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4,600 results on '"Hashimoto, Kenji"'

3. Semidirect Product Decompositions for Periodic Regular Languages

Author

Inoue, Yusuke, Hashimoto, Kenji, and Seki, Hiroyuki

Subjects
Computer Science - Formal Languages and Automata Theory, 68Q45, 68Q70
Abstract

The definition of period in finite-state Markov chains can be extended to regular languages by considering the transitions of DFAs accepting them. For example, the language $(\Sigma\Sigma)^*$ has period two because the length of a recursion (cycle) in its DFA must be even. This paper shows that the period of a regular language appears as a cyclic group within its syntactic monoid. Specifically, we show that a regular language has period $P$ if and only if its syntactic monoid is isomorphic to a submonoid of a semidirect product between a specific finite monoid and the cyclic group of order $P$. Moreover, we explore the relation between the structure of Markov chains and our result, and apply this relation to the theory of probabilities of languages. We also discuss the Krohn-Rhodes decomposition of finite semigroups, which is strongly linked to our methods.

Published
2024

6. Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis

Author

Pu, Yaoyu, Cheng, Ruijuan, Zhang, Qiuping, Huang, Tianwen, Lu, Chenyang, Tang, Zhigang, Zhong, Yutong, Wu, Liang, Hammock, Bruce D, Hashimoto, Kenji, Luo, Yubin, and Liu, Yi

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Arthritis, Rheumatoid Arthritis, Autoimmune Disease, Women's Health, 2.1 Biological and endogenous factors, Inflammatory and immune system, Animals, Humans, Rats, Arthritis, Rheumatoid, Cell Movement, Cell Proliferation, Cells, Cultured, Epoxide Hydrolases, Fibroblasts, Synovial Membrane, Synoviocytes, Fibroblast-like synoviocytes, Inflammation, Rheumatoid arthritis, Soluble epoxide hydrolase, Synovium, Immunology
Abstract

Rheumatoid arthritis (RA) is an autoimmune disease characterized by enigmatic pathogenesis. Polyunsaturated fatty acids (PUFAs) are implicated in RA's development and progression, yet their exact mechanisms of influence are not fully understood. Soluble epoxide hydrolase (sEH) is an enzyme that metabolizes anti-inflammatory epoxy fatty acids (EpFAs), derivatives of PUFAs. In this study, we report elevated sEH expression in the joints of CIA (collagen-induced arthritis) rats, concomitant with diminished levels of two significant EpFAs. Additionally, increased sEH expression was detected in both the synovium of CIA rats and in the synovium and fibroblast-like synoviocytes (FLS) of RA patients. The sEH inhibitor TPPU attenuated the migration and invasion capabilities of FLS derived from RA patients and to reduce the secretion of inflammatory factors by these cells. Our findings indicate a pivotal role for sEH in RA pathogenesis and suggest that sEH inhibitors offer a promising new therapeutic strategy for managing RA.

Published
2023

7. Free automorphism groups of K3 surfaces with Picard number 3

Author

Hashimoto, Kenji and Lee, Kwangwoo

Subjects
Mathematics - Algebraic Geometry, 14J28, 14J50
Abstract

It is known that the automorphism group of any projective K3 surface is finitely generated [24]. In this paper, we consider a certain kind of K3 surfaces with Picard number 3 whose automorphism groups are isomorphic to congruence subgroups of the modular group $PSL_2(\mathbb{Z})$. In particular, we show that a free group of arbitrarily large rank appears as the automorphism group of such a K3 surface., Comment: 34 pages; added Sections 8.2 and 9; comments are welcome

Published
2023

11. MELEW-3: Quadruped-Wheeled Robot with 4-DoFs and An Active Wheel on One Leg

Author

Yamano, Junsei, Suzuki, Taisei, Nakahara, Takatoshi, Kasahara, Yoshinobu, Hashimoto, Kenji, Ceccarelli, Marco, Series Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Agrawal, Sunil K., Advisory Editor, Lovasz, Erwin-Christian, editor, and Ciupe, Valentin, editor

Published
2024
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12. Biped Robot Terrain Adaptability Based on Improved SAC Algorithm

Author

Zhang, Yilin, Xie, Jianan, Du, Xiaohan, Sun, Huimin, Wang, Shanshan, Hashimoto, Kenji, Ceccarelli, Marco, Series Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Agrawal, Sunil K., Advisory Editor, Larochelle, Pierre, editor, McCarthy, J. Michael, editor, and Lusk, Craig P., editor

Published
2024
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13. Walking Motion Generation of Bipedal Robot Based on Planar Covariation Using Deep Reinforcement Learning

Author

Yamano, Junsei, Kurokawa, Masaki, Sakai, Yuki, Hashimoto, Kenji, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Youssef, Ebrahim Samer El, editor, Tokhi, Mohammad Osman, editor, Silva, Manuel F., editor, and Rincon, Leonardo Mejia, editor

Published
2024
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14. Leg Mechanism of a Quadruped Wheeled Robot with a 4-DoF Spherical Parallel Link Mechanism

Author

Suzuki, Taisei, Ota, Hayato, Takenaka, Hiroki, Tanaka, Takayuki, Ishizawa, Yuta, Hashimoto, Kenji, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Youssef, Ebrahim Samer El, editor, Tokhi, Mohammad Osman, editor, Silva, Manuel F., editor, and Rincon, Leonardo Mejia, editor

Published
2024
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23. Characterizing Attributed Tree Translations in Terms of Macro Tree Transducers

Author

Hashimoto, Kenji and Maneth, Sebastian

Subjects
Computer Science - Formal Languages and Automata Theory
Abstract

It is well known that attributed tree transducers can be equipped with "regular look-around" in order to obtain a more robust class of translations. We present two characterizations of this class in terms of macro tree transducers (MTTs): the first one is a static restriction on the rules of the MTTs, where the MTTs need to be equipped with regular look-around. The second characterization is a dynamic one, where the MTTs only need regular look-ahead.

Published
2022

25. The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling

Author

Luo, Ailin, Wu, Zifeng, Li, Shan, McReynolds, Cindy B, Wang, Di, Liu, Hanyu, Huang, Chaoli, He, Teng, Zhang, Xinying, Wang, Yuanyuan, Liu, Cunming, Hammock, Bruce D, Hashimoto, Kenji, and Yang, Chun

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Chronic Pain, Brain Disorders, Depression, Pain Research, Mental Health, Mental Illness, Behavioral and Social Science, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Animals, Mice, Anhedonia, Antidepressive Agents, Comorbidity, Cytochrome P-450 CYP1A1, Cytokines, Epoxide Hydrolases, Phenylurea Compounds, Receptors, Aryl Hydrocarbon, Receptors, Cytoplasmic and Nuclear, Chronic pain, Soluble epoxide hydrolase, TPPU, Translocator protein, Aryl hydrocarbon receptor, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundPatients suffering from chronic pain often also exhibit depression symptoms. Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory cytokines. However, whether inhibiting sEH signaling is beneficial for the comorbidity of pain and depression is unknown.MethodsAccording to a sucrose preference test (SPT), spared nerve injury (SNI) mice were classified into pain with or without an anhedonia phenotype. Then, sEH protein expression and inflammatory cytokines were assessed in selected tissues. Furthermore, we used sEH inhibitor TPPU to determine the role of sEH in chronic pain and depression. Importantly, agonists and antagonists of aryl hydrocarbon receptor (AHR) and translocator protein (TSPO) were used to explore the pathogenesis of sEH signaling.ResultsIn anhedonia-susceptible mice, the tissue levels of sEH were significantly increased in the medial prefrontal cortex (mPFC), hippocampus, spinal cord, liver, kidney, and gut. Importantly, serum CYP1A1 and inflammatory cytokines, such as interleukin 1β (IL-1β) and the tumor necrosis factor α (TNF-α), were increased simultaneously. TPPU improved the scores of mechanical withdrawal threshold (MWT) and SPT, and decreased the levels of serum CYP1A1 and inflammatory cytokines. AHR antagonist relieved the anhedonia behaviors but not the algesia behaviors in anhedonia-susceptible mice, whereas an AHR agonist abolished the antidepressant-like effect of TPPU. In addition, a TSPO agonist exerted a similar therapeutic effect to that of TPPU, whereas pretreatment with a TSPO antagonist abolished the antidepressant-like and analgesic effects of TPPU.ConclusionssEH underlies the mechanisms of the comorbidity of chronic pain and depression and that TPPU exerts a beneficial effect on anhedonia behaviors in a pain model via AHR and TSPO signaling.

Published
2023

37. Solving Rep-tile by Computers: Performance of Solvers and Analyses of Solutions

Author

Banbara, Mutsunori, Hashimoto, Kenji, Horiyama, Takashi, Minato, Shin-ichi, Nakamura, Kakeru, Nishino, Masaaki, Sakai, Masahiko, Uehara, Ryuhei, Uno, Yushi, and Yasuda, Norihito

Subjects
Computer Science - Discrete Mathematics
Abstract

A rep-tile is a polygon that can be dissected into smaller copies (of the same size) of the original polygon. A polyomino is a polygon that is formed by joining one or more unit squares edge to edge. These two notions were first introduced and investigated by Solomon W. Golomb in the 1950s and popularized by Martin Gardner in the 1960s. Since then, dozens of studies have been made in communities of recreational mathematics and puzzles. In this study, we first focus on the specific rep-tiles that have been investigated in these communities. Since the notion of rep-tiles is so simple that can be formulated mathematically in a natural way, we can apply a representative puzzle solver, a MIP solver, and SAT-based solvers for solving the rep-tile problem in common. In comparing their performance, we can conclude that the puzzle solver is the weakest while the SAT-based solvers are the strongest in the context of simple puzzle solving. We then turn to analyses of the specific rep-tiles. Using some properties of the rep-tile patterns found by a solver, we can complete analyses of specific rep-tiles up to certain sizes. That is, up to certain sizes, we can determine the existence of solutions, clarify the number of the solutions, or we can enumerate all the solutions for each size. In the last case, we find new series of solutions for the rep-tiles which have never been found in the communities., Comment: 14 pages, 12 figures

Published
2021

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