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The advanced treatment of bio-treated coking wastewater was carried out using peroxymonosulfate(PMS)oxidation activated by base combined with sequencing biofilm batch reactor(SBBR). The effects of pH, PMS concentration, and temperature on the removal of COD and chroma of bio-treated coking wastewater were investigated by base/PMS system with sodium hydroxide as activater. The optimal conditions were temperature of 25 ℃, pH of 10, PMS concentration of 7 mmol/L, reaction time of 4 h. Under this condition,the removal rates of COD and chroma were 45.9% and 96.1%,respectively. EPR analyse indicated that 1O2, O2·-, ∙OH and SO4·- existed in the base/PMS system. After base/PMS system,the biodegradabality of waste water improved. The COD of effluent after SBBR treatment was less than 60 mg/L. The average removal rate of COD reached 66.7% with PMS oxidation activated by base combined with sequencing biofilm batch reactor. The three-dimensional fluorescence spectrum showed that the base/PMS system combined with SBBR could remove aromatic-like protein substances and humic-like acids.

Kashin-Beck disease (KBD) is an endemic osteochondropathy. A specific gene called SRY-box transcription factor 6 (SOX6) is important for forming cartilage. This study aims to explore the potential correlation between SOX6 single nucleotide polymorphisms (SNPs) and KBD risk for the first time. In the case–control study, 735 unrelated Chinese Han individuals were enrolled. The four mutation sites of the SOX6 gene (rs4539287 G/A, rs3203295 C/A, rs7928675 C/A, and rs10832681 A/G) were screened and genotyped on the Agena MassARRAY platform. The correlation between SOX6 SNPs and KBD risk was explored based on logistic regression analysis. The interaction between SNP and SNP was analyzed based on the multi-factor dimensionality reduction (MDR) method. Overall analysis revealed a remarkable correlation between rs7928675 and rs10832681 and the reduction of KBD risk (p < 0.05). Subgroup analyses further indicated that these two SNPs have a significant protective effect on KBD risk among participants aged ≤65 years, males, and non-smokers (p < 0.05). MDR displayed a marked interaction between rs3203295 and rs10832681. Our study revealed that SOX6 rs7928675 and rs10832681 are markedly correlated with a reduced risk of KBD in the Chinese Han population, providing a new direction for the prevention, diagnosis, and treatment of KBD.

ObjectiveTo determine the characteristics， viral load and immunological status of HIV-infected persons and their spouses who became HIV-positive， and the reasons for HIV seroconversion in 55 HIV discordant couples in Dehong Dai and Jingpo Autonomous Prefecture （Dehong Prefecture）， Yunan Province.MethodsData on the 55 couples meeting the criteria of having a previously positive spouse were retrieved from the AIDS Integrated Prevention and Control Data Information System of the China Disease Control and Prevention Information System during 2015-2021. General socio-demographic information， age at diagnosis， exposure history， CD4+T lymphocyte count， and antiviral treatment were collected. Descriptive analysis and chi-square test were used to compare the distribution of pre-HIV-positive spouses and their HIV seroconverted spouses.ResultsA total of 55 spouses from HIV discordant couples had HIV seroconversion. Of them， 72.7% （40/55） of pre-HIV-positive spouses were husbands. The most recent CD4+T lymphocyte count in the pre-HIV-positive spouses was （328.31± 246.27） cells·μL-1 at the time of diagnosis of their seroconverted spouses， of which 36.3% （20/55） had a CD4+T lymphocyte count of less than 200 cells·μL-1. Furthermore， of those pre-HIV-positive spouses with low CD4+T lymphocyte count， 45.0% （9/20） had an undetectable viral load， 15.0% （3/20）

ObjectiveThis study aimed to investigate the HIV genotypic subtypes and molecular transmission clusters among men who have sex with men （MSM） with newly reported HIV infections in Dehong Dai and Jingpo Autonomous Prefecture （Dehong Prefecture）， Yunnan Province， China， between 2010 and 2019. The study aimed to identify potential high-risk transmitters and provide reference data for screening， management， and intervention of infection sources.MethodsPlasma samples from newly reported HIV-positive MSM individuals in Dehong Prefecture between 2010 and 2019 were collected. The viral pol gene fragments were amplified， sequenced， and genotyped. Genetic distances （GD） between pairwise sequences were analyzed and calculated. MEGA 7.0 and Gephi were used for phylogenetic and molecular transmission network analysis.ResultsA total of 159 newly reported HIV infections among MSM were included in the study， with successful genotyping of 100 cases. Nine HIV-1 subtypes were identified， with the most prevalent being CRF01_AE subtype （52%）， followed by CRF07_BC subtype （31%）， CRF55_01B subtype （10%）， and others （7%）. Cluster analysis revealed a total network access rate of 67%， forming three transmission clusters. CRF01_AE subtype formed two transmission clusters with 38 and 3 infected individuals， while CRF07_BC subtypes formed one transmission cluster with 26 infected individuals. The transmission network within the CRF01_AE clusters exhibited a more complex relationship. Significant differences in educational level were observed between the two main transmission clusters.ConclusionThe predominant HIV subtypes among newly reported MSM cases in Dehong Prefecture between 2010 and 2019 were CRF01_AE and CRF07_BC. Significant cultural differences are observed between the main transmission clusters. Continued monitoring of genotypic subtypes and targeted interventions within transmission clusters are warranted.

Unlike growth on tissue, microbes can grow freely on implantable devices with minimal immune system intervention and often form resilient biofilms that continuously pump out pathogenic cells. The efficacy of antibiotics used to treat infection is declining due to increased rates of pathogenic resistance. A simple, one-step zwitterionic surface modification is developed to significantly reduce protein and microbial adhesion to synthetic materials and demonstrate the successful modification of several clinically relevant materials, including recalcitrant materials such as elastomeric polydimethylsiloxane. The treated surfaces exhibit robust adhesion resistance against proteins and microorganisms in both static and flow conditions. Furthermore, the surface treatment prevents the adhesion of mammalian fibroblast cells while displaying no cytotoxicity. To demonstrate the clinical efficacy of the novel technology in the real-world, a surface-treated, commercial silicone foley catheter is developed that is cleared for use by the U.S. Food and Drug Administration (K192034). 16 long-term catheterized patients received surface-treated catheters and completed a Patient Global Impression of Improvement (PGI-I) questionnaire. 10 out of 16 patients described their urinary tract condition post implantation as "much better" or "very much better" and 72% (n = 13) of patients desire to continue using the surface-treated catheter over conventional latex or silicone catheters.

ObjectiveTo understand the epidemiological characteristics and trends of sexually transmitted diseases （STDs） in Dehong Prefecture， Yunnan Province from 2010 to 2022， so as to provide a basis for the prevention and control of STDs in Dehong Prefecture.MethodsThe 2010‒2022 epidemic cards of STD cases in Dehong Prefecture were downloaded from the China Disease Control and Prevention Information System， and descriptive analysis of the incidence rate and demographic characteristics by disease type was conducted. The syphilis screening data of various populations in Dehong Prefecture between 2014 and 2022 were obtained from the National STD Control and Management Information System， and the syphilis positivity rates of key populations were calculated.ResultsA total of 18 225 STD cases were reported in Dehong Prefecture from 2010 to 2022， and the reported incidence rate increased from 17.1/105 in 2010 to 172.0/105 in 2022， showing an increasing trend （χ2trend=42.9， P

This study analyzed the problems regarding talent training in public health colleges and universities in China by examining the gap between education demand and supply in these colleges and universities, thus to provide theoretical references for the formation of a public health personnel training system with Chinese characteristics in the context of Healthy China strategy. Relevant educational statistics were collected, questionnaires were distributed to 85 public health colleges, and in-depth interviews were conducted with principals of public health colleges, leaders of employers, leaders of administrative departments, and graduates of public health majors. Subject framework analysis was applied to explore the key factors that affect the effectiveness of talent training in colleges and universities. Although the education of public health colleges and universities in China has made certain achievements, problems including an insufficient supply of public health personnel and an unbalanced supply structure still exist. Therefore, we should incorporate the training of public health personnel into national strategic planning, increase the strategic investment in public health colleges and universities, and strengthen the integration of college, post-graduation, and continuing education. Moreover, we should promote the standardization of college education for public health, clarify the collaborative training approaches for public health personnel, explore training models for excellent public-health personnel, and strengthen the teaching staff construction in public health colleges and universities

ObjectiveTo investigate the factors that influence the first CD4+T lymphocyte counts in newly reported HIV-infected cases aged 50 and above in Dehong Prefecture of Yunnan Province during 2016 to 2021， and to understand the patient immune status and disease progression so as to provide scientific basis for HIV prevention and control strategies in the future.MethodsData was collected from the national HIV/AIDS information system. Multivariate logistic regression was used for the analysis of factors affecting the first CD4+T lymphocyte counts.ResultsA total of 642 cases of HIV infection were newly reported， among them， 571 cases had CD4+T lymphocyte counts and 200 cases （35.03%） had CD4+T lymphocyte counts

The traditional motor fault diagnosis method based on the audio signal is insufficient to obtain the feature information of the motor audio signal and the fault diagnosis precision is not high. In order to solve the above problems, a mine motor fault diagnosis method based on optimized variational mode decomposition (VMD) and convolutional neural network CNN bidirectional long short-term memory (BiLSTM) is proposed. The whale algorithm (WOA) optimized VMD is used to decompose the motor audio signal to address the issues of modal aliasing and endpoint effects. The motor audio signal is decomposed into K intrinsic mode functions (IMF). After Pearson correlation coefficient screening, the 13-dimensional static MFCC feature parameters of the main IMF component are extracted. In order to obtain the dynamic features of the signal, the first and second-order difference coefficients of the 13-dimensional static MFCC are extracted to form a 39-dimensional feature vector. By combining dynamic and static features, the performance of fault diagnosis can be improved. In order to improve the precision of fault diagnosis, a BiLSTM layer is introduced into the CNN. The CNN extracts local features of the audio signal in the spatial dimension. The BiLSTM preserves bidirectional time series information of the audio signal in the temporal dimension. It captures long-distance dependencies of the audio signal, thereby maximizing the preservation of global and local features. The experimental results show the following points. ① Each IMF component of VMD decomposition has an independent center frequency and uniform distribution, and exhibits sparsity in the frequency domain. It can effectively avoid modal aliasing problems. In IMF solving, VMD decomposition avoids endpoint effects in empirical mode decomposition (EMD) and ensemble empirical mode decomposition (EEMD) through mirror extension. ② The fault diagnosis accuracy based on 13-dimensional static MFCC features is 97.5%. The fault diagnosis accuracy based on 39-dimensional dynamic and static MFCC features is 1.11% higher than that based on 13-dimensional static MFCC features. ③ The accuracy of the diagnostic model based on CNN-BiLSTM reaches 98.61%, which is 5.83%, 4.17%, and 3.89% higher than the current universal diagnostic models CNN, BiLSTM, and CNN-LSTM, respectively.

BackgroundTo evaluate the association between postdiagnostic dairy intake and survival among patients with colorectal cancer (CRC).MethodsThis study analyzed data from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Postdiagnostic dairy intake and other dietary and lifestyle factors were obtained from validated questionnaires. Individual dairy items including milk, cheese, yogurt, and so on were reported, and total, high-fat, and low-fat dairy intakes were derived.ResultsA total of 1753 eligible CRC cases were identified until 2012, from which 703 deaths were documented after a median follow-up time of 8.2 y, and 242 were due to CRC. Overall, when comparing those who consumed 21+ servings/wk with

Aerosol microorganisms are important constituents of aerosols. They participate in physical and chemical reactions in the air and are also closely related to disease transmission and human health. With the SARS-CoV-2 pandemic， aerosol microorganisms have become a public health topic of great concern. Studying the composition and influencing factors of the air microbiome therefore has significant public health implications. Due to the limitations of traditional technologies for sampling and determination， the aerosol microbiome has not been fully understood. However， with the development and maturity of high-throughput sequencing technology， the aerosol microbiome has shown promising research prospects. This article reviews the composition， characteristics， detection methods and influencing factors of aerosol microorganisms， providing basic knowledge for further research on the air microbiome. In-depth research on microbial aerosols has significant implications on urban air quality control， national security and public health.

ObjectiveTo analyze the prevalence of HCV antibody positive and associated factors among drug users in Dehong Prefecture， Yunnan， and to provide scientific evidence for HCV prevention.MethodsQuestionnaire surveys and serological testing were conducted among 400 drug users continuously selected from four national AIDS sentinel surveillance in Dehong Prefecture between January and July during 2014‒2021.Results11 683 drug users were included. The prevalence of HCV antibody positive was 20.2% overall， and 14.9%， 20.1%， 22.4%， 19.8%， 22.5%， 20.6%， 24.5%， 19.0% from 2014 to 2021， respectively （trend Z=-3.78， P