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142 results on '"Heiß, Christiane"'

10. Diffusion-weighted imaging for non-invasive and quantitative monitoring of bone marrow infiltration in patients with monoclonal plasma cell disease: a comparative study with histology

Author

Hillengass, Jens, Bäuerle, Tobias, Bartl, Reiner, Andrulis, Mindaugas, McClanahan, Fabienne, Laun, Frederik B., Zechmann, Christian Martin, Shah, Rajiv, Wagner-Gund, Barbara, Simon, Dirk, Heiss, Christiane, Neben, Kai, Ho, Anthony D., Schlemmer, Heinz-Peter, Goldschmidt, Hartmut, Delorme, Stefan, and Stieltjes, Bram

Published
2011
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12. Biota monitoring and the water framework directive - can normalization overcome shortcomings in sampling strategies?

Author

Fliedner, Annette, Rüdel, Heinz, Teubner, Diana, Buchmeier, Georgia, Lowis, Jaqueline, Heiss, Christiane, Wellmitz, Jörg, Koschorreck, Jan, and Publica

Subjects
Environmental Specimen Bank, normalization, biota monitoring, PFOS, water framework directive, HCB, Hg
Abstract

We compare the results of different monitoring programs regarding spatial and temporal trends of priority hazardous substances of the European Water Framework Directive (WFD). Fish monitoring data for hexachlorobenzene (HCB), mercury (Hg), and perfluorooctane sulfonic acid (PFOS) sampled in German freshwaters between the mid-1990s and 2014 were evaluated according to the recommendations of the 2014 adopted WFD guidance document on biota monitoring, i.e., normalization to 5 % lipid content (HCB) or 26 % dry mass (Hg, PFOS) and adjustment to trophic level (TL) 4. Data of the German Environmental Specimen Bank (ESB) (annual pooled samples of bream) were compared to monitoring data of the German federal states (FS), which refer to individual fish of different species. Significant decreasing trends (p < 0.01) were detected for Hg in bream (Abramis brama) sampled by both, the ESB and the FS between 1993 and 2013 but not for FS samples comprising different fish species. Data for HCB and PFOS were more heterogeneous due to a smaller database and gave no consistent results. Obviously, normalization could not compensate differences in sampling strategies. The results suggest that the data treatment procedure proposed in the guidance document has shortcomings and emphasize the importance of highly standardized sampling programs in trend monitoring or whenever results between sites have to be compared.

Published
2016

14. The use of monitoring data in EU chemicals management - experiences and considerations from the German environmental specimen bank

Author

Koschorreck, Jan, Heiss, Christiane, Wellmitz, Jörg, Fliedner, Annette, Ruedel, Heinz, and Publica

Subjects
time trends, biota monitoring, chemicals management, retrospective monitoring, LOESS smoother, environmental specimenbank
Abstract

Since the 1970s, environmental specimen banks (ESB) have emerged in many countries. Their highly standardised sampling and archiving strategies make them a valuable tool in tracing time trends and spatial distributions of chemicals in ecosystem compartments. The present article intends to highlight the potential of ESBs for regulatory agencies in the European Union (EU). The arguments are supported by examples of retrospective monitoring studies conducted under the programme of the German ESB. These studies have evaluated the success of regulatory and industry provisions for substances of concern (i.e. PCB, polybrominated diphenyl ethers, perfluorinated compounds, alkylphenol compounds, organotin compounds, triclosan/methyl-triclosan, musk fragrances). Time trend studies revealed for example that levels of organotin compounds in marine biota from German coastal waters decreased significantly after the EU had decided on a total ban of organotin-based antifoulings in 2003. Similarly, concentrations of commercially relevant congeners of polybrominated diphenyl ethers decreased in herring gull eggs from the North Sea only after an EU-wide ban in 2004. The data presented demonstrate the usefulness of ESB samples for (retrospective) time trend monitoring and underline the benefit of a more intensive cooperation between chemicals management and specimen banking.

Published
2015

15. Common implementation strategy for the water framework directive (2000/60/EC):Guidance document no. 32 on biota monitoring: (the implementation of EQSbiota) under the water framework directive

Author

Deutsch, Karin, Leroy, Delphine, Belpaire, Claude, den Haan, Klaas, Vrana, Branislav, Clayton, Helen, Hanke, Georg, Ricci, Marina, Held, Andrea, Gawlik, Bernd, Babut, Marc, Perceval, Olivier, Lepom, Peter, Heiss, Christiane, Koschorreck, Jan, O'Toole, Simon, Valsecchi, Sara, Polesello, Stefano, Carere, Mario, ten Hulscher, Dorien, Verbruggen, Eric, Dulio, Valeria, Green, Norman, and Viñas, Lucia

Subjects
fishes (Pisces), legislation, Water management, Europe, Water Framework Directive, water policy, monitoring network for policy support, laboratory analysis
Published
2014

18. Multiple myeloma and monoclonal gammopathy of undetermined significance: importance of whole-body versus spinal MR imaging

Author

Tobias Bäuerle, Thomas Moehler, Lars Grenacher, Stefan Delorme, Kai Neben, Kerstin Fechtner, Hartmut Goldschmidt, Hans-Ulrich Kauczor, Christian M. Zechmann, Heiss Christiane, Barbara Wagner-Gund, and Jens Hillengass

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Paraproteinemias, Sensitivity and Specificity, Diagnosis, Differential, Immunopathology, medicine, Humans, Radiology, Nuclear Medicine and imaging, Whole Body Imaging, Multiple myeloma, Rachis, Aged, Aged, 80 and over, business.industry, Cancer, Reproducibility of Results, Middle Aged, medicine.disease, Mr imaging, Magnetic Resonance Imaging, Spine, Female, Spinal Diseases, Whole body, business, Multiple Myeloma, Monoclonal gammopathy of undetermined significance
Abstract

To examine if standard magnetic resonance (MR) imaging of the axial skeleton is sufficient for evaluation of patients with multiple myeloma (MM) or monoclonal gammopathy of undetermined significance (MGUS) or if whole-body MR is necessary.A total of 100 untreated patients with MGUS (n = 27) or any stages of MM (n = 73) were examined with whole-body MR imaging and MR imaging of the axial skeleton. The study was approved by the institutional ethics committee, and written informed consent was given. Spinal pattern ("no diffuse involvement" or "diffuse involvement" as assessed from the signal intensity of the spinal bone marrow), serum parameters, and stage of disease were correlated with the probability of detecting extra-axial lesions with and without destruction of cortical bone by using a multiple logistic regression model.Of 100 patients, 39 had lesions in the axial skeleton and 37 had lesions in the extra-axial skeleton. Of the latter group, nine patients had no axial lesions and 13 patients had lesions that violated cortical bone, which implied an increased fracture risk. Because of the extraaxial location, lesions in these patients could be diagnosed with whole-body MR only. In addition, no single or combination of clinical factors observed (stage of disease, serum parameters, and spinal pattern) allowed investigators to identify patients with a significantly increased probability of having extra-axial lesions or lesions violating cortical bone.Whole-body MR imaging has potential for use in the initial work-up of patients with MGUS or MM, since almost one-half of all observed lesions would have been missed by using spinal MR imaging only and clinical parameters could not exclude the presence of extra-axial lesions.

Published
2009

22. Combining Information Regarding Chromosomal Aberrations t(4;14), Del(17p13) and the Copy Number of 1q21 with the International Staging System Classification Allows Stratification of Myeloma Patients Undergoing Autologous Stem Cell Transplantation: Results From the HOVON-65/GMMG HD4 Trial

Author

Neben, Kai, primary, Lokhorst, Henk M., additional, Jauch, Anna, additional, Bertsch, Uta, additional, Hielscher, Thomas, additional, Heiss, Christiane, additional, van der Holt, Bronno, additional, Schmitt, Stefan, additional, Jarari, Laila el, additional, Salwender, Hans J., additional, Blau, Igor W., additional, Pfreundschuh, Michael, additional, Weisel, Katja, additional, Duehrsen, Ulrich, additional, Lindemann, Walter, additional, Teschendorf, Christian, additional, Martin, Hans, additional, Scheid, Christof, additional, Haenel, Mathias, additional, Derigs, Hans Guenter, additional, Graeven, Ullrich, additional, Schmidt-Wolf, Ingo GH, additional, Peter, Norma, additional, Wattad, Mohammed, additional, Luntz, Steffen P, additional, Broyl, Annemiek, additional, Schubert, Joerg, additional, Hoffmann, Martin, additional, Goerner, Martin, additional, Tischler, Jochen, additional, Kaufmann, Martin, additional, Raab, Marc S, additional, Ho, Anthony D., additional, van de Velde, Helgi, additional, Hose, Dirk, additional, Sonneveld, Pieter, additional, and Goldschmidt, Hartmut, additional

Published
2011
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23. Impact of Bendamustine Pretreatment on Stem Cell Mobilization and Autologous Stem Cell Transplantation in Patients with Multiple Myeloma

Author

Pönisch, Wolfram, primary, Wiesler, Julia, additional, Wagner, Ina, additional, Leiblein, Sabine, additional, Edel, Elvira, additional, Al-Ali, Haifa K., additional, Vucinic, Vladan, additional, Hegenbart, Ute, additional, Heiß, Christiane, additional, Niederwieser, Dietger, additional, and Goldschmidt, Hartmut, additional

Published
2011
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25. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging of bone marrow in healthy individuals

Author

Hillengass, Jens, primary, Stieltjes, Bram, additional, Bäuerle, Tobias, additional, McClanahan, Fabienne, additional, Heiss, Christiane, additional, Hielscher, Thomas, additional, Wagner-Gund, Barbara, additional, Habetler, Verena, additional, Goldschmidt, Hartmut, additional, Schlemmer, Heinz-Peter, additional, Delorme, Stefan, additional, and Zechmann, Christian M, additional

Published
2011
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27. Correlation of Bone Marrow Cellularity, Plasma Cell Infiltration and Microcirculation with Apparent Diffusion Coefficient of Diffusion Weighted Imaging In Patients with Monoclonal Plasma Cell Disease

Author

Hillengass, Jens, primary, Stieltjes, Bram, additional, Baeuerle, Tobias, additional, McClanahan, Fabienne, additional, Heiss, Christiane, additional, Andrulis, Mindaugas, additional, Bartl, Reiner, additional, Shah, Rajiv, additional, Simon, Dirk, additional, Hose, Dirk, additional, Ho, Anthony D., additional, Schlemmer, Heinz Peter, additional, Goldschmidt, Hartmut, additional, and Delorme, Stefan, additional

Published
2010
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29. The Proportion of Clonal Plasma Cells In the Bone Marrow Analyzed by FISH Rather Than Single Chromosomal Abnormalities Predict Progression From Smoldering to Symptomatic Multiple Myeloma

Author

Neben, Kai, primary, Jauch, Anna, additional, Hose, Dirk, additional, Heiss, Christiane, additional, Hielscher, Thomas, additional, Bertsch, Uta, additional, Seckinger, Anja, additional, Hillengass, Jens, additional, Raab, Marc S., additional, Ho, Anthony D., additional, and Goldschmidt, Hartmut, additional

Published
2010
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32. Prognostic Significance of Focal Lesions in Whole-Body Magnetic Resonance Imaging in Patients With Asymptomatic Multiple Myeloma

Author

Hillengass, Jens, primary, Fechtner, Kerstin, additional, Weber, Marc-André, additional, Bäuerle, Tobias, additional, Ayyaz, Sofia, additional, Heiss, Christiane, additional, Hielscher, Thomas, additional, Moehler, Thomas M., additional, Egerer, Gerlinde, additional, Neben, Kai, additional, Ho, Anthony D., additional, Kauczor, Hans-Ulrich, additional, Delorme, Stefan, additional, and Goldschmidt, Hartmut, additional

Published
2010
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34. Hyperdiploidy Is Rare in Patients with AL Amyloidosis – Identification of Major Cytogenetic Groups in Early Monoclonal Plasma Cell Disorders.

Author

Bochtler, Tilmann, primary, Hegenbart, Ute, additional, Heiss, Christiane, additional, Benner, Axel, additional, Pschowski-Zuck, Stephanie, additional, Kirn, Désirée, additional, Neben, Kai, additional, Moos, Marion, additional, Hose, D., additional, Bartram, Claus R, additional, Ho, Anthony D., additional, Goldschmidt, Hartmut, additional, Jauch, Anna, additional, and Schonland, Stefan, additional

Published
2009
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35. Dynamic Contrast-Enhanced Magnetic Resonance Imaging Identifies a Subgroup of Patients with Asymptomatic Monoclonal Plasma Cell Disease and Pathologic Microcirculation

Author

Hillengass, Jens, primary, Zechmann, Christian, additional, Bäuerle, Tobias, additional, Wagner-Gund, Barbara, additional, Heiss, Christiane, additional, Benner, Axel, additional, Ho, Anthony, additional, Neben, Kai, additional, Hose, Dirk, additional, Kauczor, Hans-Ulrich, additional, Goldschmidt, Hartmut, additional, Delorme, Stefan, additional, and Moehler, Thomas, additional

Published
2009
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37. High-Dose Therapy with Peripheral Blood Stem Cell Transplantation for Patients with Multiple Myeloma: Prognostic Impact of Chromosomal Aberrations and Correlation with the ISS-Score

Author

Neben, Kai, primary, Jauch, Anna, primary, Hose, Dirk, primary, Cremer, Friedrich, primary, Heiss, Christiane, primary, Hielscher, Thomas, primary, Bertsch, Uta, primary, Klein, Ulrike, primary, Hillengass, Jens, primary, Ho, Anthony D., primary, and Goldschmidt, Hartmut, primary

Published
2008
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39. Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability

Author

Bochtler, Tilmann, primary, Hegenbart, Ute, additional, Cremer, Friedrich W., additional, Heiss, Christiane, additional, Benner, Axel, additional, Hose, Dirk, additional, Moos, Marion, additional, Bila, Jelena, additional, Bartram, Claus R., additional, Ho, Anthony D., additional, Goldschmidt, Hartmut, additional, Jauch, Anna, additional, and Schonland, Stefan O., additional

Published
2008
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41. Evaluation of the Cytogenetic Aberration Pattern in AL Amyloidosis Compared to Monoclonal Gammopathies Not Requiring Treatment: Translocation t(11;14) Is More Frequent in AL Amyloidosis.

Author

Bochtler, Tilmann, primary, Schonland, Stefan O., primary, Jauch, Anna, primary, Heiss, Christiane, primary, Benner, Axel, primary, Cremer, Friedrich W., primary, Hose, Dirk, primary, Moos, Marion, primary, Bartram, Claus R., primary, Ho, Anthony D., primary, Goldschmidt, Hartmut, primary, and Hegenbart, Ute, primary

Published
2007
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42. Angiogenic Signature of Multiple Myeloma Determined by Gene Expression Profiling.

Author

Hose, Dirk, primary, Moreaux, Jerome, primary, Meissner, Tobias, primary, Rossi, Jean-Francois, primary, Benner, Axel, primary, Mahtouk, Karene, primary, Seckinger, Anja, primary, Heiss, Christiane, primary, Hundemer, Michael, primary, Reme, Thierry, primary, Hillengass, Jens, primary, Herde, Katja, primary, Bertsch, Uta, primary, DeVos, John, primary, Wenisch, Sabine, primary, Pantesco, Veronique, primary, Jauch, Anna, primary, Jourdan, Eric, primary, Goldschmidt, Hartmut, primary, Klein, Bernard, primary, and Moehler, Thomas, primary

Published
2007
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44. Clonal and Subclonal Cytogenetic Aberrations: Association with D-Type Cyclin Expression and Event-Free Survival (EFS) in Multiple Myeloma (MM).

Author

Hose, Dirk, primary, DeVos, John, additional, Müller, Nadine, additional, Rossi, Jean-Francois, additional, Heiß, Christiane, additional, Mahtouk, Karène, additional, Hundemer, Michael, additional, Reme, Thierry X., additional, Benner, Axel, additional, Moreaux, Jérôme, additional, Pantesco, Véronique, additional, Möhler, Thomas, additional, Jourdan, Eric, additional, Jauch, Anna, additional, Klein, Bernard, additional, and Goldschmidt, Hartmut, additional

Published
2006
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46. Angiogenesis in Multiple Myeloma (MM): Angiogenic Switch or Reflexion of Plasma Cell Number? A Gene Expression Based Survey in Primary Myeloma Cells and the Bone Marrow Microenvironment.

Author

Hose, Dirk, primary, DeVos, John, additional, Heiß, Christiane, additional, Rossi, Jean-Francois, additional, Rösen-Wolff, Angela, additional, Benner, Axel, additional, Mahtouk, Karène, additional, Hundemer, Michael, additional, Reme, Thierry X., additional, Hillengass, Jens, additional, Herde, Katja, additional, Mazitschek, Uta, additional, Moreaux, Jérôme, additional, Wenisch, Sabine, additional, Pantesco, Véronique, additional, Jauch, Anna, additional, Jourdan, Eric, additional, Goldschmidt, Hartmut, additional, Klein, Bernard, additional, and Möhler, Thomas, additional

Published
2006
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47. Authorities Dealing with REACH

Author

Heiß, Christiane, primary, Hoffmann, Caroline, additional, Schulte, Christoph, additional, Tietjen, Lars, additional, and Frank, Ulrike, additional

Published
2006
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48. Autologous retransplantation for patients with recurrent multiple myeloma Autologous retransplantation for patients with recurrent multiple myeloma: A single-center experience with 200 patients.

Author

Sellner, Leopold, Heiss, Christiane, Benner, Axel, Raab, Marc S., Hillengass, Jens, Hose, Dirk, Lehners, Nicola, Egerer, Gerlinde, Ho, Anthony D., Goldschmidt, Hartmut, and Neben, Kai

Subjects
*MULTIPLE myeloma treatment, *DISEASE relapse, *STEM cell transplantation, *CANCER chemotherapy, *SALVAGE therapy, *THERAPEUTICS
Abstract

BACKGROUND Therapeutic options for patients with recurrent multiple myeloma after autologous stem cell transplantation (ASCT) include novel agents, conventional chemotherapy, or salvage ASCT with no standard of care. METHODS A total of 200 patients with multiple myeloma who developed disease recurrence after treatment with upfront ASCT and received an autologous retransplantation as salvage therapy at the study center over a period of 15 years were retrospectively reviewed. The objective of the current study was to evaluate the role of salvage ASCT in terms of efficacy, particularly taking into account the impact of novel agents. RESULTS The median progression-free survival (PFS) and overall survival after salvage ASCT were 15.2 months and 42.3 months, respectively. The overall response rate (a partial response or greater) was 80.4% at day 100, excluding 6 patients who died before assessment. Factors associated with improved PFS and overall survival after salvage ASCT included an initial PFS of > 18 months after upfront ASCT, bortezomib-containing or lenalidomide-containing therapies for reinduction, response to reinduction, and an International Staging System stage of I before salvage ASCT. CONCLUSIONS Salvage ASCT is capable of achieving sustained disease control in patients with multiple myeloma. The use of lenalidomide and bortezomib for reinduction has improved the results after salvage ASCT, suggesting that novel agents and salvage ASCT are complementary rather than alternative treatment approaches. Cancer 2013;119:2438-2446. © 2013 American Cancer Society. [ABSTRACT FROM AUTHOR]

Published
2013
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49. Bewertung von diffusen Stoffeinträgen im Rahmen der nationalen Biodiversitätsstrategie.

Author

Doyle, Ulrike and Heiß, Christiane

Abstract

Copyright of Umweltwissenschaften und Schadstoff-Forschung is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2009
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50. The use of monitoring data in EU chemicals management--experiences and considerations from the German environmental specimen bank.

Author

Koschorreck J, Heiss C, Wellmitz J, Fliedner A, and Rüdel H

Subjects
Animals, Biological Specimen Banks, Charadriiformes, Environmental Pollutants analysis, Germany, Halogenated Diphenyl Ethers, Humans, North Sea, Ovum chemistry, Ecosystem, Environmental Monitoring methods, Environmental Pollution prevention & control
Abstract

Since the 1970s, environmental specimen banks (ESB) have emerged in many countries. Their highly standardised sampling and archiving strategies make them a valuable tool in tracing time trends and spatial distributions of chemicals in ecosystem compartments. The present article intends to highlight the potential of ESBs for regulatory agencies in the European Union (EU). The arguments are supported by examples of retrospective monitoring studies conducted under the programme of the German ESB. These studies have evaluated the success of regulatory and industry provisions for substances of concern (i.e. PCB, polybrominated diphenyl ethers, perfluorinated compounds, alkylphenol compounds, organotin compounds, triclosan/methyl-triclosan, musk fragrances). Time trend studies revealed for example that levels of organotin compounds in marine biota from German coastal waters decreased significantly after the EU had decided on a total ban of organotin-based antifoulings in 2003. Similarly, concentrations of commercially relevant congeners of polybrominated diphenyl ethers decreased in herring gull eggs from the North Sea only after an EU-wide ban in 2004. The data presented demonstrate the usefulness of ESB samples for (retrospective) time trend monitoring and underline the benefit of a more intensive cooperation between chemicals management and specimen banking.

Published
2015
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