422 results on '"Hegde U"'
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2. The transition to turbulence of buoyant near-critical water jets
- Author
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Hegde, U., Gotti, D., and Hicks, M.
- Published
- 2014
- Full Text
- View/download PDF
3. POS-076 PARVOVIRUS B19 DISEASE POST-RENAL TRANSPLANT PRESENTING AS REFRACTORY ANEMIA - CASE SERIES OF 20 PATIENTS
- Author
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Mittal, A., primary, Hegde, U., additional, Rajapurkar, M., additional, Gang, S., additional, Konnur, A., additional, and Patel, H., additional
- Published
- 2022
- Full Text
- View/download PDF
4. Development of Waste Bag Air Flow and Drying Models for Solid Waste Management
- Author
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Hegde, U., Yuan, Z.-G., Hall, N., Fisher, J., and Litwiller, E.
- Published
- 2007
5. POS-782 BURDEN OF GENETIC DISORDERS AND ROLE OF PRE-TRANSPLANT GENETIC ANALYSIS IN A PATIENT OF END STAGE RENAL DISEASE
- Author
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MITTAL, A., primary, konnur, A., additional, Gang, S., additional, Hegde, U., additional, Patel, H., additional, and Rajapurkar, M., additional
- Published
- 2022
- Full Text
- View/download PDF
6. Gravity Effects on Premixed and Diffusion Limited Supercritical Water Oxidation
- Author
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Hicks, M. C., Lauver, R. W., Hegde, U. G., Hall, D. G., and Sikora, T. J.
- Published
- 2005
7. The reduction of lunar regolith by carbothermal processing using methane
- Author
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Balasubramaniam, R., Gokoglu, S., and Hegde, U.
- Published
- 2010
- Full Text
- View/download PDF
8. Photoreactivation and Photoinactivation of Photosystem II after a Complete Removal of Manganese from Pea Subchloroplast Particles
- Author
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Klimov, V. V., Ananyev, G., Allakhverdiev, S. I., Zharmukhamedov, S. K., Mulay, M., Hegde, U., Padhye, S., and Baltscheffsky, M., editor
- Published
- 1990
- Full Text
- View/download PDF
9. POS-396 A RANDOMIZED CONTROL TRIAL OF RITUXIMAB VS MODIFIED PONTICELLI REGIMEN IN THE TREATMENT OF PRIMARY MEMBRANOUS NEPHROPATHY – A PILOT STUDY
- Author
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SURESH, S., primary, Hegde, U., additional, Konnur, A., additional, Gang, S., additional, Rajapurkar, M., additional, and Patel, H., additional
- Published
- 2021
- Full Text
- View/download PDF
10. POS-054 SURPRISING CAUSE OF SEVERE SYMPTOMATIC HYPERCALCAEMIA; FULLER1S EARTH INGESTION
- Author
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SURESH, S., primary, Hegde, U., additional, Konnur, A., additional, and Gang, S., additional
- Published
- 2021
- Full Text
- View/download PDF
11. POS-487 A STUDY OF CLINICAL PROFILE AND OUTCOME ANALYSIS OF PATIENTS WITH MULTIPLE MYELOMA AND KIDNEY DISEASE IN A TERTIARY CARE CENTRE IN WEST INDIA
- Author
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Konnur MD, A., primary, Gang, S., additional, Hegde, U., additional, Rajapurkar, M., additional, Patel, H., additional, Singhal, S., additional, Parikh, M., additional, and Srivastava, P., additional
- Published
- 2021
- Full Text
- View/download PDF
12. POS-732 A STUDY OF ANGIOTENSIN ii TYPE II RECEPTOR ANTIBODY IN RENAL ALLOGRAFT REJECTION
- Author
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Hegde, U., primary, Soni, P., additional, Rajapurkar, M., additional, Gabg, S., additional, Konnur, A., additional, and Patel, H., additional
- Published
- 2021
- Full Text
- View/download PDF
13. POS-163 A RANDOMIZED CONTROL TRIAL OF RITUXIMAB VERSUS MODIFIED PONTICELLI REGIMEN IN THE TREATMENT OF PRIMARY MEMBRANOUS NEPHROPATHY – A PILOT STUDY
- Author
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SURESH, S., primary, Konnur, A., additional, Gang, S., additional, Hegde, U., additional, Patel, H., additional, and Rajapurkar, M.M., additional
- Published
- 2021
- Full Text
- View/download PDF
14. POS-731 PARVOVIRUS DISEASE POST RENAL TRANSPLANT PRESENTING AS REFRACTORY ANEMIA-SINGLE CENTRE EXPERIENCE
- Author
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Hegde, U., primary, Mittal, A., additional, Rajapurkar, M., additional, Gang, S., additional, Konnur, A., additional, Patel, H., additional, and Kadam, A., additional
- Published
- 2021
- Full Text
- View/download PDF
15. POS-759 HISTOLOGICAL ANALYSIS OF 3 AND 6 MONTH PROTOCOL BIOPSIES AND OUTCOME SIN ABO INCOMPATIBLE RENAL TRANSPLANTS
- Author
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Hegde, U., primary, Prabhakar, A., additional, Gang, S., additional, Rajapurkar, M., additional, Patel, H., additional, and Konnur, A., additional
- Published
- 2021
- Full Text
- View/download PDF
16. Analysis of Water Recovery Rate from the Heat Melt Compactor
- Author
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Balasubramaniam, R, Hegde, U, and Gokoglu, S
- Subjects
Mechanical Engineering - Abstract
Human space missions generate trash with a substantial amount of plastic (20% or greater by mass). The trash also contains water trapped in food residue and paper products and other trash items. The Heat Melt Compactor (HMC) under development by NASA Ames Research Center (ARC) compresses the waste, dries it to recover water and melts the plastic to encapsulate the compressed trash. The resulting waste disk or puck represents an approximately ten-fold reduction in the volume of the initial trash loaded into the HMC. In the current design concept being pursued, the trash is compressed by a piston after it is loaded into the trash chamber. The piston face, the side walls of the waste processing chamber and the end surface in contact with the waste can be heated to evaporate the water and to melt the plastic. Water is recovered by the HMC in two phases. The first is a pre-process compaction without heat or with the heaters initially turned on but before the waste heats up. Tests have shown that during this step some liquid water may be expelled from the chamber. This water is believed to be free water (i.e., not bound with or absorbed in other waste constituents) that is present in the trash. This phase is herein termed Phase A of the water recovery process. During HMC operations, it is desired that liquid water recovery in Phase A be eliminated or minimized so that water-vapor processing equipment (e.g., condensers) downstream of the HMC are not fouled by liquid water and its constituents (i.e., suspended or dissolved matter) exiting the HMC. The primary water recovery process takes place next where the trash is further compacted while the heated surfaces reach their set temperatures for this step. This step will be referred to herein as Phase B of the water recovery process. During this step the waste chamber may be exposed to different selected pressures such as ambient, low pressure (e.g., 0.2 atm), or vacuum. The objective for this step is to remove both bound and any remaining free water in the trash by evaporation. The temperature settings of the heated surfaces are usually kept above the saturation temperature of water but below the melting temperature of the plastic in the waste during this step to avoid any encapsulation of wet trash which would reduce the amount of recovered water by blocking the vapor escape. In this paper, we analyze the water recovery rate during Phase B where the trash is heated and water leaves the waste chamber as vapor, for operation of the HMC in reduced gravity. We pursue a quasi-one-dimensional model with and without sidewall heating to determine the water recovery rate and the trash drying time. The influences of the trash thermal properties, the amount of water loading, and the distribution of the water in the trash on the water recovery rates are determined.
- Published
- 2013
17. The Salivary Mycobiome Contains 2 Ecologically Distinct Mycotypes
- Author
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Hong, B.Y., primary, Hoare, A., additional, Cardenas, A., additional, Dupuy, A.K., additional, Choquette, L., additional, Salner, A.L., additional, Schauer, P.K., additional, Hegde, U., additional, Peterson, D.E., additional, Dongari-Bagtzoglou, A., additional, Strausbaugh, L.D., additional, and Diaz, P.I., additional
- Published
- 2020
- Full Text
- View/download PDF
18. SAT-397 PAUCI-IMMUNE VASCULITIS - CLINICAL CHARACTERISTICS AND OUTCOME ANALYSIS OF 120 PATIENTS FROM A SINGLE CENTER IN INDIA
- Author
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konnur MD, A., primary, Parikh, M., additional, Gang, S., additional, Rajapurkar, M., additional, Hegde, U., additional, and Patel, H., additional
- Published
- 2020
- Full Text
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19. SAT-243 SHORT DWELL ETHANOL LOCK THERAPY FOR MANAGEMENT OF HEMODIALYSIS TUNNELLED CUFFED CATHETER RELATED BLOOD STREAM INFECTION
- Author
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Gang, S., primary, Patel, J., additional, Patel, H., additional, Konnur, A., additional, Hegde, U., additional, and Rajapurkar, M., additional
- Published
- 2020
- Full Text
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20. SUN-298 VIRAL SURVEILLANCE IN RENAL TRANSPLANT RECIPIENTS - A PROSPECTIVE OBSERVATIONAL STUDY
- Author
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RAO, A., primary, Konnur, A., additional, Gang, S., additional, and Hegde, U., additional
- Published
- 2020
- Full Text
- View/download PDF
21. Analysis of Water Extraction From Lunar Regolith
- Author
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Hegde, U, Balasubramaniam, R, and Gokoglu, S
- Subjects
Engineering (General) - Abstract
Distribution of water concentration on the Moon is currently an area of active research. Recent studies suggest the presence of ice particles, and perhaps even ice blocks and ice-cemented regolith on the Moon. Thermal extraction of the in-situ water is an attractive means of sa tisfying water requirements for a lunar mission. In this paper, a model is presented to analyze the processes occurring during the heat-up of icy regolith and extraction of the evolved water vapor. The wet regolith is assumed to be present in an initially evacuated and sealed cell which is subsequently heated. The first step of the analysis invol ves calculating the gradual increase of vapor pressure in the closed cell as the temperature is raised. Then, in the second step, the cell is evacuated to low pressure (e.g., vacuum), allowing the water vapor to leave the cell and be captured. The parameters affecting water vap or pressure build-up and evacuation for the purpose of extracting water from lunar regolith are discussed in the paper. Some comparisons wi th available experimental measurements are also made.
- Published
- 2012
22. Modeling of Melt Growth During Carbothermal Processing of Lunar Regolith
- Author
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Balasubramaniam, R, Gokoglu S, and Hegde, U
- Subjects
Engineering (General) - Abstract
The carbothermal processing of lunar regolith has been proposed as a means to produce carbon monoxide and ultimately oxygen to support human exploration of the moon. In this process, gaseous methane is pyrolyzed as it flows over the hot surface of a molten zone of lunar regolith and is converted to carbon and hydrogen. Carbon gets deposited on the surface of the melt, and mixes and reacts with the metal oxides in it to produce carbon monoxide that bubbles out of the melt. Carbon monoxide is further processed in other reactors downstream to ultimately produce oxygen. The amount of oxygen produced crucially depends on the amount of regolith that is molten. In this paper we develop a model of the heat transfer in carbothermal processing. Regolith in a suitable container is heated by a heat flux at its surface such as by continuously shining a beam of solar energy or a laser on it. The regolith on the surface absorbs the energy and its temperature rises until it attains the melting point. The energy from the heat flux is then used for the latent heat necessary to change phase from solid to liquid, after which the temperature continues to rise. Thus a small melt pool appears under the heated zone shortly after the heat flux is turned on. As time progresses, the pool absorbs more heat and supplies the energy required to melt more of the regolith, and the size of the molten zone increases. Ultimately, a steady-state is achieved when the heat flux absorbed by the melt is balanced by radiative losses from the surface. In this paper, we model the melting and the growth of the melt zone with time in a bed of regolith when a portion of its surface is subjected to a constant heat flux. The heat flux is assumed to impinge on a circular area. Our model is based on an axisymmetric three-dimensional variation of the temperature field in the domain. Heat transfer occurs only by conduction, and effects of convective heat transport are assumed negligible. Radiative heat loss from the surface of the melt and the regolith to the surroundings is permitted. We perform numerical computations to determine the shape and the mass of the melt at steady state and its time evolution. We first neglect the volume change upon melting, and subsequently perform calculations including it. Predictions from our model are compared to test data to determine the effective thermal conductivities of the regolith and the melt that are compatible with the data
- Published
- 2012
23. Hydrogen Reduction of Lunar Regolith Simulants for Oxygen Production
- Author
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Hegde, U, Balasubramaniam, R, Gokoglu, S. A, Rogers, K, Reddington, M, and Oryshchyn, L
- Subjects
Engineering (General) - Abstract
Hydrogen reduction of the lunar regolith simulants JSC-1A and LHT-2M is investigated in this paper. Experiments conducted at NASA Johnson Space Center are described and are analyzed utilizing a previously validated model developed by the authors at NASA Glenn Research Center. The effects of regolith sintering and clumping, likely in actual production operations, on the oxygen production rate are studied. Interpretations of the obtained results on the basis of the validated model are provided and linked to increase in the effective particle size and reduction in the intra-particle species diffusion rates. Initial results on the pressure dependence of the oxygen production rate are also presented and discussed
- Published
- 2011
24. The Reduction of Lunar Regolith by Carbothermal Processing Using Methane
- Author
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Balasubramaniam, R, Gokoglu, S. A, and Hegde, U
- Subjects
Lunar And Planetary Science And Exploration - Abstract
The processing of lunar regolith for the production of oxygen is a key component of the In-Situ Resource Utilization plans currently being developed by NASA. In the carbothermal process, a portion of the surface of the regolith in a container is heated by exposure to a heat source so that a small zone of molten regolith is established. A continuous flow of methane is maintained over the molten regolith zone. In this paper, we discuss the development of a chemical conversion model of the carbothermal process to predict the rate of production of carbon monoxide. Our model is based on a mechanism where methane pyrolyzes when it comes in contact with the surface of the hot molten regolith to form solid carbon and hydrogen gas. Carbon is deposited on the surface of the melt, and hydrogen is released into the gas stream above the melt surface. We assume that the deposited carbon mixes in the molten regolith and reacts with metal oxides in a reduction reaction by which gaseous carbon monoxide is liberated. Carbon monoxide bubbles through the melt and is released into the gas stream. It is further processed downstream to ultimately produce oxygen.
- Published
- 2010
25. Heating-Rate-Coupled Model for Hydrogen Reduction of JSC-1A
- Author
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Hegde, U, Balasubramaniam, R, and Gokoglu, S. A
- Subjects
Lunar And Planetary Science And Exploration - Abstract
A previously developed and validated model for hydrogen reduction of JSC-1A for a constant reaction-bed temperature is extended to account for reaction during the bed heat-up period. A quasisteady approximation is used wherein an expression is derived for a single average temperature of reaction during the heat-up process by employing an Arrhenius expression for regolith conversion. Subsequently, the regolith conversion during the heat-up period is obtained by using this representative temperature. Accounting for the reaction during heat-up provides a better estimate of the reaction time needed at the desired regolith-bed operating temperature. Implications for the efficiency of the process, as measured by the energy required per unit mass of oxygen produced, are also indicated.
- Published
- 2010
26. Determination of Chemical Kinetic Rate Constants of a Model for Carbothermal Processing of Lunar Regolith Simulant Using Methane
- Author
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Balasubramaniam, R, Gokoglu, S, and Hegde, U
- Subjects
Lunar And Planetary Science And Exploration - Abstract
We have previously developed a chemical conversion model of the carbothermal processing of lunar regolith using methane to predict the rate of production of carbon monoxide. In this carbothermal process, gaseous methane is pyrolyzed as it flows over the hot surface of a molten zone of lunar regolith and is converted to carbon and hydrogen. Hydrogen is carried away by the exiting stream of gases and carbon is deposited on the melt surface. The deposited carbon mixes with the melt and reacts with the metal oxides in it to produce carbon monoxide that bubbles out of the melt. In our model, we assume that the flux of carbon deposited is equal to the product of the surface reaction rate constant gamma and the concentration of methane adjacent to the melt surface. Similarly, the rate of consumption of carbon per unit volume in the melt is equal to the product of the melt reaction rate constant k and the concentrations of carbon and metal oxide in the melt. In this paper, we describe our effort to determine gamma and k by comparison of the predictions from our model with test data obtained by ORBITEC (Orbital Technologies Corporation). The concentration of methane adjacent to the melt surface is a necessary input to the model. It is inferred from the test data by a mass balance of methane, adopting the usual assumptions of the continuously-stirred-tank-reactor model, whereby the average concentration of a given gaseous species equals its exit concentration. The reaction rates gamma and k have been determined by a non-linear least-squares fit to the test data for the production of carbon monoxide and the fraction of the incoming methane that is converted. The comparison of test data with our model predictions using the determined chemical kinetic rate constants provides a consistent interpretation of the process over the full range of temperatures, pressures, and methane flow rates used in the tests, thereby increasing our confidence to use the model for scale-up purposes.
- Published
- 2009
27. Carbothermal Processing of Lunar Regolith Using Methane
- Author
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Balasubramaniam, R, Hegde, U, and Gokoglu, S
- Subjects
Man/System Technology And Life Support - Abstract
The processing of lunar regolith for the production of oxygen is a key component of the In-Situ Resource Utilization plans currently being developed by NASA. Among various candidate processes, the modeling of oxygen production by hydrogen reduction, molten salt electrolysis, and carbothermal processing are presently being pursued. In the carbothermal process, a portion of the surface of the regolith in a container is heated by exposure to a heat source such as a laser beam or a concentrated solar heat flux, so that a small zone of molten regolith is established. The molten zone is surrounded by solid regolith particles that are poor conductors of heat. A continuous flow of methane is maintained over the molten regolith zone. Our model is based on a mechanism where methane pyrolyzes when it comes in contact with the surface of the hot molten regolith to form solid carbon and hydrogen gas. Carbon is deposited on the surface of the melt, and hydrogen is released into the gas stream above the melt surface. We assume that the deposited carbon mixes in the molten regolith and reacts with metal oxides in a reduction reaction by which gaseous carbon monoxide is liberated. Carbon monoxide bubbles through the melt and is released into the gas stream. Oxygen is produced subsequently by (catalytically) processing the carbon monoxide downstream. In this paper, we discuss the development of a chemical conversion model of the carbothermal process to predict the rate of production of carbon monoxide.
- Published
- 2009
28. Development and Validation of a Model for Hydrogen Reduction of JSC-1A
- Author
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Hegde, U, Balasubramaniam, R, and Gokoglu, S
- Subjects
Engineering (General) - Abstract
Hydrogen reduction of lunar regolith has been proposed as a viable technology for oxygen production on the moon. Hydrogen reduces FeO present in the lunar regolith to form metallic iron and water. The water may be electrolyzed to recycle the hydrogen and produce oxygen. Depending upon the regolith composition, FeO may be bound to TiO2 as ilmenite or it may be dispersed in glassy substrates. Some testing of hydrogen reduction has been conducted with Apollo-returned lunar regolith samples. However, due to the restricted amount of lunar material available for testing, detailed understanding and modeling of the reduction process in regolith have not yet been developed. As a step in this direction, hydrogen reduction studies have been carried out in more detail with lunar regolith simulants such as JSC-1A by NASA and other organizations. While JSC-1A has some similarities with lunar regolith, it does not duplicate the wide variety of regolith types on the moon, for example, it contains almost no ilmenite. Nonetheless, it is a good starting point for developing an understanding of the hydrogen reduction process with regolith-like material. In this paper, a model utilizing a shrinking core formulation coupled with the reactor flow is described and validated against experimental data on hydrogen reduction of JSC-1A.
- Published
- 2009
29. Development of a Reactor Model for Chemical Conversion of Lunar Regolith
- Author
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Hegde, U, Balasubramaniam, R, and Gokoglu, S
- Subjects
Man/System Technology And Life Support - Abstract
Lunar regolith will be used for a variety of purposes such as oxygen and propellant production and manufacture of various materials. The design and development of chemical conversion reactors for processing lunar regolith will require an understanding of the coupling among the chemical, mass and energy transport processes occurring at the length and time scales of the overall reactor with those occurring at the corresponding scales of the regolith particles. To this end, a coupled transport model is developed using, as an example, the reduction of ilmenite-containing regolith by a continuous flow of hydrogen in a flow-through reactor. The ilmenite conversion occurs on the surface and within the regolith particles. As the ilmenite reduction proceeds, the hydrogen in the reactor is consumed, and this, in turn, affects the conversion rate of the ilmenite in the particles. Several important quantities are identified as a result of the analysis. Reactor scale parameters include the void fraction (i.e., the fraction of the reactor volume not occupied by the regolith particles) and the residence time of hydrogen in the reactor. Particle scale quantities include the time for hydrogen to diffuse into the pores of the regolith particles and the chemical reaction time. The paper investigates the relationships between these quantities and their impact on the regolith conversion. Application of the model to various chemical reactor types, such as fluidized-bed, packed-bed, and rotary-bed configurations, are discussed.
- Published
- 2009
30. Analysis of Thermal and Reaction Times for Hydrogen Reduction of Lunar Regolith
- Author
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Hegde, U, Balasubramaniam, R, and Gokoglu, S
- Subjects
Engineering (General) - Abstract
System analysis of oxygen production by hydrogen reduction of lunar regolith has shown the importance of the relative time scales for regolith heating and chemical reaction to overall performance. These values determine the sizing and power requirements of the system and also impact the number and operational phasing of reaction chambers. In this paper, a Nusselt number correlation analysis is performed to determine the heat transfer rates and regolith heat up times in a fluidized bed reactor heated by a central heating element (e.g., a resistively heated rod, or a solar concentrator heat pipe). A coupled chemical and transport model has also been developed for the chemical reduction of regolith by a continuous flow of hydrogen. The regolith conversion occurs on the surfaces of and within the regolith particles. Several important quantities are identified as a result of the above analyses. Reactor scale parameters include the void fraction (i.e., the fraction of the reactor volume not occupied by the regolith particles) and the residence time of hydrogen in the reactor. Particle scale quantities include the particle Reynolds number, the Archimedes number, and the time needed for hydrogen to diffuse into the pores of the regolith particles. The analysis is used to determine the heat up and reaction times and its application to NASA s oxygen production system modeling tool is noted.
- Published
- 2009
31. Carbothermal Processing of Lunar Regolith Using Methane
- Author
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Balasubramaniam, R, Hegde, U, and Gokoglu, S
- Subjects
Lunar And Planetary Science And Exploration - Abstract
The processing of lunar regolith for the production of oxygen is a key component of the In-Situ Resource Utilization plans currently being developed by NASA. Among various candidate processes, the modeling of oxygen production by hydrogen reduction, molten salt electrolysis, and carbothermal processing are presently being pursued. In the carbothermal process, a portion of the surface of the regolith in a container is heated by exposure to a heat source such as a laser beam or a concentrated solar heat flux, so that a small zone of molten regolith is established. The molten zone is surrounded by solid regolith particles that are poor conductors of heat. A continuous flow of methane is maintained over the molten regolith zone. Our model is based on a mechanism where methane pyrolyzes when it comes in contact with the surface of the hot molten regolith to form solid carbon and hydrogen gas. Carbon is deposited on the surface of the melt, and hydrogen is released into the gas stream above the melt surface. We assume that the deposited carbon mixes in the molten regolith and reacts with metal oxides in a reduction reaction by which gaseous carbon monoxide is liberated. Carbon monoxide bubbles through the melt and is released into the gas stream. Oxygen is produced subsequently by (catalytically) processing the carbon monoxide downstream. In this paper, we discuss the development of a chemical conversion model of the carbothermal process to predict the rate of production of carbon monoxide.
- Published
- 2008
32. Analysis of Thermal and Reaction Times for Hydrogen Reduction of Lunar Regolith
- Author
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Hegde, U, Balasubramaniam, R, and Gokoglu, S
- Subjects
Lunar And Planetary Science And Exploration - Abstract
System analysis of oxygen production by hydrogen reduction of lunar regolith has shown the importance of the relative time scales for regolith heating and chemical reaction to overall performance. These values determine the sizing and power requirements of the system and also impact the number and operational phasing of reaction chambers. In this paper, a Nusselt number correlation analysis is performed to determine the heat transfer rates and regolith heat up times in a fluidized bed reactor heated by a central heating element (e.g., a resistively heated rod, or a solar concentrator heat pipe). A coupled chemical and transport model has also been developed for the chemical reduction of regolith by a continuous flow of hydrogen. The regolith conversion occurs on the surfaces of and within the regolith particles. Several important quantities are identified as a result of the above analyses. Reactor scale parameters include the void fraction (i.e., the fraction of the reactor volume not occupied by the regolith particles) and the residence time of hydrogen in the reactor. Particle scale quantities include the particle Reynolds number, the Archimedes number, and the time needed for hydrogen to diffuse into the pores of the regolith particles. The analysis is used to determine the heat up and reaction times and its application to NASA s oxygen production system modeling tool is noted.
- Published
- 2008
33. Diffusion Limited Supercritical Water Oxidation (SCWO) in Microgravity Environments
- Author
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Hicks, M. C, Lauver, R. W, Hegde, U. G, and Sikora, T. J
- Subjects
Fluid Mechanics And Thermodynamics - Abstract
Tests designed to quantify the gravitational effects on thermal mixing and reactant injection in a Supercritical Water Oxidation (SCWO) reactor have recently been performed in the Zero Gravity Facility (ZGF) at NASA s Glenn Research Center. An artificial waste stream, comprising aqueous mixtures of methanol, was pressurized to approximately 250 atm and then heated to 450 C. After uniform temperatures in the reactor were verified, a controlled injection of air was initiated through a specially designed injector to simulate diffusion limited reactions typical in most continuous flow reactors. Results from a thermal mapping of the reaction zone in both 1-g and 0-g environments are compared. Additionally, results of a numerical model of the test configuration are presented to illustrate first order effects on reactant mixing and thermal transport in the absence of gravity.
- Published
- 2006
34. Buoyancy Effects in Strongly-Pulsed, Turbulent Diffusion Flames
- Author
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Hermanson, J. C, Johari, H, Ghaem-Maghami, E, Stocker, D. P, and Hegde, U. G
- Subjects
Spacecraft Propulsion And Power - Abstract
The objective of this experiment is to better understand the combustion behavior of pulsed, turbulent diffusion flames by conducting experiments in microgravity. The fuel jet is fully-modulated (i.e., completely shut off between pulses) by an externally controlled valve system leading to enhanced fuel/air mixing compared to acoustically excited or partially-modulated jets. Experiments are conducted both in laboratories at UW and WPI and in the GRC 2.2s Drop Tower. A single fuel nozzle with diameter d = 2 mm is centered in a combustor 20 20 cm in cross section and 67 cm in height. The gaseous fuel flow (ethylene or a 50/50 ethylene/nitrogen mixture by volume) is fully-modulated by a fast-response solenoid valve with injection times from tau = 4 to tau = 300 ms. The nominal Reynolds number based on the fuel velocity during injection, U(sub jet), is 5,000. A slow oxidizer co-flow properly ventilates the flame and an electrically heated wire loop serves as a continuous ignition source. Diagnostic techniques include video imaging, fine-wire thermocouples and thermopile radiometers, and gas sampling and standard emissions instruments (the last in the laboratory only).
- Published
- 2004
35. Effects Of Electric Field On Hydrocarbon-Fueled Flames
- Author
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Yuan, Z.-G and Hegde, U
- Subjects
Propellants And Fuels - Abstract
It has been observed that flames are susceptible to electric fields that are much weaker than the breakdown field strength of the flame gases. When an external electric field is imposed on a flame, the ions generated in the flame reaction zone drift in the direction of the electric forces exerted on them. The moving ions collide with the neutral species and change the velocity distribution in the affected region. This is often referred to as ionic wind effect. In addition, the removal of ions from the flame reaction zone can alter the chemical reaction pathway of the flame. On the other hand, the presence of space charges carried by moving ions affects the electric field distribution. As a result, the flame often changes its shape, location and color once an external electric field is applied. The interplay between the flame movement and the change of electric field makes it difficult to determine the flame location for a given configuration of electrodes and fuel source. In normal gravity, the buoyancy-induced flow often complicates the problem and hinders detailed study of the interaction between the flame and the electric field. In this work, the microgravity environment established at the 2.2 Second Drop Tower at the NASA Glenn Research Center is utilized to effectively remove the buoyant acceleration. The interaction between the flame and the electric field is studied in a one-dimensional domain. A specially designed electrode makes flame current measurements possible; thus, the mobility of ions, ion density, and ionic wind effect can be evaluated.
- Published
- 2003
36. Buoyancy Effects in Fully-Modulated, Turbulent Diffusion Flames
- Author
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Hermanson, J. C, Johari, H, Ghaem-Maghami, E, Stocker, D. P, Hegde, U. G, and Page, K. L
- Subjects
Fluid Mechanics And Thermodynamics - Abstract
Pulsed combustion appears to have the potential to provide for rapid fuel/air mixing, compact and economical combustors, and reduced exhaust emissions. The objective of this experiment (PuFF, for Pulsed-Fully Flames) is to increase the fundamental understanding of the fuel/air mixing and combustion behavior of pulsed, turbulent diffusion flames by conducting experiments in microgravity. In this research the fuel jet is fully-modulated (i.e., completely shut off between pulses) by an externally controlled valve system. This gives rise to drastic modification of the combustion and flow characteristics of flames, leading to enhanced fuel/air mixing compared to acoustically excited or partially-modulated jets. Normal-gravity experiments suggest that the fully-modulated technique also has the potential for producing turbulent jet flames significantly more compact than steady flames with no increase in exhaust emissions. The technique also simplifies the combustion process by avoiding the acoustic forcing generally present in pulsed combustors. Fundamental issues addressed in this experiment include the impact of buoyancy on the structure and flame length, temperatures, radiation, and emissions of fully-modulated flames.
- Published
- 2003
37. Sounding Rocket Microgravity Experiments Elucidating Diffusive and Radiative Transport Effects on Flame Spread over Thermally-Thick Solids
- Author
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Olson, Sandra L, Hegde, U, Bhattacharjee, S, Deering, J. L, Tang, L, and Altenkirch, R. A
- Subjects
Space Processing - Abstract
A series of 6-minute microgravity combustion experiments of opposed flow flame spread over thermally-thick PMMA has been conducted to extend data previously reported at high opposed flows to almost two decades lower in flow. The effect of flow velocity on flame spread shows a square root power law dependence rather than the linear dependence predicted by thermal theory. The experiments demonstrate that opposed flow flame spread is viable to very low velocities and more robust than expected from the numerical model, which predicts that at very low velocities (less than 5 centimeters per second), flame spread rates fall off more rapidly as flow is reduced. It is hypothesized that the enhanced flame spread observed in the experiments may be due to three- dimensional hydrodynamic effects, which are not included in the zero-gravity, two-dimensional hydrodynamic model. The effect of external irradiation was found to be more complex that the model predicted over the 0-2 Watts per square centimeter range. In the experiments, the flame compensated for the increased irradiation by stabilizing farther from the surface. A surface energy balance reveals that the imposed flux was at least partially offset by a reduced conductive flux from the increased standoff distance, so that the effect on flame spread was weaker than anticipated.
- Published
- 2003
38. Thermal Characteristics and Structure of Fully-Modulated, Turbulent Diffusion Flames in Microgravity
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Hermanson, J. C, Johari, H, Stocker, D. P, and Hegde, U. G
- Subjects
Fluid Mechanics And Thermodynamics - Abstract
Turbulent jet diffusion flames are studied in microgravity and normal gravity under fully-modulated conditions for a range of injection times and a 50% duty cycle. Diluted ethylene was injected through a 2-mm nozzle at a Reynolds number of 5,000 into an open duct, with a slow oxidizer co-flow. Microgravity tests are conducted in NASA's 2.2 Second Drop Tower. Flames with short injection times and high duty cycle exhibit a marked increase in the ensemble-averaged flame length due to the removal of buoyancy. The cycle-averaged centerline temperature profile reveals higher temperatures in the microgravity flames, especially at the flame tip where the difference is about 200 K. In addition, the cycle-averaged measurements of flame radiation were about 30% to 60% greater in microgravity than in normal gravity.
- Published
- 2003
39. Multiple myeloma and immune thrombocytopenia
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GUPTA, V., HEGDE, U. M., PARAMESWARAN, R., and NEWLAND, A. C.
- Published
- 2000
40. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study
- Author
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Burtness, B. Harrington, K.J. Greil, R. Soulières, D. Tahara, M. de Castro, G., Jr Psyrri, A. Basté, N. Neupane, P. Bratland, Å. Fuereder, T. Hughes, B.G.M. Mesía, R. Ngamphaiboon, N. Rordorf, T. Wan Ishak, W.Z. Hong, R.-L. González Mendoza, R. Roy, A. Zhang, Y. Gumuscu, B. Cheng, J.D. Jin, F. Rischin, D. Lerzo, G. Tatangelo, M. Varela, M. Zarba, J.J. Boyer, M. Gan, H. Gao, B. Hughes, B. Mallesara, G. Taylor, A. Burian, M. Barrios, C.H. de Castro Junior, D.O. Castro, G. Franke, F.A. Girotto, G. Lima, I.P.F. Nicolau, U.R. Pinto, G.D.J. Santos, L. Victorino, A.-P. Chua, N. Couture, F. Gregg, R. Hansen, A. Hilton, J. McCarthy, J. Soulieres, D. Ascui, R. Gonzalez, P. Villanueva, L. Torregroza, M. Zambrano, A. Holeckova, P. Kral, Z. Melichar, B. Prausova, J. Vosmik, M. Andersen, M. Gyldenkerne, N. Jurgens, H. Putnik, K. Reinikainen, P. Gruenwald, V. Laban, S. Aravantinos, G. Boukovinas, I. Georgoulias, V. Kwong, D. Al-Farhat, Y. Csoszi, T. Erfan, J. Horvai, G. Landherr, L. Remenar, E. Ruzsa, A. Szota, J. Billan, S. Gluck, I. Gutfeld, O. Popovtzer, A. Benasso, M. Bui, S. Ferrari, V. Licitra, L. Nole, F. Fujii, T. Fujimoto, Y. Hanai, N. Hara, H. Matsumoto, K. Mitsugi, K. Monden, N. Nakayama, M. Okami, K. Oridate, N. Shiga, K. Shimizu, Y. Sugasawa, M. Takahashi, M. Takahashi, S. Tanaka, K. Ueda, T. Yamaguchi, H. Yamazaki, T. Yasumatsu, R. Yokota, T. Yoshizaki, T. Kudaba, I. Stara, Z. Cheah, S.K. Aguilar Ponce, J. Gonzalez Mendoza, R. Hernandez Hernandez, C. Medina Soto, F. Buter, J. Hoeben, A. Oosting, S. Suijkerbuijk, K. Bratland, A. Brydoey, M. Alvarez, R. Mas, L. Caguioa, P. Querol, J. Regala, E.E. Tamayo, M.B. Villegas, E.M. Kawecki, A. Karpenko, A. Klochikhin, A. Smolin, A. Zarubenkov, O. Goh, B.C. Cohen, G. du Toit, J. Jordaan, C. Landers, G. Ruff, P. Szpak, W. Tabane, N. Brana, I. Iglesias Docampo, L. Lavernia, J. Mesia, R. Abel, E. Muratidu, V. Nielsen, N. Cristina, V. Rothschild, S. Wang, H.-M. Yang, M.-H. Yeh, S.-P. Yen, C.-J. Soparattanapaisarn, N. Sriuranpong, V. Aksoy, S. Cicin, I. Ekenel, M. Harputluoglu, H. Ozyilkan, O. Agarwala, S. Ali, H. Alter, R. Anderson, D. Bruce, J. Campbell, N. Conde, M. Deeken, J. Edenfield, W. Feldman, L. Gaughan, E. Goueli, B. Halmos, B. Hegde, U. Hunis, B. Jotte, R. Karnad, A. Khan, S. Laudi, N. Laux, D. Martincic, D. McCune, S. McGaughey, D. Misiukiewicz, K. Mulford, D. Nadler, E. Nunnink, J. Ohr, J. O'Malley, M. Patson, B. Paul, D. Popa, E. Powell, S. Redman, R. Rella, V. Rocha Lima, C. Sivapiragasam, A. Su, Y. Sukari, A. Wong, S. Yilmaz, E. Yorio, J.
- Abstract
Background: Pembrolizumab is active in head and neck squamous cell carcinoma (HNSCC), with programmed cell death ligand 1 (PD-L1) expression associated with improved response. Methods: KEYNOTE-048 was a randomised, phase 3 study of participants with untreated locally incurable recurrent or metastatic HNSCC done at 200 sites in 37 countries. Participants were stratified by PD-L1 expression, p16 status, and performance status and randomly allocated (1:1:1) to pembrolizumab alone, pembrolizumab plus a platinum and 5-fluorouracil (pembrolizumab with chemotherapy), or cetuximab plus a platinum and 5-fluorouracil (cetuximab with chemotherapy). Investigators and participants were aware of treatment assignment. Investigators, participants, and representatives of the sponsor were masked to the PD-L1 combined positive score (CPS) results; PD-L1 positivity was not required for study entry. The primary endpoints were overall survival (time from randomisation to death from any cause) and progression-free survival (time from randomisation to radiographically confirmed disease progression or death from any cause, whichever came first) in the intention-to-treat population (all participants randomly allocated to a treatment group). There were 14 primary hypotheses: superiority of pembrolizumab alone and of pembrolizumab with chemotherapy versus cetuximab with chemotherapy for overall survival and progression-free survival in the PD-L1 CPS of 20 or more, CPS of 1 or more, and total populations and non-inferiority (non-inferiority margin: 1·2) of pembrolizumab alone and pembrolizumab with chemotherapy versus cetuximab with chemotherapy for overall survival in the total population. The definitive findings for each hypothesis were obtained when statistical testing was completed for that hypothesis; this occurred at the second interim analysis for 11 hypotheses and at final analysis for three hypotheses. Safety was assessed in the as-treated population (all participants who received at least one dose of allocated treatment). This study is registered at ClinicalTrials.gov, number NCT02358031. Findings: Between April 20, 2015, and Jan 17, 2017, 882 participants were allocated to receive pembrolizumab alone (n=301), pembrolizumab with chemotherapy (n=281), or cetuximab with chemotherapy (n=300); of these, 754 (85%) had CPS of 1 or more and 381 (43%) had CPS of 20 or more. At the second interim analysis, pembrolizumab alone improved overall survival versus cetuximab with chemotherapy in the CPS of 20 or more population (median 14·9 months vs 10·7 months, hazard ratio [HR] 0·61 [95% CI 0·45–0·83], p=0·0007) and CPS of 1 or more population (12·3 vs 10·3, 0·78 [0·64–0·96], p=0·0086) and was non-inferior in the total population (11·6 vs 10·7, 0·85 [0·71–1·03]). Pembrolizumab with chemotherapy improved overall survival versus cetuximab with chemotherapy in the total population (13·0 months vs 10·7 months, HR 0·77 [95% CI 0·63–0·93], p=0·0034) at the second interim analysis and in the CPS of 20 or more population (14·7 vs 11·0, 0·60 [0·45–0·82], p=0·0004) and CPS of 1 or more population (13·6 vs 10·4, 0·65 [0·53–0·80], p
- Published
- 2019
41. Spherical Ethylene/Air Diffusion Flames Subject to Concentric DC Electric Field in Microgravity
- Author
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Yuan, Z. -G, Hegde, U, and Faeth, G. M
- Subjects
Inorganic, Organic And Physical Chemistry - Abstract
It is well known that microgravity conditions, by eliminating buoyant flow, enable many combustion phenomena to be observed that are not possible to observe at normal gravity. One example is the spherical diffusion flame surrounding a porous spherical burner. The present paper demonstrates that by superimposing a spherical electrical field on such a flame, the flame remains spherical so that we can study the interaction between the electric field and flame in a one-dimensional fashion. Flames are susceptible to electric fields that are much weaker than the breakdown field of the flame gases owing to the presence of ions generated in the high temperature flame reaction zone. These ions and the electric current of the moving ions, in turn, significantly change the distribution of the electric field. Thus, to understand the interplay between the electric field and the flame is challenging. Numerous experimental studies of the effect of electric fields on flames have been reported. Unfortunately, they were all involved in complex geometries of both the flow field and the electric field, which hinders detailed study of the phenomena. In a one-dimensional domain, however, the electric field, the flow field, the thermal field and the chemical species field are all co-linear. Thus the problem is greatly simplified and becomes more tractable.
- Published
- 2001
42. An Investigation of Fully Modulated, Turbulent Diffusion Flames in Reduced Gravity
- Author
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Hermanson, J. C, Johari, H, Usowicz, J. E, Sangras, R, Stocker, D. P, Hegde, U. G, Nagashima, T, and Obata, S
- Subjects
Inorganic, Organic And Physical Chemistry - Abstract
Pulsed combustion appears to have the potential to provide for rapid fuel/air mixing, compact and economical combustors, and reduced exhaust emissions. The objective of this Flight-Definition experiment (PuFF, for Pulsed-Fully Flames) is to increase the fundamental understanding of the fuel/air mixing and combustion behavior of pulsed, turbulent diffusion flames by conducting experiments in microgravity. In this research the fuel jet is fully modulated (i.e., completely shut off between pulses) by an externally controlled valve system. This gives rise to drastic modification of the combustion and flow characteristics of flames, leading to enhanced fuel/air mixing mechanisms not operative for the case of acoustically excited or partially-modulated jets. The fully-modulated injection approach also simplifies the combustion process by avoiding the acoustic forcing generally present in pulsed combustors. Relatively little is known about the behavior of turbulent flames in reduced-gravity conditions, even in the absence of pulsing. Fundamental issues addressed in this experiment include the impact of buoyancy on the fuel/air mixing and combustion characteristics of fully-modulated flames. It is also important for the planned space experiments to establish the effects of confinement and oxidizer co-flow on these flames.
- Published
- 2001
43. Vortex/Flame Interactions in Microgravity Pulsed Jet Diffusion Flames
- Author
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Bahadori, M. Y, Hegde, U, and Stocker, D. P
- Subjects
Inorganic, Organic And Physical Chemistry - Abstract
Significant differences have been observed between the structure of laminar, transitional, and turbulent flames under downward, upward, and microgravity conditions. These include flame height, jet shear layer, flame instability, flicker, lift-off height, blow-off Reynolds number, and radiative properties. The primary objective of this investigation is to identify the mechanisms involved in the generation and interaction of large-scale structures in microgravity flames. This involves a study of vortex/flame interactions in a space-flight experiment utilizing a controlled, well-defined set of disturbances imposed on a laminar diffusion flame. The results provide a better understanding of the naturally occurring structures that are an inherent part of microgravity turbulent flames. The paper presents the current progress in this program.
- Published
- 2001
44. Characteristics of Non-Premixed Turbulent Flames in Microgravity
- Author
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Hegde, U, Yuan, Z. G, Stocker, D. P, and Bahadori, M. Y
- Subjects
Inorganic, Organic And Physical Chemistry - Abstract
This project is concerned with the characteristics of turbulent hydrocarbon (primarily propane) gas-jet diffusion flames in microgravity. A microgravity environment provides the opportunity to study the structure of turbulent diffusion flames under momentum-dominated conditions (large Froude number) at moderate Reynolds number which is a combination not achievable in normal gravity. This paper summarizes progress made since the last workshop. Primarily, the features of flame radiation from microgravity turbulent jet diffusion flames in a reduced gravity environment are described. Tests were conducted for non-premixed, nitrogen diluted propane flames burning in quiescent air in the NASA Glenn 5.18 Second Zero Gravity Facility. Measured flame radiation from wedge-shaped, axial slices of the flame are compared for microgravity and normal gravity flames. Results from numerical computations of the flame using a k-e model for the turbulence are also presented to show the effects of flame radiation on the thermal field. Flame radiation is an important quantity that is impacted by buoyancy as has been shown in previous studies by the authors and also by Urban et al. It was found that jet diffusion flames burning under microgravity conditions have significantly higher radiative loss (about five to seven times higher) compared to their normal gravity counterparts because of larger flame size in microgravity and larger convective heat loss fraction from the flame in normal gravity. These studies, however, were confined to laminar flames. For the case of turbulent flames, the flame radiation is a function of time and both the time-averaged and time-dependent components are of interest. In this paper, attention is focused primarily on the time-averaged level of the radiation but the turbulent structure of the flame is also assessed from considerations of the radiation power spectra.
- Published
- 2001
45. SAT-324 Study of Ambulatory Blood Pressure Monitoring post kidney donation
- Author
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Parikh, M., primary, Rajapurkar, M., additional, Gang, S., additional, Patel, H., additional, Konnur, A., additional, and Hegde, U., additional
- Published
- 2019
- Full Text
- View/download PDF
46. Characteristics of Non-Premixed Turbulent Flames in Microgravity
- Author
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Hegde, U, Yuan, Z. G, Stocker, D. P, and Bahadori, M. Y
- Subjects
Materials Processing - Abstract
The momentum of the fuel (and/or air) jet is important in classifying gas-jet diffusion flame behavior. Normal-gravity data on gas-jet flames show that the flame height (non-dimensionalized with respect to an effective diameter) can be correlated to a density weighted Froude number in the buoyancy-dominated limit. In the momentum-dominated limit this non-dimensional flame height asymptotes to a constant value. The momentum-dominated limit under normal gravity conditions is usually obtained for very high injection velocities which in turn results in high values of the injection Reynolds number. This results in a complicated flame structure because of the large number of turbulence scales involved. In order to gain better insight into the structure of these flames it would be useful to reduce the injection Reynolds number while still maintaining turbulent conditions. This can be done in microgravity where momentum-dominated turbulent flames are obtained at much smaller velocities than in normal gravity. In this paper, experimental results on the effects of nozzle diameter and fuel dilution on flame height are discussed. The experimental values are compared with predictions from a numerical procedure utilizing the standard k-epsilon turbulence model. Flame height scaling with nozzle size and dilution is established. Differences between model predictions and measurements are presented. In order to explain these differences, evolutions of turbulent spectra and Taylor microscale along the flame axis are considered.
- Published
- 1999
47. Vortex/Flame Interactions in Microgravity Pulsed Jet Diffusion Flames
- Author
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Bahadori, M. Y, Hegde, U, and Stocker, D. P
- Subjects
Materials Processing - Abstract
The problem of vortex/flame interaction is of fundamental importance to turbulent combustion. These interactions have been studied in normal gravity. It was found that due to the interactions between the imposed disturbances and buoyancy induced instabilities, several overall length scales dominated the flame. The problem of multiple scales does not exist in microgravity for a pulsed laminar flame, since there are no buoyancy induced instabilities. The absence of buoyant convection therefore provides an environment to study the role of vortices interacting with flames in a controlled manner. There are strong similarities between imposed and naturally occurring perturbations, since both can be described by the same spatial instability theory. Hence, imposing a harmonic disturbance on a microgravity laminar flame creates effects similar to those occurring naturally in transitional/turbulent diffusion flames observed in microgravity. In this study, controlled, large-scale, axisymmetric vortices are imposed on a microgravity laminar diffusion flame. The experimental results and predictions from a numerical model of transient jet diffusion flames are presented and the characteristics of pulsed flame are described.
- Published
- 1999
48. Hyperferritinaemia in the absence of iron overload
- Author
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Arnold, J D, Mumford, A D, Lindsay, J O, Hegde, U, Hagan, M, and Hawkins, J R
- Published
- 1997
49. Imposed Radiation Effects on Flame Spread over Black PMMA in Low Gravity
- Author
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Olson, S. L and Hegde, U
- Subjects
Inorganic And Physical Chemistry - Abstract
The objective of this work is to determine the effect of varying imposed radiation levels on the flame spread and burning characteristics of PMMA in low gravity. The NASA Learjet is used for these experiments; it provides an environment of 10(exp -2) g's for approximately 20 seconds. Flame spread rates are found to increase non-linearly with increased external radiant flux over the range studied. This range of imposed flux values is believed to be sufficient to compensate for the radiative loss from the flame and the surface.
- Published
- 1994
50. Heat release effects on the instability of parallel shear layers
- Author
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Hegde, U
- Subjects
Fluid Mechanics And Heat Transfer - Abstract
The influence of time-dependent heat addition on the linear instablity of shear layers is of considerable interest in understanding the dynamic behavior of reacting flows and combustion-turbulence interactions. The approach is based upon the Bernoulli enthalpy aeroacoustics theory, which utilizes the specific enthalpy and specific entropy as the primary thermodynamic variables. In addition, velocity oscillations are split into Helmoholtz decomposition theorem.
- Published
- 1994
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