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11. Evaluation of the safety and efficacy of biosimilar recombinant growth hormone in children with growth hormone deficiency: non-inferiority, randomized, parallel, multicentric and Phase III trial

Author

Zaeri, Hossein, primary, Omidvar, Shahriar, additional, Servatian, Nazli, additional, Arefnia, Serajaddin, additional, Khademolreza, Nasrin, additional, Amini, Hossein, additional, Taghavi, Behnam, additional, Hashemipour, Mahin, additional, Eshraghi, Peyman, additional, Ghasemi, Mahmoud, additional, Ghergherehchi, Robabeh, additional, Maleki, Elham, additional, Moravej, Hossein, additional, Noorian, Shahab, additional, Soheilipour, Fahimeh, additional, Dalili, Setila, additional, Kharazmi, Hosseinali, additional, Didban, Abdollah, additional, Akhlaghi, Aliasghar, additional, Ghaznavi, Sina, additional, and Shahbazi, Majid, additional

Published
2024
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15. The Prospective Epidemiological Research Studies in IrAN (PERSIAN) Birth Cohort protocol: rationale, design and methodology

Author

Zare Sakhvidi, Mohammad Javad, Danaei, Navid, Dadvand, Payam, Mehrparvar, Amir Houshang, Heidari-Beni, Motahar, Nouripour, Shamsollah, Nikukar, Habib, Daniali, Seyede Shahrbanoo, Saffarieh, Elham, Noorishadkam, Mahmood, Amin, Mohammad Mehdi, Mirmohammadkhani, Majid, Lotfi, Mohammad Hassan, Vaez, Ahmad, Mirmohammadi, Seyyed Jalil, Zarean, Elaheh, Mojibian, Mahdieh, Hashemipour, Mahin, Yaghini, Omid, Rezai, Mohammad Sadegh, Esmaeili, Ali, Fahimzad, Alireza, Hakimi, Hamid, Navaeifar, Mohammad Reza, Ebrahimi, Hamid Ostad, Poustchi, Hossein, Malekzadeh, Reza, and Kelishadi, Roya

Published
2021
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16. The spectrum of clinical, hormonal findings in children with congenital adrenal hyperplasia in Isfahan province; a 20-year review.

Author

Hashemipour, Mahin and Saleh, Rana

Subjects
*ADRENOGENITAL syndrome, *ADRENAL glands, *THERAPEUTICS, *SYMPTOMS, *DEMOGRAPHIC characteristics
Abstract

Congenital adrenal hyperplasia is an autosomal recessive disorder caused by complete or partial defects in one of the several steroidogenic enzymes involved in synthesizing of cortisol from cholesterol in the adrenal gland. Prompt and proper treatment of the disease would reduce symptoms and the level of androgens in patients. The present study aimed to evaluate the demographic characteristics and clinical findings of these patients. This retrospective investigation was conducted in 146 patients with congenital adrenal hyperplasia participated. Their clinical and paraclinical findings were accurately recorded in the file and extracted from the records. Among all 146 patients, 119(81.5 %) was 21-OH Deficiency type;11-OH Deficiency type was 13(8.9 %), 10(6.8 %) was 3β-HSD type, StAR was 2(1.4 %) and 17 alpha(α)-hydroxylase Deficiency was 2(1.4 %). The mean age of disease onset in these patients was 2.45 ± 1.16 years. Macropenis was the most frequent clinical finding in 39 cases of 64 boys (60.9 %), and Clitoromgaly was the most clinical presentation in 40 cases of 82 girls (48.7 %). The levels of testosterone, dehydroepiandrosterone sulfate, and 17-OHP significantly decreased in the last visit compared to the initial diagnosis. Based on the clinical findings in every infant or child with ambiguous genitalia, macropenis, clitoromegaly, hirsutism, and premature pubarche, we should consider congenital adrenal hyperplasia. Prompt and proper treatment and disease control would reduce symptoms and the level of androgens in patients. [ABSTRACT FROM AUTHOR]

Published
2024
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18. First Iranian guidelines for the diagnosis, management, and treatment of hyperlipidemia in adults

Author

Kholenjani, Fahimeh Bagheri, primary, Shahidi, Shahla, additional, Vaseghi, Golnaz, additional, Ashoorion, Vahid, additional, Sarrafzadegan, Nizal, additional, Siavash, Mansour, additional, Heidarpour, Maryam, additional, Shahidi, Shahrzad, additional, Sadeghi, Masoumeh, additional, Mohammadifard, Noushin, additional, Jorjani, Masoumeh, additional, Mobarhan, Majid Ghayour, additional, Shafie, Davood, additional, Farshidi, Hossein, additional, Khorvash, Fariborz, additional, Ghabaei, Mojdeh, additional, Teimouri-Jervekani, Zahra, additional, Mortazavi, Mojgan, additional, Hajhashemi, Valiollah, additional, Roshanravan, Neda, additional, Yazdanpanah, Leila, additional, Davari, Majid, additional, Fatemi, Behzad, additional, Khorasani, Elaheh, additional, Hoseinkhani, Ramesh, additional, Zarean, Elaheh, additional, Ahmadi, Alireza, additional, Babadi, Maryam Eghbali, additional, Assareh, Ahmadreza, additional, Shadmani, Mehdi, additional, Kojuri, Javad, additional, Shirani, Farimah, additional, Sanjari, Mojgan, additional, Haghighatdoost, Fahimeh, additional, Hassannejad, Razieh, additional, Hashemi, Elham, additional, Moaddab, Mohammad Hassan, additional, Gheisari, Alaleh, additional, Dehghan, Bahar, additional, Naseri, Mitra, additional, Ghaemi, Nosrat, additional, Noohi, Fereidoun, additional, Haghdoost, AliAkbar, additional, Salehi-Abargouei, Amin, additional, Beigrezaie, Sara, additional, Doosti-Irani, Amin, additional, Ramezani-Jolfaie, Nahid, additional, Eraj, Bijan, additional, Hashemipour, Mahin, additional, Nematipour, Ebrahim, additional, and Kopaei, Mahmoud Rafieian, additional

Published
2024
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21. Association between maternal and cord blood thyroid hormones, and urine iodine concentration with fetal growth.

Author

Alimardani, Bita, Hashemipour, Mahin, Hovsepian, Silva, Mozafarian, Nafiseh, Khoshhali, Mehri, and Kelishadi, Roya

Abstract

We planned to evaluate the association of fetal and maternal thyroid hormones and maternal iodine status with neonates' anthropometric parameters. In this cross-sectional study, levels of thyrotropin were measured in maternal serum in the first trimester of pregnancy, and thyrotropin (TSH) and free thyroxin (fT4) were measured in cord blood serum samples at birth. Urinary iodine concentration (UIC) levels in random urine samples of mothers were measured in the third trimester of pregnancy. The relationship between UIC and thyroid hormone levels of mothers with neonates' anthropometric birth parameters of neonates was evaluated. One hundred eighty-eight mother–newborn pairs completed the study. Mean (SD) of cord blood TSH (CB-TSH), cord blood-free thyroxin (CB-FT4) values, and maternal TSH (M-TSH) levels were 8.8 (7.3) mIU/L, 1.01 (0.2) ng/dL, and 2.2 (0.9) mIU/L, respectively. After adjusting for confounders, there was a positive significant association between female neonate length and maternal TSH and log log-transformed CB TSH (LN_CB-TSH) (p<0.05). Median UIC (Q1–Q3) was 157 (53–241) μg/L, and there was no association between birth weight, birth length, and head circumferences of neonates and mothers' UIC (p>0.05). We found a positive correlation between maternal TSH in the first trimester of pregnancy and the birth length of newborns, and a negative correlation was observed between CB-TSH and birth length in girls, but it did not provide conclusive evidence for the relationship between maternal and neonatal thyroid hormone levels and birth weight. There was no association between maternal UIC levels in the third trimester and birth anthropometric parameters. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Evaluation of cardiac findings in mucopolysaccharidosis

Author

Dehghan, Bahar, primary, Rostampour, Noushin, additional, Sedighi, Mohsen, additional, Saryazdi, Mohammad Hosseini, additional, Rizi, Mohammad Jokar, additional, Mostofizadeh, Neda, additional, Hashemipour, Mahin, additional, and Khoshhali, Mehri, additional

Published
2023
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28. Visual Perception in Children with a History of Hypoglycemia due to Hyperinsulinism.

Author

GHAZAVI, Mohammad Reza, NASIRI, Jafar, MOMENI, Azin, and HASHEMIPOUR, Mahin

Subjects
CROSS-sectional method, OCCIPITAL lobe, SPEECH disorders, HYPERINSULINISM, CASE-control method, MAGNETIC resonance imaging, MOVEMENT disorders, PSYCHOLOGICAL tests, T-test (Statistics), VISUAL perception, HYPOGLYCEMIA, DESCRIPTIVE statistics, SEIZURES (Medicine), STRABISMUS
Abstract

Objectives Hyperinsulinism refers to improper insulin secretion in the presence of low plasma glucose, causing severe and persistent hypoglycemia in infants and children. The brain's occipital lobe, which includes the visual and plays an essential role in visual perception is specifically sensitive to hypoglycemia-induced damage. The present study aims to investigate the visual perception in children suffering from hyperinsulinism and to compare it with the control group. Materials & Methods This cross-sectional control study, conducted in 2020 in Isfahan, Iran, involved 20 children aged 4-13 years with hyperinsulinism and 20 healthy children of the same age and gender for comparison. In both groups, the measuring instrument was the Test of Visual Perceptual Skills (non-motor) Third Edition. Results The mean visual perceptual quotient in the case and control groups was 80.50±26.74 and 116.50±7.56 (p-value<0.001), respectively. The results overall indicated that children suffering from hyperinsulinism were weaker than healthy children in all areas of visual perception. Conclusion Based on the obtained results, it is recommended that children suffering from hyperinsulinism be screened regarding visual perceptual disorders since this screening may be helpful in initiating different rehabilitation programs among these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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41. A Novel Homozygous Pathogenic Variant in CYP11B1 in a Female Iranian Patient with 11B Hydroxylase Deficiency.

Author

Hoseinzadeh, Marziyeh, Molavi, Newsha, Norouzi, Mahnaz, Aghaei, Shahrzad, Zeinalian, Mehrdad, Hashemipour, Mahin, and Tabatabaiefar, Mohammad Amin

Subjects
ADRENOGENITAL syndrome, GENETIC mutation, SEQUENCE analysis, RESEARCH funding, OXIDOREDUCTASES, COMPUTER-assisted molecular modeling, DATA analysis software, PHENOTYPES
Abstract

Objective Congenital adrenal hyperplasia (CAH) addresses a number of autosomal recessive disorders characterized by the enzyme defects in steroid hormones biosynthesis. The second common form of CAH is caused by mutations in the CYP11B1 gene. Here, we reveal a novel mutation in the CYP11B1 gene related to the 11βOHD phenotype. Methods and Results Sequence analysis of the CYP11B1 gene in a 19-year-old Iranian woman with the 11βOHD phenotype was performed. In silico analysis and molecular docking were done. A novel missense homozygous variant c.1351C > T (p.L451F) in the CYP11B1 gene was identified in the patient and, according to American College of Medical Genetics and Genomics criteria, was categorized as likely pathogenic. Protein docking showed destructive effects of the variant on the CYP11B1 protein-ligand interactions. Conclusion This study broadens the CYP11B1 mutation spectrum and introduces the novel p.L451F likely pathogenic variant leading to destructive effects on protein-ligand interactions. Our results provide reliable information for genetic counseling and molecular diagnostics of CAH. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Molecular characterization of a large cohort of mucopolysaccharidosis patients: Iran Mucopolysaccharidosis RE‐diagnosis study (IMPRESsion)

Author

Ghaffari, Saeed R., primary, Rafati, Maryam, additional, Shadnoush, Mahdi, additional, Pourbabaee, Shokooh, additional, Aghighi, Mohammad, additional, Mirab Samiee, Siamak, additional, Kermanchi, Jamshid, additional, Alaei, Mohammad R., additional, Salehpour, Shadab, additional, Amirkashani, Davoud, additional, Setoodeh, Aria, additional, Sarkhail, Peymaneh, additional, Badv, Reza Shervin, additional, Aminzadeh, Majid, additional, Shiva, Siamak, additional, Eshraghi, Peyman, additional, Moravej, Hossein, additional, Hashemipour, Mahin, additional, Rostampour, Noushin, additional, Hamidieh, َAmir Ali, additional, Shamsian, Bibi Shahin, additional, Shams, Sedigheh, additional, Zamanfar, Daniel, additional, Ebrahimi, Ayoub, additional, Otadi, Ali, additional, Tara, Seyedeh Zahra, additional, Barati, Zeinab, additional, Fakhri, Laya, additional, Hoseini, Azadeh, additional, Amiri, Hosna, additional, Ramandi, Somayeh, additional, Mostofinezhad, Niusha, additional, Kani, Zahra Pahlevani, additional, Mohammadyari, Elham, additional, Khosravi, Mahsa, additional, Saadati, Masoome, additional, Hoseininasab, Fatemeh, additional, Khorram Khorshid, Hamid Reza, additional, and Modaberisaber, Younes, additional

Published
2022
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50. The Consensus on the Diagnosis and Management of Congenital 2 Hypothyroidism in Term Neonates.

Author

Hashemipour, Mahin, Rabbani, Ali, Rad, Afagh Hassanzadeh, and Dalili, Setila

Subjects
*NEWBORN infants, *HYPOTHYROIDISM, *HORMONE deficiencies, *ENDOCRINE diseases, *DIAGNOSIS, *CONGENITAL hypothyroidism
Abstract

Congenital hypothyroidism (CH) is one of the most treatable endocrine disorders in infants and children that can influence the function of many organs in the body. On-time diagnosis and treatment can prevent the adverse effects of thyroid hormone deficiency on the child's neurodevelopment. There are many challenges in screening, post-screening, diagnosis, and managing this disorder. Therefore, this article aimed to mention updated information on this issue. Although there are different approaches for the treatment of hypothyroidism, the authors decided to create a national approach based on the conditions of our country. [ABSTRACT FROM AUTHOR]

Published
2023
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