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1. Contents Vol. 81, 1992

Author

L. Sampieri, Jan P. Roos, Yuji Hayashi, Carel C. De Cock, Hirokazu Hayakawa, P. Krupp, Toshio Nakayama, Amos Pines, Machiel J. van Eenige, Uichi Ikeda, T. Tanabe, Yoshifumi Tomita, Kazutane Usui, Doron Schwartz, Eliska Oldrich, Kazuyuki Shimada, Takao Endo, Le Blaye, Yoram Levo, Keiji Yamamoto, Hedva Lehrman, Takeshi Nishiuchi, Miloslava Eliskova, Masaki Otaki, L. Boselli, Jan C. Roos, Yuichi Sugisaki, M. Bocciolone, Mazal Greenland, Mordechai Averbuch, Tsutomu Yamaguchi, Ran Kornowski, Teruo Takano, Hidemi Hasegawa, Koichiro Yoshioka, Masashi Akaike, L. Lonati, P. D. Bezemer, Tsuguo Hasegawa, Kiyoshi Takahasi, Ariel Finkelstein, Kenji Yokoi, G. Leonetti, Hiromichi Sekiguchi, Hisaomi Kawai, C. Cuspidi, B. Donatini, Shiro Saito, A. Zanchettí, Koichi Tamura, and Frans C. Visser

Subjects
Traditional medicine, business.industry, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business
Published
1992
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2. Combined Effect of Captopril and Aspirin in Renal Hemodynamics in Elderly Patients with Congestive Heart Failure

Author

Mazal Greenland, Mordechai Averbuch, Doron Schwartz, Hedva Lehrman, Ariel Finkelstein, Ran Kornowski, Yoram Levo, and Amos Pines

Subjects
Male, medicine.medical_specialty, Mean arterial pressure, Captopril, Myocardial Ischemia, Urology, Renal function, Hemodynamics, Kidney, Kidney Function Tests, Electrolytes, chemistry.chemical_compound, Internal medicine, medicine, Humans, Pharmacology (medical), Aged, Heart Failure, Creatinine, Aspirin, business.industry, Filtration fraction, Endocrinology, chemistry, Renal blood flow, Drug Therapy, Combination, Female, Cardiology and Cardiovascular Medicine, business, Blood Flow Velocity, medicine.drug
Abstract

Captopril and aspirin have been claimed to adversely affect renal function. This study was designed to evaluate the safety of concomitant administration of both drugs in patients with moderate to severe congestive heart failure (CHF). The study group consisted of 10 patients with a mean age of 77.6 +/- 4.4 years and a mean New York Heart Association functional class of 2.6 +/- 0.5. Captopril was administered in a rapidly escalating dose regimen over a 4-day period to a maximum dose of 75 mg/day. Aspirin 0.25 g/day was added from day 5 on. Renal plasma flow (RPF) was measured by iodohippurate scan and the creatinine clearance test (Ccr) was used as an index of glomerular filtration rate (GFR). Both Ccr and RPF remained unchanged throughout the study period; 48.9 +/- 16; 48.2 +/- 16.5; 49.4 +/- 16, and 222 +/- 67, 241 +/- 97, 237 +/- 88 ml/min, for days 0, 4, 9, respectively. Only 1 patient developed a significant decrease in Ccr following the administration of captopril. This patient had a further decrease when aspirin was added. The decrease in Ccr was accompanied by a marked reduction in filtration fraction and in mean arterial pressure. Our data suggest that the administration of aspirin to elderly patients with moderate CHF treated with captopril is relatively safe and is not associated with further deterioration in renal function.

Published
1992
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3. Subject Index, Vol. 81, 1992

Author

Takao Endo, Hisaomi Kawai, P. Krupp, Yoshifumi Tomita, Hedva Lehrman, Le Blaye, Miloslava Eliskova, L. Boselli, Tsuguo Hasegawa, Toshio Nakayama, Kenji Yokoi, Eliska Oldrich, P. D. Bezemer, Kazuyuki Shimada, Tsutomu Yamaguchi, Yoram Levo, Takeshi Nishiuchi, Hirokazu Hayakawa, Teruo Takano, Keiji Yamamoto, Shiro Saito, L. Lonati, C. Cuspidi, Masashi Akaike, Uichi Ikeda, Mordechai Averbuch, Mazal Greenland, Hidemi Hasegawa, Kazutane Usui, Doron Schwartz, Jan C. Roos, Frans C. Visser, Hiromichi Sekiguchi, A. Zanchettí, Kiyoshi Takahasi, Ariel Finkelstein, G. Leonetti, M. Bocciolone, Machiel J. Van Eenige, Koichi Tamura, Yuichi Sugisaki, B. Donatini, Ran Kornowski, Amos Pines, Masaki Otaki, Yuji Hayashi, Carel C. De Cock, T. Tanabe, L. Sampieri, Koichiro Yoshioka, and Jan P. Roos

Subjects
Index (economics), business.industry, Statistics, Medicine, Pharmacology (medical), Subject (documents), Cardiology and Cardiovascular Medicine, business
Published
1992
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