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Climate change induced disasters have increased in frequency and intensity threatening economic wellbeing of businesses and communities. Micro, small and medium enterprises (MSME) being integral part of communities makes bulk (90%) of the economic activities around the globe, 96% in Asia and 99% of in Pakistan. In disaster context, survival, recovery and resilience of MSMEs are central to realization of community's survival, recovery and wellbeing. Small businesses are marred by liability of smallness characterized by limited resources, informal structure and unity of its ownership and management. SMEs are mostly dependent on entrepreneur's capabilities and resources for management, survival and growth. Some scholar suggest that in MSME context, among other factors entrepreneur's competencies, psychological and social capitals play a pivotal role in enabling organizational resilience and their disaster performance. Recently few studies have emerged focusing on investigating the impact of various entrepreneurial specific capabilities, resources and mechanisms either on firm resilience or firm performance separately in natural disaster and pandemic context. However, investigating the impact of these on MSME disaster recovery performance in an integrated model seems to be still missing. To address the gap, a study was designed to examine the relationship between entrepreneur's psychological capital, organizational resilience and MSME disaster recovery performance (MSME-DRP). An empirical quantitative study, grounded in multi-theory perspective, the propositions were explored by collecting data through questionnaire survey from 225 valid responses from flood effected District of Nowshera, Pakistan. Findings revealed that PsyCap significantly and positively impact MSME's disaster recovery performance. Results further highlighted significant partial mediation by organizational resilience, while it having significantly positive effect on recovery as direct mechanism as well. The paper contributes to the existing streamof research on organizational resilience and organizational disaster performance in broader strategicmanagement literature. [ABSTRACT FROM AUTHOR]

Information on the real-world experience of Canadians diagnosed with chronic lymphocytic leukemia (CLL) is limited. This study was conducted to report treatment patterns and outcomes of CLL using Ontario administrative data. A retrospective cohort study was conducted in patients diagnosed with CLL between 1 January 2010 and 31 December 2017 identified in the Ontario Cancer Registry (OCR). Data were accessed using the Institute of Clinical Evaluative Sciences (ICES), which collects various population-level health information. In the Ontario Cancer Registry, 2887 CLL patients receiving treatment and diagnosed between 2010-2017 were identified. Fludarabine, cyclophosphamide and rituximab (FCR) chemoimmunotherapy was most frequently used as a first line, but use declined since ibrutinib and obinutuzumab combinations were funded in 2015. In patients treated with frontline FCR, survival at year one was 89% pre-2015 and 96% post-2015; at year four, survival was 73% and 87%, respectively. Survival in patients treated with frontline chlorambucil was 76% pre-2015 and 75% post-2015 in year 1, and 45% and 56% in year 3. Our analysis shows that, as the treatment landscape for CLL has shifted, use of newer and novel agents as a first line or earlier in the relapsed/refractory setting has resulted in improved survival outcomes. [ABSTRACT FROM AUTHOR]

Present study aims to investigate the level of mindfulness among millennial students as they are the ones leading the professional landscape in the coming future. This study was carried out in the education sector of two countries (i.e. Pakistan & USA). Five Fact Mindfulness Questionnaire (FFMQ) scale is used to measuring level of mindfulness among millennial business graduates. Chi-square test is used for analyzing and comparing the mindfulness levels among students from two countries. Results of the test shows American students with higher degree of mindfulness compared to Pakistan students. Findings indicate that American students shows higher and lower degree of mindfulness in acting with awareness and non - reactivity to internal experience respectively. Where Pakistani students shows higher degree of mindfulness in Non - Judgemental to inner experience and lower degree of mindfulness to observing and non - reactivity to internal experience. Results of the study affirms that western and eastern countries observe individualist and collectivist cultures respectively. In collectivist culture children's decisions are influenced by their parents' will. Similarly, approval and disapproval from society has a significant impact on individual's choices and decisions making. Such social and parental influencers prevent individuals from becoming mindful and paying close attention to what is happening around them. In contrast to western cultures which are dominated by individualism, prospects are independent in their lives, making choices and taking decisions by themselves. Therefore, observing things with their own sight and without the lens of societal clichés helps the, achieve and maintain high levels of mindfulness. [ABSTRACT FROM AUTHOR]

The main objective of this paper is to understand and analyse the significance of sustainability and resilience in the recent development of Pakistan's Energy Sector. In addition to this, the paper aims to analyze what role the energy sector is playing in the economic development of the country. In contrast to quantitative research approach which mainly focuses on numbers and facts, this paper applies a qualitative research design on the said matter. Based on a proposed conceptual thematic framework, underlying the concept of climate change and adaptability (resilience), the contributions of the energy sector is explored. This included understanding the perception of some key stakeholders and how they expect global and national developments to the sector. More than fifteen stakeholders belonging to private investors, Government and Public were interviewed in the context of this study. Each of them represented senior management opinion and perspective on the issues faced by the sector and the future plans for them. [ABSTRACT FROM AUTHOR]

Present paper examined the effect of Conscientiousness Trait on Job Performance as sufficient evidence from literature proved that out of Big Five Personality Traits; Conscientiousness is a valid predictor of Job Performance across occupations and cultures. Therefore, present paper aimed to investigate relationship between Conscientiousness trait and Job Performance in Pakistani context. In the study, questionnaires were administered on 612microfinance staff from various parts of Pakistan. The original version of International Personality Item Pool inventory was modified and used to measure the Conscientiousness trait and for Job Performance measurement; researchers developed the instrument. The hypotheses were tested & checked by regression analysis. The study results endorsed that Conscientiousness has strong association with and also a valid predictor of employee Job Performance. The study findings also recognized that there is stronger link between Conscientiousness and Contextual Performance with then with Conscientiousness to Task Performance. Overall Job Performance was strongly linked to Conscientiousness. [ABSTRACT FROM AUTHOR]

This study investigated the effectiveness of CBT and psychotropic medicines for depression and psychological wellbeing in patients with depression. It also examined the difference in the treatment outcomes of psychotropic medicine alone as compared to CBT in combination with psychotropic medicines. The sample comprised of 50 male and female patients with depressive disorders out of which 25 patients received psychotropic medicines and 25 patients received CBT in combination with psychotropic medicines. The age of the sample ranged between 20-50 years recruited through purposive sampling. The quasi-experimental (Pretest-Posttest) design was employed. The results indicated that there was significant effect of both treatments on the patients of depression but combine treatment of CBT with psychotropic medication has more significant effect than the psychotropic medication alone. The study have implications and pave path for future investigation. [ABSTRACT FROM AUTHOR]

Background: The NCIC CTG LY.12 study showed that gemcitabine, dexamethasone, and cisplatin (GDP) were noninferior to dexamethasone, cytarabine, and cisplatin (DHAP) in patients with relapsed or refractory aggressive histology lymphoma prior to autologous stem cell transplantation. We conducted an economic evaluation from the perspective of the Canadian public healthcare system based on trial data., Methods: The primary outcome was an incremental cost utility analysis comparing costs and benefits associated with GDP vs DHAP. Resource utilization data were collected from 519 Canadian patients in the trial. Costs were presented in 2012 Canadian dollars and disaggregated to highlight the major cost drivers of care. Benefit was measured as quality-adjusted life-years (QALYs) based on utilities translated from prospectively collected quality-of-life data. All statistical tests were two-sided., Results: The mean overall costs of treatment per patient in the GDP and DHAP arms were $19 961 (95% confidence interval (CI) = $17 286 to $24 565) and $34 425 (95% CI = $31 901 to $39 520), respectively, with an incremental difference in direct medical costs of $14 464 per patient in favor of GDP (P < .001). The predominant cost driver for both treatment arms was related to hospitalizations. The mean discounted quality-adjusted overall survival with GDP was 0.161 QALYs and 0.152 QALYs for DHAP (difference = 0.01 QALYs, P = .146). In probabilistic sensitivity analysis, GDP was associated with both cost savings and improved quality-adjusted outcomes compared with DHAP in 92.6% of cost-pair simulations., Conclusions: GDP was associated with both lower costs and similar quality-adjusted outcomes compared with DHAP in patients with relapsed or refractory lymphoma. Considering both costs and outcomes, GDP was the dominant therapy., (© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)