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34 results on '"Hausnerová, Jitka"'

5. A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrations

Author

Stružinská, Ivana, Hájková, Nikola, Hojný, Jan, Krkavcová, Eva, Michálková, Romana, Dvořák, Jiří, Němejcová, Kristýna, Matěj, Radoslav, Laco, Jan, Drozenová, Jana, Fabian, Pavel, Hausnerová, Jitka, Méhes, Gábor, Škapa, Petr, Švajdler, Marián, Cibula, David, Frühauf, Filip, Bártů, Michaela Kendall, and Dundr, Pavel

Published
2023
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6. A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors

Author

Němejcová, Kristýna, Bártů, Michaela Kendall, Michálková, Romana, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Laco, Jan, Matěj, Radoslav, Méhes, Gábor, Singh, Naveena, Stolnicu, Simona, Škapa, Petr, Švajdler, Marián, Stružinská, Ivana, Cibula, David, Kocian, Roman, Lax, Sigurd F., McCluggage, W. Glenn, and Dundr, Pavel

Published
2023
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8. Endometrial Pipelle Biopsy Computer-Aided Diagnosis: A Feasibility Study

Author

Vermorgen, Sanne, Gelton, Thijs, Bult, Peter, Kusters-Vandevelde, Heidi V.N., Hausnerová, Jitka, Van de Vijver, Koen, Davidson, Ben, Stefansson, Ingunn Marie, Kooreman, Loes F.S., Qerimi, Adelina, Huvila, Jutta, Gilks, Blake, Shahi, Maryam, Zomer, Saskia, Bartosch, Carla, Pijnenborg, Johanna M.A., Bulten, Johan, Ciompi, Francesco, and Simons, Michiel

Published
2024
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9. Microsatellite instability in non-endometrioid ovarian epithelial tumors: a study of 400 cases comparing immunohistochemistry, PCR, and NGS based testing with mutation status of MMR genes

Author

Hájková, Nikola, Bártů, Michaela Kendall, Cibula, David, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Frühauf, Filip, Hausnerová, Jitka, Hojný, Jan, Krkavcová, Eva, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, Méhes, Gábor, Michálková, Romana, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Švajdler, Marián, Zima, Tomáš, McCluggage, Wilson Glenn, Stružinská, Ivana, and Dundr, Pavel

Published
2023
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10. Refined criteria for p53 expression in ovarian mucinous tumours are highly concordant with TP53 mutation status, but p53 expression/TP53 status lack prognostic significance

Author

Dundr, Pavel, Hájková, Nikola, Kendall Bártů, Michaela, Cibula, David, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Frühauf, Filip, Hausnerová, Jitka, Hojný, Jan, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, Méhes, Gábor, Michálková, Romana, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Švajdler, Marián, Zima, Tomáš, McCluggage, W. Glenn, and Stružinská, Ivana

Published
2023
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11. The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance

Author

Dundr, Pavel, Bazalová, Barbora, Bártů, Michaela, Bosse, Tjalling, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Jakša, Radek, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, McCluggage, W. Glenn, Méhes, Gábor, Michálková, Romana, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Škapa, Petr, Švajdler, Marián, and Stružinská, Ivana

Published
2022
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12. Primary Mucinous Tumors of the Ovary: An Interobserver Reproducibility and Detailed Molecular Study Reveals Significant Overlap Between Diagnostic Categories

Author

Dundr, Pavel, Bártů, Michaela, Bosse, Tjalling, Bui, Quang Hiep, Cibula, David, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Hojný, Jan, Hájková, Nikola, Jakša, Radek, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, Méhes, Gábor, Michálková, Romana, Šafanda, Adam, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Švajdler, Marián, Zima, Tomáš, Stružinská, Ivana, and McCluggage, W. Glenn

Published
2023
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13. Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer

Author

Vyhlídalová Kotrbová, Anna, primary, Gömöryová, Kristína, additional, Mikulová, Antónia, additional, Plešingerová, Hana, additional, Sladeček, Stanislava, additional, Kravec, Marek, additional, Hrachovinová, Šárka, additional, Potěšil, David, additional, Dunsmore, Garett, additional, Blériot, Camille, additional, Bied, Mathilde, additional, Kotouček, Jan, additional, Bednaříková, Markéta, additional, Hausnerová, Jitka, additional, Minář, Luboš, additional, Crha, Igor, additional, Felsinger, Michal, additional, Zdráhal, Zbyněk, additional, Ginhoux, Florent, additional, Weinberger, Vít, additional, Bryja, Vitězslav, additional, and Pospíchalová, Vendula, additional

Published
2024
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15. Endometrial Pipelle biopsy computer-aided diagnosis (ENDO-AID): a feasibility study

Author

Vermorgen, Sanne, primary, Gelton, Thijs, additional, Bult, Peter, additional, Kusters-Vandevelde, Heidi V.N., additional, Hausnerová, Jitka, additional, Van de Vijver, Koen, additional, Davidson, Ben, additional, Stefansson, Ingunn Marie, additional, Kooreman, Loes F.S., additional, Qerimi, Adelina, additional, Huvila, Jutta, additional, Gilks, Blake, additional, Shahi, Maryam, additional, Zomer, Saskia, additional, Bartosch, Carla, additional, Pijnenborg, Johanna MA., additional, Bulten, Johan, additional, Ciompi, Francesco, additional, and Simons, Michiel, additional

Published
2023
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16. Neuroendocrine Marker Expression in Primary Non-neuroendocrine Epithelial Tumors of the Ovary: A Study of 551 Cases.

Author

Bártů, Michaela Kendall, Němejcová, Kristýna, Michálková, Romana, Quang Hiep Bui, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Laco, Jan, Matěj, Radoslav, Méhes, Gábor, Šafanda, Adam, Singh, Naveena, Škapa, Petr, Špůrková, Zuzana, Stolnicu, Simona, Švajdler, Marián, Lax, Sigurd F., McCluggage, W. Glenn, and Dundr, Pavel

Published
2024
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18. #500 Protein composition of extracellular vesicles from malignant ascites defines the key components of tumor microenvironment and predicts prognosis of ovarian cancer patients

Author

Kotrbová, Anna Vyhlídalová, primary, Gömöryová, Kristína, additional, Mikulová, Antónia, additional, Plešingerová, Hana, additional, Kravec, Marek, additional, Potešil, David, additional, Blériot, Camille, additional, Bied, Mathilde, additional, Dunsmore, Garett, additional, Kotoucek, Jan, additional, Bednaríková, Markéta, additional, Hausnerová, Jitka, additional, Minár, Luboš, additional, Crha, Igor, additional, Felsinger, Michal, additional, Zdráhal, Zbynek, additional, Ginhoux, Florent, additional, Weinberger, Vít, additional, Bryja, Vítezslav, additional, and Pospíchalová, Vendula Hlavácková, additional

Published
2023
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19. #373 The combined genomic and immunohistochemical tumor profiling as a tool of precision oncology approach in the real-world cohort of patients with gynecological cancers

Author

Bednaríková, Markéta, primary, Eid, Michal, additional, Ehrlichová, Lucie, additional, Hausnerová, Jitka, additional, Vilmanová, Sára, additional, Kopková, Alena, additional, Taslerová, Renata, additional, Jelínková, Martina, additional, Minár, Luboš, additional, Felsinger, Michal, additional, Ovesná, Petra, additional, Gryc, Martin, additional, Slabý, Ondrej, additional, and Weinberger, Vít, additional

Published
2023
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20. Neuroendocrine Marker Expression in Primary Non-neuroendocrine Epithelial Tumors of the Ovary: A Study of 551 Cases

Author

Kendall Bártů, Michaela, Němejcová, Kristýna, Michálková, Romana, Bui, Quang Hiep, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Laco, Jan, Matěj, Radoslav, Méhes, Gábor, Šafanda, Adam, Singh, Naveena, Škapa, Petr, Špůrková, Zuzana, Stolnicu, Simona, Švajdler, Marián, Lax, Sigurd F., McCluggage, W. Glenn, and Dundr, Pavel

Abstract

Expression of neuroendocrine (NE) markers in primary ovarian non-NE epithelial tumors has rarely been evaluated. The aim of our study was to evaluate the expression of the most widely used NE markers in these neoplasms and to determine any prognostic significance of NE marker expression. The cohort consisted of 551 primary ovarian tumors, including serous borderline tumors, low-grade serous carcinomas, high-grade serous carcinomas (HGSC), clear cell carcinomas, endometroid carcinomas, mucinous borderline tumors, and mucinous carcinomas. Immunohistochemical analysis was performed using antibodies against INSM1, synaptophysin, chromogranin, and CD56 on tissue microarray. Positivity for INSM1, synaptophysin, chromogranin, and CD56 was most frequently observed in mucinous tumors (48.7%, 26.0%, 41.5%, and 100%, respectively). The positivity for these NE markers was mostly restricted to nonmucinous elements distributed throughout the tumor. The mucinous borderline tumor and mucinous carcinomas groups had similar proportions of positivity (mucinous borderline tumor: 53%, mucinous carcinomas: 39%). In the other tumor types, except for HGSC, there was only focal expression (5%–10%) or negativity for NE markers. HGSC showed high CD56 expression (in 26% of cases). Survival analysis was only performed for CD56 in HGSC as this was the only group with sufficient positive cases, and it showed no prognostic significance. Except for mucinous tumors, expression of NE markers in non-NE ovarian epithelial tumors is low. CD56 expression in HGSC occurs frequently but is without diagnostic or prognostic value.

Published
2024
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21. Additional file 1 of A comprehensive immunohistochemical analysis of 26 markers in 250 cases of serous ovarian tumors

Author

Němejcová, Kristýna, Šafanda, Adam, Bártů, Michaela Kendall, Michálková, Romana, Drozenová, Jana, Fabian, Pavel, Hausnerová, Jitka, Laco, Jan, Matěj, Radoslav, Méhes, Gábor, Škapa, Petr, Stružinská, Ivana, and Dundr, Pavel

Abstract

Additional file 1: TableS1. List of antibodies. TableS2. Overview of optimal cut-offs for the selected markers distinguishingbetween HGSC vs. LGSC and LGSC vs. mSBT. Suitable markers are marked in bold,based on sensitivity and specificity.

Published
2023
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23. Refined criteria for p53 expression in ovarian mucinous tumours are highly concordant with TP53mutation status, but p53 expression/TP53status lack prognostic significance

Author

Dundr, Pavel, Hájková, Nikola, Kendall Bártů, Michaela, Cibula, David, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Frühauf, Filip, Hausnerová, Jitka, Hojný, Jan, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, Méhes, Gábor, Michálková, Romana, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Švajdler, Marián, Zima, Tomáš, McCluggage, W. Glenn, and Stružinská, Ivana

Abstract

In gynecological neoplasms, immunohistochemical (IHC) expression of p53 is generally an accurate predictor of TP53mutation status if correctly interpreted by the pathologist. However, the literature concerning cut-offs, frequency and prognostic significance of p53 staining in ovarian mucinous tumours is limited and heterogeneous. We performed an analysis of 123 primary ovarian mucinous tumours including mucinous borderline tumours (MBT), mucinous carcinomas (MC), and tumours with equivocal features between MBT and MC. We assessed p53 expression for the three recognised patterns of aberrant staining in ovarian carcinoma [overexpression (‘all’), null and cytoplasmic] but using a recently suggested cut-off for aberrant overexpression in ovarian mucinous tumours (strong nuclear p53 staining in ≥12 consecutive tumour cells) and correlated the results with next generation sequencing (NGS) in all qualitatively sufficient cases (92/123). Aberrant p53 expression was present in 25/75 (33.3%) MBT, 23/33 (69.7%) MC (75% of MC with expansile invasion and 61.5% with infiltrative invasion), and 10/15 (66.7%) tumours equivocal between MBT and MC. Regarding the 92 tumours with paired IHC and mutation results, 86 showed concordant results and six cases were discordant. Three discordant MBT cases showed aberrant expression but were TP53wild-type on sequencing. Three cases had normal p53 expression but contained a TP53mutation. Overall, IHC predicted the TP53mutation status with high sensitivity (94.1%) and specificity (92.7%). The accuracy of IHC was 93.5% with a positive predictive value of 94.1% and a negative predictive value of 92.7%. When comparing MC cases with wild-type TP53versus those with TP53mutation, there were no significant differences concerning disease-free survival, local recurrence-free survival, or metastases-free survival (p>0.05). In the MBT subgroup, there were no events for survival analyses. In conclusion, using an independent large sample set of ovarian mucinous tumours, the results of our study confirm that the suggested refined cut-off of strong nuclear p53 staining in ≥12 consecutive tumour cells reflect high accuracy, sensitivity and specificity for an underlying TP53mutation but the TP53mutation status has no prognostic significance in either MC or MBT.

Published
2023
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26. WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer

Author

Kotrbová, Anna, primary, Ovesná, Petra, additional, Gybel', Tomáš, additional, Radaszkiewicz, Tomasz, additional, Bednaříková, Markéta, additional, Hausnerová, Jitka, additional, Jandáková, Eva, additional, Minář, Luboš, additional, Crha, Igor, additional, Weinberger, Vít, additional, Záveský, Luděk, additional, Bryja, Vítězslav, additional, and Pospíchalová, Vendula, additional

Published
2020
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31. Metastatic primary non-resectable colorectal cancer mimicking ovarian cancer in a 38-year old pregnant woman

Author

Bednaříková, Markéta, primary, Weinberger, Vít, additional, Minář, Luboš, additional, Bednařík, Otakar, additional, Jandáková, Eva, additional, Hausnerová, Jitka, additional, Řehák, Zdeněk, additional, Bohatá, Šárka, additional, Valík, Dalibor, additional, Ostřížková, Lenka, additional, and Brančíková, Dagmar, additional

Published
2016
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33. Does an Endometrial Cancer Diagnosis among Asymptomatic Patients Improve Prognosis?

Author

Vinklerová, Petra, Ovesná, Petra, Bednaříková, Markéta, Minář, Luboš, Felsinger, Michal, Hausnerová, Jitka, and Weinberger, Vít

Subjects
UTERINE hemorrhage, STATISTICS, SCIENTIFIC observation, MULTIVARIATE analysis, RETROSPECTIVE studies, CANCER relapse, CANCER patients, RISK assessment, COMPARATIVE studies, ENDOMETRIAL tumors, METRORRHAGIA, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, TUMOR markers, LONGITUDINAL method, DISEASE risk factors, SYMPTOMS
Abstract

Simple Summary: Endometrial cancer is common malignancy with an excellent prognosis due to its early symptoms—abnormal bleeding. It is still common in some countries to provide a biopsy in asymptomatic patients based on ultrasound findings; even though, it is not supported by the European guidelines. The aim of our study was to find out if there is a prognostic difference among symptomatic and bleeding-free patients with similar clinical histological characteristics. Background: Endometrial cancer is the most common gynecological malignancy in developed countries with no screening available. There is still a tendency to provide invasive bioptic verification in asymptomatic women with abnormal ultrasound findings to diagnose carcinoma in a preclinical phase; even though, it is not supported by European guidelines. Our goal was to determine DFS (disease-free survival), OS (overall survival), and DSS (disease-specific survival) differences between symptom-free and symptomatic (bleeding, or spotting) endometrial cancer patients with similar stage and tumor/clinical characteristics. Methods: All of our patients with endometrial cancer following surgical treatment between 2006 and 2019 were assessed, evaluating risk factors for recurrence and death while focusing on bleeding using univariable and multivariable analysis. Results: 625 patients meeting the inclusion criteria were divided into asymptomatic (n = 144, 23%) and symptomatic (n = 481, 77%) groups. The median follow-up was 3.6 years. Using univariable analysis, symptomatic patients had a three times higher risk of recurrence (HR 3.1 (95% Cl 1.24–7.77), p = 0.016). OS (HR 1.35 (0.84–2.19), p = 0.219) and DSS (HR 1.66 (0.64–4.28), p = 0.3) were slightly worse without reaching statistical significance. In our multivariable analysis, symptomatology was deemed completely insignificant in all monitored parameters (DFS: HR 2.03 (0.79–5.24), p = 0.144; OS: HR 0.72 (0.43–1.21), p = 0.216). Conclusions: The symptomatic endometrial cancer patients risk factor of earlier recurrence and death is insignificantly higher when compared with the asymptomatic cohort. However, multivariable analysis verifies that prognosis worsens with other clinically relevant parameters, not by symptomatology itself. In terms of survival outcome in EC patients, we recognized symptomatology as a non-significant marker for the patient's prognosis. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Necrotising sarcoid granulomatosis. A rare granulomatous disease.

Author

Doubková M, Hausnerová J, Výška O, Richter S, and Merta Z

Abstract

Introduction: Necrotizing sarcoid granulomatosis (NSG) is a very rare disease of unknown etiology characterized by sarcoid-like granulomas, vasculitis and necrosis in pulmonary and extrapulmonary localizations. Case report: We describe a case of a 34-year-old Caucasian male with fever, pleural pain, and nodular pulmonary opacities on chest radiograph. Histological examination of the lung tissue confirmed NSG. Diagnostically, infectious causes, vasculitis, and malignancy were excluded. A tendency to partial regression was observed, without the need for corticosteroid treatment. Conclusion: NSG is a rare disease which must be distinguished from other systemic diseases including vasculitides. The key to diagnosis, emphasized in our paper, is the histopathological finding. The course of NSG is similar to sarcoidosis. Corticosteroids are considered the treatment of choice, but the disease exhibits a tendency towards spontaneous regression. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 395-398) ., (Copyright: © 2018 SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES.)

Published
2018
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