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1. Technical Design Report for the: PANDA Straw Tube Tracker

Author

PANDA Collaboration, Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, Q., Xu, H., Aab, A., Albrecht, M., Becker, J., Csapó, A., Feldbauer, F., Fink, M., Friedel, P., Heinsius, F. H., Held, T., Klask, L., Koch, H., Kopf, B., Leiber, S., Leyhe, M., Motzko, C., Pelizäus, M., Pychy, J., Roth, B., Schröder, T., Schulze, J., Sowa, C., Steinke, M., Trifterer, T., Wiedner, U., Zhong, J., Beck, R., Bianco, S., Brinkmann, K. T., Hammann, C., Hinterberger, F., Kaiser, D., Kliemt, R., Kube, M., Pitka, A., Quagli, T., Schmidt, C., Schmitz, R., Schnell, R., Thoma, U., Vlasov, P., Walther, D., Wendel, C., Würschig, T., Zaunick, H. G., Bianconi, A., Bragadireanu, M., Caprini, M., Pantea, D., Pantelica, D., Pietreanu, D., Serbina, L., Tarta, P. D., Kaplan, D., Fiutowski, T., Idzik, M., Mindur, B., Przyborowski, D., Swientek, K., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Lebiedowicz, P., Pysz, K., Schäfer, W., Siudak, R., Szczurek, A., Jowzaee, S., Kajetanowicz, M., Kamys, B., Kistryn, S., Korcyl, G., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Palka, M., Rudy, Z., Salabura, P., Smyrski, J., Wrońska, A., Augustin, I., Lehmann, I., Nimorus, D., Schepers, G., Al-Turany, M., Arora, R., Deppe, H., Flemming, H., Gerhardt, A., Götzen, K., Jordi, A. F., Kalicy, G., Karabowicz, R., Lehmann, D., Lewandowski, B., Lühning, J., Maas, F., Orth, H., Patsyuk, M., Peters, K., Saito, T., Schmidt, C. J., Schmitt, L., Schwarz, C., Schwiening, J., Traxler, M., Voss, B., Wieczorek, P., Wilms, A., Zühlsdorf, M., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Festchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevskiy, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Metreveli, Z., Seth, K., Tomaradze, A., Xiao, T., Bettoni, D., Carassiti, V., Ramusino, A. Cotta, Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Savriè, M., Stancari, G., Bianchi, N., Gianotti, P., Guaraldo, C., Lucherini, V., Orecchini, D., Pace, E., Bersani, A., Bracco, G., Macri, M., Parodi, R. F., Bremer, D., Dormenev, V., Drexler, P., Düren, M., Eissner, T., Föhl, K., Galuska, M., Gessler, T., Hayrapetyan, A., Hu, J., Koch, P., Kröck, B., Kühn, W., Lange, S., Liang, Y., Merle, O., Metag, V., Moritz, M., Münchow, D., Nanova, M., Novotny, R., Spruck, B., Stenzel, H., Ullrich, T., Werner, M., Euan, C., Hoek, M., Ireland, D., Keri, T., Montgomery, R., Protopopescu, D., Rosner, G., Seitz, B., Babai, M., Glazenborg-Kluttig, A., Kavatsyuk, M., Lemmens, P., Lindemulder, M., Löhner, H., Messchendorp, J., Moeini, H., Schakel, P., Schreuder, F., Smit, H., Tambave, G., van der Weele, J. C., Veenstra, R., Sohlbach, H., Büscher, M., Deermann, D., Dosdall, R., Esch, S., Gillitzer, A., Goldenbaum, F., Grunwald, D., Henssler, S., Herten, A., Hu, Q., Kemmerling, G., Kleines, H., Kozlov, V., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Orfanitski, S., Prasuhn, D., Randriamalala, T., Ritman, J., Schadmand, S., Serdyuk, V., Sterzenbach, G., Stockmanns, T., Wintz, P., Wüstner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Rigato, V., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schröder, B., Achenbach, P., Bleser, S., Cahit, U., Cardinali, M., Denig, A., Distler, M., Fritsch, M., Kangh, D., Karavdina, A., Lauth, W., Merkel, H., Michel, M., Espi, M. C. Mora, Müller, U., Pochodzalla, J., Prometeusz, J., Sanchez, S., Sanchez-Lorente, A., Schlimme, S., Sfienti, C., Thiel, M., Weber, T., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Varentsov, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Böhmer, F., Dørheim, S., Ketzer, B., Paul, S., Hergemöller, A. K., Khoukaz, A., Köhler, E., Täschner, A., Wessels, J., Varma, R., Chaterjee, A., Jha, V., Kailas, S., Roy, B., Yan, Y., Chinorat, K., Khanchai, K., Ayut, L., Pomrad, S., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Boucher, J., Chambert, V., Dbeyssi, A., Hennino, T., Imre, M., Kunne, R., Galliard, C. Le, Ma, B., Marchand, D., Maroni, A., Ong, S., Ramstein, B., Rosier, P., Sudol, M., Tomasi-Gustafsson, E., Van de Wiele, J., Boca, G., Braghieri, A., Costanza, S., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Abramov, V., Belikov, N., Davidenko, A., Derevschikov, A., Goncharenko, Y., Grishin, V., Kachanov, V., Konstantinov, D., Kormilitsin, V., Melnik, Y., Levin, A., Minaev, N., Mochalov, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Bäck, T., Cederwall, B., Makónyi, K., Tegnér, P. E., von Würtemberg, K. M., Belostotski, S., Gavrilov, G., Itzotov, A., Kashchuk, A., Kisselev, A., Kravchenko, P., Levitskaya, O., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Alberto, D., Amoroso, A., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Fava, L., Ferrero, L., Greco, M., Maggiora, M., Marcello, S., Sosio, S., Spataro, S., Zotti, L., Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Morra, O., Rivetti, A., Wheadon, R., Iazzi, F., Lavagno, A., Younis, H., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Galander, B., Balkeståhl, L. Caldeira, Calén, H., Fransson, K., Johansson, T., Kupsc, A., Marciniewski, P., Thomé, E., Wolke, M., Zlomanczuk, J., Díaz, J., Ortiz, A., Dmowski, K., Duda, P., Korzeniewski, R., Slowinski, B., Chlopik, A., Guzik, Z., Kosinski, K., Melnychuk, D., Wasilewski, A., Wojciechowski, M., Wronka, S., Wysocka, A., Zwieglinski, B., Bühler, P., Hartman, O., Kienle, P., Marton, J., Suzuki, K., Widmann, E., and Zmeskal, J.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the PANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM-stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy-loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole PANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described., Comment: accepted for publication on EPJA

Published
2012
Full Text
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17. Technical design report for the $\overline{P}$ ANDA (AntiProton Annihilations at Darmstadt) Straw Tube Tracker

Author

Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, Q., Xu, H., Aab, A., Albrecht, M., Becker, J., Csapó, A., Feldbauer, F., Fink, M., Friedel, P., Heinsius, F. H., Held, T., Klask, L., Koch, H., Kopf, B., Leiber, S., Leyhe, M., Motzko, C., Pelizäus, M., Pychy, J., Roth, B., Schröder, T., Schulze, J., Sowa, C., Steinke, M., Trifterer, T., Wiedner, U., Zhong, J., Beck, R., Bianco, S., Brinkmann, K. T., Hammann, C., Hinterberger, F., Kaiser, D., Kliemt, R., Kube, M., Pitka, A., Quagli, T., Schmidt, C., Schmitz, R., Schnell, R., Thoma, U., Vlasov, P., Walther, D., Wendel, C., Würschig, T., Zaunick, H. G., Bianconi, A., Bragadireanu, M., Caprini, M., Pantea, D., Pantelica, D., Pietreanu, D., Serbina, L., Tarta, P. D., Kaplan, D., Fiutowski, T., Idzik, M., Mindur, B., Przyborowski, D., Swientek, K., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Lebiedowicz, P., Pysz, K., Schäfer, W., Siudak, R., Szczurek, A., Jowzaee, S., Kajetanowicz, M., Kamys, B., Kistryn, S., Korcyl, G., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Palka, M., Rudy, Z., Salabura, P., Smyrski, J., Wrońska, A., Augustin, I., Lehmann, I., Nimorus, D., Schepers, G., Al-Turany, M., Arora, R., Deppe, H., Flemming, H., Gerhardt, A., Götzen, K., Jordi, A. F., Kalicy, G., Karabowicz, R., Lehmann, D., Lewandowski, B., Lühning, J., Maas, F., Orth, H., Patsyuk, M., Peters, K., Saito, T., Schmidt, C. J., Schmitt, L., Schwarz, C., Schwiening, J., Traxler, M., Voss, B., Wieczorek, P., Wilms, A., Zühlsdorf, M., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Festchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevskiy, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Metreveli, Z., Seth, K., Tomaradze, A., Xiao, T., Bettoni, D., Carassiti, V., Cotta Ramusino, A., Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Savriè, M., Stancari, G., Bianchi, N., Gianotti, P., Guaraldo, C., Lucherini, V., Orecchini, D., Pace, E., Bersani, A., Bracco, G., Macri, M., Parodi, R. F., Bremer, D., Dormenev, V., Drexler, P., Düren, M., Eissner, T., Föhl, K., Galuska, M., Gessler, T., Hayrapetyan, A., Hu, J., Koch, P., Kröck, B., Kühn, W., Lange, S., Liang, Y., Merle, O., Metag, V., Moritz, M., Münchow, D., Nanova, M., Novotny, R., Spruck, B., Stenzel, H., Ullrich, T., Werner, M., Euan, C., Hoek, M., Ireland, D., Keri, T., Montgomery, R., Protopopescu, D., Rosner, G., Seitz, B., Babai, M., Glazenborg-Kluttig, A., Kavatsyuk, M., Lemmens, P., Lindemulder, M., Löhner, H., Messchendorp, J., Moeini, H., Schakel, P., Schreuder, F., Smit, H., Tambave, G., van der Weele, J. C., Veenstra, R., Sohlbach, H., Büscher, M., Deermann, D., Dosdall, R., Esch, S., Gillitzer, A., Goldenbaum, F., Grunwald, D., Henssler, S., Herten, A., Hu, Q., Kemmerling, G., Kleines, H., Kozlov, V., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Orfanitski, S., Prasuhn, D., Randriamalala, T., Ritman, J., Röder, M., Schadmand, S., Serdyuk, V., Sterzenbach, G., Stockmanns, T., Wintz, P., Wüstner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Rigato, V., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schröder, B., Achenbach, P., Bleser, S., Cahit, U., Cardinali, M., Denig, A., Distler, M., Fritsch, M., Jasinski, P., Kangh, D., Karavdina, A., Lauth, W., Merkel, H., Michel, M., Mora Espi, M. C., Müller, U., Pochodzalla, J., Sanchez, S., Sanchez-Lorente, A., Schlimme, S., Sfienti, C., Thiel, M., Weber, T., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Varentsov, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Böhmer, F., Dørheim, S., Ketzer, B., Paul, S., Hergemöller, A. K., Khoukaz, A., Köhler, E., Täschner, A., Wessels, J., Varma, R., Chaterjee, A., Jha, V., Kailas, S., Roy, B. J., Yan, Y., Chinorat, K., Khanchai, K., Ayut, L., Pomrad, S., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Boucher, J., Chambert, V., Dbeyssi, A., Gumberidze, M., Hennino, T., Imre, M., Kunne, R., Le Galliard, C., Ma, B., Marchand, D., Maroni, A., Ong, S., Ramstein, B., Rosier, P., Tomasi-Gustafsson, E., Van de Wiele, J., Boca, G., Braghieri, A., Costanza, S., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Abramov, V., Belikov, N., Davidenko, A., Derevschikov, A., Goncharenko, Y., Grishin, V., Kachanov, V., Konstantinov, D., Kormilitsin, V., Melnik, Y., Levin, A., Minaev, N., Mochalov, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Bäck, T., Cederwall, B., Makónyi, K., Tegnér, P. E., von Würtemberg, K. M., Belostotski, S., Gavrilov, G., Itzotov, A., Kashchuk, A., Kisselev, A., Kravchenko, P., Levitskaya, O., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Alberto, D., Amoroso, A., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Fava, L., Ferrero, L., Greco, M., Maggiora, M., Marcello, S., Sosio, S., Spataro, S., Zotti, L., Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Morra, O., Rivetti, A., Wheadon, R., Iazzi, F., Lavagno, A., Younis, H., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Galander, B., Caldeira Balkeståhl, L., Calén, H., Fransson, K., Johansson, T., Kupsc, A., Marciniewski, P., Thomé, E., Wolke, M., Zlomanczuk, J., Díaz, J., Ortiz, A., Dmowski, K., Duda, P., Korzeniewski, R., Slowinski, B., Chlopik, A., Guzik, Z., Kosinski, K., Melnychuk, D., Wasilewski, A., Wojciechowski, M., Wronka, S., Wysocka, A., Zwieglinski, B., Bühler, P., Hartman, O. N., Kienle, P., Marton, J., Suzuki, K., Widmann, E., and Zmeskal, J.

Subjects
Nuclear and High Energy Physics
Published
2013

18. Technical Design Report for the: PANDA Straw Tube Tracker

Author

Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, Q., Xu, H., Aab, A., Albrecht, M., Becker, J., Csap´o, A., Feldbauer, F., Fink, M., Friedel, P., Heinsius, F. H., Held, T., Klask, L., Koch, H., Kopf, B., Leiber, S., Leyhe, M., Motzko, C., Peliz¨aus, M., Pychy, J., Roth, B., Schr¨oder, T., Schulze, J., Sowa, C., Steinke, M., Trifterer, T., Wiedner, U., Zhong, J., Beck, R., Bianco, S., Brinkmann, K. T., Hammann, C., Hinterberger, F., Kaiser, D., Kliemt, R., Kube, M., Pitka, A., Quagli, T., Schmidt, C., Schmitz, R., Schnell, R., Thoma, U., Vlasov, P., Walther, D., Wendel, C., W¨urschig, T., Zaunick, H. G., Bianconi, A., Bragadireanu, M., Caprini, M., Pantea, D., Pantelica, D., Pietreanu, D., Serbina, L., Tarta, P. D., Kaplan, D., Fiutowski, T., Idzik, M., Mindur, B., Przyborowski, D., Swientek, K., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Lebiedowicz, P., Pysz, K., Sch¨afer, W., Siudak, R., Szczurek, A., Jowzaee, S., Kajetanowicz, M., Kamys, B., Kistryn, S., Korcyl, G., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Palka, M., Rudy, Z., Salabura, P., Smyrski, J., Wro´nska, A., Augustin, I., Lehmann, I., Nimorus, D., Schepers, G., Al Turany, M., Arora, R., Deppe, H., Flemming, H., Gerhardt, A., G¨otzen, K., Jordi, A. F., Kalicy, G., Karabowicz, R., Lehmann, D., Lewandowski, B., L¨uhning, J., Maas, F., Orth, H., Patsyuk, M., Peters, K., Saito, T., Schmidt, C. J., Schmitt, L., Schwarz, C., Schwiening, J., Traxler, M., Voss, B., Wieczorek, P., Wilms, A., Z¨uhlsdorf, M., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Y. u., Batyunya, B. V., Davydov, Y. u. I., Dodokhov, V. K. h., Efremov, A. A., Fedunov, A. G., Festchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Y. u. Y. u., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevskiy, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Y. u. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. S. h., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Metreveli, Z., Seth, K., Tomaradze, A., Xiao, T., Bettoni, D., Carassiti, V., Cotta Ramusino, A., Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Savri`e, M., Stancari, G., Bianchi, N., Gianotti, P., A, Guaraldo, C., Lucherini, V., Orecchini, D., Pace, E., Bersani, A., Bracco, G., Macri, M., Parodi, R. F., Bremer, D., Dormenev, V., Drexler, P., D¨uren, M., Eissner, T., F¨ohl, K., Galuska, M., Gessler, T., Hayrapetyan, A., Hu, J., Koch, P., Kr¨ock, B., K¨uhn, W., Lange, S., Liang, Y., Merle, O., Metag, V., Moritz, M., M¨unchow, D., Nanova, M., Novotny, R., Spruck, B., Stenzel, H., Ullrich, T., Werner, M., Euan, C., Hoek, M., Ireland, D., Keri, T., Montgomery, R., Protopopescu, D., Rosner, G., Seitz, B., Babai, M., Glazenborg Kluttig, A., Kavatsyuk, M., Lemmens, P., Lindemulder, M., L¨ohner, H., Messchendorp, J., Moeini, H., Schakel, P., Schreuder, F., Smit, H., Tambave, G., van der Weele, J. C., Veenstra, R., Sohlbach, H., B¨uscher, M., Deermann, D., Dosdall, R., Esch, S., Gillitzer, A., Goldenbaum, F., Grunwald, D., Henssler, S., Herten, A., Hu, Q., Kemmerling, G., Kleines, H., Kozlov, V., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Orfanitski, S., Prasuhn, D., Randriamalala, T., Ritman, J., R¨oder, M., Schadmand, S., Serdyuk, V., Sterzenbach, G., Stockmanns, T., Wintz, P., W¨ustner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Rigato, V., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schr¨oder, B., Achenbach, P., Bleser, S., Cahit, U., Cardinali, M., Denig, A., Distler, M., Fritsch, M., Jasinski, P., Kangh, D., Karavdina, A., Lauth, W., Merkel, H., Michel, M., Mora Espi, M. C., M¨uller, U., Pochodzalla, J., Sanchez, S., Sanchezlorente, A., Schlimme, S., Sfienti, C., Thiel, M., Weber, T., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Varentsov, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., B¨ohmer, F., Dørheim, a. e. mail: p. a. o. l. a. g. i. a. n. o. t. t. i. @. l. n. f. i. n. f. n. it Page of S., Ketzer, B., Paul, S., Hergem¨oller, A. K., Khoukaz, A., K¨ohler, E., T¨aschner, A., Wessels, J., Varma, R., Chaterjee, A., Jha, V., Kailas, S., Roy, B. J., Yan, Y., Chinorat, K., Khanchai, K., Ayut, L., Pomrad, S., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Y. u., Boucher, J., Chambert, V., Dbeyssi, A., Gumberidze, M., Hennino, T., Imre, M., Kunne, R., Le Galliard, C., Ma, B., Marchand, D., Maroni, A., Ong, S., Ramstein, B., Rosier, P., Tomasi Gustafsson, E., Van de Wiele, J., Boca, G., Braghieri, A., Costanza, S., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Abramov, V., Belikov, N., Davidenko, A., Derevschikov, A., Goncharenko, Y., Grishin, V., Kachanov, V., Konstantinov, D., Kormilitsin, V., Melnik, Y., Levin, A., Minaev, N., Mochalov, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., B¨ack, T., Cederwall, B., Mak´onyi, K., Tegn´er, P. E., von W¨urtemberg, K. M., Belostotski, S., Gavrilov, G., Itzotov, A., Kashchuk, A., Kisselev, A., Kravchenko, P., Levitskaya, O., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Alberto, D., Amoroso, Antonio, Bussa, Maria Pia, Busso, Luigi, DE MORI, Francesca, Destefanis, MARCO GIOVANNI, Fava, L., Ferrero, Livio, Greco, Michela, Maggiora, Marco, Marcello, Simonetta, Sosio, Stefano, Spataro, STEFANO GIOVANNI, Zotti, Laura, Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Morra, O., Rivetti, A., Wheadon, R., Iazzi, F., Lavagno, A., Younis, H., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Galander, B., Caldeira Balkest˚ahl, L., Cal´en, H., Fransson, K., Johansson, T., Kupsc, A., Marciniewski, P., Thom´e, E., Wolke, M., Zlomanczuk, J., D´ıaz, J., Ortiz, A., Dmowski, K., Duda, P., Korzeniewski, R., Slowinski, B., Chlopik, A., Guzik, Z., Kosinski, K., Melnychuk, D., Wasilewski, A., Wojciechowski, M., Wronka, S., Wysocka, A., Zwieglinski, B., B¨uhler, P., Hartman, O. N., Kienle, P., Marton, J., Suzuki, K., Widmann, E., Zmeskal, J., Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and PANDA

Subjects
High Energy Physics - Experiment (hep-ex), Computer Science::Hardware Architecture, Physics - Instrumentation and Detectors, hep-ex, Physics::Instrumentation and Detectors, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, Nuclear Experiment, physics.ins-det, High Energy Physics - Experiment
Abstract

This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the PANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM-stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy-loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole PANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described., Comment: accepted for publication on EPJA

Published
2012
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21. Technical design report for the PANDA (AntiProton Annihilations at Darmstadt) Straw Tube Tracker

Author

Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, Q., Xu, H., Aab, A., Albrecht, M., Becker, J., Csapo, A., Feldbauer, F., Fink, M., Friedel, P., Heinsius, F. H., Held, T., Klask, L., Koch, H., Kopf, B., Leiber, S., Leyhe, M., Motzko, C., Pelizaeus, M., Pychy, J., Roth, B., Schroeder, T., Schulze, J., Sowa, C., Steinke, M., Trifterer, T., Wiedner, U., Zhong, J., Beck, R., Bianco, S., Brinkmann, K. T., Hammann, C., Hinterberger, F., Kaiser, D., Kliemt, R., Kube, M., Pitka, A., Quagli, T., Schmidt, C., Schmitz, R., Schnell, R., Thoma, U., Vlasov, P., Walther, D., Wendel, C., Wuerschig, T., Zaunick, H. G., Bianconi, A., Bragadireanu, M., Caprini, M., Pantea, D., Pantelica, D., Pietreanu, D., Serbina, L., Tarta, P. D., Kaplan, D., Fiutowski, T., Idzik, M., Mindur, B., Przyborowski, D., Swientek, K., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Lebiedowicz, P., Pysz, K., Schaefer, W., Siudak, R., Szczurek, A., Jowzaee, S., Kajetanowicz, M., Kamys, B., Kistryn, S., Korcyl, G., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Palka, M., Rudy, Z., Salabura, P., Smyrski, J., Wronska, A., Augustin, I., Lehmann, I., Nimorus, D., Schepers, G., Al-Turany, M., Arora, R., Deppe, H., Flemming, H., Gerhardt, A., Goetzen, K., Jordi, A. F., Kalicy, G., Karabowicz, R., Lehmann, D., Lewandowski, B., Luehning, J., Maas, F., Orth, H., Patsyuk, M., Peters, K., Saito, T., Schmidt, C. J., Schmitt, L., Schwarz, C., Schwiening, J., Traxler, M., Voss, B., Wieczorek, P., Wilms, A., Zuehlsdorf, M., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Festchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevskiy, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Metreveli, Z., Seth, K., Tomaradze, A., Xiao, T., Bettoni, D., Carassiti, V., Ramusino, A. Cotta, Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Savrie, M., Stancari, G., Bianchi, N., Gianotti, P., Guaraldo, C., Lucherini, V., Orecchini, D., Pace, E., Bersani, A., Bracco, G., Macri, M., Parodi, R. F., Bremer, D., Dormenev, V., Drexler, P., Dueren, M., Eissner, T., Foehl, K., Galuska, M., Gessler, T., Hayrapetyan, A., Hu, J., Koch, P., Kroeck, B., Kuehn, W., Lange, S., Liang, Y., Merle, O., Metag, V., Moritz, M., Muenchow, D., Nanova, M., Novotny, R., Spruck, B., Stenzel, H., Ullrich, T., Werner, M., Euan, C., Hoek, M., Ireland, D., Keri, T., Montgomery, R., Protopopescu, D., Rosner, G., Seitz, B., Babai, M., Glazenborg-Kluttig, A., Kavatsyuk, M., Lemmens, P., Lindemulder, M., Lohner, H., Messchendorp, J., Moeini, H., Schakel, P., Schreuder, F., Smit, H., Tambave, G., van der Weele, J. C., Veenstra, R., Sohlbach, H., Buescher, M., Deermann, D., Dosdall, R., Esch, S., Gillitzer, A., Goldenbaum, F., Grunwald, D., Henssler, S., Herten, A., Hu, Q., Kemmerling, G., Kleines, H., Kozlov, V., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Orfanitski, S., Prasuhn, D., Randriamalala, T., Ritman, J., Roeder, M., Schadmand, S., Serdyuk, V., Sterzenbach, G., Stockmanns, T., Wintz, P., Wuestner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Rigato, V., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schroder, B., Achenbach, P., Bleser, S., Cahit, U., Cardinali, M., Denig, A., Distler, M., Fritsch, M., Jasinski, P., Kangh, D., Karavdina, A., Lauth, W., Merkel, H., Michel, M., Espi, M. C. Mora, Mueller, U., Pochodzalla, J., Sanchez, S., Sanchez-Lorente, A., Schlimme, S., Sfienti, C., Thiel, M., Weber, T., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Varentsov, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Boehmer, F., Dorheim, S., Ketzer, B., Paul, S., Hergemoeller, A. K., Khoukaz, A., Koehler, E., Taeschner, A., Wessels, J., Varma, R., Chaterjee, A., Jha, V., Kailas, S., Roy, B. J., Yan, Y., Chinorat, K., Khanchai, K., Ayut, L., Pomrad, S., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Boucher, J., Chambert, V., Dbeyssi, A., Gumberidze, M., Hennino, T., Imre, M., Kunne, R., Le Galliard, C., Ma, B., Marchand, D., Maroni, A., Ong, S., Ramstein, B., Rosier, P., Tomasi-Gustafsson, E., De Wiele, J. Van, Boca, G., Braghieri, A., Costanza, S., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Abramov, V., Belikov, N., Davidenko, A., Derevschikov, A., Goncharenko, Y., Grishin, V., Kachanov, V., Konstantinov, D., Kormilitsin, V., Melnik, Y., Levin, A., Minaev, N., Mochalov, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Back, T., Cederwall, B., Makonyi, K., Tegner, P. E., von Wurtemberg, K. M., Belostotski, S., Gavrilov, G., Itzotov, A., Kashchuk, A., Kisselev, A., Kravchenko, P., Levitskaya, O., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Alberto, D., Amoroso, A., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Fava, L., Ferrero, L., Greco, M., Maggiora, M., Marcello, S., Sosio, S., Spataro, S., Zotti, L., Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Morra, O., Rivetti, A., Wheadon, R., Iazzi, F., Lavagno, A., Younis, H., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Galander, B., Balkeståhl, Li Caldeira, Calén, Hans, Fransson, Kjell E. I., Johansson, Tord, Kupsc, Andrzej, Marciniewski, Pawel, Thome, Erik, Wolke, Magnus, Zlomanczuk, Jozef, Diaz, J., Ortiz, A., Dmowski, K., Duda, P., Korzeniewski, R., Slowinski, B., Chlopik, A., Guzik, Z., Kosinski, K., Melnychuk, D., Wasilewski, A., Wojciechowski, M., Wronka, S., Wysocka, A., Zwieglinski, B., Buehler, P., Hartman, O. N., Kienle, P., Marton, J., Suzuki, K., Widmann, E., Zmeskal, J., Erni, W., Keshelashvili, I., Krusche, B., Steinacher, M., Heng, Y., Liu, Z., Liu, H., Shen, X., Wang, Q., Xu, H., Aab, A., Albrecht, M., Becker, J., Csapo, A., Feldbauer, F., Fink, M., Friedel, P., Heinsius, F. H., Held, T., Klask, L., Koch, H., Kopf, B., Leiber, S., Leyhe, M., Motzko, C., Pelizaeus, M., Pychy, J., Roth, B., Schroeder, T., Schulze, J., Sowa, C., Steinke, M., Trifterer, T., Wiedner, U., Zhong, J., Beck, R., Bianco, S., Brinkmann, K. T., Hammann, C., Hinterberger, F., Kaiser, D., Kliemt, R., Kube, M., Pitka, A., Quagli, T., Schmidt, C., Schmitz, R., Schnell, R., Thoma, U., Vlasov, P., Walther, D., Wendel, C., Wuerschig, T., Zaunick, H. G., Bianconi, A., Bragadireanu, M., Caprini, M., Pantea, D., Pantelica, D., Pietreanu, D., Serbina, L., Tarta, P. D., Kaplan, D., Fiutowski, T., Idzik, M., Mindur, B., Przyborowski, D., Swientek, K., Czech, B., Kistryn, M., Kliczewski, S., Kozela, A., Kulessa, P., Lebiedowicz, P., Pysz, K., Schaefer, W., Siudak, R., Szczurek, A., Jowzaee, S., Kajetanowicz, M., Kamys, B., Kistryn, S., Korcyl, G., Korcyl, K., Krzemien, W., Magiera, A., Moskal, P., Palka, M., Rudy, Z., Salabura, P., Smyrski, J., Wronska, A., Augustin, I., Lehmann, I., Nimorus, D., Schepers, G., Al-Turany, M., Arora, R., Deppe, H., Flemming, H., Gerhardt, A., Goetzen, K., Jordi, A. F., Kalicy, G., Karabowicz, R., Lehmann, D., Lewandowski, B., Luehning, J., Maas, F., Orth, H., Patsyuk, M., Peters, K., Saito, T., Schmidt, C. J., Schmitt, L., Schwarz, C., Schwiening, J., Traxler, M., Voss, B., Wieczorek, P., Wilms, A., Zuehlsdorf, M., Abazov, V. M., Alexeev, G., Arefiev, A., Astakhov, V. I., Barabanov, M. Yu., Batyunya, B. V., Davydov, Yu. I., Dodokhov, V. Kh., Efremov, A. A., Fedunov, A. G., Festchenko, A. A., Galoyan, A. S., Grigoryan, S., Karmokov, A., Koshurnikov, E. K., Lobanov, V. I., Lobanov, Yu. Yu., Makarov, A. F., Malinina, L. V., Malyshev, V. L., Mustafaev, G. A., Olshevskiy, A., Pasyuk, M. A., Perevalova, E. A., Piskun, A. A., Pocheptsov, T. A., Pontecorvo, G., Rodionov, V. K., Rogov, Yu. N., Salmin, R. A., Samartsev, A. G., Sapozhnikov, M. G., Shabratova, G. S., Skachkova, A. N., Skachkov, N. B., Strokovsky, E. A., Suleimanov, M. K., Teshev, R. Sh., Tokmenin, V. V., Uzhinsky, V. V., Vodopyanov, A. S., Zaporozhets, S. A., Zhuravlev, N. I., Zorin, A. G., Branford, D., Glazier, D., Watts, D., Woods, P., Britting, A., Eyrich, W., Lehmann, A., Uhlig, F., Dobbs, S., Metreveli, Z., Seth, K., Tomaradze, A., Xiao, T., Bettoni, D., Carassiti, V., Ramusino, A. Cotta, Dalpiaz, P., Drago, A., Fioravanti, E., Garzia, I., Savrie, M., Stancari, G., Bianchi, N., Gianotti, P., Guaraldo, C., Lucherini, V., Orecchini, D., Pace, E., Bersani, A., Bracco, G., Macri, M., Parodi, R. F., Bremer, D., Dormenev, V., Drexler, P., Dueren, M., Eissner, T., Foehl, K., Galuska, M., Gessler, T., Hayrapetyan, A., Hu, J., Koch, P., Kroeck, B., Kuehn, W., Lange, S., Liang, Y., Merle, O., Metag, V., Moritz, M., Muenchow, D., Nanova, M., Novotny, R., Spruck, B., Stenzel, H., Ullrich, T., Werner, M., Euan, C., Hoek, M., Ireland, D., Keri, T., Montgomery, R., Protopopescu, D., Rosner, G., Seitz, B., Babai, M., Glazenborg-Kluttig, A., Kavatsyuk, M., Lemmens, P., Lindemulder, M., Lohner, H., Messchendorp, J., Moeini, H., Schakel, P., Schreuder, F., Smit, H., Tambave, G., van der Weele, J. C., Veenstra, R., Sohlbach, H., Buescher, M., Deermann, D., Dosdall, R., Esch, S., Gillitzer, A., Goldenbaum, F., Grunwald, D., Henssler, S., Herten, A., Hu, Q., Kemmerling, G., Kleines, H., Kozlov, V., Lehrach, A., Maier, R., Mertens, M., Ohm, H., Orfanitski, S., Prasuhn, D., Randriamalala, T., Ritman, J., Roeder, M., Schadmand, S., Serdyuk, V., Sterzenbach, G., Stockmanns, T., Wintz, P., Wuestner, P., Kisiel, J., Li, S., Li, Z., Sun, Z., Rigato, V., Fissum, S., Hansen, K., Isaksson, L., Lundin, M., Schroder, B., Achenbach, P., Bleser, S., Cahit, U., Cardinali, M., Denig, A., Distler, M., Fritsch, M., Jasinski, P., Kangh, D., Karavdina, A., Lauth, W., Merkel, H., Michel, M., Espi, M. C. Mora, Mueller, U., Pochodzalla, J., Sanchez, S., Sanchez-Lorente, A., Schlimme, S., Sfienti, C., Thiel, M., Weber, T., Dormenev, V. I., Fedorov, A. A., Korzhik, M. V., Missevitch, O. V., Balanutsa, V., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Goryachev, V., Varentsov, V., Boukharov, A., Malyshev, O., Marishev, I., Semenov, A., Boehmer, F., Dorheim, S., Ketzer, B., Paul, S., Hergemoeller, A. K., Khoukaz, A., Koehler, E., Taeschner, A., Wessels, J., Varma, R., Chaterjee, A., Jha, V., Kailas, S., Roy, B. J., Yan, Y., Chinorat, K., Khanchai, K., Ayut, L., Pomrad, S., Baldin, E., Kotov, K., Peleganchuk, S., Tikhonov, Yu., Boucher, J., Chambert, V., Dbeyssi, A., Gumberidze, M., Hennino, T., Imre, M., Kunne, R., Le Galliard, C., Ma, B., Marchand, D., Maroni, A., Ong, S., Ramstein, B., Rosier, P., Tomasi-Gustafsson, E., De Wiele, J. Van, Boca, G., Braghieri, A., Costanza, S., Genova, P., Lavezzi, L., Montagna, P., Rotondi, A., Abramov, V., Belikov, N., Davidenko, A., Derevschikov, A., Goncharenko, Y., Grishin, V., Kachanov, V., Konstantinov, D., Kormilitsin, V., Melnik, Y., Levin, A., Minaev, N., Mochalov, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Back, T., Cederwall, B., Makonyi, K., Tegner, P. E., von Wurtemberg, K. M., Belostotski, S., Gavrilov, G., Itzotov, A., Kashchuk, A., Kisselev, A., Kravchenko, P., Levitskaya, O., Manaenkov, S., Miklukho, O., Naryshkin, Y., Veretennikov, D., Vikhrov, V., Zhadanov, A., Alberto, D., Amoroso, A., Bussa, M. P., Busso, L., De Mori, F., Destefanis, M., Fava, L., Ferrero, L., Greco, M., Maggiora, M., Marcello, S., Sosio, S., Spataro, S., Zotti, L., Calvo, D., Coli, S., De Remigis, P., Filippi, A., Giraudo, G., Lusso, S., Mazza, G., Morra, O., Rivetti, A., Wheadon, R., Iazzi, F., Lavagno, A., Younis, H., Birsa, R., Bradamante, F., Bressan, A., Martin, A., Clement, H., Galander, B., Balkeståhl, Li Caldeira, Calén, Hans, Fransson, Kjell E. I., Johansson, Tord, Kupsc, Andrzej, Marciniewski, Pawel, Thome, Erik, Wolke, Magnus, Zlomanczuk, Jozef, Diaz, J., Ortiz, A., Dmowski, K., Duda, P., Korzeniewski, R., Slowinski, B., Chlopik, A., Guzik, Z., Kosinski, K., Melnychuk, D., Wasilewski, A., Wojciechowski, M., Wronka, S., Wysocka, A., Zwieglinski, B., Buehler, P., Hartman, O. N., Kienle, P., Marton, J., Suzuki, K., Widmann, E., and Zmeskal, J.

Abstract

This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the PANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole PANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described., PANDA Collaboration, for complete list of authors see http://dx.doi.org/10.1103/10.1140/epja/i2013-13025-8

Published
2013
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22. MULTIVARIATE ANALYSIS OF RISK FACTORS IN STAGE IV NEUROBLASTOMA PATIENTS OVER THE AGE OF ONE YEAR TREATED WITH MEGATHERAPY AND STEM CELL TRANSPLANTATION: A REPORT FROM THE EUROPEAN BONE MARROW TRANSPLANTATION SOLID TUMOR REGISTRY

Author

Ladenstein, R., Philip, T., Lasset, C., Hartman, O., Garaventa, A., Pinkerton, R., Michon, J., Pritchard, J., Klingebiel, T., Kremens, B., Pearson, A., and Paolucci, Paolo

Subjects
stage 4 neuroblastoma, MULTIVARIATE ANALYSIS OF RISK FACTORS, myeloablative megatherapy, stem-cell transplantation
Published
1998

23. Technical design report for the $\overline{P}$ ANDA (AntiProton Annihilations at Darmstadt) Straw Tube Tracker

Author

Erni, W., primary, Keshelashvili, I., additional, Krusche, B., additional, Steinacher, M., additional, Heng, Y., additional, Liu, Z., additional, Liu, H., additional, Shen, X., additional, Wang, Q., additional, Xu, H., additional, Aab, A., additional, Albrecht, M., additional, Becker, J., additional, Csapó, A., additional, Feldbauer, F., additional, Fink, M., additional, Friedel, P., additional, Heinsius, F. H., additional, Held, T., additional, Klask, L., additional, Koch, H., additional, Kopf, B., additional, Leiber, S., additional, Leyhe, M., additional, Motzko, C., additional, Pelizäus, M., additional, Pychy, J., additional, Roth, B., additional, Schröder, T., additional, Schulze, J., additional, Sowa, C., additional, Steinke, M., additional, Trifterer, T., additional, Wiedner, U., additional, Zhong, J., additional, Beck, R., additional, Bianco, S., additional, Brinkmann, K. T., additional, Hammann, C., additional, Hinterberger, F., additional, Kaiser, D., additional, Kliemt, R., additional, Kube, M., additional, Pitka, A., additional, Quagli, T., additional, Schmidt, C., additional, Schmitz, R., additional, Schnell, R., additional, Thoma, U., additional, Vlasov, P., additional, Walther, D., additional, Wendel, C., additional, Würschig, T., additional, Zaunick, H. G., additional, Bianconi, A., additional, Bragadireanu, M., additional, Caprini, M., additional, Pantea, D., additional, Pantelica, D., additional, Pietreanu, D., additional, Serbina, L., additional, Tarta, P. D., additional, Kaplan, D., additional, Fiutowski, T., additional, Idzik, M., additional, Mindur, B., additional, Przyborowski, D., additional, Swientek, K., additional, Czech, B., additional, Kistryn, M., additional, Kliczewski, S., additional, Kozela, A., additional, Kulessa, P., additional, Lebiedowicz, P., additional, Pysz, K., additional, Schäfer, W., additional, Siudak, R., additional, Szczurek, A., additional, Jowzaee, S., additional, Kajetanowicz, M., additional, Kamys, B., additional, Kistryn, S., additional, Korcyl, G., additional, Korcyl, K., additional, Krzemien, W., additional, Magiera, A., additional, Moskal, P., additional, Palka, M., additional, Rudy, Z., additional, Salabura, P., additional, Smyrski, J., additional, Wrońska, A., additional, Augustin, I., additional, Lehmann, I., additional, Nimorus, D., additional, Schepers, G., additional, Al-Turany, M., additional, Arora, R., additional, Deppe, H., additional, Flemming, H., additional, Gerhardt, A., additional, Götzen, K., additional, Jordi, A. F., additional, Kalicy, G., additional, Karabowicz, R., additional, Lehmann, D., additional, Lewandowski, B., additional, Lühning, J., additional, Maas, F., additional, Orth, H., additional, Patsyuk, M., additional, Peters, K., additional, Saito, T., additional, Schmidt, C. J., additional, Schmitt, L., additional, Schwarz, C., additional, Schwiening, J., additional, Traxler, M., additional, Voss, B., additional, Wieczorek, P., additional, Wilms, A., additional, Zühlsdorf, M., additional, Abazov, V. M., additional, Alexeev, G., additional, Arefiev, A., additional, Astakhov, V. I., additional, Barabanov, M. Yu., additional, Batyunya, B. V., additional, Davydov, Yu. I., additional, Dodokhov, V. Kh., additional, Efremov, A. A., additional, Fedunov, A. G., additional, Festchenko, A. A., additional, Galoyan, A. S., additional, Grigoryan, S., additional, Karmokov, A., additional, Koshurnikov, E. K., additional, Lobanov, V. I., additional, Lobanov, Yu. Yu., additional, Makarov, A. F., additional, Malinina, L. V., additional, Malyshev, V. L., additional, Mustafaev, G. A., additional, Olshevskiy, A., additional, Pasyuk, M. A., additional, Perevalova, E. A., additional, Piskun, A. A., additional, Pocheptsov, T. A., additional, Pontecorvo, G., additional, Rodionov, V. K., additional, Rogov, Yu. N., additional, Salmin, R. A., additional, Samartsev, A. G., additional, Sapozhnikov, M. G., additional, Shabratova, G. S., additional, Skachkova, A. N., additional, Skachkov, N. B., additional, Strokovsky, E. A., additional, Suleimanov, M. K., additional, Teshev, R. Sh., additional, Tokmenin, V. V., additional, Uzhinsky, V. V., additional, Vodopyanov, A. S., additional, Zaporozhets, S. A., additional, Zhuravlev, N. I., additional, Zorin, A. G., additional, Branford, D., additional, Glazier, D., additional, Watts, D., additional, Woods, P., additional, Britting, A., additional, Eyrich, W., additional, Lehmann, A., additional, Uhlig, F., additional, Dobbs, S., additional, Metreveli, Z., additional, Seth, K., additional, Tomaradze, A., additional, Xiao, T., additional, Bettoni, D., additional, Carassiti, V., additional, Cotta Ramusino, A., additional, Dalpiaz, P., additional, Drago, A., additional, Fioravanti, E., additional, Garzia, I., additional, Savriè, M., additional, Stancari, G., additional, Bianchi, N., additional, Gianotti, P., additional, Guaraldo, C., additional, Lucherini, V., additional, Orecchini, D., additional, Pace, E., additional, Bersani, A., additional, Bracco, G., additional, Macri, M., additional, Parodi, R. F., additional, Bremer, D., additional, Dormenev, V., additional, Drexler, P., additional, Düren, M., additional, Eissner, T., additional, Föhl, K., additional, Galuska, M., additional, Gessler, T., additional, Hayrapetyan, A., additional, Hu, J., additional, Koch, P., additional, Kröck, B., additional, Kühn, W., additional, Lange, S., additional, Liang, Y., additional, Merle, O., additional, Metag, V., additional, Moritz, M., additional, Münchow, D., additional, Nanova, M., additional, Novotny, R., additional, Spruck, B., additional, Stenzel, H., additional, Ullrich, T., additional, Werner, M., additional, Euan, C., additional, Hoek, M., additional, Ireland, D., additional, Keri, T., additional, Montgomery, R., additional, Protopopescu, D., additional, Rosner, G., additional, Seitz, B., additional, Babai, M., additional, Glazenborg-Kluttig, A., additional, Kavatsyuk, M., additional, Lemmens, P., additional, Lindemulder, M., additional, Löhner, H., additional, Messchendorp, J., additional, Moeini, H., additional, Schakel, P., additional, Schreuder, F., additional, Smit, H., additional, Tambave, G., additional, van der Weele, J. C., additional, Veenstra, R., additional, Sohlbach, H., additional, Büscher, M., additional, Deermann, D., additional, Dosdall, R., additional, Esch, S., additional, Gillitzer, A., additional, Goldenbaum, F., additional, Grunwald, D., additional, Henssler, S., additional, Herten, A., additional, Hu, Q., additional, Kemmerling, G., additional, Kleines, H., additional, Kozlov, V., additional, Lehrach, A., additional, Maier, R., additional, Mertens, M., additional, Ohm, H., additional, Orfanitski, S., additional, Prasuhn, D., additional, Randriamalala, T., additional, Ritman, J., additional, Röder, M., additional, Schadmand, S., additional, Serdyuk, V., additional, Sterzenbach, G., additional, Stockmanns, T., additional, Wintz, P., additional, Wüstner, P., additional, Kisiel, J., additional, Li, S., additional, Li, Z., additional, Sun, Z., additional, Rigato, V., additional, Fissum, S., additional, Hansen, K., additional, Isaksson, L., additional, Lundin, M., additional, Schröder, B., additional, Achenbach, P., additional, Bleser, S., additional, Cahit, U., additional, Cardinali, M., additional, Denig, A., additional, Distler, M., additional, Fritsch, M., additional, Jasinski, P., additional, Kangh, D., additional, Karavdina, A., additional, Lauth, W., additional, Merkel, H., additional, Michel, M., additional, Mora Espi, M. C., additional, Müller, U., additional, Pochodzalla, J., additional, Sanchez, S., additional, Sanchez-Lorente, A., additional, Schlimme, S., additional, Sfienti, C., additional, Thiel, M., additional, Weber, T., additional, Dormenev, V. I., additional, Fedorov, A. A., additional, Korzhik, M. V., additional, Missevitch, O. V., additional, Balanutsa, V., additional, Chernetsky, V., additional, Demekhin, A., additional, Dolgolenko, A., additional, Fedorets, P., additional, Gerasimov, A., additional, Goryachev, V., additional, Varentsov, V., additional, Boukharov, A., additional, Malyshev, O., additional, Marishev, I., additional, Semenov, A., additional, Böhmer, F., additional, Dørheim, S., additional, Ketzer, B., additional, Paul, S., additional, Hergemöller, A. K., additional, Khoukaz, A., additional, Köhler, E., additional, Täschner, A., additional, Wessels, J., additional, Varma, R., additional, Chaterjee, A., additional, Jha, V., additional, Kailas, S., additional, Roy, B. J., additional, Yan, Y., additional, Chinorat, K., additional, Khanchai, K., additional, Ayut, L., additional, Pomrad, S., additional, Baldin, E., additional, Kotov, K., additional, Peleganchuk, S., additional, Tikhonov, Yu., additional, Boucher, J., additional, Chambert, V., additional, Dbeyssi, A., additional, Gumberidze, M., additional, Hennino, T., additional, Imre, M., additional, Kunne, R., additional, Le Galliard, C., additional, Ma, B., additional, Marchand, D., additional, Maroni, A., additional, Ong, S., additional, Ramstein, B., additional, Rosier, P., additional, Tomasi-Gustafsson, E., additional, Van de Wiele, J., additional, Boca, G., additional, Braghieri, A., additional, Costanza, S., additional, Genova, P., additional, Lavezzi, L., additional, Montagna, P., additional, Rotondi, A., additional, Abramov, V., additional, Belikov, N., additional, Davidenko, A., additional, Derevschikov, A., additional, Goncharenko, Y., additional, Grishin, V., additional, Kachanov, V., additional, Konstantinov, D., additional, Kormilitsin, V., additional, Melnik, Y., additional, Levin, A., additional, Minaev, N., additional, Mochalov, V., additional, Morozov, D., additional, Nogach, L., additional, Poslavskiy, S., additional, Ryazantsev, A., additional, Ryzhikov, S., additional, Semenov, P., additional, Shein, I., additional, Uzunian, A., additional, Vasiliev, A., additional, Yakutin, A., additional, Bäck, T., additional, Cederwall, B., additional, Makónyi, K., additional, Tegnér, P. E., additional, von Würtemberg, K. M., additional, Belostotski, S., additional, Gavrilov, G., additional, Itzotov, A., additional, Kashchuk, A., additional, Kisselev, A., additional, Kravchenko, P., additional, Levitskaya, O., additional, Manaenkov, S., additional, Miklukho, O., additional, Naryshkin, Y., additional, Veretennikov, D., additional, Vikhrov, V., additional, Zhadanov, A., additional, Alberto, D., additional, Amoroso, A., additional, Bussa, M. P., additional, Busso, L., additional, De Mori, F., additional, Destefanis, M., additional, Fava, L., additional, Ferrero, L., additional, Greco, M., additional, Maggiora, M., additional, Marcello, S., additional, Sosio, S., additional, Spataro, S., additional, Zotti, L., additional, Calvo, D., additional, Coli, S., additional, De Remigis, P., additional, Filippi, A., additional, Giraudo, G., additional, Lusso, S., additional, Mazza, G., additional, Morra, O., additional, Rivetti, A., additional, Wheadon, R., additional, Iazzi, F., additional, Lavagno, A., additional, Younis, H., additional, Birsa, R., additional, Bradamante, F., additional, Bressan, A., additional, Martin, A., additional, Clement, H., additional, Galander, B., additional, Caldeira Balkeståhl, L., additional, Calén, H., additional, Fransson, K., additional, Johansson, T., additional, Kupsc, A., additional, Marciniewski, P., additional, Thomé, E., additional, Wolke, M., additional, Zlomanczuk, J., additional, Díaz, J., additional, Ortiz, A., additional, Dmowski, K., additional, Duda, P., additional, Korzeniewski, R., additional, Slowinski, B., additional, Chlopik, A., additional, Guzik, Z., additional, Kosinski, K., additional, Melnychuk, D., additional, Wasilewski, A., additional, Wojciechowski, M., additional, Wronka, S., additional, Wysocka, A., additional, Zwieglinski, B., additional, Bühler, P., additional, Hartman, O. N., additional, Kienle, P., additional, Marton, J., additional, Suzuki, K., additional, Widmann, E., additional, and Zmeskal, J., additional

Published
2013
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27. Lees frequent catheter dressing changes decrease local cutaneous toxicity of high-dose chemotherapy in children, without increasing the rate of catheter-related infections: results of a randomised trial.

Author

Benhamou, E., Fessard, E., Com-Nougue, C., Beaussier, P.S., Nitenberg, G., Tancrede, C., Dodeman, S., and Hartman, O.

Subjects
CATHETERIZATION, BONE marrow transplantation, DRUG therapy, CHILDREN
Abstract

Presents information on a study which undertook a randomized controlled trial in children hospitalized in the Paediatric Bone Marrow Transplantation unit at the Gustave Roussy Institute in France to compare the efficacy of catheter dressing change frequencies in preventing skin toxicity at the catheter dressing site and its periphery. Methodology of the study; Results and discussion.

Published
2002
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28. Red leaf blotch {Dactuliochaeta glycines) of soybeans (Glycine max) and its relationship to yield.

Author

Hartman, O. L. and Sinclair, J. B.

Subjects
*PLANT diseases, *PESTICIDES, *WOOD preservatives, *CULTIVARS, *ACETIC acid, *LEAVES
Abstract

Red leaf blotch of soybeans, caused by Daetuliochaeta glycines was evaluated. on soybean plants in field plots located in Zambia, Two experiments were conducted in each of two seasons. Experiment 1 had four cultivars that were either fungicide-sprayed or not sprayed. Disease severity was greatest on leaves at the lowest nodes from early vegetative through the reproductive growth stages. Area under the disease progress curve (AUDPC) values and percentage of nodes defoliated at growth stage R5 were significantly (P = 0.05) greater in unsprayed plots for all cultivars in both seasons. Yield losses ranged from 8 to 37% while reduced seed size ranged from 21 to 29% for the four cultivars. Number of pods per plant in fungicide-sprayed plots did not differ from those in unsprayed plots. However, the number of seeds per plant and seeds per pod were significantly (P = 0.05) greater in sprayed than unsprayed plots for some cultivars. In experiment 2, cultivar Tunia was either fungicide-sprayed at different times or not sprayed. The lowest attached leaf had the most variation in the amount of disease while ratings of the most median leaf in the canopy were generally less variable. The AUDPC values calculated from the lowest attached leaf, the mean of all attached leaves, and the median attached leaf differed significantly (P = 0.05) the number of times plants were sprayed with fungicide. Defoliation and vertical incidence of red leaf blotch from lower to higher nodes were significantly (P = 0.05) reduced in fungicide-sprayed plots in one season, but not the other. One thousand-seed weight and yield differed significantly (P = 0.05) with treatment as one application of triphenyltin acetate increased yields by 18% over unsprayed plots in season 1. One thousand-seed weight and yield, regressed on the AUDPC for the median leaf in the canopy, explained 92 and 72% of the variation, respectively. [ABSTRACT FROM AUTHOR]

Published
1996
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33. The effect of hydroxychloroquine on cholesterol metabolism in statin treated patients after myocardial infarction.

Author

Ulander L, Simonen P, Tolppanen H, Hartman O, Rissanen TT, Eklund KK, Kalaoja M, Kurkela M, Neuvonen M, Niemi M, Backman JT, Gylling H, and Sinisalo J

Abstract

Background and Aims: To evaluate the effect of hydroxychloroquine (HCQ) on serum and lipoprotein lipids and serum biomarkers of cholesterol synthesis and absorption in myocardial infarction patients with a high-dose statin., Methods: Myocardial infarction patients (n = 59) with a constant statin dose were randomized to receive hydroxychloroquine 300 mg (n = 31) or placebo (n = 28) daily for six months and followed up for one year., Results: Statin reduced total-c (-26 ± 22% in hydroxychloroquine and -28 ± 19% in placebo group, P = 0.931), LDL-c (-38 ± 26% vs. -44 ± 23%, respectively, P = 0.299), and cholesterol synthesis biomarkers zymostenol, desmosterol, and lathosterol ratios from baseline to one year (e.g., serum lathosterol ratio -17 ± 45% vs. -15 ± 41%, respectively, P < 0.001 for both, P = 0.623 between groups). Compensatorily, cholesterol absorption increased during the intervention (e.g., serum campesterol ratio 125 ± 90% vs. 113 ± 72%, respectively, P < 0.001 for both, P = 0.488 between groups). Hydroxychloroquine did not affect cholesterol concentrations or cholesterol absorption. It prevented the statin-induced increase in cholesterol precursor, desmosterol ratio, from six months to one year in the hydroxychloroquine group (P = 0.007 at one year compared to placebo)., Conclusions: Combined with a high-dose statin, hydroxychloroquine had no additional effect on serum cholesterol concentration or cholesterol absorption. However, the findings suggest that hydroxychloroquine interferes with lanosterol synthesis, and thereafter, it temporarily interferes with the cholesterol synthesis pathway, best seen in halting the increase of the desmosterol ratio.Trial Registration ClinicalTrials.gov Identifier: NCT02648464., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)

Published
2023
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34. Hydroxychloroquine reduces interleukin-6 levels after myocardial infarction: The randomized, double-blind, placebo-controlled OXI pilot trial.

Author

Ulander L, Tolppanen H, Hartman O, Rissanen TT, Paakkanen R, Kuusisto J, Anttonen O, Nieminen T, Yrjölä J, Ryysy R, Drews T, Utriainen S, Karjalainen P, Anttila I, Nurmi K, Silventoinen K, Koskinen M, Kovanen PT, Lehtonen J, Eklund KK, and Sinisalo J

Subjects
Double-Blind Method, Humans, Hydroxychloroquine, Pilot Projects, Treatment Outcome, Interleukin-6, Myocardial Infarction diagnosis, Myocardial Infarction drug therapy
Abstract

Objectives: To determine the anti-inflammatory effect and safety of hydroxychloroquine after acute myocardial infarction., Method: In this multicenter, double-blind, placebo-controlled OXI trial, 125 myocardial infarction patients were randomized at a median of 43 h after hospitalization to receive hydroxychloroquine 300 mg (n = 64) or placebo (n = 61) once daily for 6 months and, followed for an average of 32 months. Laboratory values were measured at baseline, 1, 6, and 12 months., Results: The levels of interleukin-6 (IL-6) were comparable at baseline between study groups (p = 0.18). At six months, the IL-6 levels were lower in the hydroxychloroquine group (p = 0.042, between groups), and in the on-treatment analysis, the difference at this time point was even more pronounced (p = 0.019, respectively). The high-sensitivity C-reactive protein levels did not differ significantly between study groups at any time points. Eleven patients in the hydroxychloroquine group and four in the placebo group had adverse events leading to interruption or withdrawal of study medication, none of which was serious (p = 0.10, between groups)., Conclusions: In patients with myocardial infarction, hydroxychloroquine reduced IL-6 levels significantly more than did placebo without causing any clinically significant adverse events. A larger randomized clinical trial is warranted to prove the potential ability of hydroxychloroquine to reduce cardiovascular endpoints after myocardial infarction., Competing Interests: Declaration of Competing Interest JS reports personal fees from Abbott, Amgen, and Bayer and a grant from AstraZeneca. PTK reports personal fees from Amgen, Novartis, Raisio Group, and Sanofi., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2021
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35. Hydroxychloroquine for the prevention of recurrent cardiovascular events in myocardial infarction patients: rationale and design of the OXI trial.

Author

Hartman O, Kovanen PT, Lehtonen J, Eklund KK, and Sinisalo J

Subjects
Antirheumatic Agents therapeutic use, Atherosclerosis etiology, Double-Blind Method, Humans, Pilot Projects, Recurrence, Atherosclerosis prevention & control, Hydroxychloroquine therapeutic use, Myocardial Infarction complications, Secondary Prevention methods
Abstract

Background: Inflammation of the arterial wall plays a central role in the pathogenesis of atherosclerosis. Among patients with rheumatic diseases, anti-rheumatic medication reduces the incidence of cardiovascular (CV) diseases, but only few studies have addressed their cardioprotective effects on patients with no rheumatic diseases. Hydroxychloroquine (HCQ) is an anti-rheumatic drug commonly used in the treatment of rheumatoid arthritis and systemic lupus erythematosus. In addition to its anti-inflammatory properties, HCQ reduces cholesterol levels and the risk of type II diabetes, and has also anti-platelet effects., Design: The OXI trial is an event-driven trial that will randomize 2500 patients hospitalized for myocardial infarction (MI). Participants will receive active HCQ or placebo for at least 12 months, and until 350 CV events are confirmed. The primary trial endpoint is the composite of death, MI, hospitalization for unstable angina, urgent percutaneous coronary intervention, and urgent coronary artery bypass grafting. Secondary trial endpoints are the primary end point plus stroke, the effect of HCQ treatment on lipids, on the incidence of Type 2 diabetes, on the level of haemoglobin A1c, and on inflammatory parameters. A 6 months placebo-controlled safety pilot trial with 200 patients is currently ongoing to assess the safety of HCQ in the setting of MI., Summary: The OXI trial will determine whether treatment with HCQ, as compared with placebo, will reduce recurrent CV events among MI patients. If positive, then the OXI trial would provide an entirely novel multitarget approach for the secondary prevention of atherosclerotic cardiovascular diseases (ACVD)., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For Permissions, please email: journals.permissions@oup.com.)

Published
2017
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37. Bottom-up synthesis of anatase nanoparticles with graphene domains.

Author

Mogilevsky G, Hartman O, Emmons ED, Balboa A, DeCoste JB, Schindler BJ, Iordanov I, and Karwacki CJ

Abstract

Using alizarin and titanium isopropoxide, we have succeeded in preparing a hybrid form of nanostructured graphene-TiO2 following a bottom-up synthetic approach. This novel graphene-based composite offers a practical alternative to synthesizing photocatalytically active materials with maximized graphene-TiO2 interface. The molecular precursor alizarin was chosen because it efficiently binds to TiO2 through the hydroxyl groups and already possesses the graphene building block through its anthracene basis. XPS and Raman spectroscopy proved that the calcined material contained majority sp(2)-hybridized carbon that formed graphene-like clusters. XRD data showed the integrated structures maintained their anatase crystallography, therefore preserving the material's properties without going through phase transitions to rutile. The enhanced graphene and TiO2 interface was confirmed using DFT computational techniques. The photocatalytic activity of the graphene-TiO2 materials was demonstrated through degradation of methylene blue.

Published
2014
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38. Review of MPH practicum requirements in accredited schools of public health.

Author

Oglesby WH, Alemagno SA, Zullo MD, Hartman O, Smith K, Smith J, and Buzzelli M

Subjects
Curriculum standards, Curriculum statistics & numerical data, Data Collection, Humans, Program Evaluation, Public Health education, Schools, Public Health organization & administration, Schools, Public Health statistics & numerical data, United States, Accreditation standards, Schools, Public Health standards
Abstract

Accreditation criteria by the Council on Education for Public Health (CEPH) state that prior to graduation, Masters of Public Health (MPH) students must demonstrate the application of knowledge and skills through a practice experience, commonly called the "Practicum." The purpose of this research was to review those MPH Practicum requirements. Practicum guidelines from US-based schools of public health that were accredited as of October 2011 were reviewed. Data on each Practicum's level of coordination, timing, and credit and contact hours as well as information about written agreements, preceptors, and how the Practicum was graded were collected. Seventy-four Practicums in 46 accredited schools of public health were reviewed. The majority (85 %) of accredited schools controlled the Practicum at the school-level. Among the Practicums reviewed, most did not require completion of any credit hours or the MPH core courses (57 and 74 %, respectively) prior to starting the Practicum; 82 % required written agreements; 60 % had stated criteria for the approval of preceptors; and 76 % required students to submit a product for grading at the conclusion of the Practicum. The results of this research demonstrate that the majority of accredited schools of public health designed Practicum requirements that reflect some of the criteria established by CEPH; however, issues related to timing, credit and contact hours, and preceptor qualifications vary considerably. We propose that a national dialogue begin among public health faculty and administrators to address these and other findings to standardize the Practicum experience for MPH students.

Published
2013
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39. Biofunctionalization of electrospun PCL-based scaffolds with perlecan domain IV peptide to create a 3-D pharmacokinetic cancer model.

Author

Hartman O, Zhang C, Adams EL, Farach-Carson MC, Petrelli NJ, Chase BD, and Rabolt JF

Subjects
Biocompatible Materials metabolism, Bone Marrow anatomy & histology, Bone Marrow metabolism, Cadherins metabolism, Cell Adhesion, Cell Line, Tumor, Cell Proliferation, Focal Adhesion Protein-Tyrosine Kinases metabolism, Gelatin chemistry, Humans, Male, Models, Biological, Molecular Structure, Neoplasm Metastasis, Porosity, Prostatic Neoplasms metabolism, Tight Junctions metabolism, Electrochemical Techniques, Heparan Sulfate Proteoglycans chemistry, Peptides chemistry, Polyesters chemistry, Prostatic Neoplasms pathology, Tissue Scaffolds chemistry
Abstract

Because prostate cancer cells metastasize to bone and exhibit osteoblastic features (osteomimicry), the interrelationships between bone-specific microenvironment and prostate cancer cells at sites of bone metastasis are critical to disease progression. In this work the bone marrow microenvironment in vitro was recreated both by tailoring scaffolds physical properties and by functionalizing electrospun polymer fibers with a bioactive peptide derived from domain IV of perlecan heparan sulfate proteoglycan. Electrospun poly (epsilon-caprolactone) (PCL) fibers and PCL/gelatin composite scaffolds were modified covalently with perlecan domain IV (PlnDIV) peptide. The expression of tight junction protein (E-cadherin) and focal adhesion kinase (FAK) phosphorylation on tyrosine 397 also were investigated. The described bioactive motif significantly enhanced adherence and infiltration of the metastatic prostate cancer cells on all modified electrospun substrates by day 5 post-seeding. Cells cultured on PlnDIV-modified matrices organized stress fibers and increased proliferation at statistically significant rates. Additional findings suggest that presence of PlnDIV peptide in the matrix reduced expression of tight junction protein and binding to PlnDIV peptide was accompanied by increased focal adhesion kinase (FAK) phosphorylation on tyrosine 397. We conclude that PlnDIV peptide supports key signaling events leading to proliferation, survival, and migration of C4-2B cancer cells; hence its incorporation into electrospun matrix is a key improvement to create a successful three-dimensional (3-D) pharmacokinetic cancer model., (Copyright (c) 2010 Elsevier Ltd. All rights reserved.)

Published
2010
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40. Microfabricated electrospun collagen membranes for 3-D cancer models and drug screening applications.

Author

Hartman O, Zhang C, Adams EL, Farach-Carson MC, Petrelli NJ, Chase BD, and Rabolt JF

Subjects
Apoptosis drug effects, Biomimetic Materials, Bone Neoplasms secondary, Cell Culture Techniques, Humans, Male, Microscopy, Atomic Force, Microspheres, Prostatic Neoplasms pathology, Tissue Engineering, Tumor Cells, Cultured, Antineoplastic Agents pharmacology, Bone Neoplasms drug therapy, Collagen chemistry, Extracellular Matrix chemistry, Membranes, Artificial, Models, Anatomic, Prostatic Neoplasms drug therapy
Abstract

Invasive epithelial tumors form from cells that are released from their natural basement membrane and form 3-D structures that interact with each other and with the microenvironment of the stromal tissues around the tumor, which often contains collagen. Cancer cells, growing as monolayers on tissue culture plastic, do not reflect many of the properties of whole tumors. This shortcoming limits their ability to serve as models for testing of pharmacologically active compounds, including those that are being tested as antineoplastics. This work seeks to create new 3-D cellular materials possessing properties similar to those in native tissues surrounding cancers, specifically electrospun micro- and nanofibrous collagen scaffolds that support tumor growth in 3-D. We hypothesize that a 3-D culture system will provide a better replica of tumor growth in a native environment and, thus, better report the bioactivity of antineoplastic agents. In addition, we optimized conditions and identified physical characteristics that support growth of the highly invasive, prostate cancer bone metastatic cell line C4-2B on these matrices for use in anticancer drug studies. The effects of matrix porosity, fiber diameter, elasticity, and surface roughness on growth of cancer cells were evaluated. Data indicates that while cells attach and grow well on both nano- and microfibrous electrospun membranes, the microfibrous membrane represented a better approximation of the tumor microenvironment. It was also observed that C4-2B nonadherent cells migrated through the depth of two electrospun membranes and formed colonies resembling tumors on day 3. An apoptosis study revealed that cells on electrospun substrates were more resistant to both antineoplastic agents, docetaxel (DOC), and camptothecin (CAM) compared to the cells grown on standard collagen-coated tissue culture polystyrene (TCP). Growth, survival, and apoptosis were measured, as well as the differences in the apoptotic capabilities, of the two above-mentioned compounds compared to known clinical performance. We conclude that 3-D electrospun membranes are amenable to high throughput screening for cancer cell susceptibility and combination killing (Banerjee, S.; Hussain, M.; Wang, Z.; Saliganan, A.; Che, M.; Bonfil, D.; Cher, M.; Sarkar, F.H. Cancer Research, 2007, 67 (8), 3818-26).

Published
2009
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41. Radiation dose, chemotherapy and risk of soft tissue sarcoma after solid tumours during childhood.

Author

Menu-Branthomme A, Rubino C, Shamsaldin A, Hawkins MM, Grimaud E, Dondon MG, Hardiman C, Vassal G, Campbell S, Panis X, Daly-Schveitzer N, Lagrange JL, Zucker JM, Chavaudra J, Hartman O, and de Vathaire F

Subjects
Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Cohort Studies, Combined Modality Therapy, Humans, Middle Aged, Risk, Antineoplastic Agents adverse effects, Neoplasms therapy, Neoplasms, Second Primary etiology, Radiotherapy Dosage, Sarcoma etiology
Abstract

Soft tissue sarcoma (STS) is one of the most frequent second primary cancer that occurs during the first 20 years following treatment for a solid cancer in childhood. Our aim was to quantify the risk of STS as a second malignant neoplasm and to investigate its relationship with radiotherapy and chemotherapy. A cohort study of 4,400 3-year survivors of a first solid cancer diagnosed during childhood in France or the United Kingdom, between 1942 and 1985, was followed 15 years on average. In a partially nested case-control study, we matched 25 cases of STS and 121 controls for sex, type of first cancer, age at first cancer and duration of follow-up. Sixteen STS occurred in the cohort, as compared to 0.3 expected from the general population (Standardized Incidence Radio, SIR = 54 (95%CI: 34-89)). The SIR was 113 (95% CI: 62-185) after chemotherapy plus radiotherapy (13 STS), whereas it was 28 (95%CI: 2-125) after chemotherapy alone (1 STS) and 19 (95%CI: 3-60) after radiotherapy alone (2 STS). After adjustment for treatment, there was no evidence of variation in the annual excess of incidence or in the SIR with either age at first cancer or time since 1st cancer. In the case-control study, the risk of a STS was increased with the square of the dose of radiation to the site of STS development and with the administration of Procarbazine. The increased risk of soft tissue sarcoma that occurred after childhood cancer is independently related to exposure to radiotherapy and Procarbazine. A closer surveillance of children treated with this treatment combination is strongly recommended., (Copyright 2004 Wiley-Liss, Inc.)

Published
2004
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42. [Prophylaxis of Gram-positive infections after bone marrow graft. Controlled study of the 6-day administration of vancomycin. Intermediate analysis of 60 patients].

Author

Maraninchi D, Hartman O, Benhamou E, Viens P, Blaise D, Vassal G, Gaspard MH, Kalifa C, Stoppa AM, and Patte C

Subjects
Adolescent, Child, Child, Preschool, Drug Administration Schedule, Gram-Positive Bacteria, Humans, Infant, Infant, Newborn, Sepsis etiology, Bacterial Infections prevention & control, Bone Marrow Transplantation, Postoperative Complications prevention & control, Premedication, Vancomycin administration & dosage
Abstract

We prospectively evaluated after randomization in 60 consecutive recipients of bone marrow transplantation the efficiency of a short administration of vancomycin (10 mg/kg I.V. q 6 H, day -5 to +1). Thirty-three patients were randomized as controls and 27 were designed to receive vancomycin. Both groups were similar in terms of age, diagnosis, status, allogeneic or autologous graft, in vitro marrow treatment or not. Eighteen patients (30%) experienced bacteremias: 15/18 bacteremias were due to Gram positive organisms, including 11 streptococci. These infections occurred with a similar frequency in both groups, the relatively low incidence of bacteremias in this study needs further evaluation in new patients to insure the prophylactic effects of a course of vancomycin in bone marrow transplant recipients.

Published
1988

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