26 results on '"Hayhow, Thomas G."'
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2. Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
3. Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity.
4. Structural and Physicochemical Features of Oral PROTACs.
5. Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors
6. The design and synthesis of probe molecules to validate the inhibition of epigenetic mechanisms for phenotypic responses
7. Additional file 16 of Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
8. Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate
9. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors
10. A Buchwald–Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3‐Ligase PROTACs**
11. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor
12. Discovery and In VivoEfficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity
13. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe
14. Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives
15. Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives
16. Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor
17. Discovery of GSK345931A: An EP 1 receptor antagonist with efficacy in preclinical models of inflammatory pain
18. Discovery of brain penetrant, soluble, pyrazole amide EP 1 receptor antagonists
19. Non-acidic pyrazole EP 1 receptor antagonists with in vivo analgesic efficacy
20. Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain
21. Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists
22. Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy
23. Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain
24. Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists
25. Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy
26. A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs*.
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