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607 results on '"Hayashi, Yoshiki"'

3. Novel Mg 2+ binding sites in the cytoplasmic domain of the MgtE Mg 2+ channels revealed by X-ray crystal structures

Author

Wang Mengqi, Zhao Yimeng, Hayashi Yoshiki, Ito Koichi, and Hattori Motoyuki

Subjects
ion channels, magnesium, metal homeostasis, regulation, crystal structure, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

MgtE is a Mg 2+-selective channel regulated by the intracellular Mg 2+ concentration. MgtE family proteins are highly conserved in all domains of life and contribute to cellular Mg 2+ homeostasis. In humans, mutations in the SLC41 proteins, the eukaryotic counterparts of the bacterial MgtE, are known to be associated with various diseases. The first MgtE structure from a thermophilic bacterium, Thermus thermophilus, revealed that MgtE forms a homodimer consisting of transmembrane and cytoplasmic domains with a plug helix connecting the two and that the cytoplasmic domain possesses multiple Mg 2+ binding sites. Structural and electrophysiological analyses revealed that the dissociation of Mg 2+ ions from the cytoplasmic domain induces structural changes in the cytoplasmic domain, leading to channel opening. Thus, previous works showed the importance of MgtE cytoplasmic Mg 2+ binding sites. Nevertheless, due to the limited structural information on MgtE from different species, the conservation and diversity of the cytoplasmic Mg 2+ binding site in MgtE family proteins remain unclear. Here, we report crystal structures of the Mg 2+-bound MgtE cytoplasmic domains from two different bacterial species, Chryseobacterium hispalense and Clostridiales bacterium, and identify multiple Mg 2+ binding sites, including ones that were not observed in the previous MgtE structure. These structures reveal the conservation and diversity of the cytoplasmic Mg 2+ binding site in the MgtE family proteins.

Published
2023
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14. Regulatory Mechanisms of the Germline Stem Cell Niche in Drosophila melanogaster

Author

Hayashi, Yoshiki, Kobayashi, Satoru, Asami, Takahiro, Series Editor, Kajihara, Hiroshi, Series Editor, Kobayashi, Kazuya, Series Editor, Koizumi, Osamu, Series Editor, Motokawa, Masaharu, Series Editor, Naruse, Kiyoshi, Series Editor, Satoh, Akiko, Series Editor, Takamune, Kazufumi, Series Editor, Takeuchi, Hideaki, Series Editor, Yoshikuni, Michiyasu, Series Editor, Kitano, Takeshi, editor, Iwao, Yasuhiro, editor, and Kondo, Mariko, editor

Published
2018
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17. Continued fraction expansions and permutative representations of the Cuntz algebra ${\cal O}_{\infty}$

Author

Kawamura, Katsunori, Hayashi, Yoshiki, and Lascu, Dan

Subjects
Mathematics - Operator Algebras, Mathematics - Number Theory, 11A55, 46K10
Abstract

We show a correspondence between simple continued fraction expansions of irrational numbers and irreducible permutative representations of the Cuntz algebra ${\cal O}_{\infty}$. With respect to the correspondence, it is shown that the equivalence of real numbers with respect to modular transformations is equivalent to the unitary equivalence of representations. Furthermore, we show that quadratic irrationals are related to irreducible permutative representations of ${\cal O}_{\infty}$ with a cycle., Comment: 17 pages

Published
2009

18. Demonstration of participation in the German balancing power market using a large‐capacity hybrid battery storage system.

Author

Hirose, Keiichi, Tanaka, Hirohide, Dewaki, Masayuki, Hayashi, Kazutaka, Mikami, Yousuke, Hayashi, Yoshiki, Arita, Hiroshi, Hamamura, Saori, and Hirai, Naoki

Subjects
BATTERY storage plants, ELECTRICITY markets, SODIUM-sulfur batteries, LITHIUM cells, LITHIUM sulfur batteries, PARTICIPATION
Abstract

As one of NEDO's international demonstration projects, a large‐capacity hybrid battery storage system which consists of two types of battery cells with different charge‐discharge characteristics was constructed in the state of Lower Saxony in the Federal Republic of Germany. By using the hybrid battery system has a lithium‐ion which has an advantage in short time and high rate, and a sodium‐sulfur battery (NAS) which has an advantage in long time and low rate, the tender participation in the balancing power market in Germany had been executed. The hybrid battery storage system could successfully drive and provided services for primary and secondary control reserves, elimination of power imbalance, and reactive power injection, as well as a combination of these services. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Recurrent transient severe hypocalcaemia in two siblings with type 1 Bartter syndrome.

Author

Kanda, Juri, Kanda, Shoichiro, Hayashi, Yoshiki, Nozu, Kandai, Ariji, Shohei, Shimoda, Mai, Ono, Mayumi, Kanda, Sachiko, Yokoyama, Seiichiro, and Takahashi, Kan

Subjects
HYPOCALCEMIA, HYPOKALEMIA, PHYSIOLOGICAL stress, SYNDROMES, SIBLINGS, DYSPNEA
Abstract

Type 1 Bartter syndrome causes hypokalaemia and metabolic alkalosis owing to mutation in the SLC12A1 gene. Meanwhile, hypocalcaemia is rare in Bartter syndrome, except in type 5 Bartter syndrome. Herein, we describe two siblings with type 1 Bartter syndrome with recurrent transient severe hypocalcaemia. They each visited our hospital several times with chief complaints of numbness in the limbs, shortness of breath and tetany after stresses such as exercise or fever. Severe hypocalcaemia was also observed with a serum calcium level of approximately 6.0 mg/dL at each visit. The clinical symptoms and abnormalities in laboratory findings quickly improved with rest and intravenous treatment. In a steady state, no severe hypocalcaemia was evident, but serum intact parathyroid hormone (PTH) levels were high. In recent years, a large‐scale study has revealed that type 1 and type 2 Bartter syndrome have high PTH values. In addition, there are reports that these patients develop hypocalcaemia due to PTH resistance. Therefore, our patient was also in a PTH‐resistant state, and hypocalcaemia was thought to be exacerbated by physical stress. It is not well known that Bartter syndrome patients other than those with type 5 suffer from hypocalcaemia. And hypocalcaemia was not detected in normal examinations under steady‐state conditions. Therefore, in patients with type 1 and type 2 Bartter syndrome, severe hypocalcaemia may occur, but may go unnoticed. When following up these patients, the attending physician must keep in mind that such patients are in a PTH‐resistant state and that physical stress can cause severe hypocalcaemia. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Mutagenesis Analysis of GMN Motif in Arabidopsis thaliana Mg2+ Transporter MRS2-1

Author

Yang, Xiaoyu, I. Kobayashi, Natsuko, Hayashi, Yoshiki, Ito, Koichi, Moriwaki, Yoshitaka, Terada, Tohru, Shimizu, Kentaro, Hattori, Motoyuki, Ren, Iwata, Hisashi, Suzuki, Tomoko, Nakanishi, and Keitaro, Tanoi

Abstract

Magnesium is an important nutrient for plants, but much is still unknown about plant Mg2+ transporters. Combining with the structural prediction of AlphaFold2, we used mutagenesis and 28Mg uptake assay to study the highly conserved “GMN” motif of Arabidopsis thaliana MRS2-1 (AtMRS2-1) transporter. We demonstrated that the glycine and methionine in GMN motif are essential for AtMRS2-1 to transport Mg2+.

Published
2022

27. Efficacy and safety of intra-arterial steroid infusions in patients with steroid-resistant gastrointestinal acute graft-versus-host disease

Author

Nishimoto, Mitsutaka, Koh, Hideo, Hirose, Asao, Nakamae, Mika, Nakane, Takahiko, Hayashi, Yoshiki, Okamura, Hiroshi, Yoshimura, Takuro, Koh, Shiro, Nanno, Satoru, Nakashima, Yasuhiro, Takeshita, Toru, Yamamoto, Akira, Sakai, Yukimasa, Nishida, Norifumi, Matsuoka, Toshiyuki, Miki, Yukio, Hino, Masayuki, and Nakamae, Hirohisa

Published
2015
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32. Application to Help Learn the Process of Transforming Mathematical Expressions with a Focus on Study Logs

Author

Watabe, Takayuki, Miyazaki, Yoshinori, Hayashi, Yoshiki, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Yamamoto, Sakae, editor

Published
2013
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36. Efficacy and safety of amrubicin therapy after chemoimmunotherapy in small cell lung cancer patients

Author

Kushiro, Kohei, primary, Watanabe, Satoshi, additional, Goto, Yuka, additional, Fujisaki, Toshiya, additional, Yanagimura, Naohiro, additional, Ohtsubo, Aya, additional, Shoji, Satoshi, additional, Nozaki, Koichiro, additional, Tanaka, Tomohiro, additional, Saida, Yu, additional, Sato, Yusuke, additional, Ota, Takeshi, additional, Koshio, Jun, additional, Hayashi, Yoshiki, additional, Miyabayashi, Takao, additional, Matsumoto, Naoya, additional, Ichikawa, Kosuke, additional, Koyama, Kenichi, additional, and Kikuchi, Toshiaki, additional

Published
2022
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42. Clinical Significance of Stone Cultures for Patients Undergoing Transurethral Lithotripsy

Author

Hosokawa, Yukinari, Miyamoto, Tatsuki, Tomizawa, Mitsuru, Mizobuchi, Shinichiro, Toyoshima, Yuta, Tomioka, Atsushi, Hayashi, Yoshiki, and Fujimoto, Kiyohide

Subjects
Stone culture, TUL, 494.9
Abstract

This study aimed to evaluate the concordance of the microbiologic findings of preoperative urine cultures and intraoperative stone cultures in patients undergoing transurethral lithotripsy (TUL). A total of 164 patients treated with TUL for whom preoperative urine cultures and intraoperative stone cultures were performed were included in this study. The preoperative urine cultures were positive in 57 patients (34.8%) and the stone cultures were positive in 58 patients (35.4%). Enterococcus faecalis was the most common organism detected in the intraoperative stone cultures (22. 9%). The concordance rate between the preoperative urine cultures and intraoperative stone cultures was 45.6%. Eleven patients (6.7%) developed a fever of >38.5°C postoperatively. Among the 11 patients, 9 patients showed positive preoperative urine cultures and 10 patients showed positive stone cultures. The results of the urine culture performed when the patient had a fever of 38.5°C or higher showed 54.5% consistency with the results of the preoperative urine culture or stone culture. Although the results of the preoperative urine cultures and intraoperative stone cultures may not be highly consistent, these cultures should be actively performed because they provide useful information regarding postoperative infections.

Published
2020

45. Clinicopathological analysis of diffuse large B-cell lymphoma lacking surface immunoglobulin light chain restriction on flow cytometry

Author

Nakaya, Yosuke, primary, Sakaida, Miho, additional, Yoshida, Masahiro, additional, Shimizu, Katsujun, additional, Yagi, Naoko, additional, Tsutsumi, Minako, additional, Yoshimura, Takuro, additional, Hayashi, Yoshiki, additional, Nakao, Takafumi, additional, Inoue, Takeshi, additional, and Yamane, Takahisa, additional

Published
2022
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47. Observational Study of Re-Biopsy in EGFR-TKI-Resistant Patients with EGFR Mutation-Positive Advanced NSCLC

Author

Koyama, Kenichi, primary, Miura, Satoru, additional, Watanabe, Satoshi, additional, Shoji, Satoshi, additional, Koshio, Jun, additional, Hayashi, Yoshiki, additional, Ishikawa, Daisuke, additional, Sato, Ko, additional, Miyabayashi, Takao, additional, Okajima, Masaaki, additional, Ota, Takeshi, additional, Tanaka, Tomohiro, additional, Matsumoto, Naoya, additional, Kuriyama, Hideyuki, additional, Abe, Tetsuya, additional, Nozaki, Koichiro, additional, Ichikawa, Kosuke, additional, Kondo, Rie, additional, Tanaka, Hiroshi, additional, and Kikuchi, Toshiaki, additional

Published
2021
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