618 results on '"Heflich, Robert"'
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2. Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
3. Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
4. Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
5. Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
6. Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
7. Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
8. Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives
9. Interpretation of In Vitro Concentration‐Response Data for Risk Assessment and Regulatory Decision‐making: Report from the 2022 IWGT Quantitative Analysis Expert Working Group Meeting
10. Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model
11. Erythrocyte PIG‐A mutant frequencies in cancer patients receiving cisplatin.
12. Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
13. Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes
14. Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
15. New and Emerging Genetic Toxicity Tests and Approaches to Genetic Toxicology Testing
16. Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters
17. Detecting Mutations In Vivo
18. List of Contributors
19. Quantitative differentiation of whole smoke solution‐induced mutagenicity in the mouse lymphoma assay
20. Establishing a novel Pig‐a gene mutation assay in L5178YTk+/− mouse lymphoma cells
21. In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene
22. Nitroxide TEMPO: A genotoxic and oxidative stress inducer in cultured cells
23. Evaluating the Toxicity of Cigarette Whole Smoke Solutions in an Air-Liquid-Interface Human In Vitro Airway Tissue Model
24. Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay
25. Genotoxicity of furan in Big Blue rats
26. 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
27. Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus)
28. Improvement of in vivo genotoxicity assessment: Combination of acute tests and integration into standard toxicity testing
29. Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines
30. Manifestation of Pig-a mutant bone marrow erythroids and peripheral blood erythrocytes in mice treated with N-ethyl- N-nitrosourea: Direct sequencing of Pig-a cDNA from bone marrow cells negative for GPI-anchored protein expression
31. Effect of life stage and target tissue on dose‐response assessment of ethyl methane sulfonate‐induced genotoxicity
32. DNA Adduct Formation by 1-Nitropyrene 4,5- and 9,10-Oxide
33. Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity
34. 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
35. Key Challenges and Recommendations for In VitroTesting of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters
36. Continued progress in developing the Pig-a gene mutation assay
37. Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl- N-nitrosourea
38. Aminofluorene-DNA Adduct Formation in Salmonella typhimurium Exposed to the Carcinogen N-hydroxy-2-acetylaminofluorene
39. Formation of DNA Adducts and Induction of Mutations in Rats Treated with Tumorigenic Doses of 1,6-Dinitropyrene
40. DNA Adduct Formation in Relation to Lymphocyte Mutations and Lung Tumor Induction in F344 Rats Treated with the Environmental Pollutant 1,6-Dinitropyrene
41. DNA Adduct Formation and Mutation Induction by Nitropyrenes in Salmonella and Chinese Hamster Ovary Cells: Relationships with Nitroreduction and Acetylation
42. Arylamine-DNA Adducts in vitro and in vivo: Their Role in Bacterial Mutagenesis and Urinary Bladder Carcinogenesis
43. Analysis of In Vivo Mutation in the Hprt and Tk Genes of Mouse Lymphocytes
44. Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
45. The Human RBC PIG-A Gene Mutation Assay
46. Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
47. Analysis of in vivo mutation data can inform cancer risk assessment
48. Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice
49. Pig‐a gene mutations in bone marrow granulocytes of procarbazine‐treated F344 rats
50. Recommendations for conducting the rodent erythrocyte Pig‐a assay: A report from the HESI GTTC Pig‐a Workgroup
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