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12 results on '"Hauns, Kevin"'

2. Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

Author

Regules, Jason A., Cicatelli, Susan B., Bennett, Jason W., Paolino, Kristopher M., Twomey, Patrick S., Moon, James E., Kathcart, April K., Hauns, Kevin D., Komisar, Jack L., Qabar, Aziz N., Davidson, Silas A., Dutta, Sheetij, Griffith, Matthew E., Magee, Charles D., Wojnarski, Mariusz, Livezey, Jeffrey R., Kress, Adrian T., Waterman, Paige E., Jongert, Erik, Wille-Reece, Ulrike, Volkmuth, Wayne, Emerling, Daniel, Robinson, William H., Lievens, Marc, Morelle, Danielle, Lee, Cynthia K., Yassin-Rajkumar, Bebi, Weltzin, Richard, Cohen, Joe, Paris, Robert M., Waters, Norman C., Birkett, Ashley J., Kaslow, David C., Ballou, W. Ripley, Ockenhouse, Christian F., and Vekemans, Johan

Published
2016

4. Protection against Plasmodium falciparum malaria by PfSPZ Vaccine

Author

Epstein, Judith E., primary, Paolino, Kristopher M., additional, Richie, Thomas L., additional, Sedegah, Martha, additional, Singer, Alexandra, additional, Ruben, Adam J., additional, Chakravarty, Sumana, additional, Stafford, April, additional, Ruck, Richard C., additional, Eappen, Abraham G., additional, Li, Tao, additional, Billingsley, Peter F., additional, Manoj, Anita, additional, Silva, Joana C., additional, Moser, Kara, additional, Nielsen, Robin, additional, Tosh, Donna, additional, Cicatelli, Susan, additional, Ganeshan, Harini, additional, Case, Jessica, additional, Padilla, Debbie, additional, Davidson, Silas, additional, Garver, Lindsey, additional, Saverino, Elizabeth, additional, Murshedkar, Tooba, additional, Gunasekera, Anusha, additional, Twomey, Patrick S., additional, Reyes, Sharina, additional, Moon, James E., additional, James, Eric R., additional, KC, Natasha, additional, Li, Minglin, additional, Abot, Esteban, additional, Belmonte, Arnel, additional, Hauns, Kevin, additional, Belmonte, Maria, additional, Huang, Jun, additional, Vasquez, Carlos, additional, Remich, Shon, additional, Carrington, Mary, additional, Abebe, Yonas, additional, Tillman, Amy, additional, Hickey, Bradley, additional, Regules, Jason, additional, Villasante, Eileen, additional, Sim, B. Kim Lee, additional, and Hoffman, Stephen L., additional

Published
2017
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12. A role for Z-DNA binding in vaccinia virus pathogenesis.

Author

Yang-Gyun Kim, Muralinath, Maneesha, Brandt, Teresa, Pearcy, Matthew, Hauns, Kevin, Lowenhaupt, Ky, Jacobs, Bertram L., and Rich, Alexander

Subjects
VACCINIA, DNA
Abstract

The N-terminal domain of the E3L protein of vaccinia virus has sequence similarity to a family of Z-DNA binding proteins of defined three-dimensional structure and it is necessary for pathogenicity in mice. When other Z-DNA-binding domains are substituted for the similar E3L domain, the virus retains its lethality after intracranial inoculation. Mutations decreasing Z-DNA binding in the chimera correlate with decreases in viral pathogenicity, as do analogous mutations in wild-type E3L. A chimeric virus incorporating a related protein that does not bind Z-DNA is not pathogenic, but a mutation that creates Z-DNA binding makes a lethal virus. The ability to bind the Z conformation is thus essential to E3L activity. This finding may allow the design of a class of antiviral agents, including agents against variola (smallpox), which has an almost identical E3L. [ABSTRACT FROM AUTHOR]

Published
2003
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