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189 results on '"Heard, David"'

1. Navigating the Care of Families with a Child or Children with Autistic Spectrum Disorder

Author

Harvey, Clare, Willis, Eileen, Brown, Janie, Byrne, Amy-Louise, Baldwin, Adele, Heard, David, and Augutis, Wendy

Abstract

The aim of this project was to better understand nurse navigators work with children and families who are living with severe autism spectrum disorder to achieve improved health and wellbeing outcomes. Nurse navigators were introduced into the public health sector in Queensland in 2016, with 400 navigators currently working across 16 health services in diverse geographic and demographic settings. Narrative inquiry was used to explore one nurse navigator's journey working with children and families living with severe Autism. The challenges of rigid health systems to adapt to the requirements of children with special needs, particularly in relation to care in the emergency department and where interventional procedures are necessary were apparent. Nurse navigators can effectively co-ordinate the care of an extremely vulnerable patient cohort and provide essential advocacy in a health system that is rigid and lacking the flexibility to deal with individual needs.

Published
2023
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3. Maleidride natural products : structural and synthetic studies

Author

Heard, David and Willis, Chris

Subjects
540, Organic Synthesis, Natural Products, Total Synthesis, Biosynthesis
Abstract

The maleidrides are a class of polyketide natural products which possess a broad range of herbicidal and fungicidal properties. An introduction to their bioactivity and biosynthesis is described in chapter one, before the isolation and structural determination of two members of this family, scytalidin and deoxyscytalidin is described in chapter two. The relative stereochemistry of both natural products was determined by X-ray crystallography, and the absolute stereochemistry proposed on the basis of biosynthetic studies. In chapter three, the total synthesis of fulgenic diacids is described. The approach utilised a substitutionelimination reaction of nitroalkanes with an allylic bromide, in which two alkenes are formed concomitantly, including exclusive formation of an (E)-trisubstituted alkene moiety. This methodology is exemplified with the first total syntheses of the tricladic acids A-C, fungal natural products with interesting fungicidal and anti-cancer properties. This methodology underpinned the investigation of a biomimetic synthesis of deoxyscytalidin in chapter four. The desired cyclisation could not be achieved, however as a result of this investigation the structure of the natural product waquafranone B has been revised. Finally, a de novo approach to the synthesis of scytalidin is described in chapter five. A strategy utilising two-carbon ring expansion of cyclic β-ketoesters was devised, with which the nine-membered carbocylic ring of scytalidin would be formed. The synthesis of late-stage intermediates is described.

Published
2019

5. Quiet Riot: Part electric and part V-8, the 2024 Chevrolet Corvette E-Ray's powertrain may have a split personality, but this car is all about performance

Author

Heard, David

Subjects
Automobiles -- Product/service Evaluations, Automobiles, Chevrolet Corvette (Automobile)
Abstract

Corvette traditionalists, pour yourselves a drink and take a deep breath. Chevrolet's halo car has gone electric. We'll pause while you dry-heave. You good? There's more. It's also all-wheel drive. [...]

Published
2023

9. Navigating the care of families with a child or children with autistic spectrum disorder.

Author

Harvey, Professor Clare, Willis, Emeritus Professor Eileen, Brown, Dr Janie, Byrne, Amy-Louise, Baldwin, Associate Professor Adele, Heard, David, and Augutis, Wendy

Subjects
CHILDREN with autism spectrum disorders, CHRONIC care model, HEALTH outcome assessment
Abstract

The aim of this project was to better understand nurse navigators work with children and families who are living with severe autism spectrum disorder to achieve improved health and wellbeing outcomes. Nurse navigators were introduced into the public health sector in Queensland in 2016, with 400 navigators currently working across 16 health services in diverse geographic and demographic settings. Narrative inquiry was used to explore one nurse navigator's journey working with children and families living with severe Autism. The challenges of rigid health systems to adapt to the requirements of children with special needs, particularly in relation to care in the emergency department and where interventional procedures are necessary were apparent. Nurse navigators can effectively co-ordinate the care of an extremely vulnerable patient cohort and provide essential advocacy in a health system that is rigid and lacking the flexibility to deal with individual needs. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Examining the hurdles in defining the practice of Nurse Navigators

Author

Harvey, Clare, primary, Byrne, Amy-Louise, additional, Willis, Eileen, additional, Brown, Janie, additional, Baldwin, Adele, additional, Hegney, Adjunct Desley, additional, Palmer, Janine, additional, Heard, David, additional, Brain, David, additional, Heritage, Brody, additional, Ferguson, Bridget, additional, Judd, Jenni, additional, Mclellan, Sandy, additional, Forrest, Rachel, additional, and Thompson, Shona, additional

Published
2021
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27. Queensland Health nurse navigator evaluation. Progress report: October 2020

Author

Harvey, Clare, Heritage, Brody, Forrest, Rachel, Desley Hegney, Willis, Eileen, Amy-Louise Byrne, Baldwin, Adele, Brown, Janie, Heard, David, Palmer, Janine, Brain, David, Judd, Jennifer, Mclellan, Sandra, Ferguson, Bridget, and Thompson, Shona

Subjects
111003 Clinical Nursing: Secondary (Acute Care), 111002 Clinical Nursing: Primary (Preventative), FOS: Health sciences
Abstract

This report identified the emergent success of the navigators in improving the care of people living with multiple chronic conditions. These results are achieved through the delivery of person-centred care, evidenced by an ongoing improvement of patients’ self-reported wellbeing and self-management of their illness alongside indicative cost savings resulting from a reduction in unnecessary hospital admissions. Navigators are not new; however, there is a paucity of literature that identifies the role of nurses as navigators in the co-ordination of multimorbid conditions. Therefore, the Queensland navigators are novel. Furthermore, their uniqueness lies is in the diversity of the context within which they work, particularly regarding disparate geographic regions and cultural diversity. These factors add to the challenges that navigators face in supporting patients to achieve effective access to multiple levels of health service delivery and numerous specialist services involved in their care.

Published
2021
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29. Le don de spermatozoïdes après le vote de la loi de bioéthique du 2 août 2021 : faut-il craindre une raréfaction des donneurs ?

Author

de Vienne, Claire, Zébina, Audrey, Tong, Fabienne, Heard, David, Tsimaratos, Michel, and Jonveaux, Philippe

Subjects
SPERM donation, UNMARRIED couples, BIOETHICS, SINGLE women, STRAW
Abstract

Copyright of Médecine de la Reproduction is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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31. Understanding the impact and causes of ‘failure to attend’ on continuity of care for patients with chronic conditions

Author

Byrne, Amy-Louise, primary, Baldwin, Adele, additional, Harvey, Clare, additional, Brown, Janie, additional, Willis, Eileen, additional, Hegney, Desley, additional, Ferguson, Bridget, additional, Judd, Jenni, additional, Kynaston, Doug, additional, Forrest, Rachel, additional, Heritage, Brody, additional, Heard, David, additional, Mclellan, Sandy, additional, Thompson, Shona, additional, and Palmer, Janine, additional

Published
2021
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33. The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00717a

Author

de Mattos-Shipley, Kate M. J., Greco, Claudio, Heard, David M., Hough, Gemma, Mulholland, Nicholas P., Vincent, Jason L., Micklefield, Jason, Simpson, Thomas J., Willis, Christine L., Cox, Russell J., and Bailey, Andrew M.

Subjects
Chemistry
Abstract

The cycloaspeptide gene cluster includes a pathway-specific N-methyl transferase. Its disruption allowed incorporation of N-methylated amino acids provided in the culture medium, allowing efficient production of cycloaspeptide E and novel related products., The cycloaspeptides are bioactive pentapeptides produced by various filamentous fungi, which have garnered interest from the agricultural industry due to the reported insecticidal activity of the minor metabolite, cycloaspeptide E. Genome sequencing, bioinformatics and heterologous expression confirmed that the cycloaspeptide gene cluster contains a minimal 5-module nonribosomal peptide synthetase (NRPS) and a new type of trans-acting N-methyltransferase (N-MeT). Deletion of the N-MeT encoding gene and subsequent feeding studies determined that two modules of the NRPS preferentially accept and incorporate N-methylated amino acids. This discovery allowed the development of a system with unprecedented control over substrate supply and thus output, both increasing yields of specific metabolites and allowing the production of novel fluorinated analogues. Furthermore, the biosynthetic pathway to ditryptophenaline, another fungal nonribosomal peptide, was shown to be similar, in that methylated phenylalanine is accepted by the ditryptophenaline NRPS. Again, this allowed the directed biosynthesis of a fluorinated analogue, through the feeding of a mutant strain. These discoveries represent a new paradigm for the production of N-methylated cyclic peptides via the selective incorporation of N-methylated free amino acids.

Published
2018

35. Epigenomics - Impact for Drug Safety Sciences

Author

Lempiäinen, Harri, primary, Luisier, Raphaëlle, additional, Müller, Arne, additional, Marc, Philippe, additional, Heard, David, additional, Bolognani, Federico, additional, Moulin, Pierre, additional, Couttet, Philippe, additional, Grenet, Olivier, additional, Marlowe, Jennifer, additional, Moggs, Jonathan, additional, and Terranova, Rémi, additional

Published
2012
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36. Exploiting human genomic diversity: through alternative RNA splicing

Author

Cochet, Olivier, Heard, David j., Fehlbaum, Pascale, Ducray, Caroline, and Bracco, Laurent

Subjects
RNA splicing -- Research, Human genome -- Research, Pharmaceutical biotechnology -- Research, Pharmaceuticals and cosmetics industries, Science and technology, Research
Abstract

A microarray has been developed to address the monitoring of spliced events based on a new qualitative gene profiling technology that identifies functionally distinct mRNA variants associated with a condition. [...]

Published
2004

37. Identification of Dlk1-Dio3 Imprinted Gene Cluster Noncoding RNAs as Novel Candidate Biomarkers for Liver Tumor Promotion

Author

Lempiäinen, Harri, Couttet, Philippe, Bolognani, Federico, Müller, Arne, Dubost, Valérie, Luisier, Raphaëlle, Del Rio Espinola, Alberto, Vitry, Veronique, Unterberger, Elif B., Thomson, John P., Treindl, Fridolin, Metzger, Ute, Wrzodek, Clemens, Hahne, Florian, Zollinger, Tulipan, Brasa, Sarah, Kalteis, Magdalena, Marcellin, Magali, Giudicelli, Fanny, Braeuning, Albert, Morawiec, Laurent, Zamurovic, Natasa, Längle, Ulrich, Scheer, Nico, Schübeler, Dirk, Goodman, Jay, Chibout, Salah-Dine, Marlowe, Jennifer, Theil, Diethilde, Heard, David J., Grenet, Olivier, Zell, Andreas, Templin, Markus F., Meehan, Richard R., Wolf, Roland C., Elcombe, Clifford R., Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, and Moggs, Jonathan G.

Published
2013
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40. Exploring the nurse navigator role: A thematic analysis

Author

Byrne, Amy‐Louise, primary, Hegney, Desley, additional, Harvey, Clare, additional, Baldwin, Adele, additional, Willis, Eileen, additional, Heard, David, additional, Judd, Jenni, additional, Palmer, Janine, additional, Brown, Janie, additional, Heritage, Brody, additional, Thompson, Shona, additional, and Ferguson, Bridget, additional

Published
2020
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42. Uncovering biosynthetic relationships between antifungal nonadrides and octadrides

Author

de Mattos-Shipley, Kate M. J., primary, Spencer, Catherine E., additional, Greco, Claudio, additional, Heard, David M., additional, O'Flynn, Daniel E., additional, Dao, Trong T., additional, Song, Zhongshu, additional, Mulholland, Nicholas P., additional, Vincent, Jason L., additional, Simpson, Thomas J., additional, Cox, Russell J., additional, Bailey, Andrew M., additional, and Willis, Christine L., additional

Published
2020
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47. Keith: A Case Study of Structural Family Therapy.

Author

Heard, David B. and Evans, Richard C.

Abstract

An edited case presentation of marital therapy of a couple whose child was the original problem. The first theme is that therapy consists of stages involving critical transitional points that need to be appropriately timed. The second is the use of tasks to bring about structural realignment within the family. (Author)

Published
1978

48. Abu Dhabi: Oil and Beyond

Author

Heard, David G.

Subjects
Abu Dhabi: Oil and Beyond (Nonfiction work) -- Book reviews, Books -- Book reviews, Ethnic, cultural, racial issues/studies
Published
2010

49. Interview.

Author

Heard, David

Published
2023

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