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Your search keyword '"Hayes, Mark T."' showing total 20 results
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20 results on '"Hayes, Mark T."'

5. Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity

Author

Hayes, Mark T., Bartley, John, Parsons, Peter G., Eaglesham, Geoff K., and Prakash, Arungundrum S.

Subjects
DNA -- Analysis, Antineoplastic agents -- Analysis, Biological sciences, Chemistry
Abstract

The mechanism involving the highly reactive 2-chloroethyldiazohydroxide as intermediates with differing cytotoxic properties was determined. Electrospray ionisation mass spectrometry of antimelanoma agent fotemustine (FM) showed that FM catabolizes to generate short-lived intermediate, 2-chloroethydiazohydroxide, which stimulated the drug's activity. It was also found that the presence of two DNA-reactive helices were important in the biological activity.

Published
1997

17. Overexpression of aminoacylase 1 is associated with colorectal cancer progression.

Author

Hongjun Shi, Hayes, Mark T., Kirana, Chandra, Miller, Rosemary J., Keating, John P., and Stubbs, Richard S.

Subjects
AMINOACYLASE, IMMUNOHISTOCHEMISTRY, COLON cancer, TUMOR growth, DNA microarrays, LYMPH nodes
Abstract

Aminoacylase 1 (ACY1) is a cytosolic enzyme responsible for amino acid deacylation during intracellular protein degradation. ACY1 has been implicated in a number of human tumor types. However, the exact role of ACY1 in tumor development remains elusive because it was found to be lost in small cell lung cancer and renal cell carcinoma but overexpressed in colorectal cancer (CRC). The present study aims to further clarify the relationship of ACY1 with CRC progression. Immunohistochemical staining was performed in tissue microarrays composed of 120 cases of CRC using a monoclonal anti-ACY1 antibody. Immunoreactivity was analyzed in association with patients' clinicopathologic parameters and survival time. The role of ACY1 in cell proliferation and apoptosis was assessed by silencing its expression in HCT116 cells using a small interfering RNA. Strong expression of ACY1 was found to be significantly associated with more advanced TNM stage, lymph node metastasis, positive vascular invasion, and shorter cancer-specific survival. ACY1 knockdown significantly inhibited cell proliferation and induced apoptosis. We concluded that ACY1 expression in CRC varies with stage and appears to play a role in cell proliferation and apoptosis. Further evaluation of ACY1 as a clinically useful prognostic marker and a potential drug target for CRC would seem worthwhile. [ABSTRACT FROM AUTHOR]

Published
2013
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18. Fetuin-A: A Major Fetal Serum Protein that Promotes “Wound Closure” and Scarless Healing.

Author

Xue-Qing Wang, Hayes, Mark T., Kempf, Margit, Fraser, John F, Pei-Yun Liu, Cuttle, Leila, Friend, Lexie R. Robyn, Rothnagel, Joseph A., Saunders, Nicholas A., and Kimble, Roy M.

Subjects
*LETTERS to the editor, *REGENERATION (Biology)
Abstract

A letter to the editor is presented in response to the article about burn-wound healing, which appeared in the previous issue.

Published
2008
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