Search

Your search keyword '"Hassan, Fasilat"' showing total 23 results
Start Over Author "Hassan, Fasilat"
23 results on '"Hassan, Fasilat"'

1. Clofibrate, a Peroxisome Proliferator–Activated Receptor-Alpha (PPARα) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride–Induced Toxicity

Author

Oyagbemi, Ademola Adetokunbo, Adejumobi, Olumuyiwa Abiola, Jarikre, Theophilus Aghogho, Ajani, Olumide Samuel, Asenuga, Ebunoluwa Racheal, Gbadamosi, Idayat Titilayo, Adedapo, Aduragbenro Deborah A., Aro, Abimbola Obemisola, Ogunpolu, Blessing Seun, Hassan, Fasilat Oluwakemi, Falayi, Olufunke Olubunmi, Ogunmiluyi, Iyanuoluwa Omolola, Omobowale, Temidayo Olutayo, Arojojoye, Oluwatosin Adetola, Ola-Davies, Olufunke Eunice, Saba, Adebowale Benard, Adedapo, Adeolu Alex, Emikpe, Benjamin Obukowho, Oyeyemi, Matthew Olugbenga, Nkadimeng, Sanah Malomile, McGaw, Lyndy Joy, Kayoka-Kabongo, Prudence Ngalula, Oguntibeju, Oluwafemi Omoniyi, and Yakubu, Momoh Audu

Published
2022
Full Text
View/download PDF

2. Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway

Author

Oyagbemi, Ademola Adetokunbo, Omobowale, Temidayo Olutayo, Adejumobi, Olumuyiwa Abiola, Owolabi, Abiodun Mary, Ogunpolu, Blessing Seun, Falayi, Olufunke Olubunmi, Hassan, Fasilat Oluwakemi, Ogunmiluyi, Iyanuoluwa Omolola, Asenuga, Ebunoluwa Racheal, Ola-Davies, Olufunke Eunice, Soetan, Kehinde Olugboyega, Saba, Adebowale Benard, Adedapo, Adeolu Alex, Nkadimeng, Sanah Malomile, McGaw, Lyndy Joy, Oguntibeju, Oluwafemi Omoniyi, and Yakubu, Momoh Audu

Published
2020
Full Text
View/download PDF

3. Cardiac fibrogenesis: an immuno-metabolic perspective.

Author

Hoque, Monirul, Gbadegoye, Joy Olaoluwa, Hassan, Fasilat Oluwakemi, Raafat, Amr, and Lebeche, Djamel

Subjects
HEART fibrosis, HEART diseases, IMMUNOMODULATORS, HEART cells, HEART failure
Abstract

Cardiac fibrosis is a major and complex pathophysiological process that ultimately culminates in cardiac dysfunction and heart failure. This phenomenon includes not only the replacement of the damaged tissue by a fibrotic scar produced by activated fibroblasts/myofibroblasts but also a spatiotemporal alteration of the structural, biochemical, and biomechanical parameters in the ventricular wall, eliciting a reactive remodeling process. Though mechanical stress, post-infarct homeostatic imbalances, and neurohormonal activation are classically attributed to cardiac fibrosis, emerging evidence that supports the roles of immune system modulation, inflammation, and metabolic dysregulation in the initiation and progression of cardiac fibrogenesis has been reported. Adaptive changes, immune cell phenoconversions, and metabolic shifts in the cardiac nonmyocyte population provide initial protection, but persistent altered metabolic demand eventually contributes to adverse remodeling of the heart. Altered energy metabolism, mitochondrial dysfunction, various immune cells, immune mediators, and cross-talks between the immune cells and cardiomyocytes play crucial roles in orchestrating the transdifferentiation of fibroblasts and ensuing fibrotic remodeling of the heart. Manipulation of the metabolic plasticity, fibroblast–myofibroblast transition, and modulation of the immune response may hold promise for favorably modulating the fibrotic response following different cardiovascular pathological processes. Although the immunologic and metabolic perspectives of fibrosis in the heart are being reported in the literature, they lack a comprehensive sketch bridging these two arenas and illustrating the synchrony between them. This review aims to provide a comprehensive overview of the intricate relationship between different cardiac immune cells and metabolic pathways as well as summarizes the current understanding of the involvement of immune–metabolic pathways in cardiac fibrosis and attempts to identify some of the previously unaddressed questions that require further investigation. Moreover, the potential therapeutic strategies and emerging pharmacological interventions, including immune and metabolic modulators, that show promise in preventing or attenuating cardiac fibrosis and restoring cardiac function will be discussed. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases

Author

Akinsulie, Olalekan Chris, primary, Shahzad, Sammuel, additional, Ogunleye, Seto Charles, additional, Oladapo, Ifeoluwa Peace, additional, Joshi, Melina, additional, Ugwu, Charles Egede, additional, Gbadegoye, Joy Olaoluwa, additional, Hassan, Fasilat Oluwakemi, additional, Adeleke, Richard, additional, Afolabi Akande, Qudus, additional, and Adesola, Ridwan Olamilekan, additional

Published
2023
Full Text
View/download PDF

7. Naringenin antihypertensive power is mediated via abrogation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim‐1) signaling pathway

Author

Oyagbemi, Ademola A., primary, Omobowale, Temidayo O., additional, Adejumobi, Olumuyiwa A., additional, Owolabi, Abiodun M., additional, Ogunpolu, Blessing S., additional, Falayi, Olufunke O., additional, Hassan, Fasilat O., additional, Ogunmiluyi, Iyanuoluwa O., additional, Ola‐Davies, Olufunke E., additional, Saba, Adebowale B., additional, Adedapo, Adeolu A., additional, Oguntibeju, Oluwafemi O., additional, and Yakubu, Momoh A., additional

Published
2022
Full Text
View/download PDF

10. The therapeutic potential of the novel angiotensin-converting enzyme 2 in the treatment of coronavirus disease-19

Author

Oyagbemi, Ademola Adetokunbo, primary, Ajibade, Temitayo Olabisi, additional, Aboua, Yapo Guillaume, additional, Gbadamosi, Idayat Titilayo, additional, Adedapo, Aduragbenro Deborah A., additional, Aro, Abimbola Obemisola, additional, Adejumobi, Olumuyiwa Abiola, additional, Thamahane-Katengua, Emma, additional, Omobowale, Temidayo Olutayo, additional, Falayi, Olufunke Olubunmi, additional, Oyagbemi, Taiwo Olaide, additional, Ogunpolu, Blessing Seun, additional, Hassan, Fasilat Oluwakemi, additional, Ogunmiluyi, Iyanuoluwa Omolola, additional, Ola-Davies, Olufunke Eunice, additional, Saba, Adebowale Benard, additional, Adedapo, Adeolu Alex, additional, Nkadimeng, Sanah Malomile, additional, McGaw, Lyndy Joy, additional, Kayoka-Kabongo, Prudence Ngalula, additional, Yakubu, Momoh Audu, additional, and Oguntibeju, Oluwafemi Omoniyi, additional

Published
2021
Full Text
View/download PDF

11. Luteolin mitigates potassium dichromate‐induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim‐1/Nrf2 signaling pathways

Author

Awoyomi, Omolola Victoria, primary, Adeoye, Yemisi Dorcas, additional, Oyagbemi, Ademola Adetokunbo, additional, Ajibade, Temitayo Olabisi, additional, Asenuga, Ebunoluwa Rachael, additional, Gbadamosi, Idayat Titilayo, additional, Ogunpolu, Blessing Seun, additional, Falayi, Olufunke Olubunmi, additional, Hassan, Fasilat Oluwakemi, additional, Omobowale, Temidayo Olutayo, additional, Arojojoye, Oluwatosin Adetola, additional, Ola‐Davies, Olufunke Eunice, additional, Saba, Adebowale Benard, additional, Adedapo, Adeolu Alex, additional, Oguntibeju, Oluwafemi Omoniyi, additional, and Yakubu, Momoh Audu, additional

Published
2021
Full Text
View/download PDF

12. Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action.

Author

Oyagbemi, Ademola Adetokunbo, Hassan, Fasilat Oluwakemi, Ajibade, Temitayo Olabisi, Ola-Davies, Olufunke Eunice, Omobowale, Temidayo Olutayo, Ajani, Olumide Samuel, Jarikre, Theophilus Aghogho, Soetan, Kehinde Olugboyega, Saba, Adebowale Benard, Adedapo, Adeolu Alex, Aro, Abimbola Obemisola, Oyeyemi, Matthew Olugbenga, Emikpe, Benjamin Obukowho, Nkadimeng, Sanah Malomile, McGaw, Lyndy Joy, Kayoka-Kabongo, Prudence Ngalula, Yakubu, Momoh Audu, and Oguntibeju, Oluwafemi Omoniyi

Abstract

Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L. taraxacifolia was examined. Fifty male Wistar rats were divided into 5 groups of 10 animals per group: Group A (Distilled water), Group B (Hypertensive rats; 40mg/kg L-NAME), Group C (Hypertensive rats plus 100 mg/kg extract), Group D (Hypertensive rats plus 200 mg/kg extract) and Group E (Hypertensive rats plus 10mg/kg of Lisinopril). The treatments were orally administered for five weeks. Haemodynamic parameters, urinalysis, indices of oxidative stress and immunohistochemistry were determined. Findings from this study showed that blood pressure parameters, urinary sodium and indices of oxidative stress increased significantly while In-vivo antioxidant defence systems decreased significantly in hypertensive rats. Immunohistochemistry revealed significant increases in expressions of mineralocorticoid receptor, angiotensin converting enzyme activity and kidney injury molecule-1 in kidney of hypertensive rats. Treatment with Launeae taraxacifolia normalized blood pressure parameters, urinary sodium, oxidative stress indices, antioxidant defence system, and serum nitric oxide bioavailability. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

13. Clofibrate, a Peroxisome Proliferator–Activated Receptor-Alpha (PPARα) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride–Induced Toxicity

Author

Oyagbemi, Ademola Adetokunbo, primary, Adejumobi, Olumuyiwa Abiola, additional, Jarikre, Theophilus Aghogho, additional, Ajani, Olumide Samuel, additional, Asenuga, Ebunoluwa Racheal, additional, Gbadamosi, Idayat Titilayo, additional, Adedapo, Aduragbenro Deborah A., additional, Aro, Abimbola Obemisola, additional, Ogunpolu, Blessing Seun, additional, Hassan, Fasilat Oluwakemi, additional, Falayi, Olufunke Olubunmi, additional, Ogunmiluyi, Iyanuoluwa Omolola, additional, Omobowale, Temidayo Olutayo, additional, Arojojoye, Oluwatosin Adetola, additional, Ola-Davies, Olufunke Eunice, additional, Saba, Adebowale Benard, additional, Adedapo, Adeolu Alex, additional, Emikpe, Benjamin Obukowho, additional, Oyeyemi, Matthew Olugbenga, additional, Nkadimeng, Sanah Malomile, additional, McGaw, Lyndy Joy, additional, Kayoka-Kabongo, Prudence Ngalula, additional, Oguntibeju, Oluwafemi Omoniyi, additional, and Yakubu, Momoh Audu, additional

Published
2021
Full Text
View/download PDF

14. Potential health benefits of zinc supplementation for the management of COVID‐19 pandemic

Author

Oyagbemi, Ademola Adetokunbo, primary, Ajibade, Temitayo Olabisi, additional, Aboua, Yapo Guillaume, additional, Gbadamosi, Idayat Titilayo, additional, Adedapo, Aduragbenro Deborah A., additional, Aro, Abimbola Obemisola, additional, Adejumobi, Olumuyiwa Abiola, additional, Thamahane‐Katengua, Emma, additional, Omobowale, Temidayo Olutayo, additional, Falayi, Olufunke Olubunmi, additional, Oyagbemi, Taiwo Olaide, additional, Ogunpolu, Blessing Seun, additional, Hassan, Fasilat Oluwakemi, additional, Ogunmiluyi, Iyanuoluwa Omolola, additional, Ola‐Davies, Olufunke Eunice, additional, Saba, Adebowale Benard, additional, Adedapo, Adeolu Alex, additional, Nkadimeng, Sanah Malomile, additional, McGaw, Lyndy Joy, additional, Kayoka‐Kabongo, Prudence Ngalula, additional, Oguntibeju, Oluwafemi Omoniyi, additional, and Yakubu, Momoh Audu, additional

Published
2021
Full Text
View/download PDF

15. Luteolin Attenuates Glycerol-Induced Acute Renal Failure and Cardiac Complications Through Modulation of Kim-1/NF-κB/Nrf2 Signaling Pathways

Author

Oyagbemi, Ademola Adetokunbo, primary, Adejumobi, Olumuyiwa Abiola, additional, Ajibade, Temitayo Olabisi, additional, Asenuga, Ebunoluwa Racheal, additional, Afolabi, Jeremiah Moyinoluwa, additional, Ogunpolu, Blessing Seun, additional, Falayi, Olufunke Olubunmi, additional, Hassan, Fasilat Oluwakemi, additional, Nabofa, Enivwenaye Williams, additional, Olutayo Omobowale, Temidayo, additional, Ola-Davies, Olufunke Eunice, additional, Saba, Adebowale Benard, additional, Adedapo, Adeolu Alex, additional, Oguntibeju, Oluwafemi Omoniyi, additional, and Yakubu, Momoh Audu, additional

Published
2020
Full Text
View/download PDF

16. Antihypertensive effect of Launeae taraxacifolia on L‐Nitro Arginine Methyl Ester (L‐NAME) Induced Hypertension

Author

Hassan, Fasilat Oluwakemi, primary, Oyagbemi, Ademola Adetokunbo, additional, Ogunpolu, Blessing Seun, additional, Falayi, Olufunke Olubunmi, additional, Omobowale, Temidayo Olutayo, additional, Ola-Davies, Olufunke Eunice, additional, Saba, Adebowale Benard, additional, Adedapo, Adeolu Alex, additional, and Yakubu, Momoh Audu, additional

Published
2020
Full Text
View/download PDF

17. Luteolin Attenuates Glycerol-Induced Acute Renal Failure and Cardiac Complications Through Modulation of Kim-1/NF-κB/Nrf2 Signaling Pathways.

Author

Oyagbemi, Ademola Adetokunbo, Adejumobi, Olumuyiwa Abiola, Ajibade, Temitayo Olabisi, Asenuga, Ebunoluwa Racheal, Afolabi, Jeremiah Moyinoluwa, Ogunpolu, Blessing Seun, Falayi, Olufunke Olubunmi, Hassan, Fasilat Oluwakemi, Nabofa, Enivwenaye Williams, Olutayo Omobowale, Temidayo, Ola-Davies, Olufunke Eunice, Saba, Adebowale Benard, Adedapo, Adeolu Alex, Oguntibeju, Oluwafemi Omoniyi, and Yakubu, Momoh Audu

Subjects
CARDIOVASCULAR diseases risk factors, BLOOD pressure, BIOMARKERS, TROPONIN, ANIMAL experimentation, IMMUNOHISTOCHEMISTRY, CELLULAR signal transduction, RATS, OXIDATIVE stress, TREATMENT effectiveness, FLAVONES, DNA-binding proteins, PLANT extracts, STATISTICAL sampling, NITRIC oxide, ACUTE kidney failure, PHARMACODYNAMICS, DISEASE complications
Abstract

Acute renal failure (ARF) has been documented as a life-threatening disease with high morbidity and mortality. We investigated the protective effect of Luteolin against ARF. In this study, forty-male Wistar albino rats were randomly divided into four groups (n = 10). Group A received normal saline. Group B received glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Groups C and D were pretreated with Luteolin 100 and 200 mg/kg for 7 days, and thereafter administered Glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Administration of glycerol significantly increased systolic blood pressure, diastolic blood pressure and mean arterial pressure. Renal protein carbonyl and xanthine oxidase increased significantly while significant reduction in the activity of renal glutathione peroxidase, glutathione S-transferase and glutathione reductase was observed in the glycerol intoxicated rats. Furthermore, administration of glycerol led to significant increases in serum creatinine and blood urea nitrogen together with reduction in nitric oxide (NO) bioavailability. Immunohistochemistry revealed that glycerol intoxication enhanced expressions of kidney injury molecule 1, nuclear factor kappa beta and cardiac troponin (CTnI). However, Luteolin pretreatment normalized blood pressure, reduced markers of oxidative stress, renal damage, and improved NO bioavailability. Luteolin also downregulated the expressions of kidney injury molecule 1, nuclear factor kappa beta and cardiac troponin. Together, Luteolin might open a novel therapeutic window for the treatment of acute renal failure and cardiac complication. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

18. Clofibrate, a PPAR‐α agonist, abrogates sodium fluoride‐induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba‐1/anti‐calbindin signaling pathways

Author

Oyagbemi, Ademola A., primary, Adebiyi, Olamide E., additional, Adigun, Kabirat O., additional, Ogunpolu, Blessing S., additional, Falayi, Olufunke O., additional, Hassan, Fasilat O., additional, Folarin, Oluwabusayo R., additional, Adebayo, Adedeji K., additional, Adejumobi, Olumuyiwa A., additional, Asenuga, Ebunoluwa R., additional, Ola‐Davies, Olufunke E., additional, Omobowale, Temidayo O., additional, Olopade, James O., additional, Saba, Adebowale B., additional, Adedapo, Adeolu A., additional, Nkadimeng, Sanah M., additional, McGaw, Lyndy J., additional, Oguntibeju, Oluwafemi O., additional, and Yakubu, Momoh A., additional

Published
2019
Full Text
View/download PDF

19. Luteolin attenuates glycerol‐induced acute renal failure through modulation of Kim‐1/NF‐κB /Nrf2 signaling pathways

Author

Oyagbemi, Ademola Adetokunbo, primary, Omobowale, Temidayo Olutayo, additional, Ola‐Davies, Olufunke Eunice, additional, Asenuga, Ebunoluwa Racheal, additional, Ajibade, Temitayo Olabisi, additional, Adejumobi, Olumuyiwa Abiola, additional, Afolabi, Jeremiah Moyinoluwa, additional, Ogunpolu, Blessing Seun, additional, Falayi, Olufunke Olubunmi, additional, Hassan, Fasilat Oluwakemi, additional, Nabofa, Williams Enivwenaye, additional, Saba, Adebowale Benard, additional, Adedapo, Adeolu Alex, additional, and Yakubu, Momoh Audu, additional

Published
2019
Full Text
View/download PDF

20. Ameliorative effect of Rutin on sodium fluoride-induced hypertension through modulation of Kim-1/NF-κB/Nrf2 signaling pathway in rats

Author

Oyagbemi, Ademola Adetokunbo, primary, Omobowale, Temidayo Olutayo, additional, Ola-Davies, Olufunke Eunice, additional, Asenuga, Ebunoluwa Racheal, additional, Ajibade, Temitayo Olabisi, additional, Adejumobi, Olumuyiwa Abiola, additional, Afolabi, Jeremiah Moyinoluwa, additional, Ogunpolu, Blessing Seun, additional, Falayi, Olufunke Olubunmi, additional, Ayodeji, Fatimah, additional, Hassan, Fasilat Oluwakemi, additional, Saba, Adebowale Bernard, additional, Adedapo, Adeolu Alex, additional, and Yakubu, Momoh Audu, additional

Published
2018
Full Text
View/download PDF

21. Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways

Author

Oyagbemi, Ademola Adetokunbo, primary, Omobowale, Temidayo Olutayo, additional, Ola-Davies, Olufunke Eunice, additional, Asenuga, Ebunoluwa Racheal, additional, Ajibade, Temitayo Olabisi, additional, Adejumobi, Olumuyiwa Abiola, additional, Arojojoye, Oluwatosin Adetola, additional, Afolabi, Jeremiah Moyinoluwa, additional, Ogunpolu, Blessing Seun, additional, Falayi, Olufunke Olubunmi, additional, Hassan, Fasilat Oluwakemi, additional, Ochigbo, Grace Onyeche, additional, Saba, Adebowale Benard, additional, Adedapo, Adeolu Alex, additional, and Yakubu, Momoh Audu, additional

Published
2018
Full Text
View/download PDF

22. Quercetin attenuates Sodium fluoride (NaF)‐induced hypertension through reduction in oxidative stress and heat shock proteins (HSP 70)/extracellular signal regulated kinase (ERK) pathways in rats

Author

Afolabi, Jeremiah Moyinoluwa, primary, Oyagbemi, Ademola Adetokunbo, additional, Omobowale, Temidayo Olutayo, additional, Asenuga, Ebunoluwa Racheal, additional, Ajibade, Temitayo Olabisi, additional, Adejumobi, Olumuyiwa Abiola, additional, Hassan, Fasilat Oluwakemi, additional, Adedapo, Adeolu Alex, additional, and Yakubu, Momoh Audu, additional

Published
2017
Full Text
View/download PDF

23. Clofibrate, a PPAR‐α agonist, abrogates sodium fluoride‐induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba‐1/anti‐calbindin signaling pathways.

Author

Oyagbemi, Ademola A., Adebiyi, Olamide E., Adigun, Kabirat O., Ogunpolu, Blessing S., Falayi, Olufunke O., Hassan, Fasilat O., Folarin, Oluwabusayo R., Adebayo, Adedeji K., Adejumobi, Olumuyiwa A., Asenuga, Ebunoluwa R., Ola‐Davies, Olufunke E., Omobowale, Temidayo O., Olopade, James O., Saba, Adebowale B., Adedapo, Adeolu A., Nkadimeng, Sanah M., McGaw, Lyndy J., Oguntibeju, Oluwafemi O., and Yakubu, Momoh A.

Subjects
PEROXISOME proliferator-activated receptors, CALCIUM-binding proteins, CLOFIBRATE, GLIAL fibrillary acidic protein, OXIDATIVE stress, INFLAMMATION, PURKINJE cells
Abstract

Fluoride is an environmental contaminant that is ubiquitously present in air, water, and soil. It is commonly added in minute quantity to drinking water, toothpaste, and mouth rinses to prevent tooth decay. Epidemiological findings have demonstrated that exposure to fluoride induced neurodevelopmental toxicity, developmental neurotoxicity, and motor disorders. The neuroprotective effect of clofibrate, a peroxisome proliferator‐activated receptor alpha agonist, was investigated in the present study. Forty male Wistar rats were used for this study and randomly grouped into 10 rats per group as control, sodium fluoride (NaF) alone (300 ppm), NaF plus clofibrate (250 mg/kg), and NaF plus lisinopril (10 mg/kg), respectively, for 7 days. NaF was administered in drinking water while clofibrate and lisinopril were administered by oral gavage. Markers of neuronal inflammation and oxidative stress, acetylcholinesterase activity, and neurobehavioral (hanging wire and open field) tests were performed. Immunohistochemistry was performed on brain tissues, and they were probed with glial fibrillary acidic protein, ionized calcium‐binding adaptor molecule 1, and cerebellar Ca2+‐binding protein calbindin‐D28k. The results showed that NaF significantly increased of oxidative stress and neuroinflammation and inhibited AChE activity. Immunostaining showed reactive astrocytes, microgliosis, loss of dendritic spines, and arborization in Purkinje cells in rats administered only NaF. Neurobehavioral results showed that cotreatment of NaF with clofibrate improved muscular strength and locomotion, reduced anxiety, and significantly reduced astrocytic count. Overall, cotreatment of NaF with either clofibrate or lisinopril showed neuroprotective effects by mitigating neuronal inflammation and oxidative and motor incoordination. Hence, clofibrate could be seen as a novel drug candidate against neurodegeneration and motor disorders. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results