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11. Storage stability of phosphatidylethanol homologues in whole blood and dried blood spots of nonalcoholics at different temperatures over 60 days.

Author

Herzog, Josefine, Skopp, Gisela, Musshoff, Frank, and Hartung, Benno

Abstract

Phosphatidylethanol (PEth) has recently become a popular direct alcohol marker for evaluating drinking behavior. This study aimed at gaining further information on the long‐term stability of five PEth homologues (16:0/18:1, 16:0/18:2, 16:0/20:4, 18:0/18:1, 18:0/18:2) in whole blood (WB) and dried blood spots (DBS) stored at −80°C, 4°C, and room temperature (18°C) over a period of 60 days. Venous blood was taken from 10 volunteers (five females and five males, aged 21–40 years) with a moderate drinking behavior and a negative breath alcohol test at the time of collection. 100 μL aliquots of WB were prepared in addition to 20 μL DBS samples. The initial PEth concentrations were determined on the day of the blood collection. On days 1, 3, 5, 7, 11, 17, 40, and 60, DBS were analyzed in triplicate by means of LC–MS/MS. On these days, WB aliquots having been stored until that time were used to create further DBS in triplicate, which were subsequently stored at 18°C and analyzed in a single batch after day 60. All homologues, except PEth 16:0/20:4, were stable at −80°C in DBS and WB for 60 days. The initial PEth 16:0/18:1 concentrations remained stable in both DBS and WB in all but one volunteer's specimen at 4 and 18°C. Apart from this exception, simultaneously detected PEth homologues 16:0/18:2, 18:0/18:1, and 18:0/18:2 remained stable over at least 40 days in DBS. Nevertheless, the storage time between sample collection and analysis should be kept as short as possible if an ethanol‐free sample cannot be ensured. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Filicides - a case series analysis.

Author

Hellen, Florence, Verhülsdonk, Sandra, Janssen, Birgit, Ritz-Timme, Stefanie, and Hartung, Benno

Subjects
FORENSIC medicine, WATERSHEDS, PSYCHODYNAMICS, AUTOPSY, INFANTICIDE, HOMICIDE rates, REVENGE
Abstract

Filicides lead to questions about motives and missed opportunities for prevention. The development of preventive strategies is difficult due to heterogeneous perpetrator-victim dynamics. Eighteen child killings by parents over a period of 10 consecutive years in the catchment area of Dusseldorf's Institute of Legal Medicine were identified, and the autopsy reports and prosecution files were analysed. With regard to motives and psychodynamics, a heterogeneous group of perpetrators were identified; the perpetrators were responsible for 8 accidental filicides, 3 killings of unwanted children, 1 killing during perpetrator psychosis, 1 spousal revenge killing and 5 homicide-suicides. Except for the homicide-suicides, overburdening seemed to be the main risk factor for the killings. Preventive measures are difficult to establish. They should focus on awareness campaigns and increasing or establishing multi-professional support for affected families. [ABSTRACT FROM AUTHOR]

Published
2023
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34. The banality of head injury in The Punisher

Author

Donaldson, Daniel M, primary, Holtmann, Henrik, additional, Nitschke, Julia, additional, Karadag, Cihat, additional, Bostelmann, Richard, additional, Hartung, Benno, additional, Li, Lan, additional, and Petridis, Athanasios K, additional

Published
2021
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38. Intracerebral aneurysm rupture due to head trauma

Author

Steinmann, Julia, primary, Hartung, Benno, additional, Bostelmann, Richard, additional, Kaschner, Marius, additional, Husien, Mohammed Ben, additional, Karadag, Cihat, additional, Li, Lan, additional, Steiger, Hans-Jakob, additional, and Petridis, Athanasios K., additional

Published
2020
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41. Forensic Science International / Pupillary effects in habitual cannabis consumers quantified with pupillography

Author

Campobasso, Carlo P., Corbi, Graziamaria, Keller, Thomas, De Micco, Francesco, Hartung, Benno, Daldrup, Thomas, and Monticelli, Fabio

Subjects
Traffic medicine, Pupillary light reflex, Fitness to Drive, Infrared pupillography, Cannabis
Abstract

Driving under the influence of alcohol (DUIA) and drugs (DUID) is considered an elevated risk for traffic safety. When assessing a driver's fitness to drive, standardized and objective measurement methods are still required, in order to clarify the question whether an individual is under the influence of substances acting on the central nervous system (CNS). We exposed healthy test subjects (n = 41) as well as persons who were under the influence of cannabis after repeated inhalation to multiple light stimuli using infrared technology and measured the pupillary light reflex (PLR). Toxicological tests of blood samples taken from every subject followed. The aims of this study were to assess the differences in pupillography response between cannabis consumers after a washout period and no cannabis consumers as well as the dose related effects on pupillography parameters of cannabis in cannabis consumers. All four pupillary parameters changed according to a weakened pupil function after acute administration of cannabis in all test subjects. Furthermore, it could be observed that habitual cannabis consumers showed an altered pupillary function just before the first dose was taken, suggesting that the long-term effects and addiction also have to be taken into account, when effects of the CNS are discussed. The results of the present study show that almost all pupil parameters could be reliable indicators for the detection of subjects under the acute effect of cannabis. (VLID)5800121

Published
2020
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