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269 results on '"Hashida, Noriyasu"'

7. Unveiling Key Pathological Indicators for Disease Progression in Vogt Koyanagi Harada Disease and Sympathetic Ophthalmia Through Advanced Choroidal Volume Analysis.

Author

Tanikawa, Akira, Maruyama, Kazuichi, Liu, Shiyi, Mao, Zaixing, Wang, Zhenguo, Shiraki, Nobuhiko, Hashida, Noriyasu, Kawasaki, Ryo, Chan, Kinpui, and Nishida, Kohji

Subjects
OPTICAL coherence tomography, THREE-dimensional imaging, DISEASE relapse, RECEIVER operating characteristic curves, IMAGE analysis
Abstract

Purpose: To evaluate the association between quantitative parameters derived from volume analysis of optical coherence tomography (OCT) data and disease worsening in Vogt-Koyanagi-Harada disease (VKHD) and sympathetic ophthalmia (SO). Methods: This retrospective study, conducted at Osaka University Hospital, employed swept-source OCT scans from patients diagnosed with VKHD or SO between October 2012 and January 2021. The choroidal vessel structure was segmented and visualized in three dimensions, generating quantitative vessel volume maps. Region-specific choroidal vessel volume (CVV), choroidal volume (CV), and vessel index (VI) were scrutinized for their potential correlation with disease severity. Results: Thirty-five eyes of 18 VKHD and 2 SO patient (8 females, 10 males) were evaluated. OCT-derived CVV maps revealed regional CV alterations in VKHD and SO patients. Two parameters, i.e. CV at 3- and 6-month follow-ups (p = 0.044, p = 0.040, respectively, with area under the ROC curve of 0.70) and CVV at 6 months (p = 0.046, area under the ROC curve of 0.71), were significantly higher in recurrent VKHD and SO compared to effectively treated cases. Conclusions: The volume analysis of OCT images facilitates a three-dimensional visualization of choroidal alterations, which may serve as a reflection of disease severity in VKHD and SO patients. Furthermore, noninvasive initial CVV or CV measurements may serve as potential biomarkers for predicting disease recurrence in VKHD and SO. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Overview of Cytomegalovirus Ocular Diseases: Retinitis, Corneal Endotheliitis, and Iridocyclitis.

Author

Kobayashi, Reiko and Hashida, Noriyasu

Subjects
*AIDS, *CYTOMEGALOVIRUS diseases, *DIGESTIVE organs, *IRIDOCYCLITIS, *IMMUNOCOMPROMISED patients
Abstract

Cytomegalovirus (CMV) infection is a significant clinical concern in newborns, immunocompromised patients with acquired immunodeficiency syndrome (AIDS), and patients undergoing immunosuppressive therapy or chemotherapy. CMV infection affects many organs, such as the lungs, digestive organs, the central nerve system, and eyes. In addition, CMV infection sometimes occurs in immunocompetent individuals. CMV ocular diseases includes retinitis, corneal endotheliitis, and iridocyclitis. CMV retinitis often develops in infected newborns and immunocompromised patients. CMV corneal endotheliitis and iridocyclitis sometimes develop in immunocompetent individuals. Systemic infections and CMV ocular diseases often require systemic treatment in addition to topical treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases

Author

1000030456959, Hashida, Noriyasu, 1000040244610, 0000-0001-9069-3610, Nishida, Kohji, 1000030456959, Hashida, Noriyasu, 1000040244610, 0000-0001-9069-3610, and Nishida, Kohji

Abstract

Effective drug therapy for vitreoretinal disease is a major challenge in the field of ophthalmology; various protective systems, including anatomical and physiological barriers, complicate drug delivery to precise targets. However, as the eye is a closed cavity, it is an ideal target for local administration. Various types of drug delivery systems have been investigated that take advantage of this aspect of the eye, enhancing ocular permeability and optimizing local drug concentrations. Many drugs, mainly anti-VEGF drugs, have been evaluated in clinical trials and have provided clinical benefit to many patients. In the near future, innovative drug delivery systems will be developed to avoid frequent intravitreal administration of drugs and maintain effective drug concentrations for a long period of time. Here, we review the published literature on various drugs and administration routes and current clinical applications. Recent advances in drug delivery systems are discussed along with future prospects.

Published
2023

24. The Efficacy of Golimumab Against Non-Infectious Uveitis: A PRISMA-Compliant Systematic Review and Meta-Analysis.

Author

Okada, Katsuya, Zhou, Yi, Hashida, Noriyasu, Takagi, Tatsuya, and Tian, Yu-Shi

Subjects
UVEITIS, GOLIMUMAB, VISUAL acuity, IRIDOCYCLITIS, SAMPLE size (Statistics)
Abstract

In this PRISMA-compliant systematic review and meta-analysis, we aimed to assess the efficacy of golimumab (GOL) against non-infectious uveitis (NIU). We included eight articles in the meta-analysis. The primary outcome was inflammation remission. Secondary outcomes were changes in the number of uveitis relapses/attacks, mean best-corrected visual acuity, central macular thickness, and systemic corticosteroid-sparing effects. In total, eight case series with 172 patients (43.6% female) were collected. Patients had 75% (95% CI: 56–87%) of remission; 42% (0.12–0.80) of patients showed improved visual acuity. The average central macular thickness decline was 38 μm (−56.51–18.54). The pooled results showed a significant decrease in the use of systemic corticosteroids. This study was limited by the use of non-RCT designs, limited sample sizes for outcomes, and heterogenetic underlying diseases. Our results suggest that GOL is effective against NIU. However, further evidence and analyses are required. (Funding: None; PROSPERO registration: CRD42021266214.) [ABSTRACT FROM AUTHOR]

Published
2023
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25. Factors associated with low prevalence of Fuchs' uveitis syndrome in Japan

Author

Yoneda, Yu, Usui, Yoshihiko, Tanaka, Rie, Hase, Keitaro, Namba, Kenichi, Kamoi, Koju, Takase, Hiroshi, Takeuchi, Masaki, Matsumiya, Wataru, Kusuhara, Sentaro, Takeda, Atsunobu, Yawata, Nobuyo, Yanai, Ryoji, Hiyama, Tomona, Harada, Yosuke, Hashida, Noriyasu, Maruyama, Kazuichi, Nakai, Kei, Taguchi, Ryo, Kaburaki, Toshikatsu, Mizuki, Nobuhisa, Goto, Hiroshi, Fujino, Yujiro, and Takeuchi, Masaru

Subjects
General Medicine
Abstract

AimTo investigate the causes of low prevalence of Fuchs' uveitis syndrome (FUS) in Japan.MethodsMedical records of 160 patients diagnosed with FUS at 14 uveitis specialty facilities in Japan were reviewed retrospectively.ResultsIn 160 FUS patients, mean follow-up period before referral to our uveitis facilities was 31.6 ± 50.9 months. The most common reason for referral was idiopathic uveitis (61.9%), followed by cataract (25.0%), high intraocular pressure (IOP) including glaucoma (16.3%), and FUS (14.4%). Unilateral involvement was 96.9%. The most frequent ocular finding of FUS was anterior inflammation (91.9%), followed by stellate-shaped keratic precipitates (88.1%), cataract/pseudophakia (88.1%), diffuse iris atrophy (84.4%), vitreous opacity (62.5%), heterochromia (53.1%) and high IOP including glaucoma (36.3%). As treatments of these ocular findings, cataract surgery was performed in 52.5%, glaucoma surgery in 10.6%, and vitrectomy in 13.8%. Mean logMAR VA was 0.28 ± 0.59 at the initial visit, and decreased significantly to 0.04 ± 0.32 at the last visit. Proportions of FUS patients with BCVA ConclusionsOcular findings of FUS in Japanese FUS patients were consistent with the characteristic features. The low prevalence of FUS in Japan may be a result of being overlooked and misdiagnosed as mild idiopathic uveitis, cataract, and/or glaucoma.

Published
2022
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28. Barium-induced toxic anterior segment syndrome.

Author

Matsushita, Kenji, Kawashima, Rumi, Hashida, Noriyasu, Hamano, Yuki, Harada, Kazuo, Higashisaka, Kazuma, Baba, Koichi, Sato, Shigeru, Huang, Weiran, Matsumoto, Hiroshi, Hamanaka, Teruhiko, Quantock, Andrew J., and Nishida, Kohji

Published
2023
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33. Diagnosis of Choroidal Disease With Deep Learning-Based Image Enhancement and Volumetric Quantification of Optical Coherence Tomography

Author

Maruyama, Kazuichi, primary, Mei, Song, additional, Sakaguchi, Hirokazu, additional, Hara, Chikako, additional, Miki, Atsuya, additional, Mao, Zaixing, additional, Kawasaki, Ryo, additional, Wang, Zhenguo, additional, Sakimoto, Susumu, additional, Hashida, Noriyasu, additional, Quantock, Andrew J., additional, Chan, Kinpui, additional, and Nishida, Kohji, additional

Published
2022
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36. Barium-induced toxic anterior segment syndrome

Author

Matsushita, Kenji, primary, Kawashima, Rumi, additional, Hashida, Noriyasu, additional, Hamano, Yuki, additional, Harada, Kazuo, additional, Higashisaka, Kazuma, additional, Baba, Koichi, additional, Sato, Shigeru, additional, Huang, Weiran, additional, Matsumoto, Hiroshi, additional, Hamanaka, Teruhiko, additional, Quantock, Andrew J., additional, and Nishida, Kohji, additional

Published
2021
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39. Opposite response of lung adenocarcinoma and its choroidal metastases upon ramucirumab plus docetaxel therapy after immunotherapy: a case report

Author

Matsumoto, Kinnosuke, primary, Shiroyama, Takayuki, additional, Hashida, Noriyasu, additional, Miyake, Kotaro, additional, Yamamoto, Yuji, additional, Kuge, Tomoki, additional, Yoneda, Midori, additional, Yamamoto, Makoto, additional, Naito, Yujiro, additional, Suga, Yasuhiko, additional, Fukushima, Kiyoharu, additional, Koyama, Shohei, additional, Iwahori, Kota, additional, Hirata, Haruhiko, additional, Nagatomo, Izumi, additional, Takeda, Yoshito, additional, and Kumanogoh, Atsushi, additional

Published
2021
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47. Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens

Author

Nishimoto, Sogo, Kawane, Kohki, Watanabe-Fukunaga, Rie, Fukuyama, Hidehiro, Ohsawa, Yoshiyuki, Uchiyama, Yasuo, Hashida, Noriyasu, Ohguro, Nobuyuki, Tano, Yasuo, Morimoto, Takeshi, Fukuda, Yutaka, and Nagata, Shigekazu

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Sogo Nishimoto [1, 7]; Kohki Kawane [1, 5]; Rie Watanabe-Fukunaga [1, 6]; Hidehiro Fukuyama [1, 7]; Yoshiyuki Ohsawa [2]; Yasuo Uchiyama [2]; Noriyasu Hashida [5]; Nobuyuki Ohguro [3]; Yasuo [...]

Published
2003
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49. Identification of TIE2 as a susceptibility gene for neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

Author

Chen, Zhen Ji, primary, Ma, Li, additional, Brelen, Marten E, additional, Chen, Haoyu, additional, Tsujikawa, Motokazu, additional, Lai, Timothy Y, additional, Ho, Mary, additional, Sayanagi, Kaori, additional, Hara, Chikako, additional, Hashida, Noriyasu, additional, Tam, Pancy OS, additional, Young, Alvin L, additional, Nishida, Kohji, additional, Tham, Clement C, additional, Pang, Chi Pui, additional, and Chen, Li Jia, additional

Published
2020
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