Search

Your search keyword '"Hayashi, Taihei"' showing total 14 results
Start Over Author "Hayashi, Taihei"
Sorry, I don't understand your search. ×
14 results on '"Hayashi, Taihei"'

3. Urinary podocalyxin as a possible novel marker of intrauterine nephrogenesis and extrauterine podocyte injury

Author

Hayashi, Taihei, Tokuriki, Shuko, Okuno, Takashi, Ohta, Genrei, Igarashi, Aiko, and Ohshima, Yusei

Subjects
Nephrons -- Health aspects, Chronic kidney failure -- Risk factors -- Diagnosis -- Care and treatment -- Research, Health
Abstract

Background The number of nephrons at birth is determined during fetal development and is modulated thereafter by postnatal podocyte injury. Hyperfiltration, caused by a reduced number of nephrons, is a risk factor for chronic kidney disease. It is therefore important to monitor the formation of nephrons. Methods Urine samples were collected from infants within 1-2 days of birth, with follow-up sampling for preterm infants at 37-39 weeks of corrected age. Urinary levels of podocalyxin (PCX), [beta]2-microglobulin ([beta]2MG), N-acetyl-ß-D-glucosaminidase (NAG), total protein (TP), microalbumin (mAlb) and creatinine were measured and the relationship between these markers evaluated. Results Seventy-nine neonates were enrolled in this study. Urinary levels of PCX at birth were higher than normal adult reference values, with levels increasing up to a gestational age of 36 weeks (p = 0.0242). At 37-39 weeks corrected age, urinary levels of PCX decreased to adult levels. The levels of PCX in the urine at birth were not correlated to urinary levels of [beta]2MG, NAG, TP and mAlb. Conclusions An increased urinary level of PCX may be a marker of both active nephron formation and podocyte injury sustained at birth. As such, changes in urinary levels of PCX are likely to reflect adaptation of renal function to the extra-uterine environment., Author(s): Taihei Hayashi [sup.1] , Shuko Tokuriki [sup.1] , Takashi Okuno [sup.1] , Genrei Ohta [sup.1] , Aiko Igarashi [sup.1] , Yusei Ohshima [sup.1] Author Affiliations: (1) Department of Pediatrics, [...]

Published
2017
Full Text
View/download PDF

10. The Usefulness of T1-Weighted Magnetic Resonance Images for Diagnosis of Acute Leukemia Manifesting Musculoskeletal Symptoms prior to Appearance of Peripheral Blood Abnormalities

Author

Yoshikawa, Toshihide, Tanizawa, Akihiko, Suzuki, Koji, Tanaka, Nanae, Hayashi, Taihei, Tsuda, Masayo, Ohta, Genrei, Kikuchi, Naoko, Okamoto, Hiroyuki, Sakai, Takehiko, Taniguchi, Yoshihiro, and Ohshima, Yusei

Subjects
Article Subject
Abstract

The patients with acute leukemia occasionally present with musculoskeletal symptoms initially, including bone pain, joint pain, muscular pain, and functional impairment. Without abnormal findings of peripheral blood cell counts or smear, the correct diagnosis tends to be delayed. Magnetic resonance imaging is often performed to examine musculoskeletal abnormalities; it can simultaneously reveal the bone marrow composition with high anatomical resolution and excellent soft tissue contrast. We present 4 pediatric patients who were initially diagnosed with acute pyogenic osteomyelitis or arthritis, based on the elevated white blood cell counts and/or C-reactive protein in addition to the localized high signal intensity on T2-weighted magnetic resonance images. Finally, they were diagnosed with B-cell precursor acute lymphoblastic leukemia by bone marrow examination. The period between the onset of musculoskeletal symptoms and the diagnosis of leukemia ranged from 20 days to 6 months. In all cases, the T1-weighted magnetic resonance images taken prior to detection of peripheral blood abnormality revealed diffuse low signal intensity of the bone marrow in regions adjacent or contralateral to localized musculoskeletal symptoms. These findings should raise the suspicion of leukemia even without abnormalities in peripheral blood.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results