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4 results on '"Hatai, Hirotsugu"'

2. Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress

Author

Terahara, Kazutaka, primary, Nochi, Tomonori, additional, Yoshida, Masato, additional, Takahashi, Yuko, additional, Goto, Yoshiyuki, additional, Hatai, Hirotsugu, additional, Kurokawa, Shiho, additional, Jang, Myoung Ho, additional, Kweon, Mi-Na, additional, Domino, Steven E., additional, Hiroi, Takachika, additional, Yuki, Yoshikazu, additional, Tsunetsugu-Yokota, Yasuko, additional, Kobayashi, Kazuo, additional, and Kiyono, Hiroshi, additional

Published
2011
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3. A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing Abs but does not influence natural intestinal immunity (46.4)

Author

Yuki, Yoshikazu, primary, Nochi, Tomonori, additional, Katakai, Yuko, additional, Shibata, Hiroaki, additional, Tokuhara, Daisuke, additional, Mejima, Mio, additional, Kurokawa, Shio, additional, Takahashi, Yuko, additional, Hatai, Hirotsugu, additional, Chubachi, Aya, additional, Nakanishi, Ushio, additional, Terao, Kenji, additional, and Kiyono, Hiroshi, additional

Published
2010
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4. Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms

Author

Hatai, Hirotsugu, Lepelley, Alice, Zeng, Wangyong, Hayden, Matthew S., and Ghosh, Sankar

Subjects
Protozoan diseases, Immune response--Molecular aspects, FOS: Clinical medicine, FOS: Biological sciences, Immunology, Pathology, bacteria, Toxoplasma gondii, Microbiology, 3. Good health
Abstract

Toll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has been shown to interact with two known protein PAMPs: Salmonella and E. coli flagellin FliC and Toxoplasma gondii profilin-like protein. Given the highly divergent biology of these pathogens recognized by TLR11, it is unclear whether common mechanisms are used to recognize these distinct protein PAMPs. Here we show that TLR11 interacts with these two PAMPs using different receptor domains. Furthermore, TLR11 binding to flagellin and profilin exhibits differential dependency on pH and receptor ectodomain cleavage.

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