Ignacio I.

Published
2024
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3. Crohn's disease-associated ATG16L1 T300A genotype is associated with improved survival in gastric cancer

Author

Ma, Changqing, Storer, Chad E, Chandran, Uma, LaFramboise, William A, Petrosko, Patricia, Frank, Madison, Hartman, Douglas J, Pantanowitz, Liron, Haritunians, Talin, Head, Richard D, and Liu, Ta-Chiang

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Genetics, Digestive Diseases, Autoimmune Disease, Inflammatory Bowel Disease, Crohn's Disease, Clinical Research, Rare Diseases, Prevention, 2.1 Biological and endogenous factors, Aetiology, Aged, Aged, 80 and over, Apoptosis, Autophagy, Autophagy-Related Proteins, Carcinoma, Chemokines, Crohn Disease, ErbB Receptors, Female, Genotype, Humans, Male, Middle Aged, Mutation, PPAR gamma, Stomach Neoplasms, Survival Analysis, Transcriptome, Wnt Signaling Pathway, Genotyping, Transcriptomics, Stratification, Clinical Sciences, Public Health and Health Services, Clinical sciences, Epidemiology
Abstract

BackgroundA non-synonymous single nucleotide polymorphism of the ATG16L1 gene, T300A, is a major Crohn's disease (CD) susceptibility allele, and is known to be associated with increased apoptosis induction in the small intestinal crypt base in CD subjects and mouse models. We hypothesized that ATG16L1 T300A genotype also correlates with increased tumor apoptosis and therefore could lead to superior clinical outcome in cancer subjects.MethodsT300A genotyping by Taqman assay was performed for gastric carcinoma subjects who underwent resection from two academic medical centers. Transcriptomic analysis was performed by RNA-seq on formalin-fixed paraffin-embedded cancerous tissue. Tumor apoptosis and autophagy were determined by cleaved caspase-3 and p62 immunohistochemistry, respectively. The subjects' genotypes were correlated with demographics, various histopathologic features, transcriptome, and clinical outcome.FindingsOf the 220 genotyped subjects, 163 (74%) subjects carried the T300A allele(s), including 55 (25%) homozygous and 108 (49%) heterozygous subjects. The T300A/T300A subjects had superior overall survival than the other groups. Their tumors were associated with increased CD-like lymphoid aggregates and increased tumor apoptosis without concurrent increase in tumor mitosis or defective autophagy. Transcriptomic analysis showed upregulation of WNT/β-catenin signaling and downregulation of PPAR, EGFR, and inflammatory chemokine pathways in tumors of T300A/T300A subjects.InterpretationGastric carcinoma of subjects with the T300A/T300A genotype is associated with repressed EGFR and PPAR pathways, increased tumor apoptosis, and improved overall survival. Genotyping gastric cancer subjects may provide additional insight for clinical stratification.

Published
2021

5. Interactive Multimedia Reporting Technical Considerations: HIMSS-SIIM Collaborative White Paper

Author

Berkowitz, Seth J., Kwan, David, Cornish, Toby C., Silver, Elliot L., Thullner, Karen S., Aisen, Alex, Bui, Marilyn M., Clark, Shawn D., Clunie, David A., Eid, Monief, Hartman, Douglas J., Ho, Kinson, Leontiev, Andrei, Luviano, Damien M., O’Toole, Peter E., Parwani, Anil V., Pereira, Nielsen S., Rotemberg, Veronica, Vining, David J., Gaskin, Cree M., Roth, Christopher J., and Folio, Les R.

Published
2022
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6. Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis

Author

Kuang, Chaoyuan, Park, Yongseok, Augustin, Ryan C., Lin, Yan, Hartman, Douglas J., Seigh, Lindsey, Pai, Reetesh K., Sun, Weijing, Bahary, Nathan, Ohr, James, Rhee, John C., Marks, Stanley M., Beasley, H. Scott, Shuai, Yongli, Herman, James G., Zarour, Hassane M., Chu, Edward, Lee, James J., and Krishnamurthy, Anuradha

Published
2022
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7. Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study

Author

Acs, Balazs, Leung, Samuel C.Y., Kidwell, Kelley M., Arun, Indu, Augulis, Renaldas, Badve, Sunil S., Bai, Yalai, Bane, Anita L., Bartlett, John M.S., Bayani, Jane, Bigras, Gilbert, Blank, Annika, Buikema, Henk, Chang, Martin C., Dietz, Robin L., Dodson, Andrew, Fineberg, Susan, Focke, Cornelia M., Gao, Dongxia, Gown, Allen M., Gutierrez, Carolina, Hartman, Johan, Kos, Zuzana, Lænkholm, Anne-Vibeke, Laurinavicius, Arvydas, Levenson, Richard M., Mahboubi-Ardakani, Rustin, Mastropasqua, Mauro G., Nofech-Mozes, Sharon, Osborne, C. Kent, Penault-Llorca, Frédérique M., Piper, Tammy, Quintayo, Mary Anne, Rau, Tilman T., Reinhard, Stefan, Robertson, Stephanie, Salgado, Roberto, Sugie, Tomoharu, van der Vegt, Bert, Viale, Giuseppe, Zabaglo, Lila A., Hayes, Daniel F., Dowsett, Mitch, Nielsen, Torsten O., Rimm, David L., McShane, Lisa M., Nielsen, Torsten, Leung, Samuel, Borgquist, Signe, Chan, Angela, Denkert, Carsten, Ehinger, Anna, Ellis, Matthew, Flowers, Margaret, Galderisi, Chad, Gholap, Abhi, Hartman, Douglas J., Hugh, Judith C., Jadhav, Anagha, Kornaga, Elizabeth N., Kreipe, Hans, Levenson, Richard, Mastropasqua, Mauro, Moriya, Takuya, Pan, Hongchao, Pantanowitz, Liron, Neri, Ernesta Paola, Polley, Mei-Yin, Ruan, Jason, Sakatani, Takashi, Shepherd, Lois, Smith, Ian, Sparano, Joseph, Spears, Melanie, Srinivasan, Malini, Starczynski, Jane, Todd, Austin, Virk, Shakeel, Wang, Yihong, Yang, Hua, Zhang, Zhiwei, and Zlobec, Inti

Published
2022
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11. Tenofovir Douche as HIV Pre-Exposure Prophylaxis for Receptive Anal Intercourse: Safety, Acceptability, Pharmacokinetics, & Pharmacodynamics (DREAM 01)

Author

Weld, Ethel D, primary, McGowan, Ian, additional, Anton, Peter, additional, Fuchs, Edward J, additional, Ho, Ken, additional, Carballo-Dieguez, Alex, additional, Rohan, Lisa C, additional, Giguere, Rebecca, additional, Brand, Rhonda, additional, Edick, Stacey, additional, Bakshi, Rahul P, additional, Parsons, Teresa, additional, Manohar, Madhuri, additional, Seigel, Aaron, additional, Engstrom, Jared, additional, Elliott, Julie, additional, Jacobson, Cindy, additional, Bagia, Christina, additional, Wang, Lin, additional, Al-khouja, Amer, additional, Hartman, Douglas J, additional, Bumpus, Namandje N, additional, Spiegel, Hans M L, additional, Marzinke, Mark A, additional, and Hendrix, Craig W, additional

Published
2023
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12. Genomic Staging of Multifocal Lung Squamous Cell Carcinomas Is Independent of the Comprehensive Morphologic Assessment

Author

Dacic, Sanja, primary, Cao, Xuanye, additional, Bota-Rabassedas, Neus, additional, Sanchez-Espiridion, Beatriz, additional, Berezowska, Sabina, additional, Han, Yuchen, additional, Chung, Jin-Haeng, additional, Beasley, Mary Beth, additional, Dongmei, Lin, additional, Hwang, David, additional, Mino-Kenudson, Mari, additional, Minami, Yuko, additional, Papotti, Mauro, additional, Rekhtman, Natasha, additional, Roden, Anja C., additional, Thunnissen, Erik, additional, Tsao, Ming-Sound, additional, Yatabe, Yasushi, additional, Yoshida, Akihiko, additional, Wang, Linghua, additional, Hartman, Douglas J., additional, Jerome, Jacob A., additional, Kadara, Humam, additional, Chou, Teh-Ying, additional, and Wistuba, Ignacio I., additional

Published
2023
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17. A Practical Guide to Whole Slide Imaging: A White Paper From the Digital Pathology Association

Author

Zarella, Mark D., Bowman, Douglas, Aeffner, Famke, Farahani, Navid, Xthona, Albert, Absar, Syeda Fatima, Parwani, Anil, Bui, Marilyn, and Hartman, Douglas J.

Subjects
Diagnostic imaging -- Methods, Pathological histology -- Methods, Education, Scientists, Medical personnel training, Retirement benefits, Instructional materials industry, Technology, Medical research, Instructional materials, Health
Abstract

Context.--Whole slide imaging (WSI) represents a paradigm shift in pathology, serving as a necessary first step for a wide array of digital tools to enter the field. Its basic function is to digitize glass slides, but its impact on pathology workflows, reproducibility, dissemination of educational material, expansion of service to underprivileged areas, and intrainstitutional and interinstitutional collaboration exemplifies a significant innovative movement with far-reaching effects. Although the benefits of WSI to pathology practices, academic centers, and research institutions are many, the complexities of implementation remain an obstacle to widespread adoption. In the wake of the first regulatory clearance of WSI for primary diagnosis in the United States, some barriers to adoption have fallen. Nevertheless, implementation of WSI remains a difficult prospect for many institutions, especially those with stakeholders unfamiliar with the technologies necessary to implement a system or who cannot effectively communicate to executive leadership and sponsors the benefits of a technology that may lack clear and immediate reimbursement opportunity. Objectives.--To present an overview of WSI technology--present and future--and to demonstrate several immediate applications of WSI that support pathology practice, medical education, research, and collaboration. Data Sources.--Peer-reviewed literature was reviewed by pathologists, scientists, and technologists who have practical knowledge of and experience with WSI. Conclusions.--Implementation of WSI is a multifaceted and inherently multidisciplinary endeavor requiring contributions from pathologists, technologists, and executive leadership. Improved understanding of the current challenges to implementation, as well as the benefits and successes of the technology, can help prospective users identify the best path for success. doi: 10.5858/arpa.2018-0343-RA, Pathology as a practice vitally relies on the accurate interpretation of microscopic images in order to correctly diagnose patients and guide therapeutic decision making. With the advent of whole slide [...]

Published
2019
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18. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Author

Whitcomb, David C, LaRusch, Jessica, Krasinskas, Alyssa M, Klei, Lambertus, Smith, Jill P, Brand, Randall E, Neoptolemos, John P, Lerch, Markus M, Tector, Matt, Sandhu, Bimaljit S, Guda, Nalini M, Orlichenko, Lidiya, Alkaade, Samer, Amann, Stephen T, Anderson, Michelle A, Baillie, John, Banks, Peter A, Conwell, Darwin, Coté, Gregory A, Cotton, Peter B, DiSario, James, Farrer, Lindsay A, Forsmark, Chris E, Johnstone, Marianne, Gardner, Timothy B, Gelrud, Andres, Greenhalf, William, Haines, Jonathan L, Hartman, Douglas J, Hawes, Robert A, Lawrence, Christopher, Lewis, Michele, Mayerle, Julia, Mayeux, Richard, Melhem, Nadine M, Money, Mary E, Muniraj, Thiruvengadam, Papachristou, Georgios I, Pericak-Vance, Margaret A, Romagnuolo, Joseph, Schellenberg, Gerard D, Sherman, Stuart, Simon, Peter, Singh, Vijay P, Slivka, Adam, Stolz, Donna, Sutton, Robert, Weiss, Frank Ulrich, Wilcox, C Mel, Zarnescu, Narcis Octavian, Wisniewski, Stephen R, O'Connell, Michael R, Kienholz, Michelle L, Roeder, Kathryn, Barmada, M Michael, Yadav, Dhiraj, and Devlin, Bernie

Subjects
Biological Sciences, Genetics, Clinical Research, Human Genome, Substance Misuse, Digestive Diseases, Alcoholism, Alcohol Use and Health, Prevention, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Good Health and Well Being, Claudins, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Homozygote, Humans, Male, Mutation, Pancreatitis, Alcoholic, Sex Factors, Trypsin, Trypsinogen, Alzheimer's Disease Genetics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 (P < 1 × 10(-12)) and X-linked CLDN2 (P < 1 × 10(-21)) through a two-stage genome-wide study (stage 1: 676 cases and 4,507 controls; stage 2: 910 cases and 4,170 controls). The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous in males) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07).

Published
2012

20. Data from Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer

Author

Kvorjak, Michael, primary, Ahmed, Yasmine, primary, Miller, Michelle L., primary, Sriram, Raahul, primary, Coronnello, Claudia, primary, Hashash, Jana G., primary, Hartman, Douglas J., primary, Telmer, Cheryl A., primary, Miskov-Zivanov, Natasa, primary, Finn, Olivera J., primary, and Cascio, Sandra, primary

Published
2023
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21. Supplemental Fig. S1 from Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer

Author

Kvorjak, Michael, primary, Ahmed, Yasmine, primary, Miller, Michelle L., primary, Sriram, Raahul, primary, Coronnello, Claudia, primary, Hashash, Jana G., primary, Hartman, Douglas J., primary, Telmer, Cheryl A., primary, Miskov-Zivanov, Natasa, primary, Finn, Olivera J., primary, and Cascio, Sandra, primary

Published
2023
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22. Supplemental Table S1 from Cross-talk between Colon Cells and Macrophages Increases ST6GALNAC1 and MUC1-sTn Expression in Ulcerative Colitis and Colitis-Associated Colon Cancer

Author

Kvorjak, Michael, primary, Ahmed, Yasmine, primary, Miller, Michelle L., primary, Sriram, Raahul, primary, Coronnello, Claudia, primary, Hashash, Jana G., primary, Hartman, Douglas J., primary, Telmer, Cheryl A., primary, Miskov-Zivanov, Natasa, primary, Finn, Olivera J., primary, and Cascio, Sandra, primary

Published
2023
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44. Computational pathology in 2030: a Delphi study forecasting the role of AI in pathology within the next decade

Author

Berbís, M. Alvaro, primary, McClintock, David S., additional, Bychkov, Andrey, additional, Van der Laak, Jeroen, additional, Pantanowitz, Liron, additional, Lennerz, Jochen K., additional, Cheng, Jerome Y., additional, Delahunt, Brett, additional, Egevad, Lars, additional, Eloy, Catarina, additional, Farris, Alton B., additional, Fraggetta, Filippo, additional, García del Moral, Raimundo, additional, Hartman, Douglas J., additional, Herrmann, Markus D., additional, Hollemans, Eva, additional, Iczkowski, Kenneth A., additional, Karsan, Aly, additional, Kriegsmann, Mark, additional, Salama, Mohamed E., additional, Sinard, John H., additional, Tuthill, J. Mark, additional, Williams, Bethany, additional, Casado-Sánchez, César, additional, Sánchez-Turrión, Víctor, additional, Luna, Antonio, additional, Aneiros-Fernández, José, additional, and Shen, Jeanne, additional

Published
2023
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48. The future of computational pathology: expectations regarding the anticipated role of artificial intelligence in pathology by 2030

Author

Berbís, M Alvaro, primary, McClintock, David S., additional, Bychkov, Andrey, additional, Cheng, Jerome Y, additional, Delahunt, Brett, additional, Egevad, Lars, additional, Eloy, Catarina, additional, Farris, Alton B, additional, Fraggetta, Filippo, additional, García del Moral, Raimundo, additional, Hartman, Douglas J., additional, Herrmann, Markus D, additional, Hollemans, Eva, additional, Iczkowski, Kenneth A, additional, Karsan, Aly, additional, Kriegsmann, Mark, additional, Lennerz, Jochen K, additional, Pantanowitz, Liron, additional, Salama, Mohamed E., additional, Sinard, John, additional, Tuthill, Mark, additional, Van der Laak, Jeroen, additional, Williams, Bethany, additional, Casado-Sánchez, César, additional, Sánchez-Turrión, Víctor, additional, Luna, Antonio, additional, Aneiros-Fernández, José, additional, and Shen, Jeanne, additional

Published
2022
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