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Hepatotoxicity is a drug complication that is often found in long-term drug use because of the role of the liver in metabolizing drugs. Paracetamol is an analgesic and antipyretic drug that is often used by the community and is a safe choice when taken according to the dose. However, if consumed in excess and in the long-term it causes hepatotoxicity (liver damage). Liver damage can be prevented by giving antioxidant compounds. Rambutan’s leaves contain secondary metabolites of alkaloids, tannins and saponins which are known to have antioxidant potential. The aim of the research is to determine the hepatoprotective activity and the effective dose of Rambutan leaves ethanol extract in male mice induced by patacetamol. The research method was The Randomize Posttest-only Control Group Design using 25 white mice which were divided into 5 groups. The results showed that there was a significant difference in the treatment group of rambutans leaf ethanol extract with the negative control group and a non-significant with the positive control group. Giving extract doses of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BW because it prevents the increase in levels of SGPT, SGOT, relative liver weight and reduces the percentage of damage to the hepatocytes of mice. The effective dose of rambutan’s leaf ethanol extract as a hepatoprotector is 400 mg/kg BW.

The durian plant is believed to have medicinal properties and has a distinctive name in each region, such as durian selat from Selat Village in Jambi. Parts of the durian plant such as durian skin and durian seeds have been shown to have antibacterial activity. This study aimed to determine the antibacterial activity and the diameter of the inhibition zone of strait durian leaves (Durio zibethinus Linn.) against Propionibacterium acnes and Staphylococcus epidermidis bacteria. Antibacterial activity testing was carried out using the disc diffusion method. Based on the results obtained, n-hexane, ethyl acetate, and ethanol extract of durian leaves have antibacterial activity at 1% to 6% concentration with weak level against Propionibacterium acnes bacteria and moderate level against Staphylococcus epidermidis bacteria. The highest inhibition zone diameter was obtained from ethyl acetate extract 4.76 mm (weak category) against P. acnes bacteria and the highest inhibition zone diameter was obtained from ethyl acetate extract 6.26 mm (medium category) against S. epidermidis bacteria with MIC values ​​(Minimum Inhibitory Concentration) at 1% concentration.

A kidney stone is a disease that is quite often found in the community. Kidney stone disease is characterized by the formation of small stones due to precipitation in the urine. This stone can clog urethra and cause pain. The most common kidney stone content is calcium oxalate. Kemangi (Ocimum basilicum) contains several secondary metabolites such as flavonoids, saponins, phenols, and tannins. The content of secondary metabolites is thought to shed kidney stone. This study aims to reveal other properties of kemangi plant as anticalculi. Method: The stages in this study consisted of making kemangi leaf ethanol extract, extract characterization, phytochemical extract screening, kidney stone calcium making, and kidney stone calcium decay test stage. Testing the effect of the destruction of kidney stone is carried out in vitro by testing the rate of decay of kidney stone calcium components in various concentrations of ethanol extracts of kemangi leaf in physiological NaCl. Kidney stone calcium decay was analyzed by atomic absorption spectrophotometer (ASS). Data were analyzed with one-way ANOVA and continued with the LSD test. Results: ethanol extract of kemangi leaf at a concentration of 600 ? x ?1600 ppm could shed kidney stone calcium significantly greater than negative controls. Conclusion: the kemangi leaf ethanol extract has potential as the destruction of kidney stone.

Preservatives are one of the food additives used to preserve perishable foods. Based on Peraturan Menteri Kesehatan RI No. 033 Tahun 2012 about food additives, sodium tetraborate or borax is classified in additives, which are prohibited being used in food. However in reality, there are still used. The purpose of this study is to identify and measure levels of borax compounds in ground red chilies that are sold in the traditional markets of Jambi city. Qualitative analysis of borax in ground red chilies using a color test method using Tumeric paper. While the quantitative analysis of borax in ground red chilies using UV-Vis Spectrophotometry at the wavelength of 550 nm. Borax identification results showed that 25 samples the ground red chilies tested contained borax with average concentration 1,998 mg/gram of borax compound. Analysis of the results of the test of borax content with SPSS using the Chi-square test indicated that there was no relationship between the selection of ground red chilies with the use of borax as a food preservative.

Depression is known to be one of the causes of noncompliance therapy. This study aims to determine the correlation between depression with compliance of chronic renal failure patients. The method in this study is cross-sectional. Data is collected by judgment sampling. Depression level is assessed by using the Beck Depression Inventory-II (BDI- II). Compliance level is assessed by using the morisky scale. The result shows an average compliance level of chronic renal failure patients is included in high compliance category (53.03%). It is found that there is not a correlation between depression and compliance of chronic renal failure patients (p> 0.05). it is concluded that there is no correlation between depression and compliance of chronic renal failure patients.

Diabetes melitus merupakan penyakit degeneratif kronis yang apabila tidak ditangani dengan tepat, lama kelamaan bisa timbul berbagai komplikasi, ini cenderung menyebabkan pasien mendapatkan banyak obat dalam satu resep yang dapat menimbulkan interaksi antar obat. Tujuan dari penelitian ini adalah mengetahui persentase terjadinya interaksi obat metformin secara teori serta mengkaji efek yang mungkin timbul dan solusinya. Teknik pengambilan data dengan purpossive sampling, yaitu resep pasien rujuk balik yang menderita diabetes mellitus yang menggunakan metformin. Data yang diperoleh ditemukan bahwa obat yang berinteraksi dengan metformin dengan tingkat keparahan minor ialah sebesar 60%. Kemudian untuk tingkat keparahan moderat ialah sebesar 20%. Sedangkan untuk tingkat keparahan mayor tidak ditemukan. Dari tabel diatas juga dapat diketahui bahwa terdapat 4 obat yang saling berinteraksi dengan metformin, sedangkan untuk obat yang tidak saling berinteraksi dengan metformin terdapat 9 obat. Jumlah obat yang berinteraksi secara teori sebesar 6,85% dan yang tidak berinteraksi 93,15%. Terdapat interaksi obat metformin dengan beberapa obat yaitu furosemid, lisinopril, acarbose dan ramipril. Kata kunci: interaksi obat, metformin, diabetes mellitus STUDY OF METFORMIN INTERACTION IN MELLITUS DIABETES PATIENTS ABSTRACT Mellitus is a chronic degenerative disease which if not handled properly, over time can arise various complications, this tends to cause patients to get many drugs in one recipe that can cause interactions between drugs. The purpose of this study is to determine percentage of metformin drug interactions in theory and examine the effects that may arise and solutions. Data collection techniques using purposive sampling, which is a recipe for reconciliation patients who suffer from diabetes mellitus using metformin. The data obtained it was found that drugs that interact with metformin with minor severity were 60%. Then for moderate severity is 20%. Whereas the major severity was not found. From the table above it can also be seen that there are 4 drugs that interact with metformin, while for drugs that do not interact with metformin there are 9 drugs. The number of drugs that interacted theoretically was 6.85% and 93.15% did not interact. An interaction of the drug metformin with several drugs namely furosemide, lisinopril, acarbose and ramipril. Keywords: drug interaction, metformin, diabetes mellitus

Research has been conducted to analyze the presence of formaldehyde content in ground red chili which is sold in the traditional markets of Jambi city. The milled red chili samples were obtained from 5 markets and each market was chosen by 5 milled red chili traders. Stages in this study include sample preparation, a qualitative test of formaldehyde content using chromatophenic acid reagents, and quantitative analysis of formalin using UV-Vis spectrophotometer at a wavelength of 566 nm. The results of this study showed 6 of the 25 samples identified to contain formalin. Qualitative analysis with chromatophenic acid reagents showed a change in color to brown. Formalin levels for positive samples included A2 samples at 0.54 g / kg, B4 at 0.74 g / kg, C2 at 0.56 g / kg, D3 at 0.65 g / kg, E3 at 0.53 g / kg, and E4 of 0.65 g / kg. It can be concluded that the discovery of formaldehyde content in ground red chili at several points in the traditional markets of the city of Jambi.

The community service program aims to introduce binahong plants, and its benefits to overcome gout and how to cultivate. The community will be given the skill of how to make binahong leaf tea so that utilization of binahong leaves to overcome gout become more practical, right doses so the goal of therapy for gout can be achieved. Gout is one form of arthritis that is often associated with reddish, swollen, hot and stiff joints. The prevalence of gout from the year is increasing. Men have a higher risk of gout than women. Community efforts in treating gout using chemical drugs have been shown to cause serious side effects. The use of herbal medicine can be used as an alternative therapy in dealing with this disease. The binahong plant is an empirically widely used plant to treat various illness. One of them is gout. The use of this plant in gout support therapy is essential because, from the research result, this plant has many properties with minimal toxicity. The method used in this service is by providing counselling and training. The results of evaluating the implementation of cultivation and making of binahong leaf tea for the treatment of gout, many as 29 residents of RT 02 Mendalo Indah Jambi, Luar Kota Village. The benefits of binahong as a treatment for gout as well as residents also know how to cultivate binahong for self-treatment and economic improvement container of the citizens.

Buah pedada yaitu buah mangrove yang hidup di perairan payau yang banyak tumbuh di daerah pesisir khususnya yang ada di Kabupaten Tanjab Timur yaitu Kelurahan Kampung Laut Kecamatan Kuala Jambi. Buah Pedada bagian dasarnya dibungkus oleh kelopak bunga, dan tidak beracun. Masyarakat Kampung Laut jarang mengkonsumsi langsung buah Pedada karena rasanya asam. Buah tersebut memiliki kandungan gizi yang belum dimanfaatkan. Buah Pedada dapat diolah menjadi produk pangan seperti selai dan sirup, karena kandungan vitamin C yang cukup tinggi. Selain pengolahan produk pangan buah Pedada dapat juga diolah menjadi sabun cair antiseptik, karena kandungan zat kimia pada buah Pedada mampu membunuh dan menghambat pertumbuhan bakteri. Dengan melihat potensi ini, maka muncul ide untuk membuat teknologi pengolahan sabun cair buah Pedada sebagai antiseptik. Tujuan kegiatan pengabdian kepada masyarakat ini akan memberikan nilai tambah yang besar ditinjau dari hasil teknologi produk sabun cair antiseptik, sehingga menambah nilai ekonomis dan penghasilan bagi Masyarakat Kampung Laut serta meningkatkan pengetahuan masyarakatnya. Metode yang digunakan dalam kegiatan ini penyuluhan manfaat dan pengolahan buah Pedada. Kegiatan ini menghasilkan produk sabun cair antiseptik serta meningkatkan kreativitas sumber daya manusia di Kelurahan Kampung Laut, kecamatan Kuala Jambi, Kabupaten Tanjab Timur untuk membuat industri rumah tangga produk pangan ataupun produk sabun cair antiseptik.

Cangkang sawit Sawit (Elaeis guineensis Jacg) dahulu dianggap sebagai limbah yang tidak bermanfaat dan hanya dipakai sebagai pengeras jalan serta campuran makanan ternak. Sekarang dengan kemajuan teknologi, beberapa hasil sampingan kelapa sawit seperti sabut dan cangkang sawit dapat diolah menjadi produk yang memiliki nilai ekonomi tinggi seperti arang aktif yang dapat digunakan pada pengobatan diare karena bersifat sebagai adsorben. Metode yang digunakan untuk membuat tablet arang aktif adalah metode granulasi basah dengan 2 macam formula. Uji sifat fisik tablet yang dilakukan antara lain keseragaman bobot dan ukuran, kekerasan, kerapuhan, serta waktu hancur tablet. Dari hasil penelitian diperoleh bahwa formula yang memberikan sifat fisik tablet paling baik adalah formula 2 dengan menggunakan dosis 125 mg arang aktif.

Penelitian ini bertujuan untuk mengetahui aktifitas antioksidan dari ekstrak belut ( Monopterus albus ) yang hidup di perairan provinsi jambi. Radikal bebas cenderung menimbulkan reaksi berantai yang apabila terjadi di dalam tubuh akan dapat menimbulkan kerusakan sel yang berlanjut dan terus menerus terutama pada penyakit kronis seperti diabetes, hipertensi dan hiperkolesterol. Pencegahan dapat dilakukan dengan memberikan seyawa antioksidan, salah satunya asam amino. Di dalam al-Quran disebutkan bahwa bangkai yang halal untuk dimakan adalah ikan dan belalang. Belut merupakan salah satu jenis ikan yang memiliki kandungan albumin yang tinggi. Sampel daging belut yang telah difillet dan dipisahkan dari kepalanya, dipotong kecil-kecil dengan ukuran 1,5 cm 2 dan dibalut dengan kain tipis dalam sebuah mangkuk, lalu dikukus, dipress, dan disentrifus. diambil fase air dan minyak dan dibuang pengotornya dengan cara disaring, lalu dikeringkan menggunakan freeze drying sehingga diperoleh ekstrak belut dalam bentuk serbuk. Metode yang digunakan pada penelitian ini adalah Radical Scavenging method menggunakan senyawa kimia DPPH (2,2- difenil-1-pikrilhidrazil). Dari hasil penelitian ditemukan bahwa nilai IC50 ekstrak belut sebesar 29,0816 ppm . Ekstrak belut memiliki potensi menangkal radikal bebas dengan aktifitas kuat. Kata Kunci: Ektstrak Belut, Monopterus albus , Penangkal Radikal Bebas This study aims to determine the antioxidant activity of eel (Monopterus albus) extracts that live in the waters of the province of Jambi. Free radicals tend to cause chain reactions that occur in the body and will cause ongoing and continuous cell damage, especially in chronic diseases such as diabetes, hypertension and hypercholesterolemia. Prevention can be done by providing antioxidants, one of which is amino acids. In the Koran, it is stated that the carcasses that are lawful to eat are fish and grasshoppers. Eel is a type of fish that has a high albumin content. The eel meat sample that has been filled and given from its head, is cut into small pieces with a size of 1.5 cm2 and wrapped in a thin cloth in a container, then steamed, pressed, and centrifuged. the air and oil phases are taken and the impurities are removed by filtering, then they are dried using freeze drying in order to obtain the eel extract in powder form. The method used in this study is the Radical Scavenging Method using the chemical compound DPPH (2,2- diphenyl-1-pikrilhidrazil). From the research results it was found that the IC50 value of eel extract was 29.0816 ppm. Eel extract has the potential to ward off free radicals with strong activity.

Dalam dekade belakangan ini di tengah banyaknya jenis obat modern di pasaran dan munculnya berbagai jenis obat modern yang baru, terdapat kecenderungan global untuk kembali ke alam (back to nature). Faktor yang mendorong masyarakat untuk mendayagunakan obat bahan alam antara lain mahalnya harga obat modern/sintetis dan banyaknya efek samping. Selain itu faktor promosi melalui media masa juga ikut berperan dalam meningkatkan penggunaan obat bahan alam. Oleh karena itu obat bahan alam menjadi semakin populer dan penggunaannya meningkat tidak saja di negara sedang berkembang seperti Indonesia, tetapi juga pada negara maju. Jenis obat tradisional yang digunakan dapat berupa obat tradisional buatan sendiri, jamu gendong maupun obat tradisional industri pabrik. Penggunaan tumbuhan obat tidak sesederhana seperti yang dipikirkan orang selama ini. Semua harus dipelajari dan memerlukan pengalaman tersendiri. Pemakaian obat tradisional juga harus mempertimbangkan takaran/dosis dan cara pengolahan yang tepat agar tujuan terapi tercapai. Namun belum banyak masyarakat mengetahui cara pembuatan obat tradisional yang baik, dimulai dari bagian tanaman obat yang diambil sampai pada tahap pengolahannya. Salah mengenali tumbuhan obat yang dimaksud juga tidak akan menyembuhkan penyakit, apalagi salah menggabungkan beberapa tumbuhan obat yang khasiatnya berlawanan. Pengabdian yang dilaksanakan di Desa Mendalo Indah Kecamatan Jambi Luar Kota ini bertujuan untuk memberikan informasi mengenai cara pengolahan obat tradisional yang teapat. Metode yang dilaksanakan pada Program PKM yaitu penyuluhan dan pelatihan. Setelah pengabdian ini dilaksanakan dapat terlihat bahwa masyarakat telah mengetahui dan menerapkan cara pengolahan obat tradisional yang baik. Diharapkan dengan ini tujuan pengobatan dapat tercapai secara maksimal dan efek samping minimal sehingga berimbas pada peningkatan kualitas kesehatan masyarakat..Kata kunci: obat tradisional; pengolahan; desa mendalo indah. ABSTRACTIn the last decade amidst the many types of modern medicines on the market and the emergence of various types of new modern medicines, there is a global tendency to return to nature. Factors that encourage people to utilize natural medicines include the high price of synthetic drugs and the many side effects. In addition, promotion factors through the mass media also play a role in increasing the use of natural medicines. Therefore natural medicines have become increasingly popular and their use is increasing not only in developing countries like Indonesia but also in developed countries. The type of traditional medicine used can be in the form of homemade traditional medicine, herbal medicine as well as traditional industrial medicine. The use of medicinal plants is not as simple as people have thought so far. All must be learned and requires its own experience. The use of traditional medicine must also consider the correct dosage and treatment method so that the therapeutic goals are achieved. But not many people know how to make traditional medicines that are good, starting from the part of medicinal plants taken to the processing stage. It is also wrong to recognize the medicinal plants which will not cure the disease, moreover one combines several medicinal plants which have opposite properties. The service that was carried out in Mendalo Indah Village, Jambi, Outer City District, was aimed at providing information on how to treat traditional medicines properly. The method implemented in the PKM Program is counseling and training. After this service is carried out, it can be seen that the community has known and implemented a good method of processing traditional medicines. It is expected that using this treatment goal can be achieved optimally and minimal side effects so that the impact on improving the quality of public health. Keywords: traditional medicine; processing; mendalo indah village

Peningkatan konsumsi akohol, obat-obat anti-inflamasi nonsteroid (OAINS), dan diet yang keliru menjadi penyebab meningkatnya penyakit tukak lambung (ulkus peptikum) di seluruh dunia. Penggunaan obat sintetis jangka panjang sering menimbulkan efek yang tidak diinginkan. Belut diketahui memiliki kadar protein yang tinggi, mirip dengan ikan gabus. Penelitian tentang aktifitas ikan gabus dalam pengobatan luka bakar, luka dalam bekas operasi, serta tukak lambung telah banyak dilakukan. Diperkirakan aktifitas tersebut dipromotori oleh kandungan protein dan asam amino dari ikan. Rancangan penelitian yang digunakan adalah rancangan acak kelompok dengan 5 kelompok perlakuan masing-masing 5 ekor tikus. Diperoleh hasil rata-rata titik pendarahan pada kontrol negatif 7,6: kontrol positif 2,6; dosis ekstrak kering belut 100 mg/kgBB sejumlah 4,2; dosis ekstrak kering belut 200 mg/kgBB sejumlah 1; dan dosis ekstrak kering belut 400 mg/kgBB sejumlah 1. Sedangkan rata-rata pH cairan lambung pada kontrol negatif 4,948: kontrol positif 5,182; dosis ekstrak kering belut 100 mg/kgBB 4,224; dosis ekstrak kering belut 200 mg/kgBB 2,888; dan dosis ekstrak kering belut 400 mg/kgBB 4,89. Secara statistik terdapat perbedaan titik pendarahan yang signifikan antara dosis kontrol positif, 100, 200, dan 400 mg/kgBB dengan kontrol negatif. Tidak ditemukan adanya korelasi antara pH dengan timbulnya titik pendarahan, sehingga pH tidak dapat dijadikan parameter terjadinya tukak lambung. Dapat disimpulkan bahwa ekstrak kering belut memiliki aktifitas sebagai pengobatan tukak lambung dengan dosis terbaik pada 200 mg/kgBB.

Pasien dengan penyakit kronis memiliki kecendrungan mengalami depresi, salah satunya pada pasien gagal ginjal kronis. Tujuan: mengetahui korelasi antara karakteristik pasien gagal ginjal kronis dengan terjadinya depresi. Metode penelitian: cross sectional menggunakan data primer, dengan teknik pengambilan data judgment sampling, pengukuran tingkat depresi menggunakan Beck Depression Inventory-II (BDI- II) dan data dianalisis menggunakan uji korelasi kendall’s tau-b. Hasil: karakteristik umur (sig=0.057), tingkat Pendidikan (sig=0.246), status (sig=0.484), jaminan kesehatan (sig=0.957) dan lama menjalani tindakan hemodialisis (sig=0,396) tidak memiliki hubungan dengan terjadinya depresi sedangkan karaktersitik yang memiliki hubungan dengan terjadinya depresi yaitu jenis kelamin (sig=0.028), pekerjaan (sig= 0.001) dan tindakan hemodialisa (sig= 0.05) dengan korelasi cukup kuat. Kesimpulan: beberapa karakteristik pasien yaitu jenis kelamin, pekerjaan dan tindakan hemodialisa memiliki korelasi yang cukup kuat terhadap timbulnya depresi pada pasien gagal ginjal kronis. Kata Kunci— korelasi, karaktersitik, depresi ABSTRACT Patients with chronic diseases have a tendency to experience depression, one of them is in patients with chronic kidney failure. Objective: to determine the correlation between the characteristics of patients with chronic kidney failure with depression. Research methods: cross sectional using primary data, with judgment sampling data collection techniques, measurement of depression levels using the Beck Depression Inventory-II (BDI-II) and data analyzed using the Kendall's tau-b correlation test. Results: age characteristics (sig = 0.057), education (sig = 0.246), status (sig = 0.484), health insurance (sig = 0.957) and length of time undergoing hemodialysis (sig = 0.396) have no relationship with the occurrence of depression while the characteristics of depression which has a relationship with the occurrence of depression, namely gender (sig = 0.028), work (sig = 0.001) and hemodialysis (sig = 0.05) with a strong enough correlation. Conclusion: some of the characteristics of patients namely sex, occupation and hemodialysis have a strong correlation to the onset of depression in patients with chronic kidney failure. Keywords — correlation, characteristics, depression

Merkuri merupakan logam beracun yang dapat menimbulkan efek serius pada kesehatan meskipun pada konsentrasi yang sangat kecil. Dicurigai ada kandungan merkuri pada kosmetik krim pemutih illegal. Tujuan dari penelitian ini adalah untuk menganalisis kandungan dan mengetahui kadar merkuri pada krim pemutih merek X. Sampel krim pemutih X dipilih dengan menggunakan metode purposive sampling. Sebanyak 2 g sampel dilarutkan dengan cara dekstruksi basah untuk menghilangkan zat-zat organik. Identifikasi merkuri menggunakan uji warna dengan reagen KI, HCl, dan NaOH, sedangkan analisis kuantitatif dilakukan dengan metode Atomic Absorption Spectroscopy (AAS) pada panjang gelombang 253,7 nm. Hasil uji kualitatif menunjukkan bahwa sampel yang direaksikan dengan pereaksi KI menghasilkan endapan merah orange, yang menunjukkan hasil positif adanya merkuri. Namun, dengan pereaksi NaOH dan HCl tidak menunjukkan hasil reaksi positif. Semua sampel teridentifikasi kandungan merkuri, dengan kadar masing-masing sampel 0,29; 0,289; 0,201; 0,179; 0,265; 0,263; 0,193; 0,194; 0,328; dan 0,304 ppm. Krim pemutih ilegal merek X positif mengandung merkuri dengan kadar merkuri rata-rata 0,251 ppm.

The purpose of this study was to predict the potential effect of theoretical use and evaluation of Paracetamol and Diazepam capsules concoction preparation in poly-nerve patients in outpatient depot Pharmacy Installation of Raden Mattaher Hospital. Methods of data collection used observation techniques with retrospective study data collection techniques. It was found that 12 patients used the Paracetamol 500 mg concoction capsules and 0.5 mg Diazepam given twice a day, used every day with a minimum usage period of 1 month and a maximum of 56 months, 5 of whom were over 60 years old. The capsule concoction that is made is not derived from the pure active ingredient of Paracetamol and Diazepam, but is a trademark tablet drug which is crushed without BA and BE evaluation of the concoction form. So, it can be concluded that the use of Paracetamol and Diazepam concoction capsules is predicted to pose a risk of causing hepatotoxic and physical and psychological dependence and capsule concoction drugs that are made do not meet the criteria set by the FDA.