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15 results on '"Hausmann, Kristin"'

4. Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells

Author

Fischer, Marten A., primary, Mustafa, Al-Hassan M., additional, Hausmann, Kristin, additional, Ashry, Ramy, additional, Kansy, Anita G., additional, Liebl, Magdalena C., additional, Brachetti, Christina, additional, Piée-Staffa, Andrea, additional, Zessin, Matthes, additional, Ibrahim, Hany S., additional, Hofmann, Thomas G., additional, Schutkowski, Mike, additional, Sippl, Wolfgang, additional, and Krämer, Oliver H., additional

Published
2023
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5. Identifying Less Accurately Measured Students

Author

Moen, Ross, Liu, Kristi, Thurlow, Martha, Lekwa, Adam, Scullin, Sarah, and Hausmann, Kristin

Abstract

Some students are less accurately measured by typical reading tests than other students. By asking teachers to identify students whose performance on state reading tests would likely underestimate their reading skills, this study sought to learn about characteristics of less accurately measured students while also evaluating how well teachers can make such judgments. Twenty students identified by eight teachers participated in structured interviews and completed brief assessments matched to characteristics their teachers said impeded the students' test performance. Researchers found information from evidence provided by teachers, teacher and student interviews, and student assessments that confirmed teacher judgments for some students and information that failed to confirm or was at odds with teacher judgments for other students. Along with observations about student characteristics that affect assessment accuracy, recommendations from the study include suggestions for working with teachers who are asked to make judgments about test accuracy and procedures for confirming teacher judgments. (Contains 3 tables.)

Published
2009

6. Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Author

Marek, Martin, primary, Ramos-Morales, Elizabeth, additional, Picchi-Constante, Gisele F.A., additional, Bayer, Theresa, additional, Norström, Carina, additional, Herp, Daniel, additional, Sales-Junior, Policarpo A., additional, Guerra-Slompo, Eloise P., additional, Hausmann, Kristin, additional, Chakrabarti, Alokta, additional, Shaik, Tajith B., additional, Merz, Annika, additional, Troesch, Edouard, additional, Schmidtkunz, Karin, additional, Goldenberg, Samuel, additional, Pierce, Raymond J., additional, Mourão, Marina M., additional, Jung, Manfred, additional, Schultz, Johan, additional, Sippl, Wolfgang, additional, Zanchin, Nilson I.T., additional, and Romier, Christophe, additional

Published
2021
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7. Synthesis, crystallization studies and in vitro characterization of novel cinnamic acid derivatives as SmHDAC8 inhibitors for the treatment of Schistosomiasis

Author

Bayer, Theresa, Chakrabarti, Alokta, Lancelot, Julien, Shaik, Tajith, Hausmann, Kristin, Melesina, Jelena, Schmidtkunz, Karin, Marek, Martin, Erdmann, Frank, Schmidt, Matthias, Robaa, Dina, Romier, Christophe, Pierce, Raymond, Jung, Manfred, Sippl, Wolfgang, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)

Subjects
[CHIM.THER]Chemical Sciences/Medicinal Chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

8. Front Cover: Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as Sm HDAC8 Inhibitors for the Treatment of Schistosomiasis (ChemMedChem 15/2018)

Author

Bayer, Theresa, primary, Chakrabarti, Alokta, additional, Lancelot, Julien, additional, Shaik, Tajith B., additional, Hausmann, Kristin, additional, Melesina, Jelena, additional, Schmidtkunz, Karin, additional, Marek, Martin, additional, Erdmann, Frank, additional, Schmidt, Matthias, additional, Robaa, Dina, additional, Romier, Christophe, additional, Pierce, Raymond J., additional, Jung, Manfred, additional, and Sippl, Wolfgang, additional

Published
2018
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9. Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as Sm HDAC8 Inhibitors for the Treatment of Schistosomiasis

Author

Bayer, Theresa, primary, Chakrabarti, Alokta, additional, Lancelot, Julien, additional, Shaik, Tajith B., additional, Hausmann, Kristin, additional, Melesina, Jelena, additional, Schmidtkunz, Karin, additional, Marek, Martin, additional, Erdmann, Frank, additional, Schmidt, Matthias, additional, Robaa, Dina, additional, Romier, Christophe, additional, Pierce, Raymond J., additional, Jung, Manfred, additional, and Sippl, Wolfgang, additional

Published
2018
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13. Identifying Less Accurately Measured Students.

Author

Moen, Ross, Liu, Kristi, Thurlow, Martha, Lekwa, Adam, Scullin, Sarah, and Hausmann, Kristin

Subjects
READING Skills Competency Tests, EDUCATIONAL evaluation, TEACHER expectations, TIME on task (Education), TEACHER evaluation, STUDENT activities
Abstract

Some students are less accurately measured by typical reading tests than other students. By asking teachers to identify students whose performance on state reading tests would likely underestimate their reading skills, this study sought to learn about characteristics of less accurately measured students while also evaluating how well teachers can make such judgments. Twenty students identified by eight teachers participated in structured interviews and completed brief assessments matched to characteristics their teachers said impeded the students' test performance. Researchers found information from evidence provided by teachers, teacher and student interviews, and student assessments that confirmed teacher judgments for some students and information that failed to confirm or was at odds with teacher judgments for other students. Along with observations about student characteristics that affect assessment accuracy, recommendations from the study include suggestions for working with teachers who are asked to make judgments about test accuracy and procedures for confirming teacher judgments. [ABSTRACT FROM AUTHOR]

Published
2009

14. Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzihistone deacetylase DAC2

Author

Marek, Martin, Ramos-Morales, Elizabeth, Picchi-Constante, Gisele F.A., Bayer, Theresa, Norström, Carina, Herp, Daniel, Sales-Junior, Policarpo A., Guerra-Slompo, Eloise P., Hausmann, Kristin, Chakrabarti, Alokta, Shaik, Tajith B., Merz, Annika, Troesch, Edouard, Schmidtkunz, Karin, Goldenberg, Samuel, Pierce, Raymond J., Mourão, Marina M., Jung, Manfred, Schultz, Johan, Sippl, Wolfgang, Zanchin, Nilson I.T., and Romier, Christophe

Abstract

Writing and erasing of posttranslational modifications are crucial to phenotypic plasticity and antigenic variation of eukaryotic pathogens. Targeting pathogens’ modification machineries, thus, represents a valid approach to fighting parasitic diseases. However, identification of parasitic targets and the development of selective anti-parasitic drugs still represent major bottlenecks. Here, we show that the zinc-dependent histone deacetylases (HDACs) of the protozoan parasite Trypanosoma cruziare key regulators that have significantly diverged from their human counterparts. Depletion of T. cruziclass I HDACs tcDAC1 and tcDAC2 compromises cell-cycle progression and division, leading to cell death. Notably, tcDAC2 displays a deacetylase activity essential to the parasite and shows major structural differences with human HDACs. Specifically, tcDAC2 harbors a modular active site with a unique subpocket targeted by inhibitors showing substantial anti-parasitic effects in celluloand in vivo. Thus, the targeting of the many atypical HDACs in pathogens can enable anti-parasitic selective chemical impairment.

Published
2021
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15. Front Cover: Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis (ChemMedChem 15/2018).

Author

Bayer, Theresa, Chakrabarti, Alokta, Lancelot, Julien, Shaik, Tajith B., Hausmann, Kristin, Melesina, Jelena, Schmidtkunz, Karin, Marek, Martin, Erdmann, Frank, Schmidt, Matthias, Robaa, Dina, Romier, Christophe, Pierce, Raymond J., Jung, Manfred, and Sippl, Wolfgang

Published
2018
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