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465 results on '"Hedderich, Jürgen"'

5. Schätzen

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2020
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16. Schätzen

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2018
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18. Einführung

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2018
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22. Einführung

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2016
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29. Schätzen

Author

Hedderich, Jürgen, Sachs, Lothar, Hedderich, Jürgen, and Sachs, Lothar

Published
2016
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36. The antileukoprotease secretory leukocyte protease inhibitor (SLPI) and its role in the prevention of HPV-infections in head and neck squamous cell carcinoma

Author

Quabius, Elgar S., Görögh, Tibor, Fischer, Gerrit S., Hoffmann, Anna S., Gebhard, Maximilian, Evert, Matthias, Beule, Achim, Maune, Steffen, Knecht, Rainald, Óvári, Attila, Durisin, Martin, Hoppe, Florian, Röcken, Christoph, Hedderich, Jürgen, Ambrosch, Petra, and Hoffmann, Markus

Published
2015
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46. A Continuous Correlation Between Residual Tumor Volume and Survival Recommends Maximal Safe Resection in Glioblastoma Patients: A Nomogram for Clinical Decision Making and Reference for Non-Randomized Trials

Author

Skardelly, Marco, Kaltenstadler, Marlene, Behling, Felix, Mäurer, Irina, Schittenhelm, Jens, Bender, Benjamin, Paulsen, Frank, Hedderich, Jürgen, Renovanz, Mirjam, Gempt, Jens, Barz, Melanie, Meyer, Bernhard, Tabatabai, Ghazaleh, and Tatagiba, Marcos Soares

Subjects
nomogram, Oncology, glioblastoma, residual tumor volume, accelerated failure time, reference, extent of resection, Original Research, prognostic survival model
Abstract

Objective The exact role of the extent of resection or residual tumor volume on overall survival in glioblastoma patients is still controversial. Our aim was to create a statistical model showing the association between resection extent/residual tumor volume and overall survival and to provide a nomogram that can assess the survival benefit of individual patients and serve as a reference for non-randomized studies. Methods In this retrospective multicenter cohort study, we used the non-parametric Cox regression and the parametric log-logistic accelerated failure time model in patients with glioblastoma. On 303 patients (training set), we developed a model to evaluate the effect of the extent of resection/residual tumor volume on overall survival and created a score to estimate individual overall survival. The stability of the model was validated by 20-fold cross-validation and predictive accuracy by an external cohort of 253 patients (validation set). Results We found a continuous relationship between extent of resection or residual tumor volume and overall survival. Our final accelerated failure time model (pseudo R2 = 0.423; C-index = 0.749) included residual tumor volume, age, O6-methylguanine-DNA-methyltransferase methylation, therapy modality, resectability, and ventricular wall infiltration as independent predictors of overall survival. Based on these factors, we developed a nomogram for assessing the survival of individual patients that showed a median absolute predictive error of 2.78 (mean: 1.83) months, an improvement of about 40% compared with the most promising established models. Conclusions A continuous relationship between residual tumor volume and overall survival supports the concept of maximum safe resection. Due to the low absolute predictive error and the consideration of uneven distributions of covariates, this model is suitable for clinical decision making and helps to evaluate the results of non-randomized studies.

Published
2021

47. Exercise oscillatory ventilation in patients with advanced heart failure with and without left ventricular assist device.

Author

Wernhart, Simon, Papathanasiou, Maria, Jakstaite, Aiste, Hoffmann, Julia, Schmack, Bastian, Hedderich, Jürgen, Ruhparwar, Arjang, Rassaf, Tienush, and Luedike, Peter

Subjects
HEART assist devices, HEART failure patients, EXERCISE tests, NEUROENDOCRINE cells, AORTIC valve, AEROBIC capacity, CARDIAC catheterization, TRANSCRANIAL magnetic stimulation
Abstract

Background: Exercise oscillatory ventilation (EOV), indicating pathological fluctuations on pulmonary arterial pressure, is associated with mortality in patients with heart failure (HF). Whether left ventricular assist device (LVAD)‐induced ventricular unloading can reverse EOV and may prevent short‐term rehospitalization has not been investigated. Methods: We performed a retrospective single‐center in‐ and outpatient analysis of patients with (n = 20, LVAD) and without (n = 27, HF) circulatory support and reduced ejection fraction (EF, 22.8 ± 7.9%). The association of cardiopulmonary exercise testing (CPET) variables and 3 months‐rehospitalization (3MR) as a primary outcome was analyzed. Furthermore, CPET variables were compared regarding the presence of EOV (+/−). Results: Lower VO2peak (11.6 ± 4.9 ml/kg/min vs. 14.4 ± 4.3 ml/kg/min, p = 0.039), lower increase of PETCO2 (CI = 0.049–1.127; p = 0.068), and higher VE/VCO2 (43.8 ± 9.5 vs. 38.3 ± 10.6; p = 0.069) were associated with 3MR. Flattening of O2 pulse (CI = 0.139–2.379; p = 0.487) had no impact on 3MR. EOV was present in 59.5% (n = 28/47) of patients, without a significant difference between LVAD and HF patients (p = 0.959). Patients with HF/EOV+ demonstrated significantly lower VO2peak compared with HF/EOV− (p = 0.039). LVAD/EOV+ displayed significantly lower EF (p = 0.004) and fewer aortic valve opening than LVAD/EOV− (p = 0.027). Conclusions: Lower VO2peak, but not EOV, was associated with 3MR. EOV occurred at a similar rate in LVAD and HF patients, which may illustrate insufficient unloading during exercise in chronic LVAD therapy and may contribute to the limited exercise capacity following LVAD implantation. Simultaneous CPET and right heart catheterization studies are needed to elucidate whether EOV may serve as a non‐invasive predictor of insufficient LV unloading necessitating LVAD reprograming. [ABSTRACT FROM AUTHOR]

Published
2023
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