16 results on '"Hasibuzzaman, M. M."'
Search Results
2. Characteristics and Health Effects of Arsenic Exposure in Bangladesh
- Author
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Hossain, Khaled, primary, Hasibuzzaman, M. M., additional, and Himeno, Seiichiro, additional
- Published
- 2018
- Full Text
- View/download PDF
3. Characterization of CPH : SA microparticle‐based delivery of interleukin‐1 alpha for cancer immunotherapy
- Author
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Hasibuzzaman, M. M., primary, He, Rui, additional, Khan, Ishrat Nourin, additional, Sabharwal, Rasna, additional, Salem, Aliasger K., additional, and Simons‐Burnett, Andrean Llewela, additional
- Published
- 2022
- Full Text
- View/download PDF
4. Characterization of CPH:SA microparticle‐based delivery of interleukin‐1 alpha for cancer immunotherapy.
- Author
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Hasibuzzaman, M. M., He, Rui, Khan, Ishrat Nourin, Sabharwal, Rasna, Salem, Aliasger K., and Simons‐Burnett, Andrean Llewela
- Subjects
- *
INTERLEUKIN-1 , *TUMOR-infiltrating immune cells , *BLOOD pressure , *WEIGHT loss , *CYTOKINE release syndrome , *CIRCULATING tumor DNA , *IMMUNE response , *INTERLEUKIN-1 receptors - Abstract
Background: Interleukin‐1 alpha (IL‐1α) is a pro‐inflammatory cytokine that can activate immune effector cells and trigger anti‐tumor immune responses. However, dose‐limiting toxicities including cytokine storm and hypotension has limited its use in the clinic as a cancer therapy. We propose that polymeric microparticle (MP)‐based delivery of IL‐1α will suppress the acute pro‐inflammatory side effects by allowing for slow and controlled release of IL‐1α systemically, while simultaneously triggering an anti‐tumor immune response. Methods: Polyanhydride copolymers composed of 1,6‐bis‐(p‐carboxyphenoxy)‐hexane:sebacic 20:80 (CPH:SA 20:80) was utilized to fabricate MPs. Recombinant IL‐1α (rIL‐1α) was encapsulated into CPH:SA 20:80 MPs (IL‐1α‐MPs) and the MPs were characterized by size, charge, loading efficiency, and in‐vitro release and activity of IL‐1α. IL‐1α‐MPs were injected intraperitonially into head and neck squamous cell carcinoma (HNSCC)‐bearing C57Bl/6 mice and monitored for changes in weight, tumor growth, circulating cytokines/chemokines, hepatic and kidney enzymes, blood pressure, heart rate, and tumor‐infiltrating immune cells. Results: CPH:SA IL‐1α‐MPs demonstrated sustained release kinetics of IL‐1α (100% protein released over 8–10 days) accompanied by minimal weight loss and systemic inflammation compared to rIL‐1α‐treated mice. Blood pressure measured by radiotelemetry in conscious mice demonstrates that rIL‐1α‐induced hypotension was prevented in IL‐1α‐MP‐treated mice. Liver and kidney enzymes were within normal range for all control and cytokine‐treated mice. Both rIL‐1α and IL‐1α‐MP‐treated mice showed similar delays in tumor growth and similar increases in tumor‐infiltrating CD3+ T cells, macrophages, and dendritic cells. Conclusions: CPH:SA‐based IL‐1α‐MPs generated a slow and sustained systemic release of IL‐1α resulting in reduced weight loss, systemic inflammation, and hypotension accompanied by an adequate anti‐tumor immune response in HNSCC‐tumor bearing mice. Therefore, MPs based on CPH:SA formulations may be promising as delivery vehicles for IL‐1α to achieve safe, effective, and durable antitumor responses for HNSCC patients. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
- View/download PDF
5. Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
- Author
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Hasibuzzaman, M. M., primary, Ross, Kathleen A., primary, Salem, Aliasger K., primary, Narasimhan, Balaji, primary, and Simons, Andrean L., primary
- Published
- 2021
- Full Text
- View/download PDF
6. Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents
- Author
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Callaghan, Cameron M., primary, Hasibuzzaman, M. M., additional, Rodman, Samuel N., additional, Goetz, Jessica E., additional, Mapuskar, Kranti A., additional, Petronek, Michael S., additional, Steinbach, Emily J., additional, Miller, Benjamin J., additional, Pulliam, Casey F., additional, Coleman, Mitchell C., additional, Monga, Varun V., additional, Milhem, Mohammed M., additional, Spitz, Douglas R., additional, and Allen, Bryan G., additional
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- 2020
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- View/download PDF
7. A hybrid genetic algorithm with chemical reaction optimization for multiple sequence alignment.
- Author
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Chatterjee, Sajib, primary, barua, Promal, additional, Hasibuzzaman, M. M., additional, Iftiea, Afrin, additional, Mukharjee, Tarpan, additional, and Nova, Sinthia Sharmin, additional
- Published
- 2019
- Full Text
- View/download PDF
8. Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh
- Author
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Paul, Sudip Kumar, Islam, Md. Shofikul, Hasibuzzaman, M. M., Hossain, Faruk, Anjum, Adiba, Saud, Zahangir Alam, Haque, Md. Mominul, Sultana, Papia, Haque, Azizul, Andric, Klara Biljana, Rahman, Aminur, Karim, Md Rezaul, Siddique, Abu Eabrahim, Karim, Yeasir, Rahman, Mizanur, Miyataka, Hideki, Xin, Lian, Himeno, Seiichiro, Hossain, Khaled, Paul, Sudip Kumar, Islam, Md. Shofikul, Hasibuzzaman, M. M., Hossain, Faruk, Anjum, Adiba, Saud, Zahangir Alam, Haque, Md. Mominul, Sultana, Papia, Haque, Azizul, Andric, Klara Biljana, Rahman, Aminur, Karim, Md Rezaul, Siddique, Abu Eabrahim, Karim, Yeasir, Rahman, Mizanur, Miyataka, Hideki, Xin, Lian, Himeno, Seiichiro, and Hossain, Khaled
- Abstract
Arsenic (As) toxicity and diabetes mellitus (DM) are emerging public health concerns worldwide. Although exposure to high levels of As has been associated with DM. whether there is also an association between low and moderate As exposure and DM remains unclear. We explored the dose-dependent association between As exposure levels and hyperglycemia, with special consideration of the impact of demographic variables, in 641 subjects from rural Bangladesh. The total study participants were divided into three groups depending on their levels of exposure to As in drinking water (low, moderate and high exposure groups). Prevalence of hyperglycemia, including impaired glucose tolerance (IGT) and DM was significantly associated with the subjects' drinking water arsenic levels. Almost all exposure metrics (As levels in the subjects' drinking water, hair and nails) showed dose-dependent associations with the risk or hyperglycemia, IGT and DM. Among the variables considered, sex, age, and BMI were found to be associated with higher risk of hyperglycemia. IGT and DM. In sex-stratified analyses, As exposure showed a clearer pattern of dose-dependent risk for hyperglycemia in females than males. Finally, drinking water containing low-to-moderate levels of As (50.01-150 mu g/L) was found to confer a greater risk of hyperglycemia than safe drinking water (As <= 10 mu g/L). Thus the results suggested that As exposure was dose-dependently associated with hyperglycemia, especially in females., Funding Agencies:Ministry of Science and Technology, Government of the People's Republic of Bangladesh 39.009.006.01.00.042.2012-2013/ES-21/558 National Institutes of Health R01 CA129560 MUSC Bridge funding 20441 Center for Global Health 20438 JSPS KAKENHI program 16H05834 Rajshahi University 5/52/RU/Science-13/17-18
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- 2019
- Full Text
- View/download PDF
9. Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh
- Author
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Hasibuzzaman, M. M., primary, Hossain, Shakhawoat, additional, Islam, Md. Shofikul, additional, Rahman, Atiqur, additional, Anjum, Adiba, additional, Hossain, Faruk, additional, Mohanto, Nayan Chandra, additional, Karim, Md. Rezaul, additional, Hoque, Md. Mominul, additional, Saud, Zahangir Alam, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Hossain, Khaled, additional
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- 2017
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- View/download PDF
10. Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh
- Author
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Hossain, Khaled, primary, Suzuki, Takehiro, additional, Hasibuzzaman, M. M., additional, Islam, Md. Shofikul, additional, Rahman, Atiqur, additional, Paul, Sudip Kumar, additional, Tanu, Tanzina, additional, Hossain, Shakhawoat, additional, Saud, Zahangir Alam, additional, Rahman, Mashiur, additional, Nikkon, Farjana, additional, Miyataka, Hideki, additional, Himeno, Seiichiro, additional, and Nohara, Keiko, additional
- Published
- 2017
- Full Text
- View/download PDF
11. Characterization of CPH:SA microparticle-based delivery of interleukin-1 alpha for cancer immunotherapy.
- Author
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Hasibuzzaman MM, He R, Khan IN, Sabharwal R, Salem AK, and Simons-Burnett AL
- Abstract
Background: Interleukin-1 alpha (IL-1α) is a pro-inflammatory cytokine that can activate immune effector cells and trigger anti-tumor immune responses. However, dose-limiting toxicities including cytokine storm and hypotension has limited its use in the clinic as a cancer therapy. We propose that polymeric microparticle (MP)-based delivery of IL-1α will suppress the acute pro-inflammatory side effects by allowing for slow and controlled release of IL-1α systemically, while simultaneously triggering an anti-tumor immune response., Methods: Polyanhydride copolymers composed of 1,6-bis-(p-carboxyphenoxy)-hexane:sebacic 20:80 (CPH:SA 20:80) was utilized to fabricate MPs. Recombinant IL-1α (rIL-1α) was encapsulated into CPH:SA 20:80 MPs (IL-1α-MPs) and the MPs were characterized by size, charge, loading efficiency, and in-vitro release and activity of IL-1α. IL-1α-MPs were injected intraperitonially into head and neck squamous cell carcinoma (HNSCC)-bearing C57Bl/6 mice and monitored for changes in weight, tumor growth, circulating cytokines/chemokines, hepatic and kidney enzymes, blood pressure, heart rate, and tumor-infiltrating immune cells., Results: CPH:SA IL-1α-MPs demonstrated sustained release kinetics of IL-1α (100% protein released over 8-10 days) accompanied by minimal weight loss and systemic inflammation compared to rIL-1α-treated mice. Blood pressure measured by radiotelemetry in conscious mice demonstrates that rIL-1α-induced hypotension was prevented in IL-1α-MP-treated mice. Liver and kidney enzymes were within normal range for all control and cytokine-treated mice. Both rIL-1α and IL-1α-MP-treated mice showed similar delays in tumor growth and similar increases in tumor-infiltrating CD3+ T cells, macrophages, and dendritic cells., Conclusions: CPH:SA-based IL-1α-MPs generated a slow and sustained systemic release of IL-1α resulting in reduced weight loss, systemic inflammation, and hypotension accompanied by an adequate anti-tumor immune response in HNSCC-tumor bearing mice. Therefore, MPs based on CPH:SA formulations may be promising as delivery vehicles for IL-1α to achieve safe, effective, and durable antitumor responses for HNSCC patients., Competing Interests: No conflicts of interest to disclose., (© 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.)
- Published
- 2022
- Full Text
- View/download PDF
12. Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass.
- Author
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Mondal V, Hosen Z, Hossen F, Siddique AE, Tony SR, Islam Z, Islam MS, Hossain S, Islam K, Sarker MK, Hasibuzzaman MM, Liu LZ, Jiang BH, Hoque MM, Saud ZA, Xin L, Himeno S, and Hossain K
- Subjects
- Bangladesh, Blood Glucose, Cross-Sectional Studies, Female, Humans, Male, Muscle, Skeletal chemistry, Arsenic analysis, Arsenic toxicity, Hyperglycemia chemically induced, Insulin Resistance
- Abstract
Background: Alargebodyof evidence has shown a link between arsenic exposure and diabetes, but the underlying mechanisms have not yet been clarified., Objective: We explored the association between arsenic exposure and the reduction of skeletal muscle mass as a potential mechanism of insulin resistance for developing arsenic-related hyperglycemia., Methods: A total of 581 subjects were recruited from arsenic-endemic and non-endemic areas in Bangladesh and their fasting blood glucose (FBG), serum insulin, and serum creatinine levels were determined. Subjects' arsenic exposure levels were assessed by arsenic concentrations in water, hair, and nails. HOMA-IR and HOMA-β were used to calculate insulin resistance and β-cell dysfunction, respectively. Serum creatinine levels and lean body mass (LBM) were used as muscle mass indicators., Results: Water, hair and nail arsenic concentrations showed significant positive associations with FBG, serum insulin and HOMA-IR and inverse associations with serum creatinine and LBM in a dose-dependent manner both in males and females. Water, hair and nail arsenic showed significant inverse associations with HOMA-β in females but not in males. FBG and HOMA-IR were increased with the decreasing levels of serum creatinine and LBM. Odds ratios (ORs)of hyperglycemia were significantly increased with the increasing concentrations of arsenic in water, hair and nails and with the decreasing levels of serum creatinine and LBM. Females' HOMA-IR showed greater susceptibility to the reduction of serum creatinine and LBM, possibly causing the greater risk of hyperglycemia in females than males. Path analysis revealed the mediating effect of serum creatinine level on the relationship of arsenic exposure with HOMA-IR and hyperglycemia., Conclusion: Arsenic exposure elevates FBG levels and the risk of hyperglycemia through increasing insulin resistance with greater susceptibility in females than males. Additionally, arsenic exposure-related reduction of skeletal muscle mass may be a mechanism underlying the development of insulin resistance and hyperglycemia., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
13. Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models.
- Author
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Seyedin SN, Hasibuzzaman MM, Pham V, Petronek MS, Callaghan C, Kalen AL, Mapuskar KA, Mott SL, Spitz DR, Allen BG, and Caster JM
- Subjects
- Animals, Antigen Presentation drug effects, Benzimidazoles pharmacology, Benzimidazoles therapeutic use, Cell Transformation, Neoplastic, Colorectal Neoplasms immunology, Colorectal Neoplasms pathology, Combined Modality Therapy, Female, Humans, Male, Mice, Poly(ADP-ribose) Polymerase Inhibitors therapeutic use, Radiation-Sensitizing Agents pharmacology, Radiation-Sensitizing Agents therapeutic use, Treatment Outcome, Colorectal Neoplasms drug therapy, Colorectal Neoplasms radiotherapy, Poly(ADP-ribose) Polymerase Inhibitors pharmacology, Poly(ADP-ribose) Polymerases metabolism
- Abstract
Purpose: The majority of colorectal cancers are resistant to cancer immune checkpoint inhibitors. Ionizing radiation (IR) and several radiosensitizers, including PARP inhibitors, can enhance responsiveness to immune checkpoint inhibitors by potentially complementary mechanisms of action. We assessed the ability of radiation and PARP inhibition to induce proimmunogenic changes in tumor cells and enhance their in vivo responsiveness to anti-PD-1 antibodies., Methods and Materials: We performed a candidate drug screen and used flow cytometry to assess effects of the PARP inhibitor veliparib on IR-mediated changes in MHC-1 antigen presentation and surface localization of immune-modulating proteins including PD-L1 and calreticulin in colorectal cancer tumor models. Reverse transcription polymerase chain reaction was used to assess the effects of veliparib and radiation on the expression of proinflammatory and immunosuppressive cytokines. The ability of concurrent PARP inhibition and subablative doses of radiation therapy to enhance in vivo responsiveness to anti-PD-1 antibodies was assessed using unilateral flank-tumor models with or without T-cell depletion., Results: Veliparib was a potent radiosensitizer in both cell lines. Radiation increased surface localization of MHC-1 and PD-L1 in a dose-dependent manner, and veliparib pretreatment significantly enhanced these effects with high (8 Gy) but not with lower radiation doses. Enhancement of MHC-1 and PD-L1 surface localization by IR and IR+ veliparib remained significant 1, 3, and 7 days after treatment. IR significantly increased delayed tumoral expression of proinflammatory cytokines interferon-Ƴ and CXCL10 but had no significant effect on the expression of IL-6 or TGF-β. Concurrent administration of veliparib and subablative radiation therapy (8 Gy × 2) significantly prolonged anti-PD-1-mediated in vivo tumor growth delay and survival in both tumor models. Moreover, these effects were more pronounced in the microsatellite instability-mutated MC38 tumor model. Enhancement of anti-PD-1 mediated tumor growth delay with veliparib and IR was attenuated by CD8+ T-cell depletion., Conclusions: We provide preclinical evidence for a novel therapeutic strategy to enhance responsiveness of colorectal tumors to immune checkpoint inhibitors., (Copyright © 2020 Elsevier Inc. All rights reserved.)
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- 2020
- Full Text
- View/download PDF
14. Association between chronic arsenic exposure and the characteristic features of asthma.
- Author
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Siddique AE, Rahman M, Hossain MI, Karim Y, Hasibuzzaman MM, Biswas S, Islam MS, Rahman A, Hossen F, Mondal V, Banna HU, Huda N, Hossain M, Sultana P, Nikkon F, Saud ZA, Haque A, Nohara K, Xin L, Himeno S, and Hossain K
- Subjects
- Adult, Arsenic metabolism, Arsenic Poisoning epidemiology, Bangladesh epidemiology, Environmental Pollutants analysis, Female, Hair chemistry, Humans, Male, Middle Aged, Nails chemistry, Arsenic analysis, Asthma epidemiology, Environmental Exposure statistics & numerical data
- Abstract
Widespread contamination of arsenic (As) has become a global public health concern. Exposure to As causes respiratory complications. Asthma, a major respiratory complication, is increasing worldwide. However, the effect of chronic As exposure on the risk of asthma remains to be clarified. This study aims to examine the associations between As exposure (water, hair and nail As) and the risk of asthma among 842 individuals exposed to a wide range of As concentrations through drinking water in Bangladesh. Subjects' As exposure levels were measured with ICP-MS. Lung function was examined by a handheld spirometer. Characteristic features of asthma were evaluated by bronchodilator-mediated reversibility in airway obstruction and asthma-like symptoms through a structured questionnaire. Total serum immunoglobulin E (sIgE) levels were measured by immunoassay. As exposure metrics showed inverse associations with lung function measures (FEV1, FEV6, and FEV1/FEV6 ratio) and positive associations with the risks of airway obstruction (AO), reversible airway obstruction (RAO), and asthma-like symptoms. The majority of AO patients (70 of 97) were RAO with one or more characteristic symptoms of asthma. Intriguingly, subjects' As exposure levels showed positive associations with total sIgE levels. Total sIgE in RAO patients was significantly (p < 0.001) higher than that in the control group. Thus the results revealed that chronic As exposure was associated with the risk of the characteristic features of asthma. Additionally the association between As exposure and subjects' total sIgE levels and an elevated level of total sIgE in RAO group suggested that As exposure-related asthma might be allergic in nature., Competing Interests: Declaration of competing interest The authors declare that there is no conflict of interest., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
15. Dose-dependent relationships between chronic arsenic exposure and cognitive impairment and serum brain-derived neurotrophic factor.
- Author
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Karim Y, Siddique AE, Hossen F, Rahman M, Mondal V, Banna HU, Hasibuzzaman MM, Hosen Z, Islam MS, Sarker MK, Nikkon F, Saud ZA, Xin L, Himeno S, and Hossain K
- Subjects
- Adolescent, Adult, Arsenic analysis, Bangladesh, Biomarkers blood, Cross-Sectional Studies, Drinking Water chemistry, Female, Hair chemistry, Humans, Male, Middle Aged, Nails chemistry, Water Pollutants, Chemical analysis, Young Adult, Arsenic toxicity, Brain-Derived Neurotrophic Factor blood, Cognitive Dysfunction chemically induced, Water Pollutants, Chemical toxicity
- Abstract
Background: Arsenic poisoning is a public health problem worldwide. A few studies have reported the effects of arsenic exposure on adult cognitive function, but with limitations in the subject selection and exposure markers. Moreover, information regarding the association between arsenic exposure and biomarker of cognitive impairment is scarce., Objectives: We examined the associations between arsenic exposure and adult cognitive impairment using the Mini-Mental State Examination (MMSE) and the serum levels of brain-derived neurotrophic factor (BDNF), a potential biomarker of cognitive health status., Methods: We designed a cross-sectional study that recruited 693 adult (18-60 years old) subjects from the areas of low- and high‑arsenic exposure in rural Bangladesh. The subjects' arsenic exposure levels (drinking water, hair, and nail arsenic concentrations) were measured by inductively coupled plasma-mass spectroscopy. The Bangla version of the MMSE was used as a cognitive assessment tool. Serum BDNF (sBDNF) levels were assessed by immunoassay., Results: In this study, we found that average MMSE score and sBDNF level of the subjects in arsenic-endemic areas were significantly (p < 0.001 for both) lower than those of the subjects in non-endemic area. Our analyses revealed that both MMSE scores and sBDNF levels were decreased with the increasing concentrations of arsenic in drinking water, hair, and nails in a dose-dependent fashion. In regression analyses, significant associations of arsenic exposure metrics with MMSE scores and sBDNF levels were observed even after adjustment for several variables. Intriguingly, MMSE scores showed a significantly positive correlation with sBDNF levels., Conclusion: Our findings demonstrate that chronic exposure to arsenic dose-dependently decreases cognitive function in adults, with a concomitant reduction of sBDNF levels. A decreased BDNF level may be part of the biochemical basis of chronic arsenic exposure-related cognitive impairment., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
16. Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh.
- Author
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Paul SK, Islam MS, Hasibuzzaman MM, Hossain F, Anjum A, Saud ZA, Haque MM, Sultana P, Haque A, Andric KB, Rahman A, Karim MR, Siddique AE, Karim Y, Rahman M, Miyataka H, Xin L, Himeno S, and Hossain K
- Subjects
- Adult, Arsenic analysis, Arsenic Poisoning epidemiology, Bangladesh epidemiology, Body Mass Index, Diabetes Mellitus epidemiology, Disease Susceptibility, Drinking Water chemistry, Female, Hair chemistry, Humans, Hyperglycemia epidemiology, Male, Middle Aged, Nails chemistry, Prevalence, Water Supply, Arsenic Poisoning complications, Diabetes Mellitus physiopathology, Environmental Exposure, Hyperglycemia physiopathology, Water Pollutants, Chemical analysis
- Abstract
Arsenic (As) toxicity and diabetes mellitus (DM) are emerging public health concerns worldwide. Although exposure to high levels of As has been associated with DM, whether there is also an association between low and moderate As exposure and DM remains unclear. We explored the dose-dependent association between As exposure levels and hyperglycemia, with special consideration of the impact of demographic variables, in 641 subjects from rural Bangladesh. The total study participants were divided into three groups depending on their levels of exposure to As in drinking water (low, moderate and high exposure groups). Prevalence of hyperglycemia, including impaired glucose tolerance (IGT) and DM was significantly associated with the subjects' drinking water arsenic levels. Almost all exposure metrics (As levels in the subjects' drinking water, hair and nails) showed dose-dependent associations with the risk of hyperglycemia, IGT and DM. Among the variables considered, sex, age, and BMI were found to be associated with higher risk of hyperglycemia, IGT and DM. In sex-stratified analyses, As exposure showed a clearer pattern of dose-dependent risk for hyperglycemia in females than males. Finally, drinking water containing low-to-moderate levels of As (50.01-150 μg/L) was found to confer a greater risk of hyperglycemia than safe drinking water (As ≤10 μg/L). Thus the results suggested that As exposure was dose-dependently associated with hyperglycemia, especially in females., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
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