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26. Locally Weighted Mean Phase Angle (LWMPA) Based Tone Mapping Quality Index (TMQI-3)

Author

Hassan, Inaam Ul, Haseeb, Abdul, and Ali, Sarwan

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

High Dynamic Range (HDR) images are the ones that contain a greater range of luminosity as compared to the standard images. HDR images have a higher detail and clarity of structure, objects, and color, which the standard images lack. HDR images are useful in capturing scenes that pose high brightness, darker areas, and shadows, etc. An HDR image comprises multiple narrow-range-exposure images combined into one high-quality image. As these HDR images cannot be displayed on standard display devices, the real challenge comes while converting these HDR images to Low dynamic range (LDR) images. The conversion of HDR image to LDR image is performed using Tone-mapped operators (TMOs). This conversion results in the loss of much valuable information in structure, color, naturalness, and exposures. The loss of information in the LDR image may not directly be visible to the human eye. To calculate how good an LDR image is after conversion, various metrics have been proposed previously. Some are not noise resilient, some work on separate color channels (Red, Green, and Blue one by one), and some lack capacity to identify the structure. To deal with this problem, we propose a metric in this paper called the Tone Mapping Quality Index (TMQI-3), which evaluates the quality of the LDR image based on its objective score. TMQI-3 is noise resilient, takes account of structure and naturalness, and works on all three color channels combined into one luminosity component. This eliminates the need to use multiple metrics at the same time. We compute results for several HDR and LDR images from the literature and show that our quality index metric performs better than the baseline models.

Published
2021

41. Digestive Manifestations in Patients Hospitalized With Coronavirus Disease 2019.

Author

Elmunzer, B, Spitzer, Rebecca, Foster, Lydia, Merchant, Ambreen, Howard, Eric, Patel, Vaishali, West, Mary, Qayed, Emad, Nustas, Rosemary, Zakaria, Ali, Piper, Marc, Taylor, Jason, Jaza, Lujain, Forbes, Nauzer, Chau, Millie, Lara, Luis, Papachristou, Georgios, Volk, Michael, Hilson, Liam, Zhou, Selena, Kushnir, Vladimir, Lenyo, Alexandria, McLeod, Caroline, Amin, Sunil, Kuftinec, Gabriela, Yadav, Dhiraj, Fox, Charlie, Kolb, Jennifer, Pawa, Swati, Pawa, Rishi, Canakis, Andrew, Huang, Christopher, Jamil, Laith, Aneese, Andrew, Glamour, Benita, Smith, Zachary, Hanley, Katherine, Wood, Jordan, Patel, Harsh, Shah, Janak, Agarunov, Emil, Sethi, Amrita, Fogel, Evan, McNulty, Gail, Haseeb, Abdul, Trieu, Judy, Dixon, Rebekah, Yang, Jeong, Mendelsohn, Robin, Calo, Delia, Aroniadis, Olga, LaComb, Joseph, Scheiman, James, Sauer, Bryan, Dang, Duyen, Piraka, Cyrus, Shah, Eric, Pohl, Heiko, Tierney, William, Mitchell, Stephanie, Condon, Ashwinee, Lenhart, Adrienne, Dua, Kulwinder, Kanagala, Vikram, Kamal, Ayesha, Singh, Vikesh, Pinto-Sanchez, Maria, Hutchinson, Joy, Kwon, Richard, Korsnes, Sheryl, Singh, Harminder, Solati, Zahra, Willingham, Field, Yachimski, Patrick, Conwell, Darwin, Mosier, Evan, Azab, Mohamed, Patel, Anish, Buxbaum, James, Wani, Sachin, Chak, Amitabh, Hosmer, Amy, Keswani, Rajesh, DiMaio, Christopher, Bronze, Michael, Muthusamy, Raman, Canto, Marcia, Gjeorgjievski, V, Imam, Zaid, Odish, Fadi, Edhi, Ahmed, Orosey, Molly, Tiwari, Abhinav, Patwardhan, Soumil, Brown, Nicholas, Ordiah, Collins, Sloan, Ian, Cruz, Lilian, and Koza, Casey

Subjects
COVID-19, Digestive Manifestations, Gastrointestinal Symptoms, Hepatic Manifestations, SARS-CoV-2, Adolescent, Adult, Aged, Aged, 80 and over, COVID-19, Female, Gastrointestinal Diseases, Humans, Male, Middle Aged, North America, Young Adult
Abstract

BACKGROUND & AIMS: The prevalence and significance of digestive manifestations in coronavirus disease 2019 (COVID-19) remain uncertain. We aimed to assess the prevalence, spectrum, severity, and significance of digestive manifestations in patients hospitalized with COVID-19. METHODS: Consecutive patients hospitalized with COVID-19 were identified across a geographically diverse alliance of medical centers in North America. Data pertaining to baseline characteristics, symptomatology, laboratory assessment, imaging, and endoscopic findings from the time of symptom onset until discharge or death were abstracted manually from electronic health records to characterize the prevalence, spectrum, and severity of digestive manifestations. Regression analyses were performed to evaluate the association between digestive manifestations and severe outcomes related to COVID-19. RESULTS: A total of 1992 patients across 36 centers met eligibility criteria and were included. Overall, 53% of patients experienced at least 1 gastrointestinal symptom at any time during their illness, most commonly diarrhea (34%), nausea (27%), vomiting (16%), and abdominal pain (11%). In 74% of cases, gastrointestinal symptoms were judged to be mild. In total, 35% of patients developed an abnormal alanine aminotransferase or total bilirubin level; these were increased to less than 5 times the upper limit of normal in 77% of cases. After adjusting for potential confounders, the presence of gastrointestinal symptoms at any time (odds ratio, 0.93; 95% CI, 0.76-1.15) or liver test abnormalities on admission (odds ratio, 1.31; 95% CI, 0.80-2.12) were not associated independently with mechanical ventilation or death. CONCLUSIONS: Among patients hospitalized with COVID-19, gastrointestinal symptoms and liver test abnormalities were common, but the majority were mild and their presence was not associated with a more severe clinical course.

Published
2021

44. Comparison of Left Bundle Branch Area Pacing and Biventricular Pacing in Candidates for Resynchronization Therapy

Author

Vijayaraman, Pugazhendhi, Sharma, Parikshit S., Cano, Óscar, Ponnusamy, Shunmuga Sundaram, Herweg, Bengt, Zanon, Francesco, Jastrzebski, Marek, Zou, Jiangang, Chelu, Mihail G., Vernooy, Kevin, Whinnett, Zachary I., Nair, Girish M., Molina-Lerma, Manuel, Curila, Karol, Zalavadia, Dipen, Haseeb, Abdul, Dye, Cicely, Vipparthy, Sharath C., Brunetti, Ryan, Moskal, Pawel, Ross, Alexandra, van Stipdonk, Antonius, George, Jerin, Qadeer, Yusuf K., Mumtaz, Mishal, Kolominsky, Jeffrey, Zahra, Syeda A., Golian, Mehrdad, Marcantoni, Lina, Subzposh, Faiz A., and Ellenbogen, Kenneth A.

Published
2023
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45. Widening of the genetic and clinical spectrum of Lamb–Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency

Author

Zawerton, Ash, Mignot, Cyril, Sigafoos, Ashley, Blackburn, Patrick R, Haseeb, Abdul, McWalter, Kirsty, Ichikawa, Shoji, Nava, Caroline, Keren, Boris, Charles, Perrine, Marey, Isabelle, Tabet, Anne-Claude, Levy, Jonathan, Perrin, Laurence, Hartmann, Andreas, Lesca, Gaetan, Schluth-Bolard, Caroline, Monin, Pauline, Dupuis-Girod, Sophie, Guillen Sacoto, Maria J, Schnur, Rhonda E, Zhu, Zehua, Poisson, Alice, El Chehadeh, Salima, Alembik, Yves, Bruel, Ange-Line, Lehalle, Daphné, Nambot, Sophie, Moutton, Sébastien, Odent, Sylvie, Jaillard, Sylvie, Dubourg, Christèle, Hilhorst-Hofstee, Yvonne, Barbaro-Dieber, Tina, Ortega, Lucia, Bhoj, Elizabeth J, Masser-Frye, Diane, Bird, Lynne M, Lindstrom, Kristin, Ramsey, Keri M, Narayanan, Vinodh, Fassi, Emily, Willing, Marcia, Cole, Trevor, Salter, Claire G, Akilapa, Rhoda, Vandersteen, Anthony, Canham, Natalie, Rump, Patrick, Gerkes, Erica H, Klein Wassink-Ruiter, Jolien S, Bijlsma, Emilia, Hoffer, Mariëtte JV, Vargas, Marcelo, Wojcik, Antonina, Cherik, Florian, Francannet, Christine, Rosenfeld, Jill A, Machol, Keren, Scott, Daryl A, Bacino, Carlos A, Wang, Xia, Clark, Gary D, Bertoli, Marta, Zwolinski, Simon, Thomas, Rhys H, Akay, Ela, Chang, Richard C, Bressi, Rebekah, Sanchez Russo, Rossana, Srour, Myriam, Russell, Laura, Goyette, Anne-Marie E, Dupuis, Lucie, Mendoza-Londono, Roberto, Karimov, Catherine, Joseph, Maries, Nizon, Mathilde, Cogné, Benjamin, Kuechler, Alma, Piton, Amélie, Klee, Eric W, Lefebvre, Véronique, Clark, Karl J, and Depienne, Christel

Subjects
Intellectual and Developmental Disabilities (IDD), Pediatric, Genetics, Brain Disorders, Clinical Research, Rare Diseases, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Adult, Animals, Child, Child, Preschool, DNA-Binding Proteins, Female, Genetic Predisposition to Disease, Haploinsufficiency, Humans, Infant, Intellectual Disability, Language Development Disorders, Male, Mutation, Missense, Neurodevelopmental Disorders, Pedigree, Phenotype, SOXD Transcription Factors, Young Adult, autism, developmental delay, intellectual disability, epilepsy, missense variants, Deciphering Developmental DisorderStudy, missense variants., Clinical Sciences, Genetics & Heredity
Abstract

PurposeLamb-Shaffer syndrome (LAMSHF) is a neurodevelopmental disorder described in just over two dozen patients with heterozygous genetic alterations involving SOX5, a gene encoding a transcription factor regulating cell fate and differentiation in neurogenesis and other discrete developmental processes. The genetic alterations described so far are mainly microdeletions. The present study was aimed at increasing our understanding of LAMSHF, its clinical and genetic spectrum, and the pathophysiological mechanisms involved.MethodsClinical and genetic data were collected through GeneMatcher and clinical or genetic networks for 41 novel patients harboring various types ofSOX5 alterations. Functional consequences of selected substitutions were investigated.ResultsMicrodeletions and truncating variants occurred throughout SOX5. In contrast, most missense variants clustered in the pivotal SOX-specific high-mobility-group domain. The latter variants prevented SOX5 from binding DNA and promoting transactivation in vitro, whereas missense variants located outside the high-mobility-group domain did not. Clinical manifestations and severity varied among patients. No clear genotype-phenotype correlations were found, except that missense variants outside the high-mobility-group domain were generally better tolerated.ConclusionsThis study extends the clinical and genetic spectrum associated with LAMSHF and consolidates evidence that SOX5 haploinsufficiency leads to variable degrees of intellectual disability, language delay, and other clinical features.

Published
2020

46. Pancreatic Sphincterotomy

Author

Haseeb, Abdul, Trieu, Judy A., Freeman, Martin L., Testoni, Pier Alberto, Section editor, Testoni, Pier Alberto, editor, Inoue, Haruhiro, editor, and Wallace, Michael B., editor

Published
2022
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