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20 results on '"He, Guo-Fang"'

6. Investigation of the synergistic effects of haloperidol combined with Calculus Bovis Sativus in treating MK-801-induced schizophrenia in rats

Author

Lei, Kai, He, Guo-Fang, Zhang, Cheng-Liang, Liu, Ya-Nan, Li, Juan, He, Guang-Zhao, Li, Xi-Ping, Ren, Xiu-Hua, and Liu, Dong

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, Biological Products, Original, Administration, Oral, Biological Availability, Drug Synergism, behavioral disciplines and activities, Calculus Bovis Sativus, Rats, Sprague-Dawley, Disease Models, Animal, synergism, pharmacodynamics, Schizophrenia, Animals, Haloperidol, Drug Therapy, Combination, Dizocilpine Maleate, Erratum, pharmacokinetics, Antipsychotic Agents, Drugs, Chinese Herbal, Phytotherapy
Abstract

Clinical studies that focused on treating schizophrenia showed that Calculus Bovis Sativus (CBS), a substitute of Calculus Bovis, when used in combination with haloperidol could significantly lower the dosage of haloperidol compared with treatment with haloperidol alone, whereas efficacy was maintained. The aim of this study was to investigate the synergetic anti-schizophrenia effects in rats using CBS in combination with haloperidol. An open field test was conducted to verify the pharmacodynamic effects of a combination treatment of CBS and haloperidol on MK-801-induced schizophrenic rats. Rat plasma concentrations of intragastric haloperidol and intravenous haloperidol were determined after oral administration of a single dose or 1-week of pretreatment with CBS (50 mg/kg). The pharmacodynamic data showed a significant decrease in locomotor activity and an increase in the percentage of the central distance when haloperidol was concomitantly administered with CBS compared with haloperidol administration alone. The AUC0-∞ and Cmax of haloperidol in the orally coadministered groups were significantly higher compared with the oral treatment with haloperidol alone. In conclusion, oral coadministration of CBS with haloperidol resulted in a synergistic effect in rats. The enhanced oral bioavailability of haloperidol when combined with CBS might be attributed to the interaction between them.

Published
2017

18. ( E, E)-4,4′-Dichloro-2,2′-(1,1′-azinodiethylene)diphenol.

Author

Chang, Jian-Guo, Zhao, Dong-Feng, He, Guo-Fang, and Li, Ji-Kun

Subjects
*HYDRAZINE, *HYDROGEN bonding, *CRYSTALS, *HYDRATES, *MOLECULES
Abstract

The title compound, C18H18Cl2N2O2, was synthesized by the reaction of 1-(5-chloro-2-hydroxyphenyl)propan-1-one with hydrazine hydrate. The molecule possesses a crystallographically imposed centre of symmetry at the midpoint of the N—N bond. Intramolecular O—H...N hydrogen bonds, together with C—H...π interactions, help to stabilize the structure. [ABSTRACT FROM AUTHOR]

Published
2007
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20. [Density functional theory investigations of the spectroscopic characteristics and luminescent mechanisms of dipterex and dichlorvos].

Author

Li LQ, Cheng XL, Zhao YY, He GF, and Li F

Abstract

By using G09 program package, the ground-state structures, infrared spectra, NMR spectra, UV-Vis spectra as well as the excited structures and fluorescence/phosphorescence spectra of dipterex and dichlorvos were investigated systematically, and luminescence principles were analyzed with the molecular orbitals to provide the theoretical foundation for the detection of trace dipterex and dichlorvos. Our theoretical model revealed that the IR spectra of dipterex and dichlorvos bear strong absorptions at about 1107 cm(-1), which belong to the P-O stretch modes, but dipterex has strong absorption peaks involving the O-H bond; for UV-Vis spectra, dichlorvos has a strong absorption peak at 182.03 nm, but dipterex has a weak one at 192.42 nm, which are assigned to pipi* and sigmapi* transitions, respectively; the emission spectra of dichlorvos are very weak, and has double fluorescence/phosphorescence characteristics, which may be attributed to the resonance structures of dichlorvos; the fluorescence of dipterex has a unique broad peak at 1849.22 nm, corresponding to the LUMO-->HOMO transition of S1 state.

Published
2014

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