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Three novel sesterterpenoids glasesterterpenoids A−C (1 − 3), featuring an unprecedented 7-cyclohexyldecahydronaphthalene carbon skeleton, were isolated from the root of Lindera glauca (L. glauca). Their structures were elucidated by quantum chemical calculations and spectroscopic methods. The biogenetic pathway for 1 − 3 is proposed. In the bioassay, glasesterterpenoid C exhibited DNA topoisomerase 1 (Top1) inhibitory activity compared with the positive control, camptothecin. These findings represent the first examples of sesterterpenoids with a 7-cyclohexyldecahydronaphthalene carbon skeleton from the root of L. glauca. [ABSTRACT FROM AUTHOR]

Aim: We aim to determine workplace bullying in relation to the professional quality of life of nurses and the mediating role of resilience between workplace bullying and the professional quality of life. Background: Workplace bullying is an increasingly serious problem worldwide and deleteriously affects the occupational health and quality of life of nurses. However, it has not attracted adequate managerial attention. Method: A cross‐sectional study was conducted using a sample of 493 clinical nurses from two tertiary grade A hospitals in Guangzhou, China. Data were collected through an online questionnaire survey in July 2020 and analysed with structural equation modelling. Results: Workplace bullying had negative and direct effects on the professional quality of life of nurses. Resilience mediated the relationship between workplace bullying and the professional quality of life. Conclusion: Resilience is a protective factor that helps nurses cope with workplace bullying. Managers can improve the professional quality of life of nurses by reducing workplace bullying and strengthening the resilience of nurses. Implications for Nursing Management: Managers must take measures to prevent the workplace bullying of nurses. In addition, nurse supervisors should pay attention to the resilience of nurses and strengthen resilience training to help nurses withstand the pressure of workplace bullying and improve their professional quality of life. [ABSTRACT FROM AUTHOR]

Dendrite growth in solid-state sodium batteries (SSBs) is one of the most concerned issues that critically affect the battery efficiency and cycling performance. Here, by designing a fluorescent Eu 3+ -doped Na 3 Zr 2 Si 2 PO 12 solid electrolyte (SE) to facilitate three-dimensional (3D) optical imaging on a confocal laser scanning microscopy, a fluorescence tomography (FT) method is developed for observing the sodium dendrite growth during charge/discharge cycles of the SSBs in a 3D view. It is quantitatively revealed that small-size sodium islands appear after several cycles, and with the cycles increasing, large-size dendrites in tens of micrometers gradually form until a critical sodium dendrite volume arrives where a short circuit or severe performance deterioration occurs. Furthermore, by regulating the Eu 3+ doping ratio, a record-high sodium plating/stripping cycling stability for more than 1 year (487.5 days) is achieved at 25°C. This work demonstrates an FT method observing sodium dendrite growth in SSBs and will promote the functional design of high-performance SEs.

Three novel sesterterpenoids glasesterterpenoids A-C (1-3), featuring an unprecedented 7-cyclohexyldecahydronaphthalene carbon skeleton, were isolated from the root of Lindera glauca (L. glauca). Their structures were elucidated by quantum chemical calculations and spectroscopic methods. The biogenetic pathway for 1-3 is proposed. In the bioassay, glasesterterpenoid C exhibited DNA topoisomerase 1 (Top1) inhibitory activity compared with the positive control, camptothecin. These findings represent the first examples of sesterterpenoids with a 7-cyclohexyldecahydronaphthalene carbon skeleton from the root of L. glauca., (Copyright © 2024 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.)

Objectives: Clinically effective analgesia treatment for patients afflicted with osteocarcinoma lessens the intensity of pain. The midbrain periaqueductal gray (PAG) plays a critical role in pain modulation, and activation of P 2 X 3 receptors in this region mediates pain processing. Neurotropin is a small molecule drug used for analgesic treatment of a number of chronic pain conditions. The present study aims at determining whether P 2 X 3 receptor activation in PAG is responsible for the analgesic effect of neurotropin in rats with osteocarcinoma pain., Materials and Methods: The tibia of female Sprague-Dawley rats was inoculated with breast carcinoma cells to establish the osteocarcinoma pain model. The effects of intraperitoneal injection of 6, 12, and 18 neurotropin units (NU)/kg on pain threshold and receptor expression of P 2 X 3 in the ventrolateral PAG (vlPAG) were assessed. The P 2 X 3 receptor antagonist A-317491 (1.5 nmol/0.3 µl) was administered into vlPAG with a high-dose neurotropin (18 NU/kg) to determine the role of this receptor in the analgesic effect., Results: The pain thresholds of the rats with osteocarcinoma pain continuously decreased, whereas P 2 X 3 receptor expression in vlPAG only slightly increased after osteocarcinoma cell inoculation. Neurotropin substantially elevated the pain threshold and P 2 X 3 receptor expression in vlPAG in a dose-dependent manner. A-317491 microinjection into vlPAG significantly reduced the analgesic effects of neurotropin in the rats with osteocarcinoma pain., Conclusion: Through these findings, it is shown that vlPAG P 2 X 3 receptor activation participates in neurotropin-mediated analgesia mechanism in osteocarcinoma pain., Competing Interests: The authors declare that there are no potential interest conflicts in the authorship and/or publication of this paper herein.