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The Old Testament is clearly a mixture of myths and real historical figures with their events. There is no question about the contribution of mythology, since much of Genesis has been formed from common mythological accounts from all over the ancient Near East. The stories of Creation, the primordial couple, the Garden of Eden, Cain and Abel, the Great Flood, and much more, are a commonplace of narratives throughout the region. Although these accounts are mythological, it does not mean that they have not been shaped by real events. Specialists speculate about a great flood that took place in the Near East as a result of rising water levels at the end of the last Ice Age (around 5000 BC). This coincided at a time when the Agricultural Revolution had taken over the Fertile Crescent and Egypt. Various peoples of the Levant adopted mythological narratives and reformulated them to create their own unique and original tales. Some of the main figures of the Bible, such as Adam and Eve, Noah, Lot, finally the patriarchs (Abraham, Isaac and Jacob) were their own compositions but, as can be seen with the patriarch Abraham, who was not an exclusive figure of the Hebrew people, his conversion to monotheism is, however, something peculiar to the spiritual creativity of the Jews. Here as in the composition of the New Testament, archeology is the necessary aid to locate the reality and the truth of sacred history and its development in human time.

Energy harvesters that scavenge biomechanical energy are promising power supply candidates for wearable and implantable electronics. Of the most widely used energy harvesters, piezoelectric generators can generate more electric charge than their triboelectric counterparts with similar device size, thus are more suitable to make compact wearable devices. However, most high-power piezoelectric generators are made from lead zirconate titanate, making them undesirable for wearable applications due to the toxic lead element. In this study, a flexible piezoelectric generator (F-PEG) is fabricated with chemically stable and biocompatible Group-III-nitride (III-N) thin film by a layer-transfer method. The III-N thin-film F-PEG can generate an open-circuit voltage of 50 V, a short-circuit current of 15 µA, and a maximum power of 167 µW at a load resistance of 5 MΩ. Applications of the III-N thin-film F-PEG are demonstrated by directly powering electronics such as light-emitting diodes and electric watches, and by charging commercial capacitors and batteries to operate an optical pulse sensor. Furthermore, the III-N thin-film F-PEG shows good durability and a stable output after being subjected to severe buckling tests of over 30,000 cycles.

Consumers are widely adopting Artificially Intelligent Voice Assistants (AIVAs). AIVAs now handle many different everyday tasks and are also increasingly assisting consumers with purchasing decisions, making AIVAs a rich topic for marketing researchers. We develop a series of propositions regarding how consumer decision-making processes may change when moved from traditional online purchase environments to AI-powered voice-based dialogs, in the hopes of encouraging further academic thinking and research in this rapidly developing, high impact area of consumer-firm interaction. We also provide suggestions for marketing managers and policymakers on points to pay attention to when they respond to the proposed effects of AIVAs on consumer decisions.

Informal caregiving is a critical component of the US long-term care system, but can have significant negative impacts on caregiver employment, finances, and well-being. An online survey of Colorado caregivers was piloted in 2016-17 to explore whether workplace and social policies such as access to paid family leave and public health insurance can buffer the negative financial impacts of caregiving and help caregivers to remain in the workforce. Using standardized measures, the survey assessed caregivers' employment and financial status, well-being (physical and mental health, caregiver strain, benefits of caregiving), access to workplace supports, and covariates (e.g., caregiver demographics, health, social support, and service utilization). Ninety-five caregivers, recruited through community agency partners, completed the survey. Respondents were predominately female (89%), middle-aged (M = 57), non-Hispanic White (64%) or Latino/a (22%), and caring for a parent (40%) or spouse (30%) for over one year. Half (51%) reported working full- or part-time jobs, while 16.4% had stopped working because of caregiving. In multivariate regression modeling, predictors of financial strain included the care recipients' financial strain and the caregiver's reduction or ceasing of work. Medicare may be protective to minimize caregivers' need to reduce or cease work. Implications for caregivers' ability to stay engaged in the workforce and prepare for their own retirement are explored.

The Consumer Financial Protection Bureau (CFPB) has authority over several consumer financial protection laws that include mandatory disclosures to provide consumers with the information needed to make financial decisions. Mandatory disclosure is a common regulatory tool that presents opportunities to support consumers in their decision making; however, many aspects of disclosure effectiveness remain understudied. The CFPB is committed to studying mandatory disclosure to better inform policy makers about whether and how best to use disclosures to achieve policy goals. This research effort focuses on three primary areas: (1) identifying how the dimensions of a disclosure influence its efficacy; (2) examining how different methodologies should best be deployed for disclosure testing; and (3) studying the market effects of mandatory disclosures, particularly through firms’ responses. The CFPB will use a range of methodologies for this research, including qualitative and quantitative testing of disclosures, laboratory studies, field trials, survey research, and administrative data analysis. The authors hope that identifying these critical questions will encourage the academic community to contribute policy-relevant research.

This article focuses on the great projects carried out in North Yorkshire and beyond that use music to boost confidence and participation among mums and children, while highlighting the observable benefits.

Type 2 diabetes mellitus (T2D) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance, which the CDC estimates currently afflicts one in ten U.S. adults and is projected to continue to rise sharply over the next 50 years. Acyl peptide enzyme hydrolase (APEH), an enzyme circulating in peripheral blood, has been implicated in rodent models of diabetes. To understand if APEH is affected in diabetes, the APEH activity was measured in the blood serum of patients with T2D compared to age-matched controls. Our results show that APEH activity is 22% lower (p = 0.0163) in T2D patients compared to matched controls. Importantly, there was no observable difference in APEH protein expression between cohorts, suggesting that APEH activity is regulated at the protein level. This work is important as it contributes to our knowledge of T2D and the role of APEH in human disease.

We present recent development in flexible wide-bandgap semiconductor materials and devices. Especially, we focus on mechanically bendable group-III-nitride (III-N) thin-film heterostructures and their photonic, electronic, and energy-harvesting devices in energy applications. The presentation will cover various topics including (1) multi-functionality of flexible III-N devices, (2) direct growth of high-quality single-crystal-like GaN semiconductor thin films on low-cost flexible metal tapes, and (3) piezoelectric generators and sensors for self-powered wearable systems by harvesting and sensing ambient biomechanical energy. Flexible III-N thin-film heterostructures have an implication of more than just mechanically flexible materials. Bendable devices based on III-N heterostructures can be equipped with new functionalities and even further improved performance characteristics using a new concept of active polarization engineering by controlled external strains. We propose to develop multi-functional and/or further-improved-performance devices by utilizing the interactions between electronic and optical properties and mechanical forces in the flexible III-N heterostructures. The concept will enable new mechano-electro-photonic (MEP) devices. We will show by device modeling that new device concept in flexible transistors based on AlGaInN/GaN heterostructure is possible, including modulation of 2-dimensional electron gas (2DEG) density by bending, strain-effect transistors (Figure 1: I-V characteristics of strain-effect transistors), and high-hole-mobility transistors. Furthermore, photon emitters based on flexible III-N heterostructure can result in higher internal quantum efficiency (IQE), higher wall-plug efficiency (WPE), and color modulation by optimum bending conditions (Figure 2: Concept of color-tunable white light-emitting diodes). We study and develop nearly-single-crystalline GaN thin film on flexible metal tapes by a direct deposition technique for the demonstration of a new wide-bandgap semiconductor platform, targeting high-performance yet economical, flexible, and versatile device technology. Data and analysis are presented for the single-crystal-like film, as representatively shown in Figure 3 (Flexible hybrid tape substrate consisting of GaN thin film and Cu tape with crystallinity-transformational buffer layers). Energy harvesters that scavenge biomechanical energy are promising power supply candidates for wearable and implantable electronics. Of the most widely used energy harvesters, piezoelectric generators can generate more electric charge than their triboelectric counterparts with similar device size, thus are more suitable to make compact wearable devices. We develop a flexible piezoelectric generator (F-PEG) with chemically stable and biocompatible III-N thin film. Data and analysis are presented for the flexible III-N F-PEG. We also demonstrate that the F-PEG can directly power electronics such as light-emitting diodes and electric watches, and charge commercial capacitors and batteries to operate an optical pulse sensor, as representatively shown in Figure 4 (Pulse sensor powered by F-PEG and heart rate measurement on a fingertip). Figure 1

The Behavioral Life‐Cycle hypothesis (Thaler & Shefrin, 1981) models consumers as having both impatient “doer” preferences, representing their desire to spend now, and patient “planner” preferences, representing long‐run welfare considerations. The Behavioral Life‐Cycle hypothesis suggests that those with doer preferences may benefit from strategies that constrain their present behavior and promote saving for the future, like automating deposits into savings accounts. We analyze over 4,000 responses from the nationally representative National Financial Well‐Being Survey to (a) describe consumer characteristics associated with the decision to automate savings deposits, and (b) explore whether automation is related to improved financial welfare, especially for impatient consumers. We find that savings automation is positively associated with financial socialization (whether the respondent's family discussed financial matters growing up) and financial skill (the ability to act on financial knowledge). We also find that impatient consumers — relative to those with stronger planner preferences — have fewer liquid savings, lower financial well‐being, less confidence in their ability to raise $2,000, and more difficulty paying bills. However, as predicted, these differences between consumers with doer and planner preferences largely disappear for those who automate savings deposits. We discuss implications of this research for financial planners in helping clients improve financial welfare. Full Text Available Here: https://doi.org/10.1002/cfp2.1020

The study's aim was to determine migraine prevalence, severity, and educational impact in medical students.A 23-item survey of all medical students of one US medical school addressed migraine frequency, triggers, pattern and severity of symptoms, medication use, impact on educational activities and career choices.The response rate was 48% (359 students). Eighty-nine (24.8%) self-reported migraine, and all were confirmed by reported symptoms. Of these students, 54% had a physician-confirmed diagnosis. Migraine prevalence was 35% in women and 14.1% in men. About half of migraineurs reported one or more attacks monthly. Stress and sleep disturbances were the most common triggers. Pain severity was rated 7 or higher on a 10-point scale by 73%. NSAIDs were the most common medications used. Only 13% used prophylaxis. More than 80% reported reduced productivity during migraine, but 76% felt obliged to attend educational activities despite symptoms. A total of 81% of students did not endorse informing faculty about migraine status, and 95% would not disclose it in residency application. Migraine was not a factor in choice of medical specialty or specific residency program.Migraine is common in medical students, especially women. Only half have consulted a physician for migraine, and students may be using suboptimal treatments. Although more than half experience severe symptoms that impair performance, the majority attend educational sessions during migraine attacks, and they believe this is expected. Students are unwilling to disclose migraine status to faculty or during application to residency. Migraine does not influence career choices.

The Community Development Block Grant (CDBG) program is one of the longest running programs of the U.S. Department of Housing and Urban Development’s (HUD) Office of Community Planning and Development (CPD). CDBG is a grant to states and local governments that is distributed by a need-based formula. Fiscal year (FY) 2012 marks the first year that the CDBG allocation formula will rely on the Census Bureau’s new annual data source — the American Community Survey (ACS) — and the 2010 Census population counts. This report introduces the ACS to CDBG stakeholders and provides detailed information on how using the 2010 Census and ACS data shifts funding amounts. This analysis compares actual FY 2011 allocations with alternate allocations using FY 2011 appropriations, the FY 2011 grantee universe, and the new data that will be used in FY 2012. Allocations presented should not be interpreted as actual FY 2012 grant amounts.The supplemental data table provides detailed information on the specific data used for each community to determine its CDBG formula allocation. The table also shows the change in its relative share of that variable among all communities and the resulting impact of the change in relative share on each grantee’s allocation. In order to demonstrate the impact of the data change, this table does not reflect the change in appropriation between FY 2011 and FY 2012. The actual change in a grantee’s funding from FY 2011 to FY 2012 will be due to both a change in the data and a change in appropriation amount. This table only shows the impact of the data change.

PURPOSE The purpose of this study was to compare the Pediatric Evaluation of Disability Inventory (PEDI) and the Mullen Scales of Early Learning (MSEL) as measures of change in children who received early intervention services. METHODS Thirty-four children were stratified into 2 groups according to the presence of gross motor delay. The PEDI and MSEL were administered 3 times: at an average age of 18, 31, and 53 months of age. Data were analyzed using a repeated-measures multivariate analysis of variance. RESULTS The findings suggest that PEDI Functional Skills Scaled Scores were capable of measuring change in both groups of children. The standard scores on the PEDI Functional Skills Social Scale were found to be more sensitive to change than the MSEL Receptive and Expressive Language scores for children with motor delays. CONCLUSION Using PEDI scaled scores may be an effective strategy for measuring change in children receiving early intervention services.

Principal Component Analysis (PCA) has proven to be a valuable tool for remote sensing data compression, pattern recognition, and for filtering out measurement noise. In this pa per, we present preliminary results on the application of PCA technique to reduce random noise present in lidar observations. Typically, the SNR at a given range can be improved either by increasing the integration time of the meas urements or by applying spatia l averaging. Th is procedure, however, improves the SNR at the expense of the instrument’s temporal and spatial resolution. The number of range bins needed to characterize backscatter features is far less than the number of components needed to characterize the distribution of these features in the atmosphere. The higher-order PCA components, which mainly serve to characterize noise, can be eliminated along with the noise that they characterize. The results of PCA noise filtering of lidar observations strongly depend on the variability of aerosol plum es. To avoid loss of information in the presence of highly variable aerosol plumes, it is necessary to use a conservative number of principal components higher then optimum for maximum noise reduction. Nevertheless, noise reduction factors of 2-8, depending on the lidar range and atmospheric variability, can still be achieved. Keywords: Remote sensing, Principal Component Analysis, lidar, aerosols, pollution, air quality

Background and Purpose The purpose of this study was to qualitatively explore clinical instructors’ (CIs) perceptions of students’ behaviors that comprise entry-level clinical performance, as well as how those perceptions were integrated into their decision making. Subjects The participants were 21 physical therapists who were CIs for physical therapist students. Methods Using a grounded theory approach, we conducted interviews, asking the question, “What is it about students’ performance that makes you see them as entry-level therapists?” We determined common themes among the interviews and developed a schema to explain the decision-making process. Results Participants identified 7 attributes that, when demonstrated to a sufficient degree, illustrated to them students’ ability to practice at the entry level. Those attributes were knowledge, clinical skills, safety, clinical decision making, self-directed learning, interpersonal communication, and professional demeanor. Participants viewed these attributes in concert to form a subjective “gut feeling” that a student demonstrated entry-level performance. A final theme emerged suggesting a definition of entry-level performance as “mentored independence.” Discussion and Conclusions Participants reported evaluating students’ performance based on attributes similar to those suggested by the American Physical Therapy Association's Physical Therapist Clinical Performance Instrument and previous research. However, subjectivity also was involved in their decision about whether students were able to practice at the entry level. Participants also concluded that entry-level students need not be independent in all clinical situations.

Centrosome amplification plays a key role in the origin of chromosomal instability during cancer development and progression. In this study, breast cancer cell lines with different p53 backgrounds were used to investigate the relationship between genotoxic stress, G(1)/S cell cycle checkpoint integrity, and the development of centrosome amplification. Introduction of DNA damage in the MCF-7 cell line by treatment with hydroxyurea (HU) or daunorubicin (DR) resulted in the arrest of both G(1)/S cell cycle progression and centriole duplication. In these cells, which carry functional p53, HU treatment also led to nuclear accumulation of p53 and p21(WAF1), retinoblastoma hypophosphorylation, and downregulation of cyclin A. MCF-7 cells carrying a recombinant dominant-negative p53 mutant (vMCF-7(DNp53)) exhibited a shortened G(1) phase of the cell cycle and retained a normal centrosome phenotype. However, these cells developed amplified centrosomes following HU treatment. The MDA-MB 231 cell line, which carries mutant p53 at both alleles, showed amplified centrosomes at the outset, and developed a hyperamplified centrosome phenotype following HU treatment. In cells carrying defective p53, the development of centrosome amplification also occurred following treatment with another DNA damaging agent, DR. Taken together, these findings demonstrate that loss of p53 function alone is not sufficient to drive centrosome amplification, but plays a critical role in this process following DNA damage through abrogation of the G(1)/S cell cycle checkpoint. Furthermore, these studies have important clinical implications because they suggest that breast cancers with compromised p53 function may develop centrosome amplification and consequent chromosomal instability following treatment with genotoxic anticancer drugs.