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406 results on '"Hebuterne X"'

2. Risk of anti-TNF therapy on pregnancy, breastfeeding, live vaccines and related information in patients with inflammatory bowel disease: Real-world data from a nationwide study

Author

Bendaoud, S., Nahon, S., Beaugerie, L., Gornet, J.M., Wils, P., Amiot, A., Peyrin-Biroulet, L., Abitbol, V., Hébuterne, X., Altwegg, R., Rosa, I., Amil, M., Heluwaert, F., Plastaras, L., Stefanescu, C., Quentin, V., Antoni, M., Bideau, K., Boualit, M., Cuillerier, E., Locher, C., Skinazi, F., Boureille, A., Buisson, A., and Simon, M.

Published
2024
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4. P903 Persistence, efficacy and tolerance of subcutaneous Infliximab after switch from intravenous infliximab in IBD patients in remission: one-year results from a multicenter prospective cohort

Author

Mathieu, N, primary, Heluwaert, F, additional, Riviere, P, additional, Hebuterne, X, additional, Chupin, A, additional, Abitbol, V, additional, Bouguen, G, additional, Vuitton, L, additional, Allez, M, additional, Montuclard, C, additional, Nancey, S, additional, Biron, A, additional, Wils, P, additional, Gilletta, C, additional, De Maissin, A, additional, Altwegg, R, additional, Chanteloup, E, additional, Plastaras, L, additional, Ah-Soune, P, additional, Bourreille, A, additional, Bouhnik, Y, additional, Seksik, P, additional, Simon, M, additional, Uzzan, M, additional, Andrau, P, additional, Rouillon, C, additional, Arondel, Y, additional, Peyrin-Biroulet, L, additional, Laharie, D, additional, Vicaut, E, additional, and Hupe, M, additional

Published
2024
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6. Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn’s Disease After Ileocolonic Resection

Author

Debinski, H., Florin, T., Hetzel, D., Lawrance, I., Radford-Smith, G., Sloss, A., Sorrentino, D., Gassner, S., Haas, T., Reicht, G., Reinisch, W., Strasser, M., Vogelsang, H., Bossuyt, P., DeWit, O., D'Haens, G., Franchimont, D., Louis, E., Vermeire, S., Bernstein, C.N., Bourdages, R., Chiba, N., Dhalla, S.S., Feagan, B.G., Fedorak, R.N., Lachance, J.R., Panaccione, R., Ropeleski, M., Singh Salh, B., Lukas, M, Colombel, J-F, Allez, M., Desreumaux, P., Dupas, J.L., Grimaud, J-C., Hebuterne, X., Laharie, D., Lerebours, E., Peyrin-Biroulet, L., Reimund, J-M., Viennot, S., Zerbib, F., Antoni, C., Atreya, R., Baumgart, D.C., Berg, C., Boecker, U., Bramkamp, G., Bünning, C., Ehehalt, R., Howaldt, S., Kucharzik, T., Lamprecht, H.G., Mudter, J., Preiss, J.C., Schreiber, S., Seidler, U., Altorjay, I., Banai, J., Lakatos, P.L., Varga, M., Vincze, A., Avni-Biron, I., Fishman, S., Fraser, G.M., Goldin, E., Rachmilewitz, D., Annese, V., Ardizzone, S., Biancone, L., Bossa, F., Danese, S., Fries, W., Gionchetti, P., Maconi, G., Terrosu, G., Usai, P., D'Haens, G.R., Gearry, R.B., Hill, J., Rowbotham, D.S., Schultz, M., Stubbs, R.S., Wallace, D., Walmsley, R.S., Wyeth, J., Malecka-Panas, E., Paradowski, L., Regula, J., Beales, I.P., Campbell, S., Hawthorne, A.B., Parkes, M., Travis, S.P., Achkar, J.P., Behm, B.W., Bickston, S.J., Brown, K.J., Chiorean, M.V., DeVilliers, W.J.S., Elliott, D.E., Grunkmeier, D., Hamilton, J.W., Hanauer, S.B., Hanson, J.S., Hardi, R., Helper, D.J., Herfarth, H., Higgins, P.D.R., Holderman, W.H., Kottoor, R., Kreines, M.D., Leman, B.I., Li, X., Loftus, E.V., Jr., Noar, M., Oikonomou, I., Onken, J., Peterson, K.A., Phillips, R.P., Randall, C.W., Ricci, M., Ritter, T., Rubin, D.T., Safdi, M., Sandborn, W.J., Sauberman, L., Scherl, E., Schwarz, R.P., Sedghi, S., Shafran, I., Sninsky, C.A., Stein, I., Swoger, J., Vecchio, J., Weinberg, D.I., Wruble, L.D., Yajnik, V., Younes, Z., Regueiro, Miguel, Feagan, Brian G., Zou, Bin, Johanns, Jewel, Blank, Marion A., Chevrier, Marc, Plevy, Scott, Popp, John, Cornillie, Freddy J., Lukas, Milan, Danese, Silvio, Gionchetti, Paolo, Hanauer, Stephen B., Reinisch, Walter, Sandborn, William J., Sorrentino, Dario, and Rutgeerts, Paul

Published
2016
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13. P511 Baseline characteristics of ulcerative colitis patients in the vedolizumab PASS study: a cohort study assessing the safety and effectiveness of vedolizumab compared to other biologic agents (01)

Author

Wolf, D., Lewis, J.D., Siegmund, B., Lichtenstein, G., Sebastian, S., Siegel, C.A., Louis, E., Haas, T., Nedd, K., Subramanian, S., Aguilar, H., Egan, L., Gasche, C., Doherty, G., Lobo, A., Spearman, D., Patel, A., Moparty, R., Brookes, M., Hebuterne, X., Moum, B., and Dolin, P.

Published
2017
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14. P501 Baseline characteristics of Crohnʼs disease patients in the vedolizumab PASS study: a cohort study assessing the safety and effectiveness of vedolizumab compared to other biologic agents (02)

Author

Siegel, C.A., Lichtenstein, G., Siegmund, B., Lewis, J.D., Wolf, D., Louis, E., Sebastian, S., Hebuterne, X., Bell, A., Söderman, C., Schubert, S., Atreya, R., Polyak, S., Hoque, S., Krummenerl, A., Bokemeyer, B., Krummenerl, T., Shulmann, S., Karlén, P., Moum, B., and Dolin, P.

Published
2017
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18. Is golimumab serum level predictive of clinical remission after intensification for loss of response in patients with ulcerative colitis?

Author

Filippi, J., Altwegg, R., Hebuterne, X., Boschetti, G., Veyrard, P., Yzet, Clara, Paul, S., Roblin, X., Fumery, Mathurin, Nancey, S., Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de Gastroentérologie, Hôpital de l'Archet 2, Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), and Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2022

23. COMBIO : efficacité et tolérance des associations de thérapies ciblées chez les patients atteints de maladies inflammatoires à médiation immunitaire

Author

Flachaire, B., primary, Guillo, L., additional, Avouac, J., additional, Nachury, M., additional, Carbonnel, F., additional, Bouguen, G., additional, Buisson, A., additional, Caillo, L., additional, Fumery, M., additional, Gilleta, C., additional, Hebuterne, X., additional, Lafforgue, P., additional, Laharie, D., additional, Mahé, E., additional, Marotte, H., additional, Nancey, S., additional, Ottaviani, S., additional, Salmon, J.H., additional, Guillaume, S., additional, Serrero, M., additional, Uzzan, M., additional, Viguier, M.A., additional, Richez, C., additional, Peyrin-Biroulet, L., additional, Seksik, P., additional, and Pham, T., additional

Published
2021
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27. Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome

Author

Piche, T., Saint-Paul, M.C., Dainese, R., Marine-Barjoan, E., Iannelli, A., Montoya, M.L., Peyron, J.F., Czerucka, D., Cherikh, F., Filippi, J., Tran, A., and Hebuterne, X.

Subjects
Irritable bowel syndrome -- Development and progression, Irritable bowel syndrome -- Psychological aspects, Irritable bowel syndrome -- Research, Fatigue -- Development and progression, Depression, Mental -- Development and progression, Mast cells -- Physiological aspects, Mast cells -- Research, Health
Published
2008

28. Un traitement concomitant par curcumine orale ne permet pas de diminuer le taux de récidive post-opératoire endoscopique chez les patients atteints de maladie de Crohn traités par thiopurines : résultats de l’essai contrôlé randomisé POPCUR

Author

Buisson, Anthony, Laharie, D., Nancey, S., Hebuterne, X., Roblin, X., Nachury, M., Peyrin-Biroulet, L, Fumery, Mathurin, Coban, Dilek, Goutorbe, François, Allimant, C., Vazeille, Emilie, Pereira, Brigitte, Goutte, M., Bommelaer, Gilles, CHU Clermont-Ferrand, Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Service d'Hépato-gastroentérologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Hôpital Claude Huriez [Lille], CHU Lille, Registre EPIMAD, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and OUERTANI, jeannette

Subjects
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

34. Fatigue is associated with high circulating leptin levels in chronic hepatitis C. (Liver Disease)

Author

Piche, T., Gelsi, E., Schneider, S.M., Hebuterne, X., Giudicelli, J., Ferrua, B., Laffont, C., Benzaken, S., Hastier, P., Montoya, M.L., Longo, F., Rampal, P., and Tran, A.

Subjects
Body composition -- Measurement -- Physiological aspects, Fatigue -- Causes of -- Measurement -- Physiological aspects, Leptin -- Physiological aspects -- Measurement, Hepatitis C -- Physiological aspects -- Measurement, Health
Abstract

Background and aims: Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC). Its mechanism is poorly understood. Recent attention has focused on the role [...]

Published
2002

36. Vedolizumab versus Adalimumab for Moderate-to-Severe Ulcerative Colitis

Author

Sands BE1, Peyrin-Biroulet L1, Loftus EV Jr1, Danese S1, Colombel JF1, Törüner M1, Jonaitis L1, Abhyankar B1, Chen J1, Rogers R1, Lirio RA1, Bornstein JD1, Schreiber S1, Calvo S, Gimenez E, Resk JH, Tron EP, Al-Ansari M, Andrews J, Bampton P, Debinski H, Hendy P, Holtmann G, Leong R, Moore G, Hindryckx P, Barac T, Draganova R, Kotzev I, Marinova I, Markov M, Mihaylov Y, Pavlov D, Penkova M, Petrov A, Spassova Z, Stoyanova D, Velev E, Vladimirov B, Yanev F, Axler J, Fedorak R, Fowler S Jr, Halder S, Jairath V, Ponich T, Wong K, Baez E, Ricardo J, Velasquez M, Banic M, Bogadi I, Borzan V, Zgrablic JC, Duvnjak M, Gusej M, Krznaric Z, Cechova I, Hala T, Janu L, Kohout P, Lukas M, Machkova M, Matous J, Ulbrych J, Vanasek T, Klinge L, Rannem T, Theede K, Borissova J, Kull K, Amil M, Bouhnik Y, Gilleta C, Fumery M, Grimaud JC, Hebuterne X, Laharie D, Moreau J, Peyrin-Biroulet L, Roblin X, Baumgart D, Buening C, Dinter J, Gauss A, Kuehbacher T, Fareed Rahman K, Schiefke I, Schreiber S, Von Amim U, Zeuzem S, Leung WK, Kin Kong Li M, Altorjay I, Bene L, Lakatos P, Molnar T, Salamon A, Schnabel R, Tulassay Z, Avni Y, Barkay O, Fishman S, Goldin E, Keret D, Lahat-Zok A, Melzer E, Naftali T, Nimer A, Ovadia B, Zittan E, Andriulli A, Cappello M, Castiglione F, Danese S, Fries W, Gionchetti P, Kohn A, Maconi G, Santino M, Savarino E, Privitera A, Romano M, Vecchi M, Villa E, Cheon JH, Han DS, Jang BI, Jeen YT, Kim JS, Kim SK, Kim HJ, Kim Y, Lee KM, Lee BI, Park DI, Park YS, Song GA, Ye BD, Pokrotnieks J, Tolmanis I, Denapiene G, Kancauskas A, Jakovlevaite V, Jonaitis L, Cruz Palacios A, Larriva de Los Reyes E, Asela Lujano Nicolas L, Mendoza Fuerte E, D'Haens G, Pierik M, Van Der Woude J, Adrych K, Danilkiewicz WC, Gawdis-Wojnarska B, Hartleb M, Karczewski M, Kierkus J, Malecka-Panas E, Petryka R, Piotrowski W, Regula J, Romatowski J, Rozciecha J, Rydzewska G, Smolinski P, Walczak P, Walczak M, Wozniak-Stolarska B, Cotter J, Lopes L, Portela F, Rodrigues Carvalho J, Simona Gheorghe L, Goldis AE, Mateescu RB, Abdulkhakov R, Agafyina A, Alexeeva O, Alikhanov B, Bunkova E, Dvorkin M, Gubonina I, Kashnikov V, Livzan M, Osipenko M, Parfenov A, Pershko A, Pesegova M, Rafalskiy V, Reshetko O, Simanenkov V, Tsybulko S, Valuyskikh E, Yakovlev A, Cvetkovic M, Damjanov D, Djuranovic S, Dugalic P, Nagorni A, Svorcan P, Zdravkovic Petrovic N, Bunganic I, Gregus M, Hlavaty T, Horvath F, Domenech Morral E, Jover Martinez R, Mendoza MIV, Shieh MJ, Wei CC, Altintas E, Atug O, Gonen C, Hamzaoglu H, Hulagu S, Toruner M, Chopey I, Danyliuk S, Datsenko O, Golovchenko N, Golovchenko O, Hospodarskyy I, Ivanov V, Klymenko V, Levchenko O, Lizogub V, Mostovoy Y, Oliinyk O, Polianskyi I, Pyrohovskyi V, Shevchuk S, Ursol G, Vdovychenko V, Vyshyvanyuk V, Beales I, Brookes M, Nwokolo C, Winter J, Aggarwal A, Aguilar H, Alnoah Z, Arce-Nunez E, Arimie C, Arterburn J, Baum C, Bellaguarda E, Bock B, Boone T, Callahan N, Chapman J, Chen S, Chiorean M, Coates A, Connor M, Dellon S, Dryden G, Du Vall G, Flores L, Fogel R, Frias J, Ginsburg P, Greenberg E, Grunkemeier D, Hellstern P, Herfarth H, Hoffman B, Horst S, Idarraga S, Iskandar H, Jain R, Jenkins E, Kaufman B, Khaleq A, Khan A, Khurana S, Lake J, Leavitt J, Leman B, Lewis D, Lindenberg D, Loftus EV, Korman L, Martin J, McCullough M, McNair A, Mehta N, Mutlu E, Narayen V, Paoli-Bruno J, Perez N, Phillips R, Raijman I, Ramirez-Vega R, Randall C, Rinesmith S, Ritter T, Safdi A, Saltzman M, Sands B, Seminerio J, Schulman M, Sedghi S, Shafran I, Shankar M, Silvers D, Soloman N, Tatum H, Tepper R, Tiongco F, Valdes M, Weber J, Zhang C., Sands, Be1, Peyrin-Biroulet, L1, Loftus EV, Jr1, Danese, S1, Colombel, Jf1, Törüner, M1, Jonaitis, L1, Abhyankar, B1, Chen, J1, Rogers, R1, Lirio, Ra1, Bornstein, Jd1, Schreiber, S1, Calvo, S, Gimenez, E, Resk, Jh, Tron, Ep, Al-Ansari, M, Andrews, J, Bampton, P, Debinski, H, Hendy, P, Holtmann, G, Leong, R, Moore, G, Hindryckx, P, Barac, T, Draganova, R, Kotzev, I, Marinova, I, Markov, M, Mihaylov, Y, Pavlov, D, Penkova, M, Petrov, A, Spassova, Z, Stoyanova, D, Velev, E, Vladimirov, B, Yanev, F, Axler, J, Fedorak, R, Fowler, S Jr, Halder, S, Jairath, V, Ponich, T, Wong, K, Baez, E, Ricardo, J, Velasquez, M, Banic, M, Bogadi, I, Borzan, V, Zgrablic, Jc, Duvnjak, M, Gusej, M, Krznaric, Z, Cechova, I, Hala, T, Janu, L, Kohout, P, Lukas, M, Machkova, M, Matous, J, Ulbrych, J, Vanasek, T, Klinge, L, Rannem, T, Theede, K, Borissova, J, Kull, K, Amil, M, Bouhnik, Y, Gilleta, C, Fumery, M, Grimaud, Jc, Hebuterne, X, Laharie, D, Moreau, J, Peyrin-Biroulet, L, Roblin, X, Baumgart, D, Buening, C, Dinter, J, Gauss, A, Kuehbacher, T, Fareed Rahman, K, Schiefke, I, Schreiber, S, Von Amim, U, Zeuzem, S, Leung, Wk, Kin Kong Li, M, Altorjay, I, Bene, L, Lakatos, P, Molnar, T, Salamon, A, Schnabel, R, Tulassay, Z, Avni, Y, Barkay, O, Fishman, S, Goldin, E, Keret, D, Lahat-Zok, A, Melzer, E, Naftali, T, Nimer, A, Ovadia, B, Zittan, E, Andriulli, A, Cappello, M, Castiglione, F, Danese, S, Fries, W, Gionchetti, P, Kohn, A, Maconi, G, Santino, M, Savarino, E, Privitera, A, Romano, M, Vecchi, M, Villa, E, Cheon, Jh, Han, D, Jang, Bi, Jeen, Yt, Kim, J, Kim, Sk, Kim, Hj, Kim, Y, Lee, Km, Lee, Bi, Park, Di, Park, Y, Song, Ga, Ye, Bd, Pokrotnieks, J, Tolmanis, I, Denapiene, G, Kancauskas, A, Jakovlevaite, V, Jonaitis, L, Cruz Palacios, A, Larriva de Los Reyes, E, Asela Lujano Nicolas, L, Mendoza Fuerte, E, D'Haens, G, Pierik, M, Van Der Woude, J, Adrych, K, Danilkiewicz, Wc, Gawdis-Wojnarska, B, Hartleb, M, Karczewski, M, Kierkus, J, Malecka-Panas, E, Petryka, R, Piotrowski, W, Regula, J, Romatowski, J, Rozciecha, J, Rydzewska, G, Smolinski, P, Walczak, P, Walczak, M, Wozniak-Stolarska, B, Cotter, J, Lopes, L, Portela, F, Rodrigues Carvalho, J, Simona Gheorghe, L, Goldis, Ae, Mateescu, Rb, Abdulkhakov, R, Agafyina, A, Alexeeva, O, Alikhanov, B, Bunkova, E, Dvorkin, M, Gubonina, I, Kashnikov, V, Livzan, M, Osipenko, M, Parfenov, A, Pershko, A, Pesegova, M, Rafalskiy, V, Reshetko, O, Simanenkov, V, Tsybulko, S, Valuyskikh, E, Yakovlev, A, Cvetkovic, M, Damjanov, D, Djuranovic, S, Dugalic, P, Nagorni, A, Svorcan, P, Zdravkovic Petrovic, N, Bunganic, I, Gregus, M, Hlavaty, T, Horvath, F, Domenech Morral, E, Jover Martinez, R, Mendoza, Miv, Shieh, Mj, Wei, Cc, Altintas, E, Atug, O, Gonen, C, Hamzaoglu, H, Hulagu, S, Toruner, M, Chopey, I, Danyliuk, S, Datsenko, O, Golovchenko, N, Golovchenko, O, Hospodarskyy, I, Ivanov, V, Klymenko, V, Levchenko, O, Lizogub, V, Mostovoy, Y, Oliinyk, O, Polianskyi, I, Pyrohovskyi, V, Shevchuk, S, Ursol, G, Vdovychenko, V, Vyshyvanyuk, V, Beales, I, Brookes, M, Nwokolo, C, Winter, J, Aggarwal, A, Aguilar, H, Alnoah, Z, Arce-Nunez, E, Arimie, C, Arterburn, J, Baum, C, Bellaguarda, E, Bock, B, Boone, T, Callahan, N, Chapman, J, Chen, S, Chiorean, M, Coates, A, Connor, M, Dellon, S, Dryden, G, Du Vall, G, Flores, L, Fogel, R, Frias, J, Ginsburg, P, Greenberg, E, Grunkemeier, D, Hellstern, P, Herfarth, H, Hoffman, B, Horst, S, Idarraga, S, Iskandar, H, Jain, R, Jenkins, E, Kaufman, B, Khaleq, A, Khan, A, Khurana, S, Lake, J, Leavitt, J, Leman, B, Lewis, D, Lindenberg, D, Loftus, Ev, Korman, L, Martin, J, Mccullough, M, Mcnair, A, Mehta, N, Mutlu, E, Narayen, V, Paoli-Bruno, J, Perez, N, Phillips, R, Raijman, I, Ramirez-Vega, R, Randall, C, Rinesmith, S, Ritter, T, Safdi, A, Saltzman, M, Sands, B, Seminerio, J, Schulman, M, Sedghi, S, Shafran, I, Shankar, M, Silvers, D, Soloman, N, Tatum, H, Tepper, R, Tiongco, F, Valdes, M, Weber, J, and Zhang, C.

Published
2019

40. Acceptability of treatment regimen in inflammatory bowel disease: Results from a prospective nationwide study (ACCEPT2)

Author

Buisson, A., Fumery, Mathurin, Serrero, M., Orsat, L., Nancey, S., Riviere, P., Altwegg, R., Peyrin-Biroulet, L., Nachury, M., Hebuterne, X., Gilletta, C., Flamant, M., Viennot, S., Bouguen, G., Amiot, A., Mathieu, S., Vuitton, L., Plastaras, L., Bourreille, A., Caillo, L., Goutorbe, F., Chambrun, G. Pineton, Attar, A., Roblin, X., Pereira, B., Pariente, B., and DESSAIVRE, Louise

Subjects
[SDV] Life Sciences [q-bio]
Published
2020

42. Compression tumorale des voies biliaires d’origine metastatique: etude retrospective de 62 cas a l’hopital de l’Archet II a Nice en France

Author

Zoungrana, S.I., Caroli-Bosc, F.X., Demarquay, J.F., Vanbiervlit, G, Ouattara, Z.D., Sombié, R, Bougouma, A, and Hebuterne, X

Subjects
compression tumorale-voies biliaires-endoscopie-France, tumor compression-biliary tracts-endoscopy-France
Abstract

Objectifs: Evaluer la fréquence et l’étiologie des compressions biliaires d’origine métastatique et analyser l’impact sur la survie de la pose de prothèse biliaire.Méthodes: Etude rétrospective réalisée sur 62 patients sélectionnés à partir des comptes rendus de 1387 CPRE à l’Unité d’endoscopie de la Fédération des maladies de l’appareil digestif au CHU de Nice en France sur une période de 5 ans.Résultats: Il s’agissait de 38 hommes et 24 femmes d’âge moyen, 65 ans. L’origine de la compression a été rapportée à des adénopathies pour 55 malades. Des métastases hépatiques étaient présentes dans 22 cas (35,5%) mais seulement 4 parmi eux avaient plus de 3 métastases. Une prothèse plastique a été positionnée dans 14 cas et une prothèse métallique dans 48 cas. Les principales étiologies tumorales retrouvées ont été : le colo-rectum (46,8%), l’estomac (27,4%), et les seins (11,3%). La survie à 1 an était de 11 ,3%. Il y avait une différence de survie en faveur des sujets porteurs de prothèse plastique. Il y avait de même une différence de survie en faveur des patients n’ayant pas de métastases hépatiques. Un remplacement de prothèse plastique par prothèse métallique a dû être réalisé dans 57% des cas, aussi 19 patients ayant bénéficié de la pose initiale d’une prothèse métallique (39,5%) ont nécessité un geste de désobstruction.Conclusion: les cancers du tube digestif représentent la principale cause de compression tumorale de la voie biliaire si l’on excepte les tumeurs bilio-pancréatiques. En accord avec les données connues de la littérature, les complications secondaires à la pose des prothèses sont rares. Cependant une obstruction prothétique par envahissement tumoral est relativement fréquente (1/3 des cas) dans un délai de 3 mois. La survie à 1 an reste faible mais des survies prolongées peuvent s’observer.Mots-clés: compression tumorale-voies biliaires-endoscopie-FranceEnglish Title: Biliary tracts compression by metastatic tumor: a retrospective study of 62 cases at the Archet II Hospital in Nice, FranceEnglish AbstractObjectives: Evaluate the frequency and etiology of metastatic biliary compression and analyze the impact on survival of biliary prosthesis.Methods: Retrospective study performed on 62 patients selected from the reports of 1387 CPRE at the Endoscopy Unit of the Federation of Digestive System Diseases at Nice University Hospital in France over a period of 5 years.Results: There were 38 men and 24 middle-aged women, 65 years old. The origin of compression has been reported in lymphadenopathies for 55 patients. Hepatic metastases were present in 22 cases (35.5%) but only 4 of them had more than 3 metastases. A plastic prosthesis was placed in 14 cases and a metal prosthesis in 48 cases. The main tumor etiologies found were: colo-rectum (46.8%), stomach (27.4%), and breasts (11.3%). Survival at 1 year was 11.3%. There was a difference in survival for subjects with plastic prostheses. There was also a difference in survival in favor of patients without liver metastases. A plastic prosthesis replacement with metal prosthesis had to be performed in 57% of the cases, and 19 patients who had benefited from the initial placement of a metal prosthesis (39.5%) required a clearing gesture.Conclusion: Cancers of the digestive tract are the main cause of tumor compression of the biliary tract, with the exception of bilio-pancreatic tumors. In agreement with known data from the literature, complications secondary to prosthesis placement are rare. However, a prosthetic obstruction by tumor invasion is relatively common (1/3 of the cases) within 3 months. 1-year survival remains low but prolonged survivals may be observedKeywords: tumor compression-biliary tracts-endoscopy-France

Published
2019

43. Cobitolimod for moderate-to-severe, left-sided ulcerative colitis (CONDUCT): a phase 2b randomised, double-blind, placebo-controlled, dose-ranging induction trial

Author

Atreya, R., Peyrin-Biroulet, L., Klymenko, A., Augustyn, M., Bakulin, I., Slankamenac, D., Miheller, P., Gasbarrini, Antonio, Hebuterne, X., Arnesson, K., Knittel, T., Kowalski, J., Neurath, M. F., Sandborn, W. J., Reinisch, W., Gasbarrini A. (ORCID:0000-0002-7278-4823), Atreya, R., Peyrin-Biroulet, L., Klymenko, A., Augustyn, M., Bakulin, I., Slankamenac, D., Miheller, P., Gasbarrini, Antonio, Hebuterne, X., Arnesson, K., Knittel, T., Kowalski, J., Neurath, M. F., Sandborn, W. J., Reinisch, W., and Gasbarrini A. (ORCID:0000-0002-7278-4823)

Abstract

Background: Cobitolimod is a topically administered, DNA-based oligonucleotide that activates Toll-like receptor 9 (TLR9), and previous research has shown clinical efficacy in patients with moderate-to-severe ulcerative colitis. Here we assessed the efficacy and safety of different dose regimens of cobitolimod for induction therapy in patients with moderate-to-severe, left-sided ulcerative colitis. Methods: CONDUCT was a randomised, double-blind, five-arm, placebo-controlled, dose-ranging phase 2b study that recruited patients with moderate-to-severe, left-sided ulcerative colitis, with inadequate response to conventional or biological therapies, from 91 hospitals or outpatient clinics in 12 European countries. Eligible patients had a Mayo score of 6–12 with a centrally read endoscopic subscore (modified to exclude friability from grade 1) of 2 or higher and no individual subscore of less than 1, and confirmation of left-sided disease. Patients were randomised (1:1:1:1:1; block size of ten) via a computer-generated schedule and centralised interactive voice and web response system to receive rectal enemas of cobitolimod at 31 mg, 125 mg, or 250 mg at weeks 0 and 3 (2 × 31 mg, 2 × 125 mg, and 2 × 250 mg groups), cobitolimod at 125 mg at weeks 0, 1, 2, and 3 (4 × 125 mg group), or placebo. Randomisation was stratified by current glucocorticosteroid and previous tumour necrosis factor inhibitor treatment. Patients and all study personnel were masked to treatment allocation. The primary endpoint was the proportion of patients achieving clinical remission (Mayo subscores for rectal bleeding of 0, for stool frequency of 0 or 1 [with ≥1-point decrease from baseline], and for endoscopy of 0 or 1 [excluding friability]) at week 6. The primary analysis (based on intention to treat) and safety analysis were done in all randomly assigned patients who received at least one dose of active study drug or placebo. In this exploratory study, statistical tests were one-sided; p values

Published
2020

44. CDEIS score of 2 is optimal cut-off associated with lower risk of disease progression in early Crohn's disease : Data from the CALM study

Author

Ungaro, R., Jordan, R., Yzet, C., Bossuyt, P., Baert, F., Vanasek, T., D'Haens, G. R., Joustra, V. Wilhelmus, Panaccione, R., Novacek, G., Reinisch, W., Armuzzi, A., Golovchenko, O., Prymak, O., Goldis, A., Travis, S., Hebuterne, X., Ferrante, M., Rogler, G., Fumery, M., Danese, S., Rydzewska, G., Pariente, B., Hertervig, E., Stanciu, C., Serrero, M., Diculescu, M., Peyrin-Biroulet, L., Laharie, D., Wright, J. P., Gomollon, F., Irina, G., Schreiber, S., Motoya, S., Hellström, P. M., Halfvarson, Jonas, Colombel, J. F., Ungaro, R., Jordan, R., Yzet, C., Bossuyt, P., Baert, F., Vanasek, T., D'Haens, G. R., Joustra, V. Wilhelmus, Panaccione, R., Novacek, G., Reinisch, W., Armuzzi, A., Golovchenko, O., Prymak, O., Goldis, A., Travis, S., Hebuterne, X., Ferrante, M., Rogler, G., Fumery, M., Danese, S., Rydzewska, G., Pariente, B., Hertervig, E., Stanciu, C., Serrero, M., Diculescu, M., Peyrin-Biroulet, L., Laharie, D., Wright, J. P., Gomollon, F., Irina, G., Schreiber, S., Motoya, S., Hellström, P. M., Halfvarson, Jonas, and Colombel, J. F.

Published
2020
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49. P730 Effectiveness and safety of endoscopic balloon dilation of colorectal strictures in Crohn’s disease

Author

TILMANT, M, primary, serrero, M, additional, Poullenot, F, additional, Bouguen, G, additional, Pariente, B, additional, Altwegg, R, additional, Basile, P, additional, Filippi, J, additional, Vanelslander, P, additional, Buisson, A, additional, Vuitton, L, additional, Desjeux, A, additional, Laharie, D, additional, Le Balch, E, additional, Nachury, M, additional, Boivineau, L, additional, Savoye, G, additional, Hebuterne, X, additional, Poincloux, L, additional, Lamrani, A, additional, and Fumery, M, additional

Published
2020
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