1. Syntheses and spectroscopic studies of potential antitumor copper(II) complexes with 5-phenylazo-3-methoxy salicylidene thiosemicarbazone and N4 substituted thiosemicarbazones.
- Author
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Patil BG, Havinale BR, Shallom JM, and Chitnis MP
- Subjects
- Animals, Antineoplastic Agents analysis, Copper analysis, Copper pharmacology, Doxorubicin pharmacology, Drug Resistance, Drug Screening Assays, Antitumor, Electron Spin Resonance Spectroscopy, Leukemia P388 pathology, Ligands, Mice, Mice, Inbred Strains, Organometallic Compounds analysis, Organometallic Compounds pharmacology, Spectrophotometry, Spectrophotometry, Ultraviolet, Thiosemicarbazones analysis, Thiosemicarbazones pharmacology, Antineoplastic Agents chemical synthesis, Organometallic Compounds chemical synthesis, Thiosemicarbazones chemical synthesis, Tumor Cells, Cultured drug effects
- Abstract
Five new copper(II) complexes of 5-phenylazo-3-methoxy salicylidene thiosemicarbazone and N4 substituted thiosemicarbazones have been synthesized. They have been characterized by chemical analyses, magnetic, conductance data, and by ultraviolet (UV)--visible, infrared, and electron spin resonance spectra. The complexes have the general formula CuL2, where HL is the ligand. One representative complex has been screened in vitro and in vivo against P388 lymphocytic leukemia cells sensitive and resistant to adriamycin (P388/S and P388/R). It has shown promising growth inhibition activity. We are reporting here for the first time the antineoplastic activity of this complex against experimental tumor systems.
- Published
- 1989
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