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Aim: The aim of the study was to determine the potential drug drug interactions of patients receiving inpatient treatment in the intensive care unit and infectious diseases ward and using quinolone group antibiotics by using different interaction software programs.Material and Methods: The prescriptions of 100 patients who received inpatient treatment in infectious diseases service and intensive care unit at Selçuk University Faculty of Medicine Hospital between January 2022 and December 2022 and who were treated with quinolone group antibiotics during treatment were analyzed retrospectively.Results: Of the patients included in the study, 62 were male and 38 were female. The mean age of men was 65.76 ± 16.22 years, while the mean age of women was 68.63 ± 16.29 years. While Medscape® detected a total of 1776 interactions, this number was 1432 in Lexicomp® and 1693 in Drugs®.While 0.33% of the interactions detected in the Medscape® software program were contraindicated, 3.77% of the interactions were contraindicated in Lexicomp®. Kendall W coefficient 0.94, Chi-Square test 281.12, p

Metronidazole is an imidazole group bactericidal antibiotic used against anaerobic bacteria and some protozoa. There is no detailed information about the embryotoxic effect of Metronidazole. This study aims to determine the embryotoxic activity of Metronidazole using an in ovo method. A total of 210 fertile chicken eggs were placed in an incubator, divided into seven equal groups of 30. The first group was considered as the control group. On the seventh day of the study, Metronidazole was administered to the other six groups within 50 µL saline solution at doses of 250, 125, 62.5, 31.25, and 15.62 µg·egg-1 (5; 2.5; 1.25; 0.625; 0.312 mg·kg-1). At the end of the incubation period, the eggs hatched, and the number of live and dead embryos was determined. There were no significant differences in deaths between the groups (P>0.05 in all cases). No anomaly was detected in the macroscopic morphology of the embryos. As a result, it can be stated that Metronidazole may be safe for use during pregnancy. However, it is necessary to conduct molecular and histopathological studies to investigate the effects of this drug on organogenesis, especially in mammalian embryos.

Atipamezole is a specific α2-adrenergic receptor antagonist, and there exists insufficient information on its use during pregnancy. The aim of this study was to determine the embryotoxic activity of Atipamezole through an in ovo method. During the first stage of the study, 210 fertile eggs were divided into seven groups of 30 fertile eggs and placed in an incubator. On the seventh day of the first stage, no application was made to the control group. The second group was administered 50 microliters (µL) of saline solution, while the other groups were given Atipamezole at doses of 250, 125, 62.5, 31.25 and 15.62 micrograms·egg-1 (µg·egg-1) in 50 µL saline solution. In the second stage, according to the embryotoxic dose range determined from the first stage, 150 fertile eggs were divided into five groups of 30 fertile eggs and placed in an incubator. On the seventh day of the second stage, no application was made to the control group. Fifty µL of saline solution was administered to the second group. The other groups were given Atipamezole at doses of 220, 190 and 160 µg·egg-1 in 50 µL saline solution. After the incubation period, the eggs hatched, and the embryonic mortality rates were calculated. The mortality rate was determined to be 39.3% at the highest dose (250 µg·egg-1 = 5 miligrams·kilograms-1 –mg·kg-1–) (P0.05). In conclusion, it can be stated that the dose determined for Atipamezole in this study was very high compared to the recommended doses and it can be used in pregnancy as a benefit-loss calculation when necessary. However molecular or histopathological studies regarding the development of organ drafts are necessary to determine the safety of its use during pregnancy.

Aim: The purpose of this study was to assess the effect of administering Nerium oleander distillate on hypercholesterolemic rats' serum biochemical parameters. Materials and Methods: Three equal groups of 30 male Sprague-Dawley rats were formed. No application was made for the control group. The second group received a high cholesterol diet, while the third group received a high cholesterol diet in addition to lyophilized Nerium oleander distillate by oral gavage once daily. After three months, blood was drawn after sedation and they were euthanized. Serum fasting blood glucose, triglyceride, highdensity lipoprotein, total cholesterol, low-density lipoprotein, alanine aminotransferase, aspartate aminotransferase, albumin, and total protein levels, as well as alkaline phosphatase, lactate dehydrogenase, creatinine, and urea levels, were determined using an autoanalyzer. Results: Alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholesterol, glucose, low-density lipoprotein, and triglyceride levels increased (p < 0.05) in the group fed a high cholesterol diet compared to the control group, but Nerium oleander treatment decreased the elevated aspartate aminotransferase, cholesterol, low-density lipoprotein, and triglyceride (p < 0.05). Conclusion: To summarize, it can be stated that Nerium oleander distillate has antihypercholesterolemic and liver-protective properties.