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The increasing prevalence of multi-drug resistance in pathogenic bacteria has rendered antibiotics ineffective, necessitating the exploration of alternative antibacterial approaches. Consequently, research efforts have shifted towards developing new antibiotics and improving the efficacy of existing ones. In the present study, novel core shell graphene oxide@platinum nanoparticles (GRO@Pt-NPs) and their unchanging form have been synthesized using the two-step pulsed laser ablation in liquid (PLAL) technique. The first step involved using the graphene target to create graphene nanoparticles (GRO-NPs), followed by the ablation of GRO-NPs inside platinum nanoparticles (Pt-NPs). To characterize the nanoparticles, various methods were employed, including UV-VIS, transmission electron microscopy (TEM), energy dispersive X-ray (EDX), mapping tests, and X-ray diffraction (XRD). The anti-bacterial and anti-biofilm properties of the nanoparticles were investigated. TEM data confirm the creation of GRO@Pt-NPs. The average particle size was 11 nm for GRO-NPs, 14 nm for Pt-NPs, and 26 nm for GRO@Pt-NPs. The results demonstrate that the created GRO@Pt-NPs have strong antibacterial properties. This pattern is mostly produced through the accumulation of GRO@Pt-NPs on the bacterial surface of Klebsiella pneumoniae (K. pneumoniae) and Enterococcus faecium (E. faecium). The inhibition zones against K. pneumoniae and E. faecium when GRO-NPs were used alone were found to be 11.80 mm and 11.50 mm, respectively. For Pt-NPs, the inhibition zones of E. faecium and K. pneumoniae were 20.50 mm and 16.50 mm, respectively. The utilization of GRO@Pt-NPs resulted in a significant increase in these values, with inhibitory rates of 25.50 mm for E. faecium and 20.45 mm for K. pneumoniae. The antibacterial results were more potent in the core–shell structure than the GRO-NPs alone or Pt-NPs alone. The current work uses, for the first time, a fast and effective technique to synthesize the GRO@Pt-NPs by PLAL method, and the preparation has high clinical potential for prospective use as an antibacterial agent. [ABSTRACT FROM AUTHOR]

This study is aimed at the preparation and characterization of the coumarin derivative, 4-((5-amino-1, 3, 4-thiadiazol-2-yl) methoxy) coumarin (ATMC) and the determination of the antitumor activity of the compound. The compound was prepared through a synthetic route starting with 4–hydroxycoumarin by undergoing a sequence of chemical reactions. The confirmation of ATMC structure was done by different spectroscopy methods such as FT-IR, 1H-NMR, 13C-NMR, and also further chemical analysis. In a biological activity profiling experiment, antibacterial activity, antifungal activity, and antioxidant activity of the compound ATMC were examined. The in vitro efficacy of antimicrobial activity was shown by the zone of inhibitory zone which was ranged 15 to 22 mm against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, and Staphylococcus aureus. In addition to this antifungal study also shows that the ATMC has strong inhibition against Aspergillus niger and Candida alb. Based on the provided data, it can be suggested that ATMC possesses various biological effects, which demonstrates the prospect of its application as a therapeutic drug. [ABSTRACT FROM AUTHOR]

The strategic synthesis of 4-((4-Phenyl-5-Thioxo-1,2,4-Triazol-3- yl)methoxy)coumarin (PTTC) derived from 4-hydroxycoumarin is imperative, given its industrial, therapeutic relevance, and structural adaptability. This investigation delves into its multifaceted potential, particularly focusing on its anticorrosion, antibacterial, and antioxidant properties. Antibacterial efficacy against a spectrum of bacterial strains including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, and Staphylococcus aureus was evaluated via the disk diffusion method, revealing robust microbiological activity with inhibition zones ranging from 11 to 28 mm. Furthermore, PTTC exhibited notable antioxidant prowess, demonstrating a maximum scavenging capacity of 95% in the DPPH radical scavenging assay. These results underscore PTTC's versatility as a therapeutic agent with promising applications. Its corrosion resistance potential for mild steel in 1.0 M hydrochloric acid was studied using weight loss methods. Parameters that influence corrosion inhibition such as PTTC concentration, which is a structural parameter, environmental temperature and immersion duration were all studied systematically. Particularly, the PTTC achieved high inhibition efficiencies that were at 96% at a 1.0mM concentration at 303K. The adsorption process on the metal surface was in accordance with the Langmuir adsorption isotherm, and both the experimental and theoretical results were in good agreement. The study presented discusses the PTTC's various functions and thereby, making it a good choice for different therapeutic purposes, corrosion prevention, and antioxidative activities. [ABSTRACT FROM AUTHOR]