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Your search keyword '"He, Mengyun"' showing total 34 results
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34 results on '"He, Mengyun"'

14. Quantum anomalous Hall interferometer.

Author

He, Mengyun, Huang, Yu, Sun, Huimin, Fu, Yu, Zhang, Peng, Zhao, Chenbo, Wang, Kang L., Yu, Guoqiang, and He, Qing Lin

Subjects
*AHARONOV-Bohm effect, *MAGNETIC flux, *QUANTUM states, *INTERFEROMETRY, *QUBITS, *INTERFEROMETERS, *MICHELSON interferometer
Abstract

Electronic interferometries in integer and fractional quantum Hall regimes have unfolded the coherence, correlation, and statistical properties of interfering constituents. This is addressed by investigating the roles played by the Aharonov–Bohm effect and Coulomb interactions on the oscillations of transmission/reflection. Here, we construct magnetic interferometers using Cr-doped (Bi,Sb)2Te3 films and demonstrate the electronic interferometry using chiral edge states in the quantum anomalous Hall regime. By controlling the extent of edge coupling and the amount of threading magnetic flux, distinct interfering patterns were observed, which highlight the interplay between the Coulomb interactions and Aharonov–Bohm interference by edge states. The observed interference is likely to exhibit a long-range coherence and robustness against thermal smearing probably owing to the long-range magnetic order. Our interferometer establishes a platform for (quasi)particle interference and topological qubits. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Biomineralized metal–organic framework nanoparticles enable a primer exchange reaction-based DNA machine to work in living cells for imaging and gene therapy† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0sc00339e

Author

Zhang, Juan, He, Mengyun, Nie, Cunpeng, He, Manman, Pan, Qingshan, Liu, Chang, Hu, Yanlei, Chen, Tingting, and Chu, Xia

Subjects
Chemistry
Abstract

Sensitive tumor imaging and precise tumor therapy play critical roles in cancer combat., Sensitive tumor imaging and precise tumor therapy play critical roles in the cancer combat. Herein, we build a DNA machine based on a primer exchange reaction (PER) for mRNA imaging and gene therapy. By using zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) to co-deliver the components including a primer, hairpin and strand displacing polymerase to the living cells, the PER-based DNA machine can be initiated by intracellular survivin mRNA and continuously produce Bcl-2 antisense DNA (ASD), which enables the DNA machine not only to image survivin mRNA but also to implement gene therapy. The results demonstrate that ZIF-8 NPs can protect the polymerases and nucleic acid probes from protease attack and nuclease degradation. After internalization, pH-responsive ZIF-8 NPs can efficiently release cargos from endo-lysosomes due to the protonation effect. The intracellular PER-based DNA machine has been demonstrated to be able to sensitively image survivin mRNA expression levels and selectively kill the cancer cells and has no effect on the normal cells. The PER-based DNA machine may provide a promising platform for early stage tumor diagnosis and more precise tumor therapy.

Published
2020

34. Aptamer-Functionalized DNA Origami for Targeted Codelivery of Antisense Oligonucleotides and Doxorubicin to Enhance Therapy in Drug-Resistant Cancer Cells

Author

Pan, Qingshan, Nie, Cunpeng, Hu, Yanlei, Yi, Jintao, Liu, Chang, Zhang, Juan, He, Manman, He, Mengyun, Chen, Tingting, and Chu, Xia

Abstract

Drug resistance is a major obstacle to the efficient therapy of drug-resistant cancer. To overcome this problem, we constructed a multifunctional DNA origami-based nanocarrier for codelivery of a chemotherapeutic drug (doxorubicin, Dox) and two different antisense oligonucleotides (ASOs; B-cell lymphoma 2 (Bcl2) and P-glycoprotein (P-gp)) into drug-resistant cancer cells for enhanced therapy. To increase the targeting ability of origami, staple strands with 5′-end extended MUC1 sequences were used in the preparation of aptamer-functionalized origami carrying ASOs (Apt-origami-ASO). Dox-loaded Apt-origami-ASO (Apt-Dox-origami-ASO) was prepared by electrostatic adsorption of Dox in origami. Atomic force microscopy (AFM) images demonstrated the successful preparation of Apt-origami-ASO. In vitro studies showed that the Apt-Dox-origami-ASO (Apt-DOA) could controllably release Dox in pH 5.0 phosphate-buffered saline (PBS) buffer and release ASOs in response to glutathione. Further experiments revealed that the origami could protect ASOs against nuclease degradation in 10% FBS. Confocal imaging showed that the Apt-DOA nanocarrier could efficiently enter the Hela/adriamycin (ADR) cells and escape from lysosomes for codelivery of Dox and ASOs into the cytoplasm. The quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and western blot assays testified the efficient silencing of Bcl2 and P-gp mRNA and downregulation of the corresponding protein expressions by Apt-DOA in Hela/ADR cells. Moreover, with the synergetic effect by codelivery of multi-ASOs and Dox, the anticancer assay showed that Apt-DOA could circumvent multidrug resistance and significantly enhance cancer therapy in Hela/ADR and MCF-7/ADR cells. Hence, this multifunctional origami-based codelivery nanocarrier presents a new strategy for efficient therapy of drug-resistant cancer.

Published
2020
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