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3. Psychometric properties of the updated EORTC module for assessing quality of life in patients with lung cancer (QLQ-LC29): an international, observational field study

Author

Koller, Michael, Shamieh, Omar, Hjermstad, Marianne J, Hornslien, Kjersti, Young, Teresa, Chalk, Tara, Ioannidis, Georgios, Harle, Amelie, Johnson, Colin D, Tomaszewski, Krzysztof A, Serpentini, Samantha, Pinto, Monica, van der Weijst, Lotte, Janssens, Annelies, Morag, Ofir, Chie, Wei-Chu, Arraras, Juan I, Pompili, Cecilia, Jungraithmayr, Wolfgang, Hechtner, Marlene, Katsochi, Despina, Müller, Karolina, Gräfenstein, Laura, Schulz, Christian, and Bottomley, Andrew

Published
2020
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16. Evaluating patients for psychosocial distress and supportive care needs based on health-related quality of life in primary brain tumors: a prospective multicenter analysis of patients with gliomas in an outpatient setting

Author

Hickmann, Anne-Katrin, Hechtner, Marlene, Nadji-Ohl, Minou, Janko, Mareile, Reuter, Ann Katrin, Kohlmann, Karoline, Haug, Markus, Grüninger, Sonja, Deininger, Monika, Ganslandt, Oliver, König, Jochem, Wirtz, Christian Rainer, Coburger, Jan, and Renovanz, Mirjam

Published
2017
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20. Quality of Life in NSCLC Survivors - A Multicenter Cross-Sectional Study

Author

Hechtner, Marlene, Eichler, Martin, Wehler, Beatrice, Buhl, Roland, Sebastian, Martin, Stratmann, Jan, Schmidberger, Heinz, Gohrbandt, Bernhard, Peuser, Jessica, Kortsik, Cornelius, Nestle, Ursula, Wiesemann, Sebastian, Wirtz, Hubert, Wehler, Thomas, Bals, Robert, Blettner, Maria, and Singer, Susanne

Subjects
Quality of life, Lung cancer, Survivor, Patient-reported outcome, Predictor
Published
2022
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21. Costs and Clinical Consequences of Compliance with COPD GOLD Recommendations or National Guidelines Compared with Current Clinical Practice in Belgium, Germany, Sweden, and the United States

Author

Sethi,Sanjay, Wright,Antony, Hartgers-Gubbels,Elisabeth Sophia, Hechtner,Marlene, Clark,Brendan, Wright,Ciara, Langham,Sue, Buhl,Roland, Sethi,Sanjay, Wright,Antony, Hartgers-Gubbels,Elisabeth Sophia, Hechtner,Marlene, Clark,Brendan, Wright,Ciara, Langham,Sue, and Buhl,Roland

Abstract

Sanjay Sethi,1 Antony Wright,2 Elisabeth Sophia Hartgers-Gubbels,3 Marlene Hechtner,3 Brendan Clark,4 Ciara Wright,2 Sue Langham,2 Roland Buhl5 1Pulmonary/Critical Care/Sleep Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA; 2Maverex Ltd., Newcastle Upon Tyne, NE6 2HL, UK; 3Boehringer Ingelheim GmbH, Ingelheim Am Rhein, Germany; 4Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA; 5Pulmonary Department, Mainz University Hospital, Mainz, GermanyCorrespondence: Antony Wright, Maverex Ltd, Newcastle Upon Tyne, NE6 2HL, UK, Tel +44 (0) 161 4646838, Email antonywright@maverex.comPurpose: The objective of this study was to assess the clinical and cost benefits of treating patients with chronic obstructive pulmonary disease (COPD) according to global and national guidelines compared to real-life clinical practice in the United States and three European countries (Belgium, Germany, Sweden).Patients and Methods: A cost-consequence model was developed to compare current prescribing patterns with two alternative scenarios, the first aligned with the Global Initiative for Chronic Obstructive Lung Disease (GOLD 2022) recommendations and the second with national guidelines. Costs and clinical outcomes were modeled for these alternative scenarios over a time horizon of one year, based on real-world evidence and health insurance data.Results: Current clinical practice in each of the countries was inconsistent with published recommendations. A redistribution to prescribing patterns according to global and national recommendations led to a substantial decrease in the use of inhaled corticosteroid (ICS) containing therapies of more than 80% and 44%, respectively. There was a reduced incidence of up to 16% of mild-to-moderate pneumonia and up to 29% of severe pneumonia. Exacerbations decreased across all countries apart from Sweden, where a small increase in the rate of exacerbations was due to the redistribution of some patients currently un

Published
2022

22. Real-World Treatment of Patients Newly Diagnosed with Chronic Obstructive Pulmonary Disease: A Retrospective German Claims Data Analysis

Author

Buhl,Roland, Wilke,Thomas, Picker,Nils, Schmidt,Olaf, Hechtner,Marlene, Kondla,Anke, Maywald,Ulf, Vogelmeier,Claus F, Buhl,Roland, Wilke,Thomas, Picker,Nils, Schmidt,Olaf, Hechtner,Marlene, Kondla,Anke, Maywald,Ulf, and Vogelmeier,Claus F

Abstract

Roland Buhl,1 Thomas Wilke,2 Nils Picker,3 Olaf Schmidt,4 Marlene Hechtner,5 Anke Kondla,5 Ulf Maywald,6 Claus F Vogelmeier7 1Pulmonary Department, Mainz University Hospital, Mainz, Germany; 2IPAM e.V, Wismar, Germany; 3Cytel Inc - Ingress-Health HWM GmbH, Wismar, Germany; 4Pulmonary Group Practice, Koblenz, Germany; 5Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany; 6AOK PLUS, Dresden, Germany; 7Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Marburg, GermanyCorrespondence: Roland Buhl, Medizinische Klinik und Poliklinik - Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstraße 1, Mainz, 55131, Germany, Tel +49 6131 17 7271, Email roland.buhl@unimedizin-mainz.dePurpose: This study aimed to describe the real-world treatment of German incident COPD patients, compare that treatment with clinical guidelines, and provide insight into disease development after incident diagnosis. In addition, the economic burden of the disease by assessing COPD-related healthcare costs was described.Patients and Methods: Based on a German claims dataset, continuously insured individuals (04/2014-03/2019) aged 40 years or older with at least two incident pulmonologist’s diagnoses or one inpatient diagnosis of COPD (ICD-10-GM code J44.-; no respective diagnosis in a 12-month baseline period) were selected. Treatment patterns after incident diagnosis considering inhaled maintenance therapies identified by ATC codes (outpatient prescriptions) were analyzed. Prescription patterns were compared with recommendations of German COPD treatment guidelines. Severe exacerbations were assessed as hospitalizations with main diagnosis ICD-10-GM code J44.1. COPD-associated costs from the perspective of the health insurance fund AOK PLUS were calculated per patient-year (PY).Results: The sample comprised 17,464 incident COPD patients with a mean age of 71.5

Published
2022

30. Real-world treatment of patients with incident chronic obstructive pulmonary disease, stratified by airflow limitation at time of diagnosis

Author

Vogelmeier, Claus, Picker, Nils, Hechtner, Marlene, Kondla, Anke, Hofmann, Patrick, Maywald, Ulf, Wilke, Thomas, and Buhl, Roland

Subjects
ddc: 610, Medicine and health, respiratory tract diseases
Abstract

Background: Long-acting bronchodilators (LABA/LAMA) are the cornerstone of pharmacotherapy in COPD, and current guidelines recommend their use as first-line therapy in symptomatic COPD patients. Given the course of COPD, patients are likely to switch drugs in daily practice. Research question [for full text, please go to the a.m. URL]

Published
2021
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35. What is the best time for psychosocial counselling from the perspective of cancer patients and their relatives? A multi‐centre qualitative study.

Author

Singer, Susanne, Kojima, Erika, Deppisch, Larissa, Taylor, Katherine, Wickert, Martin, Riedel, Petra, Alt, Jürgen, Heß, Georg, Hechtner, Marlene, and Bayer, Oliver

Subjects
TUMOR diagnosis, RESEARCH, COUNSELING, SOCIAL support, UNEMPLOYMENT, TIME, INTERVIEWING, MEDICAL screening, CANCER patients, PATIENTS' attitudes, FAMILY attitudes, QUALITATIVE research, SEX distribution, CONTENT analysis, EMPLOYMENT reentry, LONGITUDINAL method
Abstract

Purpose: The aim of this study was to identify at what time patients with cancer and their relatives want to be informed about and receive psychosocial counselling. Methods: In a multi‐centre prospective study, both users and non‐users of psychosocial cancer counselling were asked to participate in a qualitative interview about their preferences for psychosocial counselling. A second interview was scheduled 3–6 months thereafter. Interviews were transcribed verbatim and coded according to content analysis. Results: Altogether, 61 patients and 42 relatives participated, resulting in 183 interviews (103 at t1, 80 at t2). Most often, the optimal time‐point for cancer counselling was defined by the participants according to the treatment trajectory, and the most frequently mentioned preferred time‐point was 'as early as possible': at the time of cancer diagnosis (mentioned in 22% of interviews with men and 10% of interviews with women). In particular, men also said that they wanted psychosocial counselling while waiting for test results (5%), at the point of returning to work and/or when under the threat of unemployment (3%). Women especially preferred this support during therapy (4%) and 'when one has the capacity for it' (4%), in terms of time and emotional capacity. Conclusions: Healthcare providers should inform their cancer patients and the relatives about the possibilities of professional psychosocial support early on in the disease trajectory (i.e. at the time of diagnosis) and repeatedly thereafter, especially in times of uncertainty, while ensuring the patients' capacity to process information at each time‐point is taken into consideration. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Returning to work in lung cancer survivors—a multi-center cross-sectional study in Germany

Author

Rashid, Humayra, primary, Eichler, Martin, additional, Hechtner, Marlene, additional, Gianicolo, Emilio, additional, Wehler, Beatrice, additional, Buhl, Roland, additional, Schmidberger, Heinz, additional, Stratmann, Jan A., additional, Gohrbandt, Bernhard, additional, Kortsik, Cornelius, additional, Nestle, Ursula, additional, Wirtz, Hubert, additional, Blettner, Maria, additional, and Singer, Susanne, additional

Published
2020
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40. Perception of esthetic orthodontic appliances: An eye tracking and cross-sectional study.

Author

Försch, Moritz, Krull, Lena, Hechtner, Marlene, Rahimi, Roman, Wriedt, Susanne, Wehrbein, Heiner, Jacobs, Cornelius, and Jacobs, Collin

Subjects
ORTHODONTIC appliances, EYE tracking, CROSS-sectional method, VISUAL analog scale, SENSORY perception
Abstract

To evaluate the perception of esthetic orthodontic appliances by means of eye-tracking measurements and survey investigation. En face and close-up images with different orthodontic appliances (aligner appliance [a], aligner appliance and attachments [b], lingual appliance [c], ceramic brackets [d], no appliance [e; control]) were shown to 140 participants. Eye movement and gaze direction was recorded by eye-tracking system. For different anatomical areas and areas of the appliances, time to first fixation and total fixation time were recorded. The questions included in a visual analog scale regarding individual sentiency were answered by the participants. For all groups, the anatomical landmarks were inspected in the following order: (1) eyes, (2) mouth, (3) nose, (4) hair, and (5) ears. Only in group d, first fixation was on the mouth region (1.10 ± 1.05 seconds). All appliances except the lingual appliance (1.87 ± 1.31 seconds) resulted in a longer fixation on the mouth area (a, 2.97 ± 1.32 seconds; b, 3.35 ± 1.38 seconds; d, 3.29 ± 1.36 seconds). For close-up pictures, the fastest (0.58 seconds) and longest (3.14 seconds) fixation was found for group d, followed by group b (1.02 seconds/2.3 seconds), group a (2.57 seconds/0.83 seconds), and group c (3.28 seconds/0.05 seconds). Visual analog scale scoring of questions on visibility were consistent with eye-tracking measurements. With increasing visibility, the feeling of esthetic impairment was considered higher. Lingual orthodontic appliances do not change how the face is perceived. Other esthetic orthodontic appliances may change the pattern of facial inspection and are different in subjective perception. [ABSTRACT FROM AUTHOR]

Published
2020
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42. Psychological distress in lung cancer survivors at least 1 year after diagnosis-Results of a German multicenter cross-sectional study

Author

Eichler, Martin, primary, Hechtner, Marlene, additional, Wehler, Beatrice, additional, Buhl, Roland, additional, Stratmann, Jan, additional, Sebastian, Martin, additional, Schmidberger, Heinz, additional, Peuser, Jessica, additional, Kortsik, Cornelius, additional, Nestle, Ursula, additional, Wiesemann, Sebastian, additional, Wirtz, Hubert, additional, Wehler, Thomas, additional, Blettner, Maria, additional, and Singer, Susanne, additional

Published
2018
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45. Is it 'enough' to assess quality of life in a neurooncological patient? Association between health-related quality of life (HRQoL), psychosocial distress and supportive care needs in patients with malignant brain tumors: A prospective multicenter analysis of 175 patients with malignant gliomas in an outpatient setting

Author

Hickmann, Anne-Katrin, Hechtner, Marlene, Renovanz, Mirjam, Nadji-Ohl, Minou, König, Jochem, and Coburger, Jan

Subjects
ddc: 610, Neurooncology, Health Related Quality of Life, Glioma, 610 Medical sciences, Medicine
Abstract

Objective: In the era of patient-centered neurooncologic therapy, the association between health-related quality of life (HRQoL), psychosocial distress, and supportive care needs should be in the focus of research. In a prospective study those needs were assessed using three established instruments [for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2015

46. Identification of supportive care needs in patients with high-grade gliomas using the SCNS-SF34-G questionnaire - 'mission impossible'? Results of the prospective multicentric trial 'ERASMUS' of 175 patients

Author

Renovanz, Mirjam, Hechtner, Marlene, Hickmann, Anne-Katrin, Singer, Susanne, Coburger, Jan, and Giese, Alf

Subjects
supportive care, quality of life, ddc: 610, 610 Medical sciences, Medicine, glioma patients
Abstract

Objective: Improving quality, effectiveness, and efficiency of therapy and care in patients with malignant gliomas involves assessment of psychosocial and supportive care needs. The aim of this study was to test the feasibility of the German version of the Supportive Care Needs Survey (SCNS-SF34-G) [for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2015

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