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Donepezil hydrochloride is a widely used medication for treating Alzheimer's disease. This study utilized terahertz time-domain spectroscopy to analyze the fingerprint spectra of donepezil hydrochloride, identifying five characteristic absorption peaks at 1.65, 2.44, 2.56, 3.31, and 3.75 THz. The vibrational spectrum of the donepezil hydrochloride crystal was further examined using solid-state density functional theory. Based on simulation calculations, the characteristic peaks were identified and analyzed in detail, focusing on long-range ordering and weak interaction networks. The results demonstrate that terahertz spectroscopy is an effective tool for studying intermolecular interactions in drug crystals. [ABSTRACT FROM AUTHOR]

The internal waves in the South China Sea are highly correlated with the tidal currents in the Luzon Strait, which makes it possible to establish an internal wave prediction model based on internal wave kinematics. However, the kinematic model requires the input of the exact location and time of the initial internal wave for which the generation mechanism of internal waves in the northern South China Sea must be well understood. By analyzing the internal wave field in the northern South China Sea (SCS) simulated using the MIT General Circulation Model (MITgcm) and observations from satellite synthetic aperture radar (SAR) and mooring temperature–salinity–depth (TSD) chains, the source regions and propagation initiation times of internal waves are identified for three typical tidal phases, i.e., the diurnal-tide-dominated phase (DTP), transition tide phase (TTP), and semidiurnal-tide-dominated phase (STP). The generation procedures of Type A and Type B internal waves are discussed in detail with those data. The present study reveals that Type A and Type B waves are generated at the eastern and western ridges, respectively, and both commence their westward propagation at the peak of the eastward tidal flow. The dynamics of lee waves and the resonance effect with double ridges constitute the generation mechanisms of internal waves in the northern SCS. Combined with varying configurations of tidal conditions, topography, and stratification, the generation procedures of Type A and Type B waves in the DTP, TTP, and STP are elucidated with the generation mechanism in a unified and self-consistent way. In short, during DTP, weaker A waves alternate with weaker B waves each day; during TTP, strong A waves and strong B waves appear alternately every day; and there are two weak A waves per day during the STP. The generation mechanism can help in developing future empirical models for generating internal waves using tidal currents, topography, and stratification without requiring complex fluid dynamics calculations. [ABSTRACT FROM AUTHOR]

Transition metal doping is an ideal strategy to construct multifunctional and efficient nanozymes for biosensing. In this work, a metal-doped CoMnOx nanozyme was designed and synthesized by hydrothermal reaction and high-temperature calcination. Based on its oxidase activity, an "on-off-on" smartphone sensing platform was established to detect ziram and Cu2+. The obtained flower-shaped CoMnOx could exhibit oxidase-, catalase-, and laccase-like activities. The oxidase activity mechanism of CoMnOx was deeply explored. O2 molecules adsorbed on the surface of CoMnOx were activated to produce a large amount of O2·-, and then, O2·- could extract acidic hydrogen from TMB to produce blue oxTMB. Meanwhile, TMB was oxidized directly to the blue product oxTMB via the high redox ability of Co species. According to the excellent oxidase-like activity of CoMnOx, a versatile colorimetric detection platform for ziram and Cu2+ was successfully constructed. The linear detection ranges for ziram and Cu2+ were 5~280 μM and 80~360 μM, and the detection limits were 1.475 μM and 3.906 μM, respectively. In addition, a portable smartphone platform for ziram and Cu2+ sensing was established for instant analysis, showing great application promise in the detection of real samples including environmental soil and water. [ABSTRACT FROM AUTHOR]

Certain types of primary tumor, particularly triple primary tumors with germline mutations, are rare. The present study reports a novel case of the metachronous occurrence of three pathological conditions, namely, non-small-cell lung cancer (NSCLC), early T cell precursor acute lymphoblastic leukemia (ETP-ALL) and SCLC. The present study used next-generation sequencing to aid diagnosis. A 44-year-old male patient presented to The First Affiliated Hospital Zhejiang University School of Medicine (Hangzhou, China) in September 2016.) with a nodule in the right lower lung during an annual checkup. Then, the patient was diagnosed with poorly differentiated NSCLC (T1N2M0; stage IIIA) and underwent surgical resection and biopsy. In September 2018, the patient was diagnosed with ETP-ALL with superficial lymphadenopathy. Germline testing demonstrated germ cell variants of ERCC excision repair 6, chromatin remodeling factor (ERCC6; c.1322A>G) and LYL1 basic helix-loop-helix family member (LYL1; c.587T>A). In November 2020, the patient was diagnosed with SCLC by bronchoscopic biopsy following allogeneic hematopoietic stem cell transplantation. The patient was diagnosed with lung cancer in October 2016 and the treatment were: surgery, chemotherapy, radiotherapy, and targeted therapy. In October 2018, the patient was diagnosed with ETP-ALL and the treatment were: chemotherapy and allogeneic hematopoietic stem cell transplantation. In November 2020, the patient was diagnosed with small cell lung cancer and received chemotherapy and radiotherapy. The patient died at September 2022. The present case highlighted the importance of monitoring germline mutations in patients and their families to facilitate early diagnosis, appropriate treatment and prognostic evolution in the face of rapid recurrent cancer. [ABSTRACT FROM AUTHOR]