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Your search keyword '"He, Jianbo"' showing total 773 results
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773 results on '"He, Jianbo"'

7. First-in-human phase I/Ib study of QL1706 (PSB205), a bifunctional PD1/CTLA4 dual blocker, in patients with advanced solid tumors

Author

Zhao, Yuanyuan, Ma, Yuxiang, Zang, Aimin, Cheng, Ying, Zhang, Yiping, Wang, Xiangcai, Chen, Zhendong, Qu, Song, He, Jianbo, Chen, Chuanben, Jin, Chuan, Zhu, Dongyuan, Li, Qingshan, Liu, Xianling, Su, Wuyun, Ba, Yi, Hao, Yanrong, Chen, Junmin, Zhang, Guoping, Qu, Shenhong, Li, Yong, Feng, Weineng, Yang, Mengxiang, Liu, Baorui, Ouyang, Weiwei, Liang, Jin, Yu, Zhuang, Kang, Xiaoyan, Xue, Shilin, Yang, Guihong, Yan, Wei, Yang, Yingying, Liu, Zhi, Peng, Yufeng, Fanslow, Bill, Huang, Xian, Zhang, Li, and Zhao, Hongyun

Published
2023
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22. Determining landscape-level drivers of variability for over fifty soil chemical elements

Author

Ren, Haiyan, Zhou, Quanping, He, Jianbo, Hou, Ying, Jiang, Yuehua, Rodrigues, Jorge LM, Cobb, Adam B, Wilson, Gail WT, Hu, Jian, and Zhang, Yingjun

Subjects
Environmental Sciences, Biological Sciences, Ecology, Soil Sciences, Life on Land, Topsoil, Biogeochemistty, Biogeography of soil chemistry, Climate, Temperature, Precipitation, Soil elements, Soil pH, Biogeochemistry
Abstract

Syntheses of large datasets have allowed increased clarity of distribution patterns and variation in soil major and trace elements. However, the drivers of variation in topsoil elements across biogeographical scales are not well understood. Our aim was to (1) identify how landscape-scale climate, geographical features, and edaphic factors influence soil elements, and (2) determine key environmental thresholds for shifts in soil element concentration. We analyzed patterns of variation in topsoil elements using 9830 samples collected across 39,000km2 in subtropical land in southeast China. Canonical correlations and multiple linear regressions were used to model variations of each element across mean annual temperature (MAT), mean annual precipitation (MAP), land use, spatial topography, and soil pH. Element concentrations show significant latitudinal and longitudinal trends, and are significantly influenced by climate, land use, spatial topography, and soil pH. Longitude, pH, MAT, and MAP were the environmental factors most tightly correlated with element concentrations. Climate and soil pH drove positive or negative alterations in soil elements, with threshold indicators of MAP=1000mm/1500mm, MAT=17.8°C/18.0°C, and pH=5.8/5.0, respectively. Our results indicate topsoil elements have structural and functional thresholds of climate and soil pH in relatively wet and acidic environments. Our findings can facilitate holistic soil element concentration predictions and help elucidate the specific influences of climate and soil pH, enabling development of more complete biogeochemical models.

Published
2019

46. Multi-Physics Model Development for Polonium Transport Behavior in a Lead-Cooled Fast Reactor

Author

Deng Lilin, Wang Yuqing, Zhai Zian, Huang Bochen, Wu Jiewei, He Jianbo, and Ni Muyi

Subjects
polonium, LBE, fast reactor, Gen-IV, nuclear safety, General Works
Abstract

210Po, a highly toxic element with strong volatility, is one of the main source terms of a Gen-IV lead-cooled fast reactor (LFR). Therefore, the radioactive safety caused by 210Po has become an important topic in LFR-related research. In order to simulate the behavior of 210Po in an LFR, this work developed a multi-physics model of an LFR from the perspective of radioactive transport. Considering the effects of nuclide decay, cover gas leakage, containment ventilation, and Po aerosol deposition, a comprehensive simulation was carried out to evaluate the sensitivity of those effects on the 210Po distribution in detail. Preliminary results indicate that during normal operation, most of the 210Po in the LBE exist in the form of PbPo, and around 10–9 of 210Po could evaporate from the LBE into the cover gas, and then further leak into the containment. In addition, even if the leakage rate of 210Po in the cover gas into the containment is maintained at 5‰ per day, due to the deposition of Po aerosol, the 210Po contamination on the inner surface of the containment is still below the radioactivity concentration limits.

Published
2021
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50. Comparison of Survival Rates Based on Recommended Treatment Algorithms of BCLC or HKLC Staging Systems for Hepatocellar Carcinoma Patients

Author

DENG Guoyu, CHEN Jie, HUANG Shan, LI Kezhi, HE Jianbo, WU Guobin, and CHEN Chuang

Subjects
primary liver cancer, hepatocellular carcinoma, barcelona clinic liver cancer staging, hong kong liver cancer staging, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objective To evaluate the effect of the recommended treatment algorithms of the Barcelona Clinic Liver Cancer (BCLC) or Hong Kong Liver Cancer (HKLC) staging systems on the survival rate of patients with HCC. Methods A total of 436 patients newly diagnosed as HCC were analyzed. The prognostic performance and efficacy of treatment recommendations were compared between the two systems. All patients were first classified into a tumour stage according to the HKLC and BCLC staging systems respectively, and then they were divided into groups depending on whether they ultimately received the treatment recommended by the two staging systems. The efficacy of treatment algorithms of BCLC and HKLC systems was evaluated by comparing the patients who received treatment recommendations of either BCLC or HKLC stage to those who did not. Results HCC patients who received the recommended treatment algorithms of the BCLC and HKLC systems had a significantly favourable 5-year survival probability compared with the patients who did not (BCLC: 48% vs. 30%, P < 0.001; HKLC: 41% vs. 29%, P < 0.001). Patients receiving resection had a significantly favourable 5-year survival rate in BCLC-B/HKLC-Ⅰ+Ⅱa+Ⅱb, BCLC-B/HKLC-Ⅲa+Ⅲb and BCLC-C/HKLC-Ⅲa+Ⅲb groups than those receiving TACE, Sorafenib or best supportive care(all P < 0.05). Conclusion The recommended treatment algorithms of the BCLC and HKLC systems could improve survival rates of HCC patients. Curative therapies are superior to standard of care for BCLC-B/HKLC-Ⅰ+Ⅱa+Ⅱb, BCLC-B/HKLC-Ⅲa+Ⅲb and BCLC-C/HKLC-Ⅲa+Ⅲb patients. Some patients can achieve better survival through active radical treatment.

Published
2019
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