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1. Prospective Multicenter Validation of the Detection of ALK Rearrangements of Circulating Tumor Cells for Noninvasive Longitudinal Management of Patients With Advanced NSCLC

Author

Israel-Biet, Dominique, Pison, Christophe, Moro-Sibilot, Denis, Lantuejoul, Sylvie, Stephanov, Olivier, Juliette, Meyzenc, Mendozat, Christophe, Zaidi, Manel, Coulouvrat, Sandra, Col, Edwige, Chanez, Pascal, Greillier, Laurent, Tomasini, Pascale, Barlesi, Fabrice, Mascaux, Céline, Jourdan, Sandrine, Roger, Aurélie, Biemar, Julie, Randriamampionona, Rondro, Chabot, François, Tiotiu, Angélica, Clement-Duchene, Christelle, Vignaud, Jean-Michel, Lacomme, Stéphanie, Lomazzi, Sandra, Laurent, Carine, Bulsei, Xavier, Bischoff, Laura, Rakotonirina, Raymond, Layouni, Mehdi, Deslee, Gaëtan, Mal, Hervé, Kessler, Romain, Vergnon, Jean-Michel, Pelissier, Isabelle, Cuvelier, Antoine, Bourdin, Arnaud, Jounieaux, Vincent, Roche, Nicolas, Jouneau, Stéphane, Bonniaud, Philippe, Scherpereel, Arnaud, Mornex, Jean François, Steenhouwer, François, Leroy, Sylvie, Marquette, Charles Hugo, Benzaquen, Jonathan, Mazzette, Andrea, Padovani, Bernard, Hofman, Paul, Ilié, Marius, Hofman, Véronique, Fayada, Julien, Long-Mira, Elodie, Lassalle, Sandra, Pradelli, Johanna, Martinez, Estelle, Habault, Marine, Bonnard, Mélanie, Moutarde, Julie, Yatimi, Rachida, Labsi, Hakima, Gazoppi, Loïc, Lpce, Tumorothèque, Griffonnet, Jennifer, Fontaine, Maureen, Guillemart, Ariane, Butori, Catherine, Selva, Eric, Poudenx, Michel, Otto, Josiane, Hebert, Christophe, Botchiellini, Delphine, Boudouf, Soukaina, Menier, Margaux, Occeli, Estelle, Bellentani, Sophie, Pion, Carine, Fournier, Elodie, Thariat, Juliette, Gervais, Radj, Hamond, Karim, Marchand-Adam, Sylvain, Plantier, Laurent, Fajolle, Gaelle, Rayez, Mélanie, Cadranel, Jacques, Fallet, Vincent, Wislez, Marie, Antoine, Martine, Cote, Jean-François, Chaabane, Nouha, Ruppert, Anne Marie, Bertrand, Eliane, Rodenas, Anita, Pontdeme, Gwenaëlle, Mathiot, Nathalie, Ribert, Tamazouzt, Mazières, Julien, Guibert, Nicolas, Rouviere, Damien, Bousquet, Emilie, Bigay-Game, Laurence, Hermant, Christophe, Plat, Gavin, Rouquette, Isabelle, Evrard, Solène, Gouin, Sandrine, Clermont, Estelle Taranchon, Dormoy, Inge, Coulomb, Christelle, Pradine, Anne, Lambert, Véronique, Laborde, Lilian, Castelnau, Olivier, Chamorey, Emmanuel, Heeke, Simon, Thamphya, Brice, Boutros, Jacques, Clément-Duchêne, Christelle, and Marquette, Charles-Hugo

Published
2021
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3. Nutritional status and feeding-tube placement in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy-based larynx preservation program

Author

Bozec, Alexandre, Benezery, Karen, Chamorey, Emmanuel, Ettaiche, Marc, Vandersteen, Clair, Dassonville, Olivier, Poissonnet, Gilles, Riss, Jean-Christophe, Hannoun-Lévi, Jean-Michel, Chand, Marie-Eve, Leysalle, Axel, Saada, Esma, Sudaka, Anne, Haudebourg, Juliette, Hebert, Christophe, Falewee, Marie-Noelle, Demard, François, Santini, José, and Peyrade, Frédéric

Published
2016
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4. Efficacy and Safety of Rovalpituzumab Tesirine Compared With Topotecan as Second-Line Therapy in DLL3-High SCLC: Results From the Phase 3 TAHOE Study

Author

Ilié, Marius, Mazières, Julien, Chamorey, Emmanuel, Heeke, Simon, Benzaquen, Jonathan, Thamphya, Brice, Boutros, Jacques, Tiotiu, Angélica, Fayada, Julien, Cadranel, Jacques, Poudenx, Michel, Moro-Sibilot, Denis, Barlesi, Fabrice, Thariat, Juliette, Clément-Duchêne, Christelle, Tomasini, Pascale, Hofman, Véronique, Marquette, Charles-Hugo, Hofman, Paul, Israel-Biet, Dominique, Pison, Christophe, Lantuejoul, Sylvie, Stephanov, Olivier, Juliette, Meyzenc, Mendozat, Christophe, Zaidi, Manel, Coulouvrat, Sandra, Col, Edwige, Chanez, Pascal, Greillier, Laurent, Mascaux, Céline, Jourdan, Sandrine, Roger, Aurélie, Biemar, Julie, Randriamampionona, Rondro, Chabot, François, Vignaud, Jean-Michel, Lacomme, Stéphanie, Lomazzi, Sandra, Laurent, Carine, Bulsei, Xavier, Bischoff, Laura, Rakotonirina, Raymond, Layouni, Mehdi, Deslee, Gaëtan, Mal, Hervé, Kessler, Romain, Vergnon, Jean-Michel, Pelissier, Isabelle, Cuvelier, Antoine, Bourdin, Arnaud, Jounieaux, Vincent, Roche, Nicolas, Jouneau, Stéphane, Bonniaud, Philippe, Scherpereel, Arnaud, Mornex, Jean François, Steenhouwer, François, Leroy, Sylvie, Marquette, Charles Hugo, Mazzette, Andrea, Padovani, Bernard, Long-Mira, Elodie, Lassalle, Sandra, Pradelli, Johanna, Martinez, Estelle, Habault, Marine, Bonnard, Mélanie, Moutarde, Julie, Yatimi, Rachida, Labsi, Hakima, Gazoppi, Loïc, Lpce, Tumorothèque, Griffonnet, Jennifer, Fontaine, Maureen, Guillemart, Ariane, Butori, Catherine, Selva, Eric, Otto, Josiane, Hebert, Christophe, Botchiellini, Delphine, Boudouf, Soukaina, Menier, Margaux, Occeli, Estelle, Bellentani, Sophie, Pion, Carine, Fournier, Elodie, Gervais, Radj, Hamond, Karim, Marchand-Adam, Sylvain, Plantier, Laurent, Fajolle, Gaelle, Rayez, Mélanie, Fallet, Vincent, Wislez, Marie, Antoine, Martine, Cote, Jean-François, Chaabane, Nouha, Ruppert, Anne Marie, Bertrand, Eliane, Rodenas, Anita, Pontdeme, Gwenaëlle, Mathiot, Nathalie, Ribert, Tamazouzt, Guibert, Nicolas, Rouviere, Damien, Bousquet, Emilie, Bigay-Game, Laurence, Hermant, Christophe, Plat, Gavin, Rouquette, Isabelle, Evrard, Solène, Gouin, Sandrine, Clermont, Estelle Taranchon, Dormoy, Inge, Coulomb, Christelle, Pradine, Anne, Lambert, Véronique, Laborde, Lilian, Castelnau, Olivier, University of Manchester [Manchester], Hôpital du Sacré-Coeur de Montréal, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Yonsei University College of Medicine [Séoul, Corée du Sud], August Pi i Sunyer Biomedical Research Institute - IDIBAPS [Barcelona, Spain], Hospital de la Santa Creu i Sant Pau, University Hospitals Leuven [Leuven], National and Kapodistrian University of Athens (NKUA), Odense University Hospital (OUH), Oregon Health and Science University [Portland] (OHSU), Kyushu University, Hacettepe University = Hacettepe Üniversitesi, University of Copenhagen = Københavns Universitet (UCPH), University of Groningen [Groningen], Abbvie Inc. [North Chicago], Asklepios Klinikum Uckermark GmbH, Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Cancérologie de Marseille (CRCM), and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut Paoli-Calmettes

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, medicine.medical_treatment, CELL LUNG-CANCER, Population, Peripheral edema, Phases of clinical research, [SDV.CAN]Life Sciences [q-bio]/Cancer, Delta-like protein 3, Rovalpituzumab tesirine, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, DRUG, education, ComputingMilieux_MISCELLANEOUS, Chemotherapy, education.field_of_study, Small cell lung cancer, business.industry, Hazard ratio, Confidence interval, 030104 developmental biology, 030220 oncology & carcinogenesis, Topotecan, medicine.symptom, business, medicine.drug
Abstract

INTRODUCTION: DLL3, an atypical Notch ligand, is expressed in SCLC tumors but is not detectable in normal adult tissues. Rovalpituzumab tesirine (Rova-T) is an antibody-drug conjugate containing a DLL3-targeting antibody tethered to a cytotoxic agent pyrrolobenzodiazepine by means of a protease-cleavable linker. The efficacy and safety of Rova-T compared with topotecan as second-line therapy in patients with SCLC expressing high levels of DLL3 (DLL3-high) was evaluated. METHODS: The TAHOE study was an open-label, two-to-one randomized, phase 3 study comparing Rova-T with topotecan as second-line therapy in DLL3-high advanced or metastatic SCLC. Rova-T (0.3 mg/kg) was administered intravenously on day 1 of a 42-day cycle for two cycles, with two additional cycles available to patients who met protocol-defined criteria for continued dosing. Topotecan (1.5 mg/m2) was administered intravenously on days 1 to 5 of a 21-day cycle. The primary end point was overall survival (OS). RESULTS: Patients randomized to Rova-T (n = 296) and topotecan (n = 148) were included in the efficacy analyses. The median age was 64 years, and 77% had the extensive disease at initial diagnosis. The median OS (95% confidence interval) was 6.3 months (5.6-7.3) in the Rova-T arm and 8.6 months (7.7-10.1) in the topotecan arm (hazard ratio, 1.46 [95% confidence interval: 1.17-1.82]). An independent data monitoring committee recommended that enrollment be discontinued because of the shorter OS observed with Rova-T compared with topotecan. Safety profiles for both drugs were consistent with previous reports. CONCLUSIONS: Compared with topotecan, which is the current standard second-line chemotherapy, Rova-T exhibited an inferior OS and higher rates of serosal effusions, photosensitivity reaction, and peripheral edema in patients with SCLC. A considerable unmet therapeutic need remains in this population. ispartof: JOURNAL OF THORACIC ONCOLOGY vol:16 issue:9 pages:1547-1558 ispartof: location:United States status: published

Published
2021

6. Prospective Multicenter Validation of the Detection of ALK Rearrangements of Circulating Tumor Cells for Noninvasive Longitudinal Management of Patients With Advanced NSCLC

Author

Ilié, Marius, primary, Mazières, Julien, additional, Chamorey, Emmanuel, additional, Heeke, Simon, additional, Benzaquen, Jonathan, additional, Thamphya, Brice, additional, Boutros, Jacques, additional, Tiotiu, Angélica, additional, Fayada, Julien, additional, Cadranel, Jacques, additional, Poudenx, Michel, additional, Moro-Sibilot, Denis, additional, Barlesi, Fabrice, additional, Thariat, Juliette, additional, Clément-Duchêne, Christelle, additional, Tomasini, Pascale, additional, Hofman, Véronique, additional, Marquette, Charles-Hugo, additional, Hofman, Paul, additional, Israel-Biet, Dominique, additional, Pison, Christophe, additional, Lantuejoul, Sylvie, additional, Stephanov, Olivier, additional, Juliette, Meyzenc, additional, Mendozat, Christophe, additional, Zaidi, Manel, additional, Coulouvrat, Sandra, additional, Col, Edwige, additional, Chanez, Pascal, additional, Greillier, Laurent, additional, Mascaux, Céline, additional, Jourdan, Sandrine, additional, Roger, Aurélie, additional, Biemar, Julie, additional, Randriamampionona, Rondro, additional, Chabot, François, additional, Clement-Duchene, Christelle, additional, Vignaud, Jean-Michel, additional, Lacomme, Stéphanie, additional, Lomazzi, Sandra, additional, Laurent, Carine, additional, Bulsei, Xavier, additional, Bischoff, Laura, additional, Rakotonirina, Raymond, additional, Layouni, Mehdi, additional, Deslee, Gaëtan, additional, Mal, Hervé, additional, Kessler, Romain, additional, Vergnon, Jean-Michel, additional, Pelissier, Isabelle, additional, Cuvelier, Antoine, additional, Bourdin, Arnaud, additional, Jounieaux, Vincent, additional, Roche, Nicolas, additional, Jouneau, Stéphane, additional, Bonniaud, Philippe, additional, Scherpereel, Arnaud, additional, Mornex, Jean François, additional, Steenhouwer, François, additional, Leroy, Sylvie, additional, Marquette, Charles Hugo, additional, Mazzette, Andrea, additional, Padovani, Bernard, additional, Ilié, Marius, additional, Long-Mira, Elodie, additional, Lassalle, Sandra, additional, Pradelli, Johanna, additional, Martinez, Estelle, additional, Habault, Marine, additional, Bonnard, Mélanie, additional, Moutarde, Julie, additional, Yatimi, Rachida, additional, Labsi, Hakima, additional, Gazoppi, Loïc, additional, Lpce, Tumorothèque, additional, Griffonnet, Jennifer, additional, Fontaine, Maureen, additional, Guillemart, Ariane, additional, Butori, Catherine, additional, Selva, Eric, additional, Otto, Josiane, additional, Hebert, Christophe, additional, Botchiellini, Delphine, additional, Boudouf, Soukaina, additional, Menier, Margaux, additional, Occeli, Estelle, additional, Bellentani, Sophie, additional, Pion, Carine, additional, Fournier, Elodie, additional, Gervais, Radj, additional, Hamond, Karim, additional, Marchand-Adam, Sylvain, additional, Plantier, Laurent, additional, Fajolle, Gaelle, additional, Rayez, Mélanie, additional, Fallet, Vincent, additional, Wislez, Marie, additional, Antoine, Martine, additional, Cote, Jean-François, additional, Chaabane, Nouha, additional, Ruppert, Anne Marie, additional, Bertrand, Eliane, additional, Rodenas, Anita, additional, Pontdeme, Gwenaëlle, additional, Mathiot, Nathalie, additional, Ribert, Tamazouzt, additional, Guibert, Nicolas, additional, Rouviere, Damien, additional, Bousquet, Emilie, additional, Bigay-Game, Laurence, additional, Hermant, Christophe, additional, Plat, Gavin, additional, Rouquette, Isabelle, additional, Evrard, Solène, additional, Gouin, Sandrine, additional, Clermont, Estelle Taranchon, additional, Dormoy, Inge, additional, Coulomb, Christelle, additional, Pradine, Anne, additional, Lambert, Véronique, additional, Laborde, Lilian, additional, and Castelnau, Olivier, additional

Published
2021
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7. Collaborateurs

Author

Albert, Sébastien, primary, Allais, Dominique, additional, Atallah, Ihab, additional, Aubry, Karine, additional, Babin, Emmanuel, additional, Bach, Christine, additional, Baujat, Bertrand, additional, Blanchard, David, additional, Bozec, Alexandre, additional, Bozec, Le Moal Laurence, additional, Brasnu, Daniel, additional, Céruse, Philippe, additional, Chabolle, Frédéric, additional, Chibaudel, Benoist, additional, Cosmidis, Alain, additional, Cuny, Florence, additional, d'Hauthuille, Cédric, additional, Dakpé, Stéphanie, additional, Dassonville, Olivier, additional, Dauchy, Sarah, additional, Davrou, Julien, additional, de Raucourt, Dominique, additional, Devauchelle, Bernard, additional, Dolivet, Gilles, additional, Dumont, Clément, additional, Falewee, Marie-Noëlle, additional, Garrel, Renaud, additional, Gavid, Marie, additional, Gelsi, Ève, additional, Giraud, Philippe, additional, Guigay, Joël, additional, Grandazzi, Guillaume, additional, Hammoudi, Karim, additional, Hans, Stéphane, additional, Hebert, Christophe, additional, Heutte, Natacha, additional, Housset, Martin, additional, Jaffré, Sébastien, additional, Jégoux, Franck, additional, Laccourreye, Laurent, additional, Laccourreye, Ollivier, additional, Makeieff, Marc, additional, Malard, Olivier, additional, Moriniere, Sylvain, additional, Mortuaire, Geoffrey, additional, Navez, Malou, additional, Oudard, Stéphane, additional, Pelicier, Nicole, additional, Phulpin, Bérengère, additional, Plisson, Laetitia, additional, Prades, Jean-Michel, additional, Prévost, Virginie, additional, Puech, Michèle, additional, Rebiere, Christine, additional, Reich, Michel, additional, Reyt, Émile, additional, Righini, Christian-Adrien, additional, Schultz, Philippe, additional, Scotte, Florian, additional, Testelin, Sylvie, additional, Thariat, Juliette, additional, Timochenko, Andreï, additional, Vergez, Sébastien, additional, and Woisard, Virginie, additional

Published
2013
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13. Malnutrition in Patients With Cancer

Author

Gyan, Emmanuel, primary, Raynard, Bruno, additional, Durand, Jean-Philippe, additional, Lacau Saint Guily, Jean, additional, Gouy, Sébastien, additional, Movschin, Marie Lespiau, additional, Khemissa, Faiza, additional, Flori, Nicolas, additional, Oziel-Taieb, Sandrine, additional, Bannier Braticevic, Cécile, additional, Zeanandin, Gilbert, additional, Hebert, Christophe, additional, Savinelli, Francesco, additional, Goldwasser, François, additional, and Hébuterne, Xavier, additional

Published
2017
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15. Malnutrition in Patients With Cancer: Comparison of Perceptions by Patients, Relatives, and Physicians-Results of the NutriCancer2012 Study.

Author

Gyan, Emmanuel, Raynard, Bruno, Durand, Jean-Philippe, Guily, Jean Lacau Saint, Gouy, Sebastien, Movschin, Marie Lespiau, Khemissa, Faiza, Flori, Nicolas, Oziel-Taieb, Sandrine, Braticevic, Cecile Bannier, Zeanandin, Gilbert, Hebert, Christophe, Savinelli, Francesco, Goldwasser, Francois, Hebuterne, Xavier, NutriCancer2012 Investigator Group, Lacau Saint Guily, Jean, Gouy, Sébastien, Bannier Braticevic, Cécile, and Goldwasser, François

Subjects
MALNUTRITION, CANCER patients, MEDICAL cooperation, QUESTIONNAIRES, RESEARCH, DISEASE prevalence, CROSS-sectional method, HEALTH literacy, PATIENTS' attitudes, PHYSICIANS' attitudes, FAMILY attitudes, NUTRITIONAL status
Abstract

Background: Malnutrition is a critical predictor of toxicity and outcome in patients with cancer and may be perceived differently by patients, relatives, and physicians.Aims: To assess the prevalence of malnutrition in oncology departments and to compare it with the perceptions of nutrition status by patients themselves, their closest relatives, and attending physicians.Materials and Methods: A 1-day multicentric cross-sectional survey on the prevalence of malnutrition was conducted in different oncology departments using patient-, relative-, and physician-specific questionnaires. Malnutrition was defined by a weight loss ≥5% within 1 month or ≥10% within 6 months, a body mass index ≤18.5 kg/m2 in patients aged <70 years or ≤21 kg/m2 in patients aged ≥70 years, and/or albuminemia <35 g/L. Questionnaires for assessing medical condition, knowledge of nutrition status, and perceptions of the impact of malnutrition on daily life were distributed to consenting patients, attending physicians, and closest relatives.Results: A total of 2197 patients were included, and 2071 and 976 questionnaires were collected from patients and relatives, respectively. Prevalence of malnutrition was 39%. Physicians overestimated malnutrition (44%), whereas patients and relatives underestimated it (22% and 23%, respectively, P < .001). Conversely, malnutrition-associated symptoms were underestimated by physicians compared with patients and relatives.Conclusion: We found a prevalence of malnutrition of 39%: it was underestimated by patients and relatives and overestimated by physicians. [ABSTRACT FROM AUTHOR]

Published
2018
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16. Nutritional status and feeding-tube placement in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy-based larynx preservation program

Author

Bozec, Alexandre, primary, Benezery, Karen, additional, Chamorey, Emmanuel, additional, Ettaiche, Marc, additional, Vandersteen, Clair, additional, Dassonville, Olivier, additional, Poissonnet, Gilles, additional, Riss, Jean-Christophe, additional, Hannoun-Lévi, Jean-Michel, additional, Chand, Marie-Eve, additional, Leysalle, Axel, additional, Saada, Esma, additional, Sudaka, Anne, additional, Haudebourg, Juliette, additional, Hebert, Christophe, additional, Falewee, Marie-Noelle, additional, Demard, François, additional, Santini, José, additional, and Peyrade, Frédéric, additional

Published
2015
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18. Efficacy of Trastuzumab in Routine Clinical Practice and After Progression for Metastatic Breast Cancer Patients: The Observational Hermine Study

Author

Extra, Jean-Marc, primary, Antoine, Eric C., additional, Vincent-Salomon, Anne, additional, Delozier, Thierry, additional, Kerbrat, Pierre, additional, Bethune-Volters, Anne, additional, Guastalla, Jean-Paul, additional, Spielmann, Marc, additional, Mauriac, Louis, additional, Misset, Jean-Louis, additional, Serin, Daniel, additional, Campone, Mario, additional, Hebert, Christophe, additional, Remblier, Céline, additional, Bergougnoux, Loïc, additional, Campana, Frank, additional, and Namer, Moïse, additional

Published
2010
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19. Treatment of Good Prognosis CD20+ Large-Cell Lymphomas in Patients Aged 65 to 80, with 3 Cycles of R-CHOP14 Followed by An Injection of 90Y Ibritumomab Tiuxetan

Author

Peyrade Frederic, Antoine Thyss, Gastaud Lauris, Mariano Provencio, Carrier Patricia, Hebert Christophe, Lepeu Gérard, Broglia Jean-Marc, Fontana Xavier, and Chamorey Emmanuel

Subjects
CD20, medicine.medical_specialty, Chemotherapy, Blood transfusion, biology, business.industry, Large cell, medicine.medical_treatment, Immunology, Ibritumomab tiuxetan, Cell Biology, Hematology, medicine.disease, Biochemistry, Surgery, medicine.anatomical_structure, Internal medicine, medicine, biology.protein, Bone marrow, business, Adverse effect, Diffuse large B-cell lymphoma, medicine.drug
Abstract

Background : Treatment of newly diagnosed DLBCL in patients aged 65 to 80 is based on 6 to 8 cycles of R-CHOP at 14 to 21 day intervals. Recent data suggest that for patients with an IPI of 0 or 1, a shorter treatment may be considered. Furthermore, early negative PET-CT results after chemotherapy are an important favourable prognostic factor. Patients and methods : We propose carrying out two cycles of R-CHOP 14 in patients aged 65 to 80 with newly diagnosed DLBCL and an IPI of 0 or 1. PET-CT will be performed on D28. If the results are normal, an R-CHOP cycle followed by an injection of ibritumomab tiuxetan 90Y will be administered. The anticipated total treatment period is 51 days. Ten patients were included from June 2007 to June 2008 (7 women and 3 men), the age-adjusted IPI was 0 and 1 in 6 and 4 cases, respectively. None of the patients had bone marrow involvement and the PS was 0 or 1 in every case. Results : CT and PET-CT showed complete remission in 9 out of 10 patients, who therefore received the full protocol. The average age was 72 (range, 68–77). The average duration of treatment for these patients was 54 days. As regards to safety, hospitalisation or the prescription of antibiotics was not necessary in any case. No serious adverse event was reported. Mean platelet and leukocyte nadirs were 23,000/mm3 and 1,180/mm3, respectively. Two transfusions of red cell concentrates and one of platelet concentrate were necessary in one patient. To date, all patients are in complete remission. Conclusion : The treatment regimen of 3 cycles of R-CHOP14 followed by an injection of 90Y ibritumomab tiuxetan appears to be tolerated by patients aged 65 to 80 with newly diagnosed DLBCL. Longer follow-up and the inclusion of more patients are necessary to confirm these preliminary data.

Published
2008

20. Prospective multi-center validation of the detection of ALKrearrangements of circulating tumor cells for non-invasive longitudinal management of patients with advanced non-small cell lung cancer

Author

ILIE, Marius, MAZIÈRES, Julien, CHAMOREY, Emmanuel, HEEKE, Simon, BENZAQUEN, Jonathan, THAMPHYA, Brice, BOUTROS, Jacques, TIOTIU, Angelica, FAYADA, Julien, CADRANE, Jacques, POUDENX, Michel, MORO-SIBILOT, Denis, BARLESI, Fabrice, THARIAT, Juliette, CLEMENT-DUCHENE, Christelle, TOMASINI, Pascale, HOFMAN, Véronique, MARQUETTE, Charles-Hugo, HOFMAN, Paul, ISRAEL-BIET, Dominique, PISON, Christophe, MORO-SIBILOT, Denis, LANTUEJOUL, Sylvie, STEPHANOV, Olivier, Juliette, M.E.Y.Z.E.N.C., MENDOZAT, Christophe, ZAIDI, Manel, COULOUVRAT, Sandra, COL, Edwige, CHANEZ, Pascal, GREILLIER, Laurent, TOMASINI, Pascale, BARLESI, Fabrice, MASCAUX, Céline, JOURDAN, Sandrine, ROGER, Aurélie, BIEMAR, Julie, RANDRIAMAMPIONONA, Rondro, CHABOT, François, TIOTIU, Angélica, CLEMENT-DUCHENE, Christelle, Jean-Michel, V.I.G.N.A.U.D., LACOMME, Stéphanie, LOMAZZI, Sandra, LAURENT, Carine, BULSEI, Xavier, BISCHOFF, Laura, RAKOTONIRINA, Raymond, LAYOUNI, Mehdi, DESLEE, Gaëtan, MAL, Hervé, KESSLER, Romain, VERGNON, Jean-Michel, PELISSIER, Isabelle, CUVELIER, Antoine, BOURDIN, Arnaud, JOUNIEAUX, Vincent, ROCHE, Nicolas, JOUNEAU, Stéphane, BONNIAUD, SCHERPEREEL, Arnaud, MORNEX, Jean François, STEENHOUWER, François, LEROY, Sylvie, MARQUETTE, Charles Hugo, BENZAQUEN, Jonathan, MAZZETTE, Andrea, PADOVANI, Bernard, HOFMAN, Paul, ILIE, Marius, HOFMAN, Véronique, FAYADA, Julien, LONG-MIRA, Elodie, LASSALLE, Sandra, PRADELLI, Johanna, MARTINEZ, Estelle, HABAULT, Marine, BONNARD, Mélanie, MOUTARDE, Julie, YATIMI, Rachida, LABSI, Hakima, GAZOPPI, Loïc, LPCE, Tumorothèque, GRIFFONNET, Jennifer, FONTAINE, Maureen, GUILLEMART, Ariane, BUTORI, Catherine, SELVA, Eric, POUDENX, Michel, OTTO, Josiane, HEBERT, Christophe, BOTCHIELLINI, Delphine, BOUDOUF, Soukaina, MENIER, Margaux, OCCELI, Estelle, BELLENTANI, Sophie, PION, Carine, FOURNIER, Elodie, THARIAT, Juliette, GERVAIS, Radj, HAMOND, Karim, MARCHAND-ADAM, Sylvain, PLANTIER, Laurent, FAJOLLE, Gaelle, RAYEZ, Mélanie, CADRANEL, Jacques, FALLET, Vincent, WISLEZ, Marie, ANTOINE, Martine, COTE, Jean-François, CHAABANE, Nouha, RUPPERT, Anne Marsie, BERTRAND, Eliane, RODENAS, Anita, PONTDEME, Gwenaëlle, MATHIOT, Nathalie, RIBERT, Tamazouzt, MAZIÈRES, Julien, GUIBERT, Nicolas, ROUVIERE, Damien, BOUSQUET, Emilie, BIGAY-GAME, Laurence, HERMANT, Christophe, PLAT, Gavin, ROUQUETTE, Isabelle, EVRARD, Solène, GOUIN, Sandrine, TARANCHON CLERMONT, Estelle, DORMOY, Inge, COULOMB, Christelle, PRADINE, Anne, LAMBERT, Véronique, LABORDE, Lilian, and CASTELNAU, Olivier

Abstract

Patients with advanced-stage non-small cell lung cancer (NSCLC) whose tumors harbor an anaplastic lymphoma kinase (ALK) gene rearrangement benefit from treatment with multiple ALK inhibitors (ALKi). Approximately 30% of tumor biopsies contain insufficient tissue for successful ALKmolecular characterization. This study evaluated the added value of analyzing circulating tumor cells (CTCs) as a surrogate to ALKtissue analysis and as a function of the response to ALKi.

Published
2021
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