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1. COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

Author

McDonnell, John, Cousins, Kimberley, Younger, M. Elizabeth M., Lane, Adam, Abolhassani, Hassan, Abraham, Roshini S., Al-Tamemi, Salem, Aldave-Becerra, Juan Carlos, Al-Faris, Eman Hesham, Alfaro-Murillo, Alberto, AlKhater, Suzan A., Alsaati, Nouf, Doss, Alexa Michelle Altman, Anderson, Melissa, Angarola, Ernestina, Ariue, Barbara, Arnold, Danielle E., Assa’ad, Amal H., Aytekin, Caner, Bank, Meaghan, Bergerson, Jenna R. E., Bleesing, Jack, Boesing, John, Bouso, Carolina, Brodszki, Nicholas, Cabanillas, Diana, Cady, Carol, Callahan, Meghan A., Caorsi, Roberta, Carbone, Javier, Carrabba, Maria, Castagnoli, Riccardo, Catanzaro, Jason R., Chan, Samantha, Chandra, Sharat, Chapdelaine, Hugo, Chavoshzadeh, Zahra, Chong, Hey Jin, Connors, Lori, Consonni, Filippo, Correa-Jimenez, Oscar, Cunningham-Rundles, Charlotte, D’Astous-Gauthier, Katherine, Delmonte, Ottavia Maria, Demirdag, Yesim Yilmaz, Deshpande, Deepti R., Diaz-Cabrera, Natalie M., Dimitriades, Victoria R., El-Owaidy, Rasha, ElGhazali, Gehad, Al-Hammadi, Suleiman, Fabio, Giovanna, Faure, Astrid Schellnast, Feng, Jin, Fernandez, James M., Fill, Lauren, Franco, Guacira R., Frenck, Robert W., Fuleihan, Ramsay L., Giardino, Giuliana, Galant-Swafford, Jessica, Gambineri, Eleonora, Garabedian, Elizabeth K., Geerlinks, Ashley V., Goudouris, Ekaterini, Grecco, Octavio, Pan-Hammarström, Qiang, Khani, Hedieh Haji Khodaverdi, Hammarström, Lennart, Hartog, Nicholas L., Heimall, Jennifer, Hernandez-Molina, Gabriela, Horner, Caroline C., Hostoffer, Robert W., Hristova, Nataliya, Hsiao, Kuang-Chih, Ivankovich-Escoto, Gabriela, Jaber, Faris, Jalil, Maaz, Jamee, Mahnaz, Jean, Tiffany, Jeong, Stephanie, Jhaveri, Devi, Jordan, Michael B., Joshi, Avni Y., Kalkat, Amanpreet, Kanarek, Henry J., Kellner, Erinn S., Khojah, Amer, Khoury, Ruby, Kokron, Cristina M., Kumar, Ashish, Lecerf, Kelsey, Lehman, Heather K., Leiding, Jennifer W., Lesmana, Harry, Lim, Xin Rong, Lopes, Joao Pedro, López, Ana Laura, Tarquini, Lucia, Lundgren, Ingrid S., Magnusson, Julieann, Marinho, Ana Karolina B. B., Marseglia, Gian Luigi, Martone, Giulia M., Mechtler, Annamaria G., Mendonca, Leonardo, Milner, Joshua D., Mustillo, Peter J., Naderi, Asal Gharib, Naviglio, Samuele, Nell, Jeremy, Niebur, Hana B., Notarangelo, Luigi, Oleastro, Matias, Ortega-López, María Claudia, Patel, Neil R., Petrovic, Gordana, Pignata, Claudio, Porras, Oscar, Prince, Benjamin T., Puck, Jennifer M., Qamar, Nashmia, Rabusin, Marco, Raje, Nikita, Regairaz, Lorena, Risma, Kimberly A., Ristagno, Elizabeth H., Routes, John, Roxo-Junior, Persio, Salemi, Negin, Scalchunes, Christopher, Schuval, Susan J., Seneviratne, Suranjith L., Shankar, Ashwin, Sherkat, Roya, Shin, Junghee Jenny, Siddiqi, Abeer, Signa, Sara, Sobh, Ali, Lima, Fabiana Mascarenhas Souza, Stenehjem, Kristen K., Tam, Jonathan S., Tang, Monica, Barros, Myrthes Toledo, Verbsky, James, Vergadi, Eleni, Voelker, Dayne H., Volpi, Stefano, Wall, Luke A., Wang, Christine, Williams, Kelli W., Wu, Eveline Y., Wu, Shan Shan, Zhou, Jessie J., Cook, Alexandria, Sullivan, Kathleen E., and Marsh, Rebecca

Published
2024
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2. A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology

Author

Lieberman, Jay A., Chu, Derek K., Ahmed, Tasnuva, Dribin, Timothy E., Abrams, Elissa M., Anagnostou, Aikaterini, Blumenthal, Kimberly G., Boguniewicz, Mark, Chase, Nicole M., Golden, David B.K., Hartog, Nicholas L., Heimall, Jennifer R., Ho, Tina, Lawrence, Monica G., Khan, David A., Minniear, Timothy Dean, Mustafa, S. Shahzad, Oppenheimer, John J., Phillips, Elizabeth J., Ramsey, Allison, Rider, Nicholas L., Schneider, Lynda, Shaker, Marcus S., Spergel, Jonathan M., Stone, Cosby A., Jr, Stukus, David R., Wang, Julie, and Greenhawt, Matthew J.

Published
2024
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3. Use of Vaccines in Patients Receiving Dupilumab, A Systematic Review and Expert Delphi Consensus Recommendation: A position paper of the American College of Allergy, Asthma and Immunology

Author

Lieberman, Jay A, primary, Chu, Derek K, additional, Ahmed, Tasnuva, additional, Dribin, Timothy E, additional, Abrams, Elissa M, additional, Anagnostou, Aikaterini, additional, Blumenthal, Kimberly G, additional, Boguniewicz, Mark, additional, Chase, Nicole M, additional, Golden, David BK, additional, Hartog, Nicholas L, additional, Heimall, Jennifer R, additional, Ho, Tina, additional, Lawrence, Monica G, additional, Khan, David A, additional, Minniear, Timothy Dean, additional, Mustafa, S Shahzad, additional, Oppenheimer, John J, additional, Phillips, Elizabeth J, additional, Ramsey, Allison, additional, Rider, Nicholas L, additional, Schneider, Lynda, additional, Shaker, Marcus S, additional, Spergel, Jonathan M, additional, Stone, Cosby A, additional, Stukus, David R, additional, Wang, Julie, additional, and Greenhawt, Matthew J, additional

Published
2024
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4. Validation of Risk Factors for Early Mortality in Cartilage-Hair Hypoplasia.

Author

Vakkilainen, Svetlana, Ahonen, Kira, Marsh, Rebecca, Secord, Elizabeth, Puck, Jennifer, Pozos, Tamara, Seroogy, Christine M., Sullivan, Kathleen E., Walkovich, Kelly, Hartog, Nicholas L., Lugar, Patricia, Herget, Theresia, Garcia-Prat, Marina, Martin-Nalda, Andrea, Ciznar, Peter, Edgar, John David, Candotti, Fabio, Hellige, Antje, Kindle, Gerhard, and Dabrowska-Leonik, Nel

Subjects
SEVERE combined immunodeficiency, RUBELLA, MORTALITY risk factors, HERPES simplex
Abstract

This study examines the clinical features and risk factors associated with early mortality in patients with cartilage-hair hypoplasia (CHH), a rare genetic disorder. The study compares data from three international registries and finds that uncontrolled Epstein-Barr virus (EBV) infection is the only factor significantly correlated with early mortality. The study also notes that allogeneic hematopoietic stem cell transplantation (HSCT) was more common in the USIDNET registry, and that the median age at latest follow-up was shortest in the USIDNET cohort. The study concludes that screening for EBV infection and early management of uncontrolled EBV proliferation should be considered in CHH patients. [Extracted from the article]

Published
2024
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5. Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure

Author

Kobernick, Aaron K., Mohammad, Acklema, Cherry, Adam T., Fein, Alan, Gaines, Alan, Allison Ramsey, Michaud, Amanda L., Palmer, Amy, Kim, Andrew S., Smith, Andrew M., White, Andrew A., Ricci, Anthony R., Kettelhut, Brett V., Modena, Brian D., Stone, Brian, Rolston, B. Steele, Schnapf, Bruce M., Krajicek, Bryan, Kraft, Cara, Hopkins, Carly, Natalie, Chitra R., Anderson, Christine, Czajkowski, Christine, Arce, Daisy, Hamlin, Danuel, Hill, David G., Mares, David C., Pham, David, Liao, Da-Wei, Simmons, Deborah, Johnson, Derek K., Jhaveri, Devi K., Maselli, Diego J., Kerwin, Edward, Schuman, Edward, Sher, Ellen R., Bleecker, Eugene, Rakowski, Ewa, Ida Hsu, Florence, Averill, Francis J., Barsanti, Franco, Gross, Gary N., Chupp, Geoffrey Lowell, Head, G. Gilbert, Nasir, Hassan, Lee, Howard J., Barjaktarevic, Igor, Cook, J. Paul, Krainson, James P., Pearl, James E., Bellak, Jason M., Perez-Fernandez, Javier, Rehm, Jeffrey, Trevor, Jennifer, Freyer Most, Jessica, Hanson, Jill, Blessing-Moore, Joann, Biller, Jodi H., Gedell, John, Southard, John G., Chancellor, Jon Eric, Ilowite, Jonathan, Romeo, Jonathan R., Manuel Mercado, Jorge, Dominic Fisher, Joseph, Greiwe, Justin, Gregory, Karen L., Nadeau, Kari, Shenoy, Kartik V., Tan, Laren D., Stefanowicz, Leslie A., Humes, Lindsay D., Bowers, Lori A., Edel O’Connor, Maeve, Perez, Mario F., White, Martha V., Hegewald, Matthew, Wilson, Matthew C., Sikora, Maxcie M., Lee Morganroth, Melvin, Smith, Mitchell, Farooqui, Nabeel, James Lesch, Nathan, Jain, Neal, Parikh, Neil, Hartog, Nicholas L., Luthin, Patricia L., Stewart, Patricia H., Rubio O’Connor, Peggy, Schochet, Peter, Goldberg, Pinkus, Patel, Pulin P., Chinthrajah, R. Sharon, Sidhu, Rabinder, Ayinla, Raji M., Brown, Randall, Stadtler, Reneé, Wachs, Richard A., Balkissoon, Ronald C., Duplantier, Rory L., Puente, Rosalba E., Settipane, Russell, Mustafa, S. Shahzad, Surani, Salim, Abdul Jawad, Sami, Adams, Sandra G., Villegas, Sarah, Al-Farra, Sherif, Subramanian, Shyamsunder, Bains, Sonia N., Kelsen, Steven G., Wise, Steven L., Estrella-Eades, Susan, Smith, Susan M., Qureshi, Tabarak, Chen, Taiwen, Kelbel, Theodore E., Miller, Thomas P., Jain, Vipin, Soong, Weily, Soler, Xavier, Mattar, Ziad R., Murphy, Kevin R., Chipps, Bradley, Beuther, David A., Wise, Robert A., McCann, William, Gilbert, Ileen, Eudicone, James M., Gandhi, Hitesh N., Harding, Gale, Coyne, Karin S., and Zeiger, Robert S.

Published
2020
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6. Gene Therapy for Genetic Syndromes: Understanding the Current State to Guide Future Care

Author

Henderson, Marian L., primary, Zieba, Jacob K., additional, Li, Xiaopeng, additional, Campbell, Daniel B., additional, Williams, Michael R., additional, Vogt, Daniel L., additional, Bupp, Caleb P., additional, Edgerly, Yvonne M., additional, Rajasekaran, Surender, additional, Hartog, Nicholas L., additional, Prokop, Jeremy W., additional, and Krueger, Jena M., additional

Published
2024
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9. Review of Treatment for Adenosine Deaminase Deficiency (ADA) Severe Combined Immunodeficiency (SCID)

Author

Secord,Elizabeth and Hartog,Nicholas L

Subjects
Therapeutics and Clinical Risk Management
Abstract

Elizabeth Secord,1 Nicholas L Hartog2 1Pediatrics, Division of Allergy and Immunology, Wayne State University School of Medicine, Detroit, MI, USA; 2Pediatrics, Division of Allergy and Immunology, Michigan State University College of Human Medicine, Helen DeVos Children’s Hospital, Grand Rapids, MI, USACorrespondence: Elizabeth Secord, Wayne State University School of Medicine, Wayne Pediatrics, 400 Mack Avenue, Detroit, MI, 48201, USA, Tel +1-313-448-9600, Fax +1-313-448-9978, Email esecord@med.wayne.eduAbstract: Adenosine deaminase deficiency (ADA) is a purine salvage pathway deficiency that results in buildup of toxic metabolites causing death in rapidly dividing cells, especially lymphocytes. The most complete form of ADA leads to severe combined immune deficiency (SCID). Treatment with enzyme replacement therapy (ERT) was developed in the 1970s and became the treatment for ADA SCID by the 1980s. It remains an option for some infants with SCID, and a stopgap measure for others awaiting curative therapy. For some infants with ADA SCID who have matching family donors hematopoietic stem cell transplant (HSCT) is an option for cure. Gene therapy for ADA SCID, approved in some countries and in trials in others, is becoming possible for more infants with this disorder. This review covers the history of ADA SCID, the treatment options to date and particularly the history of the development of gene therapy for ADA SCID and the current state of the risks and benefits of the gene therapy option.Keywords: adenosine deaminase deficiency, ADA, severe combined immunodeficiency, SCID, enzyme replacement therapy, ERT, gene therapy

Published
2022

10. CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications

Author

Bauss, Jacob, primary, Morris, Michele, additional, Shankar, Rama, additional, Olivero, Rosemary, additional, Buck, Leah N., additional, Stenger, Cynthia L., additional, Hinds, David, additional, Mills, Joshua, additional, Eby, Alexandra, additional, Zagorski, Joseph W., additional, Smith, Caitlin, additional, Cline, Sara, additional, Hartog, Nicholas L., additional, Chen, Bin, additional, Huss, John, additional, Carcillo, Joseph A., additional, Rajasekaran, Surender, additional, Bupp, Caleb P., additional, and Prokop, Jeremy W., additional

Published
2021
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13. High-Density Blood Transcriptomics Reveals Precision Immune Signatures of SARS-CoV-2 Infection in Hospitalized Individuals

Author

Prokop, Jeremy W., primary, Hartog, Nicholas L., additional, Chesla, Dave, additional, Faber, William, additional, Love, Chanise P., additional, Karam, Rachid, additional, Abualkheir, Nelly, additional, Feldmann, Benjamin, additional, Teng, Li, additional, McBride, Tamara, additional, Leimanis, Mara L., additional, English, B. Keith, additional, Holsworth, Amanda, additional, Frisch, Austin, additional, Bauss, Jacob, additional, Kalpage, Nathisha, additional, Derbedrossian, Aram, additional, Pinti, Ryan M., additional, Hale, Nicole, additional, Mills, Joshua, additional, Eby, Alexandra, additional, VanSickle, Elizabeth A., additional, Pageau, Spencer C., additional, Shankar, Rama, additional, Chen, Bin, additional, Carcillo, Joseph A., additional, Sanfilippo, Dominic, additional, Olivero, Rosemary, additional, Bupp, Caleb P., additional, and Rajasekaran, Surender, additional

Published
2021
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14. Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis

Author

Gupta, Ruchir, primary, Leimanis, Mara L., additional, Adams, Marie, additional, Bachmann, André S., additional, Uhl, Katie L., additional, Bupp, Caleb P., additional, Hartog, Nicholas L., additional, Kort, Eric J., additional, Olivero, Rosemary, additional, Comstock, Sarah S., additional, Sanfilippo, Dominic J., additional, Lunt, Sophia Y., additional, Prokop, Jeremy W., additional, and Rajasekaran, Surender, additional

Published
2021
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15. Geographic Variability and Pathogen-Specific Considerations in the Diagnosis and Management of Chronic Granulomatous Disease

Author

Prince,Benjamin T, Thielen,Beth K, Williams,Kelli W, Kellner,Erinn S, Arnold,Danielle E, Cosme-Blanco,Wilfredo, Redmond,Margaret T, Hartog,Nicholas L, Chong,Hey J, and Holland,Steven M

Subjects
Pediatric Health, Medicine and Therapeutics
Abstract

Benjamin T Prince,1 Beth K Thielen,2 Kelli W Williams,3 Erinn S Kellner,4 Danielle E Arnold,5 Wilfredo Cosme-Blanco,6 Margaret T Redmond,1 Nicholas L Hartog,7 Hey J Chong,8 Steven M Holland9 1Division of Allergy and Immunology, Nationwide Children’s Hospital, The Ohio State University College of Medicine, Columbus, OH, USA; 2Division of Pediatric Infectious Diseases and Immunology, University of Minnesota, Minneapolis, MN, USA; 3Department of Pediatrics, Division of Pediatric Pulmonology, Allergy & Immunology, Medical University of South Carolina, Charleston, SC, USA; 4Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; 5Division of Allergy and Immunology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA; 6Department of Allergy and Immunology, Veteran Affairs Caribbean Healthcare System, San Juan, Puerto Rico; 7Department of Allergy and Immunology, Spectrum Health Helen DeVos Children’s Hospital, Michigan State University College of Human Medicine, Grand Rapids, MI, USA; 8Division of Allergy and Immunology, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA; 9National Institute of Allergy and Infectious Diseases, Bethesda, Maryland National Institutes of Health, Bethesda, MD, USACorrespondence: Benjamin T PrinceNationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USATel +1 (614) 722-4404Fax +1 (614) 722-4423Email Benjamin.Prince@Nationwidechildrens.orgAbstract: Chronic granulomatous disease (CGD) is a rare but serious primary immunodeficiency with varying prevalence and rates of X-linked and autosomal recessive disease worldwide. Functional defects in the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex predispose patients to a relatively narrow spectrum of bacterial and fungal infections that are sometimes fastidious and often difficult to identify. When evaluating and treating patients with CGD, it is important to consider their native country of birth, climate, and living situation, which may predispose them to types of infections that are atypical to your routine practice. In addition to recurrent and often severe infections, patients with CGD and X-linked female carriers are also susceptible to developing many non-infectious complications including tissue granuloma formation and autoimmunity. The DHR-123 oxidation assay is the gold standard for making the diagnosis and it along with genetic testing can help predict the severity and prognosis in patients with CGD. Disease management focuses on prophylaxis with antibacterial, antifungal, and immunomodulatory medications, prompt identification and treatment of acute infections, and prevention of secondary granulomatous complications. While hematopoietic stem-cell transplantation is the only widely available curative treatment for patients with CGD, recent advances in gene therapy may provide a safer, more direct alternative.Keywords: CGD, primary immunodeficiency diseases, nicotinamide adenine dinucleotide phosphate oxidase complex, DHR-123 oxidation assay

Published
2020

16. Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19

Author

Prokop, Jeremy W., primary, Shankar, Rama, additional, Gupta, Ruchir, additional, Leimanis, Mara L., additional, Nedveck, Derek, additional, Uhl, Katie, additional, Chen, Bin, additional, Hartog, Nicholas L., additional, Van Veen, Jason, additional, Sisco, Joshua S., additional, Sirpilla, Olivia, additional, Lydic, Todd, additional, Boville, Brian, additional, Hernandez, Angel, additional, Braunreiter, Chi, additional, Kuk, ChiuYing Cynthia, additional, Singh, Varinder, additional, Mills, Joshua, additional, Wegener, Marc, additional, Adams, Marie, additional, Rhodes, Mary, additional, Bachmann, Andre S., additional, Pan, Wenjing, additional, Byrne-Steele, Miranda L., additional, Smith, D. Casey, additional, Depinet, Mollye, additional, Brown, Brittany E., additional, Eisenhower, Mary, additional, Han, Jian, additional, Haw, Marcus, additional, Madura, Casey, additional, Sanfilippo, Dominic J., additional, Seaver, Laurie H., additional, Bupp, Caleb, additional, and Rajasekaran, Surender, additional

Published
2020
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17. Viral Induced Genetics Revealed by Multi-Dimensional Precision Medicine Transcriptional Workflow

Author

Prokop, Jeremy W, primary, Gupta, Ruchir, additional, Leimanis, Mara L., additional, Nedveck, Derek, additional, Shankar, Rama, additional, Uhl, Katie, additional, Chen, Bin, additional, Hartog, Nicholas L., additional, Van Veen, Jason, additional, Sisco, Joshua S., additional, Sirpilla, Olivia, additional, Lydic, Todd, additional, Boville, Brian, additional, Hernandez, Angel, additional, Braunreiter, Chi, additional, Kuk, ChiuYing Cynthia, additional, Singh, Varinder, additional, Mills, Joshua, additional, Wegener, Marc, additional, Adams, Marie, additional, Rhodes, Mary, additional, Bachmann, Andre S, additional, Pan, Wenjing, additional, Byrne-Steele, Miranda L., additional, Smith, D. Casey, additional, Depinet, Mollye, additional, Brown, Brittany E., additional, Eisenhower, Mary, additional, Han, Jian, additional, Haw, Marcus, additional, Madura, Casey, additional, Sanfilippo, Dominic J, additional, Seaver, Laurie H., additional, Bupp, Caleb, additional, and Rajasekaran, Surender, additional

Published
2020
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24. Corrigendum to <‘A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology’> <[Annals of Allergy, Asthma & Immunology 133 (2024) 286-94]>

Author

Lieberman, Jay A., Chu, Derek K., Ahmed, Tasnuva, Dribin, Timothy E., Abrams, Elissa M., Anagnostou, Aikaterini, Blumenthal, Kimberly G., Boguniewicz, Mark, Chase, Nicole M., Golden, David B.K., Hartog, Nicholas L., Heimall, Jennifer R., Ho, Tina, Lawrence, Monica G., Khan, David A., Minniear, Timothy Dean, Mustafa, S. Shahzad, Oppenheimer, John J., Phillips, Elizabeth J., Ramsey, Allison, Rider, Nicholas L., Schneider, Lynda, Shaker, Marcus S., Spergel, Jonathan M., Stone, Cosby A., Stukus, David R., Wang, Julie, and Greenhawt, Matthew J.

Published
2024
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30. Development of the Asthma Impairment and Risk Questionnaire (AIRQ): A Composite Control Measure

Author

Murphy, Kevin R., Chipps, Bradley, Beuther, David A., Wise, Robert A., McCann, William, Gilbert, Ileen, Eudicone, James M., Gandhi, Hitesh N., Harding, Gale, Coyne, Karin S., Zeiger, Robert S., Kobernick, Aaron K., Mohammad, Acklema, Cherry, Adam T., Fein, Alan, Gaines, Alan, Ramsey, Allison, Michaud, Amanda L., Palmer, Amy, Kim, Andrew S., Smith, Andrew M., White, Andrew A., Ricci, Anthony R., Kettelhut, Brett V., Modena, Brian D., Stone, Brian, Rolston, B. Steele, Schnapf, Bruce M., Krajicek, Bryan, Kraft, Cara, Hopkins, Carly, Natalie, Chitra R., Anderson, Christine, Czajkowski, Christine, Arce, Daisy, Hamlin, Danuel, Hill, David G., Mares, David C., Pham, David, Liao, Da-Wei, Simmons, Deborah, Johnson, Derek K., Jhaveri, Devi K., Maselli, Diego J., Kerwin, Edward, Schuman, Edward, Sher, Ellen R., Bleecker, Eugene, Rakowski, Ewa, Ida Hsu, Florence, Averill, Francis J., Barsanti, Franco, Gross, Gary N., Chupp, Geoffrey Lowell, Head, G. Gilbert, Nasir, Hassan, Lee, Howard J., Barjaktarevic, Igor, Cook, J. Paul, Krainson, James P., Pearl, James E., Bellak, Jason M., Perez-Fernandez, Javier, Rehm, Jeffrey, Trevor, Jennifer, Freyer Most, Jessica, Hanson, Jill, Blessing-Moore, Joann, Biller, Jodi H., Gedell, John, Southard, John G., Chancellor, Jon Eric, Ilowite, Jonathan, Romeo, Jonathan R., Manuel Mercado, Jorge, Dominic Fisher, Joseph, Greiwe, Justin, Gregory, Karen L., Nadeau, Kari, Shenoy, Kartik V., Tan, Laren D., Stefanowicz, Leslie A., Humes, Lindsay D., Bowers, Lori A., Edel O’Connor, Maeve, Perez, Mario F., White, Martha V., Hegewald, Matthew, Wilson, Matthew C., Sikora, Maxcie M., Lee Morganroth, Melvin, Smith, Mitchell, Farooqui, Nabeel, James Lesch, Nathan, Jain, Neal, Parikh, Neil, Hartog, Nicholas L., Luthin, Patricia L., Stewart, Patricia H., Rubio O’Connor, Peggy, Schochet, Peter, Goldberg, Pinkus, Patel, Pulin P., Chinthrajah, R. Sharon, Sidhu, Rabinder, Ayinla, Raji M., Brown, Randall, Stadtler, Reneé, Wachs, Richard A., Balkissoon, Ronald C., Duplantier, Rory L., Puente, Rosalba E., Settipane, Russell, Mustafa, S. Shahzad, Surani, Salim, Abdul Jawad, Sami, Adams, Sandra G., Villegas, Sarah, Al-Farra, Sherif, Subramanian, Shyamsunder, Bains, Sonia N., Kelsen, Steven G., Wise, Steven L., Estrella-Eades, Susan, Smith, Susan M., Qureshi, Tabarak, Chen, Taiwen, Kelbel, Theodore E., Miller, Thomas P., Jain, Vipin, Soong, Weily, Soler, Xavier, and Mattar, Ziad R.

Abstract

Asthma exacerbation risk increases with worsening asthma control. Prevailing numerical control tools evaluate only current symptom impairment despite the importance of also assessing risk based on exacerbation history. An easy-to-use questionnaire addressing impairment and risk domains of control is needed.

Published
2020
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31. Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis.

Author

Gupta R, Leimanis ML, Adams M, Bachmann AS, Uhl KL, Bupp CP, Hartog NL, Kort EJ, Olivero R, Comstock SS, Sanfilippo DJ, Lunt SY, Prokop JW, and Rajasekaran S

Subjects
Bronchiolitis, Viral blood, Humans, Respiratory Syncytial Virus Infections immunology, Respiratory Syncytial Virus, Human drug effects, Respiratory Syncytial Virus, Human pathogenicity, Severity of Illness Index, Transcriptome immunology, Virus Diseases drug therapy, Virus Diseases virology, Bronchiolitis, Viral virology, Minor Histocompatibility Antigens pharmacology, Respiratory Syncytial Virus Infections drug therapy, Transcriptome drug effects
Abstract

Viral infections affecting the lower respiratory tract place enormous burdens on hospitals. As neither vaccines nor antiviral agents exist for many viruses, understanding risk factors and outcomes in each patient using minimally invasive analysis, such as blood, can lead to improved health care delivery. A cohort of PAXgene RNA sequencing of infants admitted with moderate or severe acute bronchiolitis and respiratory syncytial virus were compared with case-control statistical analysis and cohort-based outlier mapping for precision transcriptomics. Patients with severe bronchiolitis had signatures connected to the immune system, interferon signaling, and cytokine signaling, with marked sex differences in XIST , RPS4Y1 , KDM5D , and LINC00278 for severity. Several patients had unique secondary infections, cytokine activation, immune responses, biological pathways, and immune cell activation, highlighting the need for defining patient-level transcriptomic signatures. Balancing relative contributions of cohort-based biomarker discoveries with patient's biological responses is needed to understand the totality of mechanisms of adverse outcomes in viral bronchiolitis.

Published
2021
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