140 results on '"Heikkila, K"'
Search Results
2. Editor's Choice – Delays to Surgery and Procedural Risks Following Carotid Endarterectomy in the UK National Vascular Registry
- Author
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Loftus, I.M., Paraskevas, K.I., Johal, A., Waton, S., Heikkila, K., Naylor, A.R., and Cromwell, D.A.
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- 2016
- Full Text
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3. Long-term survival after endovascular and open repair of unruptured abdominal aortic aneurysm
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Johal, AS, Loftus, IM, Boyle, JR, Heikkila, K, Waton, S, and Cromwell, DA
- Abstract
BACKGROUND: The aim of this study was to examine patterns of 10-year survival after elective repair of unruptured abdominal aortic aneurysms (AAAs) in different patient groups. METHODS: Patients having open repair or endovascular aneurysm repair (EVAR) in the English National Health Service between January 2006 and December 2015 were identified from Hospital Episode Statistics data. Postoperative survival among patients of different age and Royal College of Surgeons of England (RCS) modified Charlson co-morbidity score profiles were analysed using flexible parametric survival models. The relationship between patient characteristics and risk of rupture after repair was also analysed. RESULTS: Some 37 138 patients underwent elective AAA repair, of which 15 523 were open and 21 615 were endovascular. The 10-year mortality rate was 38·1 per cent for patients aged under 70 years, and the survival trajectories for open repair and EVAR were similar when patients had no RCS-modified Charlson co-morbidity. Among older patients or those with co-morbidity, the 10-year mortality rate rose, exceeding 70 per cent for patients aged 80 years. Mean survival times over 10 years for open repair and EVAR were often similar in subgroups of older and more co-morbid patients, but their survival trajectories became increasingly dissimilar, with open repair showing greater short-term risk within 6 months but lower 10-year mortality rates. The risk of rupture over 9 years was 3·4 per cent for EVAR and 0·9 per cent for open repair, and was weakly associated with patient factors. CONCLUSION: Long-term survival patterns after elective open repair and EVAR for unruptured AAA vary markedly across patients with different age and co-morbidity profiles.
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- 2019
4. P60 Job strain and peripheral artery disease: a multi-cohort study
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Heikkila, K, primary and Consortium, IPD-Work, additional
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- 2020
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5. Changing Patterns of Carotid Endarterectomy Between 2011 and 2017 in England: A Population-Based Cohort Study
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Johal, A.S., primary, Loftus, I.M., additional, Boyle, J.R., additional, Naylor, R., additional, Watson, S., additional, and Heikkila, K., additional
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- 2019
- Full Text
- View/download PDF
6. GENOME-WIDE GENETIC LINKAGE ANALYSIS OF A QUANTITATIVE TRAIT IN AN AUSTRALIAN AND FINNISH STUDY OF NICOTINE DEPENDENCE
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Saccone, S., Agrawal, A., Pergadia, M., Dick, D., Todorov, A., Loukola, A., Broms, U., Maunu, H., Widen, E., Heikkila, K., Rice, J., Montgomery, G., Martin, N., Kaprio, J., Peltonen, L., and Madden, P.
- Published
- 2009
7. GENOME-WIDE GENETIC LINKAGE ANALYSIS OF A QUANTITATIVE TRAIT IN AN AUSTRALIAN AND FINNISH STUDY OF NICOTINE DEPENDENCE
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Saccone, S., Agrawal, A., Pergadia, M., Dick, D., Todorov, A., Loukola, A., Broms, U., Maunu, H., Widen, E., Heikkila, K., Rice, J., Montgomery, G., Martin, N., Kaprio, J., Peltonen, L., and Madden, P.
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- 2005
8. Genome Wide Scan and Candidate Gene Analysis in a Family Study on Nicotine Dependence - Session: Genetics of Nicotine Dependence (Symposium)
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Loukola, A, Maunu, H, Salo, A, Laiho, S, Widen, E, Broms, U, Siivola, M, Heikkila, K, Martin, NG, Peltonen, L, Madden, PAF, and Kaprio, J
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- 2004
9. Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project
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Jelenkovic, A, Yokoyama, Y, Sund, R, Hur, Y-M, Harris, JR, Brandt, I, Nilsen, TS, Ooki, S, Ullemar, V, Almqvist, C, Magnusson, PKE, Saudino, KJ, Stazi, MA, Fagnani, C, Brescianini, S, Nelson, TL, Whitfield, KE, Knafo-Noam, A, Mankuta, D, Abramson, L, Cutler, TL, Hopper, JL, Llewellyn, CH, Fisher, A, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Bjerregaard-Andersen, M, Nielsen, HB, Sodemann, M, Krueger, RF, McGue, M, Pahlen, S, Burt, SA, Klump, KL, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Willemsen, G, Bartels, M, van Beijsterveld, CEM, Craig, JM, Saffery, R, Rasmussen, F, Tynelius, P, Heikkila, K, Pietilainen, KH, Bayasgalan, G, Narandalai, D, Haworth, CMA, Plomin, R, Ji, F, Ning, F, Pang, Z, Rebato, E, Tarnoki, AD, Tarnoki, DL, Kim, J, Lee, J, Lee, S, Sung, J, Loos, RJF, Boomsma, DI, Sorensen, TIA, Kaprio, J, Silventoinen, K, Jelenkovic, A, Yokoyama, Y, Sund, R, Hur, Y-M, Harris, JR, Brandt, I, Nilsen, TS, Ooki, S, Ullemar, V, Almqvist, C, Magnusson, PKE, Saudino, KJ, Stazi, MA, Fagnani, C, Brescianini, S, Nelson, TL, Whitfield, KE, Knafo-Noam, A, Mankuta, D, Abramson, L, Cutler, TL, Hopper, JL, Llewellyn, CH, Fisher, A, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Bjerregaard-Andersen, M, Nielsen, HB, Sodemann, M, Krueger, RF, McGue, M, Pahlen, S, Burt, SA, Klump, KL, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Willemsen, G, Bartels, M, van Beijsterveld, CEM, Craig, JM, Saffery, R, Rasmussen, F, Tynelius, P, Heikkila, K, Pietilainen, KH, Bayasgalan, G, Narandalai, D, Haworth, CMA, Plomin, R, Ji, F, Ning, F, Pang, Z, Rebato, E, Tarnoki, AD, Tarnoki, DL, Kim, J, Lee, J, Lee, S, Sung, J, Loos, RJF, Boomsma, DI, Sorensen, TIA, Kaprio, J, and Silventoinen, K
- Abstract
BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. RESULTS: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. CONCLUSION: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.
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- 2018
10. Genetic studies of body mass index yield new insights for obesity biology
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Locke, A, Kahali, B, Berndt, S, Justice, A, Pers, T, Day, F, Powell, C, Vedantam, S, Buchkovich, M, Yang, J, Croteau-Chonka, D, Esko, T, Fall, T, Ferreira, T, Gustafsson, S, Kutalik, Z, Luan, J, Magi, R, Randall, J, Winkler, T, Wood, A, Workalemahu, T, Faul, J, Smith, J, Zhao, J, Zhao, W, Chen, J, Fehrmann, R, Hedman, A, Karjalainen, J, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bolton, J, Bragg-Gresham, J, Buyske, S, Demirkan, A, Deng, G, Ehret, G, Feenstra, B, Feitosa, M, Fischer, K, Goel, A, Gong, J, Jackson, A, Kanoni, S, Kleber, M, Kristiansson, K, Lim, U, Lotay, V, Mangino, M, Leach, I, Medina-Gomez, C, Medland, S, Nalls, M, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Shungin, D, Stancakova, A, Strawbridge, R, Sung, Y, Tanaka, T, Teumer, A, Trompet, S, van der Laan, S, van Setten, J, Van Vliet-Ostaptchouk, J, Wang, Z, Yengo, L, Zhang, W, Isaacs, A, Albrecht, E, Arnlov, J, Arscott, G, Attwood, A, Bandinelli, S, Barrett, A, Bas, I, Bellis, C, Bennett, A, Berne, C, Blagieva, R, Bluher, M, Bohringer, S, Bonnycastle, L, Bottcher, Y, Boyd, H, Bruinenberg, M, Caspersen, I, Chen, Y, Clarke, R, Daw, E, de Craen, A, Delgado, G, Dimitriou, M, Doney, A, Eklund, N, Estrada, K, Eury, E, Folkersen, L, Fraser, R, Garcia, M, Geller, F, Giedraitis, V, Gigante, B, Go, A, Golay, A, Goodall, A, Gordon, S, Gorski, M, Grabe, H, Grallert, H, Grammer, T, Grassler, J, Gronberg, H, Groves, C, Gusto, G, Haessler, J, Hall, P, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heard-Costa, N, Helmer, Q, Hengstenberg, C, Holmen, O, Hottenga, J, James, A, Jeff, J, Johansson, A, Jolley, J, Juliusdottir, T, Kinnunen, L, Koenig, W, Koskenvuo, M, Kratzer, W, Laitinen, J, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindstrom, J, Lo, K, Lobbens, S, Lorbeer, R, Lu, Y, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Mclachlan, S, Menni, C, Merger, S, Mihailov, E, Milani, L, Moayyeri, A, Monda, K, Morken, M, Mulas, A, Muller, G, Muller-Nurasyid, M, Musk, A, Nagaraja, R, Nothen, M, Nolte, I, Pilz, S, Rayner, N, Renstrom, F, Rettig, R, Ried, J, Ripke, S, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Schumacher, F, Scott, W, Seufferlein, T, Shi, J, Smith, A, Smolonska, J, Stanton, A, Steinthorsdottir, V, Stirrups, K, Stringham, H, Sundstrom, J, Swertz, M, Swift, A, Syvanen, A, Tan, S, Tayo, B, Thorand, B, Thorleifsson, G, Tyrer, J, Uh, H, Vandenput, L, Verhulst, F, Vermeulen, S, Verweij, N, Vonk, J, Waite, L, Warren, H, Waterworth, D, Weedon, M, Wilkens, L, Willenborg, C, Wilsgaard, T, Wojczynski, M, Wong, A, Wright, A, Zhang, Q, Brennan, E, Choi, M, Dastani, Z, Drong, A, Eriksson, P, Franco-Cereceda, A, Gadin, J, Gharavi, A, Goddard, M, Handsaker, R, Huang, J, Karpe, F, Kathiresan, S, Keildson, S, Kiryluk, K, Kubo, M, Lee, J, Liang, L, Lifton, R, Ma, B, Mccarroll, S, Mcknight, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Okada, Y, Perry, J, Dorajoo, R, Reinmaa, E, Salem, R, Sandholm, N, Scott, R, Stolk, L, Takahashi, A, Van't Hooft, F, Vinkhuyzen, A, Westra, H, Zheng, W, Zondervan, K, Heath, A, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Bovet, P, Campbell, H, Caulfield, M, Cesana, G, Chakravarti, A, Chasman, D, Chines, P, Collins, F, Crawford, D, Cupples, L, Cusi, D, Danesh, J, de Faire, U, Den Ruijter, H, Dominiczak, A, Erbel, R, Erdmann, J, Eriksson, J, Farrall, M, Felix, S, Ferrannini, E, Ferrieres, J, Ford, I, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gejman, P, Gieger, C, Gottesman, O, Gudnason, V, Gyllensten, U, Hall, A, Harris, T, Hattersley, A, Hicks, A, Hindorff, L, Hingorani, A, Hofman, A, Homuth, G, Hovingh, G, Humphries, S, Hunt, S, Hypponen, E, Illig, T, Jacobs, K, Jarvelin, M, Jockel, K, Johansen, B, Jousilahti, P, Jukema, J, Jula, A, Kaprio, J, Kastelein, J, Keinanen-Kiukaanniemi, S, Kiemeney, L, Knekt, P, Kooner, J, Kooperberg, C, Kovacs, P, Kraja, A, Kumari, M, Kuusisto, J, Lakka, T, Langenberg, C, Marchand, L, Lehtimaki, T, Lyssenko, V, Mannisto, S, Marette, A, Matise, T, Mckenzie, C, Mcknight, B, Moll, F, Morris, A, Murray, J, Nelis, M, Ohlsson, C, Oldehinkel, A, Ong, K, Madden, P, Pasterkamp, G, Peden, J, Peters, A, Postma, D, Pramstaller, P, Price, J, Qi, L, Raitakari, O, Rankinen, T, Rao, D, Rice, T, Ridker, P, Rioux, J, Ritchie, M, Rudan, I, Salomaa, V, Samani, N, Saramies, J, Sarzynski, M, Schunkert, H, Schwarz, P, Sever, P, Shuldiner, A, Sinisalo, J, Stolk, R, Strauch, K, Tonjes, A, Tregouet, D, Tremblay, A, Tremoli, E, Virtamo, J, Vohl, M, Volker, U, Waeber, G, Willemsen, G, Witteman, J, Zillikens, M, Adair, L, Amouyel, P, Asselbergs, F, Assimes, T, Bochud, M, Boehm, B, Boerwinkle, E, Bornstein, S, Bottinger, E, Bouchard, C, Cauchi, S, Chambers, J, Chanock, S, Cooper, R, de Bakker, P, Dedoussis, G, Ferrucci, L, Franks, P, Froguel, P, Groop, L, Haiman, C, Hamsten, A, Hui, J, Hunter, D, Hveem, K, Kaplan, R, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Martin, N, Marz, W, Melbye, M, Metspalu, A, Moebus, S, Munroe, P, Njolstad, I, Oostra, B, Pedersen, N, Perola, M, Perusse, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T, Saleheen, D, Sattar, N, Schadt, E, Schlessinger, D, Slagboom, P, Snieder, H, Spector, T, Thorsteinsdottir, U, Stumvoll, M, Tuomilehto, J, Uitterlinden, A, Uusitupa, M, van der Harst, P, Walker, M, Wallaschofski, H, Wareham, N, Watkins, H, Weir, D, Wichmann, H, Wilson, J, Zanen, P, Borecki, I, Deloukas, P, Fox, C, Heid, I, O'Connell, J, Strachan, D, Stefansson, K, van Duijn, C, Abecasis, G, Franke, L, Frayling, T, Mccarthy, M, Visscher, P, Scherag, A, Willer, C, Boehnke, M, Mohlke, K, Lindgren, C, Beckmann, J, Barroso, I, North, K, Ingelsson, E, Hirschhorn, J, Loos, R, Speliotes, E, Thompson, J, Goldstein, B, Konig, I, Cazier, J, Grundberg, E, Havulinna, A, Ho, W, Hopewell, J, Eriksson, N, Lundmark, P, Lyytikainen, L, Rafelt, S, Tikkanen, E, Van Zuydam, N, Voight, B, Ziegler, A, Altshuler, D, Balmforth, A, Braund, P, Burgdorf, C, Claudi-Boehm, S, Cox, D, Do, R, El Mokhtari, N, Fontanillas, P, Hager, J, Han, B, Kang, H, Kessler, T, Knowles, J, Kolovou, G, Langford, C, Lokki, M, Lundmark, A, Meisinger, C, Melander, O, Maouche, S, Nikus, K, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M, Schafer, A, Sivananthan, M, Song, C, Stewart, A, Thorgeirsson, G, van der Schoot, C, Wagner, P, Wells, G, Wild, P, Tsun-Po, Y, Basart, H, Brambilla, P, Cambien, F, Cupples, A, Dehghan, A, Diemert, P, Epstein, S, Evans, A, Ferrario, M, Gauguier, D, Hazen, S, Holm, H, Iribarren, C, Jang, Y, Kahonen, M, Kee, F, Kim, H, Klopp, N, Kuulasmaa, K, Laaksonen, R, Ouwehand, W, Parish, S, Park, J, Rader, D, Shah, S, Stark, K, Wallentin, L, Zimmermann, M, Nieminen, M, Sandhu, M, Pastinen, T, Zalloua, P, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S, O'Donnell, C, Reilly, M, Collins, R, Roberts, R, Pattaro, C, Kottgen, A, Garnaas, M, Boger, C, Fuchsberger, C, Olden, M, Chen, M, Tin, A, Taliun, D, Li, M, Gao, X, Yang, Q, Hundertmark, C, Foster, M, O'Seaghdha, C, Glazer, N, Liu, C, Struchalin, M, Li, G, Johnson, A, Gierman, H, Hwang, S, Atkinson, E, Lohman, K, Cornelis, M, Chouraki, V, Holliday, E, Sorice, R, Deshmukh, H, Ulivi, S, Chu, A, Murgia, F, Imboden, M, Kollerits, B, Pistis, G, Launer, L, Aspelund, T, Eiriksdottir, G, Mitchell, B, Schmidt, H, Cavalieri, M, Rao, M, Hu, F, de Andrade, M, Turner, S, Ding, J, Andrews, J, Freedman, B, Doring, A, Kolcic, I, Zemunik, T, Boban, M, Minelli, C, Wheeler, H, Igl, W, Zaboli, G, Wild, S, Ellinghaus, D, Nothlings, U, Jacobs, G, Biffar, R, Endlich, K, Ernst, F, Kroemer, H, Nauck, M, Stracke, S, Volzke, H, Aulchenko, Y, Polasek, O, Hastie, N, Vitart, V, Helmer, C, Wang, J, Ruggiero, D, Bergmann, S, Viikari, J, Nikopensius, T, Province, M, Ketkar, S, Colhoun, H, Robino, A, Giulianini, F, Kramer, B, Portas, L, Buckley, B, Adam, M, Thun, G, Paulweber, B, Haun, M, Sala, C, Metzger, M, Mitchell, P, Ciullo, M, Kim, S, Vollenweider, P, Gasparini, P, Pirastu, M, Probst-Hensch, N, Kronenberg, F, Toniolo, D, Coresh, J, Schmidt, R, Siscovick, D, Kardia, S, Curhan, G, Franke, A, Parsa, A, Goessling, W, Kao, W, de Boer, I, Peralta, C, Akylbekova, E, Kramer, H, Arking, D, Franceschini, N, Egan, J, Hernandez, D, Townsend, R, Lumley, T, Psaty, B, Kestenbaum, B, Haritunians, T, Mooser, V, Florez, J, Meigs, J, Lu, X, Leak, T, Aasarod, K, Skorpen, F, Baumert, J, Devuyst, O, Mychaleckyj, J, Kedenko, L, Coassin, S, Hallan, S, Navis, G, Shlipak, M, Bull, S, Paterson, A, Rotter, J, Dreisbach, A, Anderson, C, Guo, Q, Henders, A, Lambert, A, Lee, S, Kraft, P, Kennedy, S, Macgregor, S, Missmer, S, Painter, J, Roseman, F, Treloar, S, Wallace, L, Forsblom, C, Isakova, T, Mckay, G, Williams, W, Sadlier, D, Makinen, V, Swan, E, Boright, A, Ahlqvist, E, Keller, B, Huang, H, Ahola, A, Fagerholm, E, Gordin, D, Harjutsalo, V, He, B, Heikkila, O, Hietala, K, Kyto, J, Lahermo, P, Lehto, M, Osterholm, A, Parkkonen, M, Pitkaniemi, J, Rosengard-Barlund, M, Saraheimo, M, Sarti, C, Soderlund, J, Soro-Paavonen, A, Syreeni, A, Thorn, L, Tikkanen, H, Tolonen, N, Tryggvason, K, Waden, J, Gill, G, Prior, S, Guiducci, C, Mirel, D, Taylor, A, Hosseini, M, Parving, H, Rossing, P, Tarnow, L, Ladenvall, C, Alhenc-Gelas, F, Lefebvre, P, Rigalleau, V, Roussel, R, Maestroni, A, Maestroni, S, Falhammar, H, Gu, T, Mollsten, A, Cimponeriu, D, Mihai, I, Mota, M, Mota, E, Serafinceanu, C, Stavarachi, M, Hanson, R, Nelson, R, Kretzler, M, Panduru, N, Gu, H, Brismar, K, Zerbini, G, Hadjadj, S, Marre, M, Lajer, M, Waggott, D, Savage, D, Bain, S, Martin, F, Godson, C, Groop, P, Maxwell, A, Sengupta, S, Peloso, G, Ganna, A, Mora, S, Chang, H, Den Hertog, H, Donnelly, L, Freitag, D, Gurdasani, D, Heikkila, K, Johnson, T, Kaakinen, M, Kettunen, J, Li, X, Montasser, M, Petersen, A, Saxena, R, Service, S, Sidore, C, Surakka, I, Teslovich, T, Van den Herik, E, Volcik, K, Wu, Y, Asiki, G, Been, L, Burnett, M, Elliott, P, Eyjolfsson, G, Goodarzi, M, Gravito, M, Hartikainen, A, Hung, Y, Jones, M, Kaleebu, P, Khaw, K, Kim, E, Komulainen, P, Lin, S, Narisu, N, Nieminen, T, Nsubuga, R, Olafsson, I, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Ruokonen, A, Seeley, J, Silander, K, Tiret, L, van Pelt, L, Wainwright, N, Wijmenga, C, Young, E, Bennett, F, Boomsma, D, Burnier, M, Feranil, A, Freimer, N, Hsiung, C, Kesaniemi, A, Koudstaal, P, Krauss, R, Kyvik, K, Meneton, P, Moilanen, L, Sanghera, D, Sheu, W, Whitfield, J, Wolffenbuttel, B, Ordovas, J, Rich, S, Johnson, L, Larson, M, Levy, D, Newton-Cheh, C, O'Reilly, P, Palmas, W, Rice, K, Snider, H, Tobin, M, Verwoert, G, Pihur, V, Heath, S, Sober, S, Arora, P, Zhang, F, Lucas, G, Milaneschi, Y, Parker, A, Fava, C, Fox, E, Go, M, Sjogren, M, Vinay, D, Alexander, M, Tabara, Y, Shaw-Hawkins, S, Whincup, P, Shi, G, Seielstad, M, Sim, X, Nguyen, K, Matullo, G, Gaunt, T, Onland-Moret, N, Cooper, M, Platou, C, Org, E, Hardy, R, Dahgam, S, Palmen, J, Kuznetsova, T, Uiterwaal, C, Adeyemo, A, Ludwig, B, Tomaszewski, M, Tzoulaki, I, Palmer, N, Chang, Y, Steinle, N, Grobbee, D, Morrison, A, Najjar, S, Hadley, D, Brown, M, Connell, J, Day, I, Lawlor, D, Lawrence, R, Ongen, H, Li, Y, Young, J, Bis, J, Chaturvedi, N, Islam, M, Jafar, T, Kulkarni, S, Howard, P, Guarrera, S, Ricceri, F, Emilsson, V, Plump, A, Weder, A, Sun, Y, Scott, L, Peltonen, L, Vartiainen, E, Brand, S, Staessen, J, Wang, T, Burton, P, Artigas, M, Dong, Y, Wang, X, Zhu, H, Rudock, M, Heckbert, S, Smith, N, Wiggins, K, Doumatey, A, Shriner, D, Veldre, G, Viigimaa, M, Kinra, S, Prabhakaran, D, Tripathy, V, Langefeld, C, Rosengren, A, Thelle, D, Corsi, A, Singleton, A, Hilton, G, Salako, T, Iwai, N, Kita, Y, Ogihara, T, Ohkubo, T, Okamura, T, Ueshima, H, Umemura, S, Eyheramendy, S, Meitinger, T, Cho, Y, Scott, J, Sehmi, J, Hedblad, B, Nilsson, P, Smith, G, Raffel, L, Yao, J, Schwartz, S, Ikram, M, W, L, Mosley, T, Seshadri, S, Shrine, N, Wain, L, Zitting, P, Cooper, J, van Gilst, W, Janipalli, C, Mani, K, Yajnik, C, Mattace-Raso, F, 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P., Swan E. J., Boright A. P., Ahlqvist E., Keller B. J., Huang H., Ahola A., Fagerholm E., Gordin D., Harjutsalo V., He B., Heikkila O., Hietala K., Kyto J., Lahermo P., Lehto M., Osterholm A. M., Parkkonen M., Pitkaniemi J., Rosengard-Barlund M., Saraheimo M., Sarti C., Soderlund J., Soro-Paavonen A., Syreeni A., Thorn L. M., Tikkanen H., Tolonen N., Tryggvason K., Waden J., Gill G. V., Prior S., Guiducci C., Mirel D. B., Taylor A., Hosseini M., Parving H. H., Rossing P., Tarnow L., Ladenvall C., Alhenc-Gelas F., Lefebvre P., Rigalleau V., Roussel R., Maestroni A., Maestroni S., Falhammar H., Gu T., Mollsten A., Cimponeriu D., Mihai I., Mota M., Mota E., Serafinceanu C., Stavarachi M., Hanson R. L., Nelson R. G., Kretzler M., Panduru N. M., Gu H. F., Brismar K., Zerbini G., Hadjadj S., Marre M., Lajer M., Waggott D., Savage D. A., Bain S. C., Martin F., Godson C., Groop P. H., Maxwell A. P., Sengupta S., Peloso G. M., Ganna A., Mora S., Chang H. Y., Den Hertog H. M., Donnelly L. A., Freitag D. F., Gurdasani D., Heikkila K., Johnson T., Kaakinen M., Kettunen J., Li X., Montasser M. E., Petersen A. K., Saxena R., Service S. K., Sidore C., Surakka I., Teslovich T. M., Van den Herik E. G., Volcik K. A., Wu Y., Asiki G., Been L. F., Burnett M. S., Elliott P., Eyjolfsson G. I., Goodarzi M. O., Gravito M. L., Hartikainen A. L., Hung Y. J., Jones M. R., Kaleebu P., Khaw K. T., Kim E., Komulainen P., Lin S. Y., Narisu N., Nieminen T. V., Nsubuga R. N., Olafsson I., Palotie A., Papamarkou T., Pomilla C., Pouta A., Ruokonen A., Seeley J., Silander K., Tiret L., van Pelt L., Wainwright N., Wijmenga C., Young E. H., Bennett F., Boomsma D. I., Burnier M., Chen Y. D., Feranil A. B., Freimer N. B., Hsiung C. A., Kesaniemi A., Koudstaal P. J., Krauss R. M., Kyvik K. O., Meneton P., Moilanen L., Sanghera D. K., Sheu W. H., Whitfield J. B., Wolffenbuttel B. H., Ordovas J. M., Rich S. S., Johnson A., Johnson L., Larson M., Levy D., Newton-Cheh C., O'reilly P., Palmas W., Rice K., Smith A., Snider H., Tobin M., Verwoert G., Rice K. M., Verwoert G. C., Pihur V., Heath S., Sober S., Arora P., Zhang F., Lucas G., Milaneschi Y., Parker A. N., Fava C., Fox E. R., Go M. J., Sjogren M., Vinay D., Alexander M., Tabara Y., Shaw-Hawkins S., Whincup P. H., Shi G., Seielstad M., Sim X., Nguyen K. D., Matullo G., Gaunt T. R., Onland-Moret N. C., Cooper M. N., Platou C. G., Org E., Hardy R., Dahgam S., Palmen J., Kuznetsova T., Uiterwaal C. S., Adeyemo A., Ludwig B., Tomaszewski M., Tzoulaki I., Palmer N. D., Chang Y. P., Steinle N. I., Grobbee D. E., Morrison A. C., Najjar S., Hadley D., Brown M. J., Connell J. M., Day I. N., Lawlor D. A., Lawrence R. W., Ongen H., Li Y., Young J. H., Bis J. C., Bolton J. A., Chaturvedi N., Islam M., Jafar T. H., Kulkarni S. R., Howard P., Guarrera S., Ricceri F., Emilsson V., Plump A., Weder A. B., Sun Y. V., Scott L. J., Peltonen L., Vartiainen E., Brand S. M., Staessen J. A., Wang T. J., Burton P. R., Artigas M. S., Dong Y., Wang X., Zhu H., Rudock M. E., Heckbert S. R., Smith N. L., Wiggins K. L., Doumatey A., Shriner D., Veldre G., Viigimaa M., Kinra S., Prabhakaran D., Tripathy V., Langefeld C. D., Rosengren A., Thelle D. S., Corsi A. M., Singleton A., Hilton G., Salako T., Iwai N., Kita Y., Ogihara T., Ohkubo T., Okamura T., Ueshima H., Umemura S., Eyheramendy S., Meitinger T., Cho Y. S., Kim H. L., Scott J., Sehmi J. S., Hedblad B., Nilsson P., Smith G. D., Raffel L. J., Yao J., Schwartz S. M., Ikram M., W L., Mosley T. H., Seshadri S., Shrine N. R., Wain L. V., Zitting P., Cooper J. A., van Gilst W. H., Janipalli C. S., Mani K., Yajnik C. S., Mattace-Raso F. U., Lakatta E. G., Orru M., Scuteri A., Ala-Korpela M., Kangas A. J., Soininen P., Tukiainen T., Wurtz P., Ong R. T., Dorr M., Galan P., Hercberg S., Lathrop M., Zelenika D., Zhai G., Meschia J. F., Sharma P., Terzic J., Kumar M., Denniff M., Zukowska-Szczechowska E., Wagenknecht L. E., Fowkes F., Charchar F. J., Guo X., Rotimi C., Bots M. L., Brand E., Talmud P. J., Nyberg F., Laan M., Palmer L. J., van der Schouw Y. T., Casas J. P., Vineis P., Ganesh S. K., Wong T. Y., Tai E. S., Morris R. W., Marmot M. G., Miki T., Chandak G. R., Zhu X., Elosua R., Soranzo N., Sijbrands E. J., Uda M., Vasan R. S., Alizadeh B. Z., de Boer R. A., Boezen H. M., Hillege H. L., van der Klauw M. M., Ormel J., Rosmalen J. G., Slaets J. P., Lagou V., Welch R. P., Wheeler E., Rehnberg E., Rasmussen-Torvik L. J., Lecoeur C., Johnson P. C., Sennblad B., Salo P., Timpson N. J., Evans D. M., St Pourcain B., Bielak L. F., Horikoshi M., Navarro P., Raychaudhuri S., Chen H., Rybin D., Willems S. M., Song K., An P., Marullo L., Jansen H., Pankow J. S., Edkins S., Varga T. V., Oksa H., Antonella M., Kong A., Herder C., Antti J., Small K., Miljkovic I., Atalay M., Kiess W., Smit J. H., Campbell S., Fowkes G. R., Rathmann W., Maerz W., Watanabe R. M., de Geus E. J., Penninx B. W., Toenjes A., Peyser P. A., Korner A., Dupuis J., Cucca F., Balkau B., Bouatia-Naji N., Purcell S., Musunuru K., Ardissino D., Mannucci P. M., Anand S., Engert J. C., Morgan T., Spertus J. A., Stoll M., Girelli D., McKeown P. P., Patterson C. C., Merlini P. A., Berzuini C., Bernardinelli L., Peyvandi F., Tubaro M., Celli P., Fetiveau R., Marziliano N., Casari G., Galli M., Ribichini F., Rossi M., Bernardi F., Zonzin P., Piazza A., Yee J., Friedlander Y., Marrugat J., Subirana I., Sala J., Ramos R., Williams G., Nathan D. M., Macrae C. A., Berglund G., Asselta R., Duga S., Spreafico M., Daly M. J., Nemesh J., Korn J. M., Surti A., Gianniny L., Parkin M., Burtt N., Gabriel S. B., Wright B. J., Ball S. G., Schunkert I., Linsel-Nitschke P., Lieb W., Fischer M., Grosshennig A., Preuss M., Scholz M., Chen Z., Wilensky R., Matthai W., Qasim A., Hakonarson H. H., Devaney J., Pichard A. D., Kent K. M., Satler L., Lindsay J. M., Waksman R., Knouff C. W., Scheffold T., Berger K., Huge A., Martinelli N., Olivieri O., Corrocher R., Xie C., Ahmadi K. R., Ainali C., Bataille V., Bell J. T., Buil A., Dermitzakis E. T., Dimas A. S., Durbin R., Glass D., Hassanali N., Ingle C., Knowles D., Krestyaninova M., Lowe C. E., Meduri E., Di Meglio P., Montgomery S. B., Nestle F. O., Nica A. C., Nisbet J., O'rahilly S., Parts L., Potter S., Sekowska M., Shin S. Y., Surdulescu G., Travers M. E., Tsaprouni L., Tsoka S., Wilk A., Yang T. P., Higashio J., Williams R., Nato A., Ambite J. L., Deelman E., Manolio T., Heiss G., Taylor K., Avery C., Graff M., Lin D., Quibrera M., Cochran B., Kao L., Umans J., Cole S., Maccluer J., Person S., Gross M., Fornage M., Durda P., Jenny N., Patsy B., Arnold A., Buzkova P., Haines J., Murdock D., Glenn K., Brown-Gentry K., Thornton-Wells T., Dumitrescu L., Bush W. S., Mitchell S. L., Goodloe R., Wilson S., Boston J., Malinowski J., Restrepo N., Oetjens M., Fowke J., Spencer K., Pendergrass S., Le Marchand L., Park L., Tiirikainen M., Kolonel L., Cheng I., Wang H., Shohet R., Stram D., Henderson B., Monroe K., Anderson G., Carlson C., Prentice R., Lacroix A., Wu C., Carty C., Rosse S., Young A., Kocarnik J., Lin Y., Jackson R., Duggan D., Kuller L., He C., Sulem P., Barbalic M., Broer L., Byrne E. M., Gudbjartsson D. F., McArdle P. F., Porcu E., van Wingerden S. W., Zhuang W. V., Lauc L. B., Broekmans F. J., Burri A., Chen C., Corre T., Coviello A. D., D'adamo P., Davies G., Deary I. J., Ebrahim S., Fauser B. C., Ferreli L., Folsom A. R., Hankinson S. E., Hass M., Janssens A. C., Karasik D., Keyzer J., Kiel D. P., Lahti J., Lai S., Laisk T., Laven J. S., Liu J., Lopez L. M., Louwers Y. V., Marongiu M., Klaric I. M., Masciullo C., Melzer D., Newman A. B., Pare G., Peeters P. H., Pop V. J., Raikkonen K., Salumets A., Stacey S. N., Starr J. M., Stathopoulou M. G., Styrkarsdottir U., Tenesa A., Tryggvadottir L., Tsui K., van Dam R. M., van Gils C. H., van Nierop P., Vink J. M., Voorhuis M., Widen E., Wijnands-Van Gent C. J., Yerges-Armstrong L. M., Zgaga L., Zygmunt M., Buring J. E., Crisponi L., Demerath E. W., Streeten E. A., Murray A., Visser J. A., Lunetta K. L., Elks C. E., Cousminer D. L., Koller D. L., Lin P., Smith E. N., Warrington N. M., Alavere H., Berenson G. S., Blackburn H., Busonero F., Chen W., Couper D., Easton D. F., Eriksson J., Foroud T., Kilpelainen T. O., Li S., Murray S. S., Ness A. R., Northstone K., Peacock M., Pennell C. E., Pharoah P., Rafnar T., Rice J. P., Ring S. M., Schork N. J., Segre A. V., Sovio U., Srinivasan S. R., Tammesoo M. L., van Meurs J. B., Young L., Bierut L. J., and Econs M. J.
- Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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- 2015
11. Job strain as a risk factor for clinical depression : systematic review and meta-analysis with additional individual participant data
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Madsen, I. E. H., Nyberg, S. T., Hanson, L. L. Magnusson, Ferrie, J. E., Ahola, K., Alfredsson, L., Batty, G. D., Bjorner, J. B., Borritz, M., Burr, H., Chastang, J. -F., de Graaf, R., Dragano, N., Hamer, M., Jokela, M., Knutsson, A., Koskenvuo, M., Koskinen, A., Leineweber, C., Niedhammer, I., Nielsen, M. L., Nordin, M., Oksanen, T., Pejtersen, J. H., Pentti, J., Plaisier, I., Salo, P., Singh-Manoux, A., Suominen, S., ten Have, M., Theorell, T., Toppinen-Tanner, S., Vahtera, J., Vaananen, A., Westerholm, P. J. M., Westerlund, H., Fransson, E. I., Heikkila, K., Virtanen, M., Rugulies, R., Kivimaki, M., IPD Work Consortium, Medicum, University of Helsinki, Department of Psychology and Logopedics, Markku Koskenvuo / Principal Investigator, Department of Public Health, and Clinicum
- Subjects
ENVIRONMENT ,STRESS ,515 Psychology ,PSYCHIATRIC-DISORDERS ,MAJOR DEPRESSION ,work stress ,DECISION-MAKING ,COMPREHENSIVE DEVELOPMENTAL MODEL ,3124 Neurology and psychiatry ,WORKING-CONDITIONS ,CARDIOVASCULAR-DISEASE ,occupational health ,MENTAL-DISORDERS ,PSYCHOSOCIAL FACTORS ,Observational studies - Abstract
Background. Adverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for clinical depression. Method. We identified published cohort studies from a systematic literature search in PubMed and PsycNET and obtained 14 cohort studies with unpublished individual-level data from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium. Summary estimates of the association were obtained using random-effects models. Individual-level data analyses were based on a pre-published study protocol. Results. We included six published studies with a total of 27 461 individuals and 914 incident cases of clinical depression. From unpublished datasets we included 120 221 individuals and 982 first episodes of hospital-treated clinical depression. Job strain was associated with an increased risk of clinical depression in both published [relative risk (RR) = 1.77, 95% confidence interval (CI) 1.47-2.13] and unpublished datasets (RR = 1.27, 95% CI 1.04-1.55). Further individual participant analyses showed a similar association across sociodemographic subgroups and after excluding individuals with baseline somatic disease. The association was unchanged when excluding individuals with baseline depressive symptoms (RR = 1.25, 95% CI 0.94-1.65), but attenuated on adjustment for a continuous depressive symptoms score (RR = 1.03, 95% CI 0.81-1.32). Conclusions. Job strain may precipitate clinical depression among employees. Future intervention studies should test whether job strain is a modifiable risk factor for depression.
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- 2017
12. Population-based study of mortality and major amputation following lower limb revascularization
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Heikkila, K, primary, Loftus, I M, additional, Mitchell, D C, additional, Johal, A S, additional, Waton, S, additional, and Cromwell, D A, additional
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- 2018
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13. Safety of intraoperative blood salvage during liver transplantation in patients with hepatocellular carcinoma; systematic review and meta-analysis
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Rutten, V., primary, Aijtink, V., additional, Meijer, B., additional, Scalera, I., additional, Mihaylov, V., additional, Heikkila, K., additional, Pengel, L., additional, Perera, T., additional, and Hartog, H., additional
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- 2018
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14. Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project
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Jelenkovic, A, Yokoyama, Y, Sund, R, Pietilainen, KH, Hur, Y-M, Willemsen, G, Bartels, M, van Beijsterveldt, TCEM, Ooki, S, Saudino, KJ, Stazi, MA, Fagnani, C, D'Ippolito, C, Nelson, TL, Whitfield, KE, Knafo-Noam, A, Mankuta, D, Abramson, L, Heikkila, K, Cutler, TL, Hopper, JL, Wardle, J, Llewellyn, CH, Fisher, A, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, LTarnoki, D, Burt, SA, Klump, KL, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Harris, JR, Brandt, L, Nilsen, TS, Craig, JM, Saffery, R, Rasmussen, F, Tynelius, P, Bayasgalan, G, Narandalai, D, Haworth, CMA, Plomin, R, Ji, F, Ning, F, Pang, Z, Rebato, E, Krueger, RF, Mcgue, M, Pahlen, S, Boomsma, DI, Sorensen, TIA, Kaprio, J, Silventoinen, K, Jelenkovic, A, Yokoyama, Y, Sund, R, Pietilainen, KH, Hur, Y-M, Willemsen, G, Bartels, M, van Beijsterveldt, TCEM, Ooki, S, Saudino, KJ, Stazi, MA, Fagnani, C, D'Ippolito, C, Nelson, TL, Whitfield, KE, Knafo-Noam, A, Mankuta, D, Abramson, L, Heikkila, K, Cutler, TL, Hopper, JL, Wardle, J, Llewellyn, CH, Fisher, A, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, LTarnoki, D, Burt, SA, Klump, KL, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Harris, JR, Brandt, L, Nilsen, TS, Craig, JM, Saffery, R, Rasmussen, F, Tynelius, P, Bayasgalan, G, Narandalai, D, Haworth, CMA, Plomin, R, Ji, F, Ning, F, Pang, Z, Rebato, E, Krueger, RF, Mcgue, M, Pahlen, S, Boomsma, DI, Sorensen, TIA, Kaprio, J, and Silventoinen, K
- Abstract
BACKGROUND: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. RESULTS: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. CONCLUSIONS: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.
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- 2017
15. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine (vol 48, pg 856, 2016)
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Gormley, P., Anttila, V., Winsvold, B.S., Palta, P., Esko, T., Pers, T.H., Farh, K.H., Cuenca-Leon, E., Muona, M., Furlotte, N.A., Kurth, T., Ingason, A., McMahon, G., Ligthart, L., Terwindt, G.M., Kallela, M., Freilinger, T.M., Ran, C., Gordon, S.G., Stam, A.H., Steinberg, S., Borck, G., Koiranen, M., Quaye, L., Adams, H.H.H., Lehtimaki, T., Sarin, A.P., Wedenoja, J., Hinds, D.A., Buring, J.E., Schurks, M., Ridker, P.M., Hrafnsdottir, M.G., Stefansson, H., Ring, S.M., Hottenga, J.J., Penninx, B.W.J.H., Farkkila, M., Artto, V., Kaunisto, M., Vepsalainen, S., Malik, R., Heath, A.C., Madden, P.A.F., Martin, N.G., Montgomery, G.W., Kurki, M.I., Kals, M., Magi, R., Parn, K., Hamalainen, E., Huang, H.L., Byrnes, A.E., Franke, L., Huang, J., Stergiakouli, E., Lee, P.H., Sandor, C., Webber, C., Cader, Z., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Eriksson, J.G., Salomaa, V., Heikkila, K., Loehrer, E., Uitterlinden, A.G., Hofman, A., Duijn, C.M. van, Cherkas, L., Pedersen, L.M., Stubhaug, A., Nielsen, C.S., Mannikko, M., Mihailov, E., Milani, L., Gobel, H., Esserlind, A.L., Christensen, A.F., Hansen, T.F., Werge, T., Kaprio, J., Aromaa, A.J., Raitakari, O., Ikram, M.A., Spector, T., Jarvelin, M.R., Metspalu, A., Kubisch, C., Strachan, D.P., Ferrari, M.D., Belin, A.C., Dichgans, M., Wessman, M., Maagdenberg, A.M.J.M. van den, Zwart, J.A., Boomsma, D.I., Smith, G.D., Stefansson, K., Eriksson, N., Daly, M.J., Neale, B.M., Olesen, J., Chasman, D.I., Nyholt, D.R., Palotie, A., and Int Headache Genetics Consortium
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- 2016
16. Delays to Surgery and Procedural Risks Following Carotid Endarterectomy in the UK National Vascular Registry
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Loftus, IM, Paraskevas, KI, Johal, A, Waton, S, Heikkila, K, Naylor, AR, and Cromwell, DA
- Abstract
Guidelines recommend that patients suffering an ischaemic transient ischaemic attack (TIA) or stroke caused by carotid artery stenosis should undergo carotid endarterectomy (CEA) within 14 days. : The degree to which UK vascular units met this standard was examined and whether rapid interventions were associated with procedural risks. The study analysed patients undergoing CEA between January 2009 and December 2014 from 100 UK NHS hospitals. Data were collected on patient characteristics, intervals of time from symptoms to surgery, and 30-day postoperative outcomes. The relationship between outcomes and time from symptom to surgery was evaluated using multilevel multivariable logistic regression. : In 23,235 patients, the median time from TIA/stroke to CEA decreased over time, from 22 days (IQR 10-56) in 2009 to 12 days (IQR 7-26) in 2014. The proportion of patients treated within 14 days increased from 37% to 58%. This improvement was produced by shorter times across the care pathway: symptoms to referral, from medical review to being seen by a vascular surgeon, and then to surgery. The spread of the median time from symptom to surgery among NHS hospitals shrank between 2009 and 2013 but then grew slightly. Low-, medium-, and high-volume NHS hospitals all improved their performance similarly. Performing CEA within 48 h of symptom onset was associated with a small increase in the 30-day stroke and death rate: 3.1% (0-2 days) compared with 2.0% (3-7 days); adjusted odds ratio 1.64 (95% CI 1.04-2.59) but not with longer delays. : The delay from symptom to CEA in symptomatic patients with ipsilateral 50-99% carotid stenoses has reduced substantially, although 42% of patients underwent CEA after the recommended 14 days. The risk of stroke after CEA was low, but there may be a small increase in risk during the first 48 h after symptoms.
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- 2016
17. Index
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Heikkila, Kim
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- 2021
18. Notes
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Heikkila, Kim
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- 2021
19. Back Cover
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Heikkila, Kim
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- 2021
20. Beginnings and Endings
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Heikkila, Kim
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- 2021
21. Acknowledgments
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Heikkila, Kim
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- 2021
22. 7. Reunited
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Heikkila, Kim
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- 2021
23. 5. Surrender
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Heikkila, Kim
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- 2021
24. 4. Booth Girl
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Heikkila, Kim
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- 2021
25. 6. Fresh Start
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Heikkila, Kim
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- 2021
26. 3. Under the Eaves
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Heikkila, Kim
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- 2021
27. 2. California Dreaming
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Heikkila, Kim
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- 2021
28. 1. Good Girl
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Heikkila, Kim
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- 2021
29. A Note About Language
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Heikkila, Kim
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- 2021
30. Origins
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Heikkila, Kim
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- 2021
31. Contents
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Heikkila, Kim
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- 2021
32. Title Page, Copyright, Dedication
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Heikkila, Kim
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- 2021
33. P35 Are patient outcomes improving? major amputation and death following lower limb revascularisation procedures in england
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Heikkila, K, primary, Mitchell, DC, additional, Loftus, IM, additional, and Cromwell, DA, additional
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- 2017
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34. Delays to Surgery and Procedural Risks Following Carotid Endarterectomy in the UK National Vascular Registry
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Loftus, I.M., primary, Paraskevas, K.I., additional, Johal, A., additional, Waton, S., additional, Heikkila, K., additional, Naylor, A.R., additional, and Cromwell, D.A., additional
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- 2016
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35. Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
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Jelenkovic, A, Hur, Y-M, Sund, R, Yokoyama, Y, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Tan, Q, Zhang, D, Pang, Z, Aaltonen, S, Heikkila, K, Oncel, SY, Aliev, F, Rebato, E, Tarnoki, AD, Tarnoki, DL, Christensen, K, Skytthe, A, Kyvik, KO, Silberg, JL, Eaves, LJ, Maes, HH, Cutler, TL, Hopper, JL, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Cozen, W, Hwang, AE, Mack, TM, Sun, J, Song, Y-M, Yang, S, Lee, K, Franz, CE, Kremen, WS, Lyons, MJ, Busjahn, A, Nelson, TL, Whitfield, KE, Kandler, C, Jang, KL, Gatz, M, Butler, DA, Stazi, MA, Fagnani, C, D'Ippolito, C, Duncan, GE, Buchwald, D, Derom, CA, Vlietinck, RF, Loos, RJF, Martin, NG, Medland, SE, Montgomery, GW, Jeong, H-U, Swan, GE, Krasnow, R, Magnusson, PKE, Pedersen, NL, Dahl-Aslan, AK, McAdams, TA, Eley, TC, Gregory, AM, Tynelius, P, Baker, LA, Tuvblad, C, Bayasgalan, G, Narandalai, D, Lichtenstein, P, Spector, TD, Mangino, M, Lachance, G, Bartels, M, van Beijsterveldt, TCEM, Willemsen, G, Burt, SA, Klump, KL, Harris, JR, Brandt, I, Nilsen, TS, Krueger, RF, McGue, M, Pahlen, S, Corley, RP, Hjelmborg, JVB, Goldberg, JH, Iwatani, Y, Watanabe, M, Honda, C, Inui, F, Rasmussen, F, Huibregtse, BM, Boomsma, DI, Sorensen, TIA, Kaprio, J, Silventoinen, K, Jelenkovic, A, Hur, Y-M, Sund, R, Yokoyama, Y, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Tan, Q, Zhang, D, Pang, Z, Aaltonen, S, Heikkila, K, Oncel, SY, Aliev, F, Rebato, E, Tarnoki, AD, Tarnoki, DL, Christensen, K, Skytthe, A, Kyvik, KO, Silberg, JL, Eaves, LJ, Maes, HH, Cutler, TL, Hopper, JL, Ordonana, JR, Sanchez-Romera, JF, Colodro-Conde, L, Cozen, W, Hwang, AE, Mack, TM, Sun, J, Song, Y-M, Yang, S, Lee, K, Franz, CE, Kremen, WS, Lyons, MJ, Busjahn, A, Nelson, TL, Whitfield, KE, Kandler, C, Jang, KL, Gatz, M, Butler, DA, Stazi, MA, Fagnani, C, D'Ippolito, C, Duncan, GE, Buchwald, D, Derom, CA, Vlietinck, RF, Loos, RJF, Martin, NG, Medland, SE, Montgomery, GW, Jeong, H-U, Swan, GE, Krasnow, R, Magnusson, PKE, Pedersen, NL, Dahl-Aslan, AK, McAdams, TA, Eley, TC, Gregory, AM, Tynelius, P, Baker, LA, Tuvblad, C, Bayasgalan, G, Narandalai, D, Lichtenstein, P, Spector, TD, Mangino, M, Lachance, G, Bartels, M, van Beijsterveldt, TCEM, Willemsen, G, Burt, SA, Klump, KL, Harris, JR, Brandt, I, Nilsen, TS, Krueger, RF, McGue, M, Pahlen, S, Corley, RP, Hjelmborg, JVB, Goldberg, JH, Iwatani, Y, Watanabe, M, Honda, C, Inui, F, Rasmussen, F, Huibregtse, BM, Boomsma, DI, Sorensen, TIA, Kaprio, J, and Silventoinen, K
- Abstract
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.
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- 2016
36. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts
- Author
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Jelenkovic, A, Sund, R, Hur, Y-M, Yokoyama, Y, Hjelmborg, JVB, Moller, S, Honda, C, Magnusson, PKE, Pedersen, NL, Ooki, S, Aaltonen, S, Stazi, MA, Fagnani, C, D'Ippolito, C, Freitas, DL, Maia, JA, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Heikkila, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M, van Beijsterveldt, TCEM, Craig, JM, Saffery, R, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Swan, GE, Krasnow, R, Tynelius, P, Lichtenstein, P, Haworth, CMA, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Spector, T, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Skytthe, A, Kyvik, KO, Christensen, K, Oncel, SY, Aliev, F, Rasmussen, F, Goldberg, JH, Sorensen, TIA, Boomsma, DI, Kaprio, J, Silventoinen, K, Jelenkovic, A, Sund, R, Hur, Y-M, Yokoyama, Y, Hjelmborg, JVB, Moller, S, Honda, C, Magnusson, PKE, Pedersen, NL, Ooki, S, Aaltonen, S, Stazi, MA, Fagnani, C, D'Ippolito, C, Freitas, DL, Maia, JA, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Heikkila, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M, van Beijsterveldt, TCEM, Craig, JM, Saffery, R, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Swan, GE, Krasnow, R, Tynelius, P, Lichtenstein, P, Haworth, CMA, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Spector, T, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Skytthe, A, Kyvik, KO, Christensen, K, Oncel, SY, Aliev, F, Rasmussen, F, Goldberg, JH, Sorensen, TIA, Boomsma, DI, Kaprio, J, and Silventoinen, K
- Abstract
Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
- Published
- 2016
37. Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project
- Author
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Yokoyama, Y, Jelenkovic, A, Sund, R, Sung, J, Hopper, JL, Ooki, S, Heikkila, K, Aaltonen, S, Tarnoki, AD, Tarnoki, DL, Willemsen, G, Bartels, M, van Beijsterveldt, TCEM, Saudino, KJ, Cutler, TL, Nelson, TL, Whitfield, KE, Wardle, J, Llewellyn, CH, Fisher, A, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Song, Y-M, Yang, S, Lee, K, Jeong, H-U, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Ordonana, JR, Sanhez-Romera, JF, Colodro-Conde, L, Harris, JR, Brandt, I, Nilsen, TS, Craig, JM, Saffery, R, Ji, F, Ning, F, Pang, Z, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Magnusson, PKE, Pedersen, NL, Aslan, AKD, Tynelius, P, Haworth, CMA, Plomin, R, Rebato, E, Rose, RJ, Goldberg, JH, Rasmussen, F, Hur, Y-M, Sorensen, TIA, Boomsma, DI, Kaprio, J, Silventoinen, K, Yokoyama, Y, Jelenkovic, A, Sund, R, Sung, J, Hopper, JL, Ooki, S, Heikkila, K, Aaltonen, S, Tarnoki, AD, Tarnoki, DL, Willemsen, G, Bartels, M, van Beijsterveldt, TCEM, Saudino, KJ, Cutler, TL, Nelson, TL, Whitfield, KE, Wardle, J, Llewellyn, CH, Fisher, A, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Song, Y-M, Yang, S, Lee, K, Jeong, H-U, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Ordonana, JR, Sanhez-Romera, JF, Colodro-Conde, L, Harris, JR, Brandt, I, Nilsen, TS, Craig, JM, Saffery, R, Ji, F, Ning, F, Pang, Z, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Magnusson, PKE, Pedersen, NL, Aslan, AKD, Tynelius, P, Haworth, CMA, Plomin, R, Rebato, E, Rose, RJ, Goldberg, JH, Rasmussen, F, Hur, Y-M, Sorensen, TIA, Boomsma, DI, Kaprio, J, and Silventoinen, K
- Abstract
We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.
- Published
- 2016
38. Directional dominance on stature and cognition in diverse human populations
- Author
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Joshi, PK, Esko, T, Mattsson, H, Eklund, N, Gandin, I, Nutile, T, Jackson, AU, Schurmann, C, Smith, AV, Zhang, WH, Okada, Y, Stancakova, A, Faul, JD, Zhao, W, Bartz, TM, Concas, MP, Franceschini, N, Enroth, S, Vitart, V, Trompet, S, Guo, XQ, Chasman, DI, O'Connel, JR, Corre, T, Nongmaithem, SS, Chen, Y, Mangino, M, Ruggiero, D, Michela, T, Farmaki, AE, Kacprowski, T, Bjonnes, A, van der Spek, Ashley, Wu, Y, Giri, AK, Yanek, LR, Wang, LH, Hofer, E, Rietveld, CA, McLeod, O, Cornelis, MC, Pattaro, C, Verweij, N, Baumbach, C, Abdellaoui, A, Warren, HR, Vuckovic, D, Mei, H, Bouchard, C, Perry, JRB, Cappellani, S, Mirza, Saira, Benton, MC, Broeckel, U, Medland, SE, Lind, P, Malerba, G, Drong, A, Yengo, L, Bielak, LF, Zhi, DG, van der Most, PJ, Shriner, D, Magi, R, Hemani, G, Karaderi, T, Wang, ZM, Liu, T, Demuth, I, Zhao, JH, Meng, WH, Lataniotis, L, Laan, Sander, Bradfield, JP, Wood, AR, Bonnefond, A, Ahluwalia, TS, Hall, L, Salvi, E, Yazar, S, Carstensen, L, de Haan, HG, Abney, M, Afzal, U, Allison, MA, Amin, Najaf, Asselbergs, FW, Bakker, SJL, Barr, RG, Baumeister, SE, Benjamin, DJ, Bergmann, S, Boerwinkle, E, Bottinger, EP, Campbell, A (Archie), Chakravarti, A, Chan, YL, Chanock, SJ, Chen, C (Christopher Li Hsian), Chen, YDI, Collins, FS, Connell, J, Correa, A, Cupples, LA, Smith, GD, Davies, G, Dorr, M, Ehret, G, Ellis, SB, Feenstra, B, Feitosa, MF, Ford, I, Fox, CS, Frayling, TM, Friedrich, N, Geller, F, Scotland, G, Gillham-Nasenya, I, Gottesman, O, Graff, M, Grodstein, F, Gu, C, Haley, C, Hammond, CJ, Harris, SE, Harris, TB, Hastie, ND, Heard-Costa, NL, Heikkila, K, Hocking, LJ, Homuth, G, Hottenga, Jouke-Jan, Huang, JY, Huffman, JE, Hysi, Pirro G., Arfan Ikram, M., Ingelsson, E, Joensuu, A, Johansson, A, Jousilahti, P, Jukema, JW, Kahonen, M, Kamatani, Y, Kanoni, S, Kerr, SM, Khan, NM, Koellinger, P, Koistinen, HA, Kooner, MK, Kubo, M, Kuusisto, J, Lahti, J, Launer, Lenore J., Lea, RA, Lehne, B, Lehtimaki, T, Liewald, DCM, Lind, L, Loh, M, Lokki, ML, London, SJ, Loomis, SJ, Loukola, A, Lu, YC, Lumley, T, Lundqvist, A, Mannisto, S, Marques-Vidal, P, Masciullo, C, Matchan, A, Mathias, RA, Matsuda, K, Meigs, JB, Meisinger, C, Meitinger, T, Menni, C, Mentch, FD, Mihailov, E, Milani, L, Montasser, ME, Montgomery, G, Morrison, A, Myers, RH, Nadukuru, R, Navarro, P, Nelis, M, Nieminen, MS, Nolte, Ilja M., O'Connor, GT, Ogunniyi, A, Padmanabhan, S, Palmas, WR, Pankow, JS, Patarcic, I, Pavani, F, Peyser, PA, Pietilainen, K, Poulter, N, Prokopenko, I, Ralhan, S, Redmond, P, Rich, SS, Rissanen, H, Robino, A, Rose, LM, Rose, R, Sala, C, Salako, B, Salomaa, V, Sarin, AP, Saxena, R, Schmidt, Heléna, Scott, LJ, Scott, WR, Sennblad, B, Seshadri, S, Sever, P, Shrestha, S, Smith, BH, Smith, JA, Soranzo, N, Sotoodehnia, N, Southam, L, Stanton, AV, Stathopoulou, MG, Strauch, K, Strawbridge, RJ, Suderman, MJ, Tandon, N, Tang, ST, Taylor, KD, Tayo, BO, Toglhofer, AM, Tomaszewski, M, Tsernikova, N, Tuomilehto, J, Uitterlinden, André, Vaidya, D, Vlieg, AV, van Setten, J, Vasankari, T, Vedantam, S, Vlachopoulou, E, Vozzi, D, Vuoksimaa, E, Waldenberger, M, Ware, EB, Wentworth-Shields, W, Whitfield, JB, Wild, S, Willemsen, G, Yajnik, CS, Yao, J, Zaza, G, Zhu, XF, Salem, RM, Melbye, M, Bisgaard, H, Samani, NJ, Cusi, D, Mackey, DA, Cooper, RS, Froguel, P, Pasterkamp, G, Grant, SFA, Hakonarson, H, Ferrucci, L, Scott, RA, Morris, AD, Palmer, CNA, Dedoussis, G, Deloukas, P, Bertram, L, Lindenberger, U, Berndt, SI, Lindgren, CM, Timpson, NJ, Tonjes, A, Munroe, PB, Sorensen, TIA, Rotimi, CN, Arnett, DK, Oldehinkel, Albertine J., Kardia, SLR, Balkau, B, Gambaro, G, Morris, AP, Eriksson, JG, Wright, MJ, Martin, NG, Hunt, SC, Starr, JM, Deary, IJ, Griffiths, LR, Tiemeier, Henning, Pirastu, N, Kaprio, J, Wareham, NJ, Peerusse, L, Wilson, JG, Girotto, G, Caulfield, MJ, Raitakari, O, Boomsma, DI, Gieger, C, van der Harst, P, Hicks, AA, Kraft, P, Sinisalo, J, Knekt, P, Johannesson, M, Magnusson, PKE, Hamsten, A, Schmidt, R, Borecki, IB, Vartiainen, E, Becker, DM, Bharadwaj, D, Mohlke, KL, Boehnke, M, van Duijn, Cornelia M., Sanghera, DK, Teumer, A, Zeggini, E, Metspalu, A, Gasparini, P, Ulivi, S, Ober, C, Toniolo, D, Rudan, I, Porteous, DJ, Ciullo, M, Spector, Tim D., Hayward, C, Dupuis, J, Loos, RJF, Wright, AF, Chandak, GR, Vollenweider, P, Shuldiner, AR, Ridker, PM, Rotter, JI, Sattar, N, Gyllensten, U, North, KE, Pirastu, M, Psaty, Bruce M., Weir, DR, Laakso, M, Gudnason, V, Takahashi, A, Chambers, JC, Kooner, JS, Strachan, DP, Campbell, H, Hirschhorn, JN, Perola, M, Polasek, O, Wilson, JF, Joshi, PK, Esko, T, Mattsson, H, Eklund, N, Gandin, I, Nutile, T, Jackson, AU, Schurmann, C, Smith, AV, Zhang, WH, Okada, Y, Stancakova, A, Faul, JD, Zhao, W, Bartz, TM, Concas, MP, Franceschini, N, Enroth, S, Vitart, V, Trompet, S, Guo, XQ, Chasman, DI, O'Connel, JR, Corre, T, Nongmaithem, SS, Chen, Y, Mangino, M, Ruggiero, D, Michela, T, Farmaki, AE, Kacprowski, T, Bjonnes, A, van der Spek, Ashley, Wu, Y, Giri, AK, Yanek, LR, Wang, LH, Hofer, E, Rietveld, CA, McLeod, O, Cornelis, MC, Pattaro, C, Verweij, N, Baumbach, C, Abdellaoui, A, Warren, HR, Vuckovic, D, Mei, H, Bouchard, C, Perry, JRB, Cappellani, S, Mirza, Saira, Benton, MC, Broeckel, U, Medland, SE, Lind, P, Malerba, G, Drong, A, Yengo, L, Bielak, LF, Zhi, DG, van der Most, PJ, Shriner, D, Magi, R, Hemani, G, Karaderi, T, Wang, ZM, Liu, T, Demuth, I, Zhao, JH, Meng, WH, Lataniotis, L, Laan, Sander, Bradfield, JP, Wood, AR, Bonnefond, A, Ahluwalia, TS, Hall, L, Salvi, E, Yazar, S, Carstensen, L, de Haan, HG, Abney, M, Afzal, U, Allison, MA, Amin, Najaf, Asselbergs, FW, Bakker, SJL, Barr, RG, Baumeister, SE, Benjamin, DJ, Bergmann, S, Boerwinkle, E, Bottinger, EP, Campbell, A (Archie), Chakravarti, A, Chan, YL, Chanock, SJ, Chen, C (Christopher Li Hsian), Chen, YDI, Collins, FS, Connell, J, Correa, A, Cupples, LA, Smith, GD, Davies, G, Dorr, M, Ehret, G, Ellis, SB, Feenstra, B, Feitosa, MF, Ford, I, Fox, CS, Frayling, TM, Friedrich, N, Geller, F, Scotland, G, Gillham-Nasenya, I, Gottesman, O, Graff, M, Grodstein, F, Gu, C, Haley, C, Hammond, CJ, Harris, SE, Harris, TB, Hastie, ND, Heard-Costa, NL, Heikkila, K, Hocking, LJ, Homuth, G, Hottenga, Jouke-Jan, Huang, JY, Huffman, JE, Hysi, Pirro G., Arfan Ikram, M., Ingelsson, E, Joensuu, A, Johansson, A, Jousilahti, P, Jukema, JW, Kahonen, M, Kamatani, Y, Kanoni, S, Kerr, SM, Khan, NM, Koellinger, P, Koistinen, HA, Kooner, MK, Kubo, M, Kuusisto, J, Lahti, J, Launer, Lenore J., Lea, RA, Lehne, B, Lehtimaki, T, Liewald, DCM, Lind, L, Loh, M, Lokki, ML, London, SJ, Loomis, SJ, Loukola, A, Lu, YC, Lumley, T, Lundqvist, A, Mannisto, S, Marques-Vidal, P, Masciullo, C, Matchan, A, Mathias, RA, Matsuda, K, Meigs, JB, Meisinger, C, Meitinger, T, Menni, C, Mentch, FD, Mihailov, E, Milani, L, Montasser, ME, Montgomery, G, Morrison, A, Myers, RH, Nadukuru, R, Navarro, P, Nelis, M, Nieminen, MS, Nolte, Ilja M., O'Connor, GT, Ogunniyi, A, Padmanabhan, S, Palmas, WR, Pankow, JS, Patarcic, I, Pavani, F, Peyser, PA, Pietilainen, K, Poulter, N, Prokopenko, I, Ralhan, S, Redmond, P, Rich, SS, Rissanen, H, Robino, A, Rose, LM, Rose, R, Sala, C, Salako, B, Salomaa, V, Sarin, AP, Saxena, R, Schmidt, Heléna, Scott, LJ, Scott, WR, Sennblad, B, Seshadri, S, Sever, P, Shrestha, S, Smith, BH, Smith, JA, Soranzo, N, Sotoodehnia, N, Southam, L, Stanton, AV, Stathopoulou, MG, Strauch, K, Strawbridge, RJ, Suderman, MJ, Tandon, N, Tang, ST, Taylor, KD, Tayo, BO, Toglhofer, AM, Tomaszewski, M, Tsernikova, N, Tuomilehto, J, Uitterlinden, André, Vaidya, D, Vlieg, AV, van Setten, J, Vasankari, T, Vedantam, S, Vlachopoulou, E, Vozzi, D, Vuoksimaa, E, Waldenberger, M, Ware, EB, Wentworth-Shields, W, Whitfield, JB, Wild, S, Willemsen, G, Yajnik, CS, Yao, J, Zaza, G, Zhu, XF, Salem, RM, Melbye, M, Bisgaard, H, Samani, NJ, Cusi, D, Mackey, DA, Cooper, RS, Froguel, P, Pasterkamp, G, Grant, SFA, Hakonarson, H, Ferrucci, L, Scott, RA, Morris, AD, Palmer, CNA, Dedoussis, G, Deloukas, P, Bertram, L, Lindenberger, U, Berndt, SI, Lindgren, CM, Timpson, NJ, Tonjes, A, Munroe, PB, Sorensen, TIA, Rotimi, CN, Arnett, DK, Oldehinkel, Albertine J., Kardia, SLR, Balkau, B, Gambaro, G, Morris, AP, Eriksson, JG, Wright, MJ, Martin, NG, Hunt, SC, Starr, JM, Deary, IJ, Griffiths, LR, Tiemeier, Henning, Pirastu, N, Kaprio, J, Wareham, NJ, Peerusse, L, Wilson, JG, Girotto, G, Caulfield, MJ, Raitakari, O, Boomsma, DI, Gieger, C, van der Harst, P, Hicks, AA, Kraft, P, Sinisalo, J, Knekt, P, Johannesson, M, Magnusson, PKE, Hamsten, A, Schmidt, R, Borecki, IB, Vartiainen, E, Becker, DM, Bharadwaj, D, Mohlke, KL, Boehnke, M, van Duijn, Cornelia M., Sanghera, DK, Teumer, A, Zeggini, E, Metspalu, A, Gasparini, P, Ulivi, S, Ober, C, Toniolo, D, Rudan, I, Porteous, DJ, Ciullo, M, Spector, Tim D., Hayward, C, Dupuis, J, Loos, RJF, Wright, AF, Chandak, GR, Vollenweider, P, Shuldiner, AR, Ridker, PM, Rotter, JI, Sattar, N, Gyllensten, U, North, KE, Pirastu, M, Psaty, Bruce M., Weir, DR, Laakso, M, Gudnason, V, Takahashi, A, Chambers, JC, Kooner, JS, Strachan, DP, Campbell, H, Hirschhorn, JN, Perola, M, Polasek, O, and Wilson, JF
- Abstract
Homozygosity has long been associated with rare, often devastating, Mendelian disorders(1), and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness(2). However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power(3,4). Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 x 10(-300), 2.1 x 10(-6), 2.5 x 10(-10) and 1.8 x 10(-10), respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months' less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples(5,6), no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection(7), this study provides evidence that increased stature and cognitive function have been positively sele
- Published
- 2015
39. Long working hours and alcohol use: systematic review and meta-analysis of published studies and unpublished individual participant data
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Virtanen, M., primary, Jokela, M., additional, Nyberg, S. T., additional, Madsen, I. E. H., additional, Lallukka, T., additional, Ahola, K., additional, Alfredsson, L., additional, Batty, G. D., additional, Bjorner, J. B., additional, Borritz, M., additional, Burr, H., additional, Casini, A., additional, Clays, E., additional, De Bacquer, D., additional, Dragano, N., additional, Erbel, R., additional, Ferrie, J. E., additional, Fransson, E. I., additional, Hamer, M., additional, Heikkila, K., additional, Jockel, K.-H., additional, Kittel, F., additional, Knutsson, A., additional, Koskenvuo, M., additional, Ladwig, K.-H., additional, Lunau, T., additional, Nielsen, M. L., additional, Nordin, M., additional, Oksanen, T., additional, Pejtersen, J. H., additional, Pentti, J., additional, Rugulies, R., additional, Salo, P., additional, Schupp, J., additional, Siegrist, J., additional, Singh-Manoux, A., additional, Steptoe, A., additional, Suominen, S. B., additional, Theorell, T., additional, Vahtera, J., additional, Wagner, G. G., additional, Westerholm, P. J. M., additional, Westerlund, H., additional, and Kivimaki, M., additional
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- 2015
- Full Text
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40. Job strain and the risk of severe asthma exacerbations : a meta-analysis of individual-participant data from 100 000 European men and women
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Heikkila, K., Madsen, I. E. H., Nyberg, S. T., Fransson, E. I., Westerlund, H., Westerholm, Peter J. M., Virtanen, M., Vahtera, J., Vaananen, A., Theorell, T., Suominen, S. B., Shipley, M. J., Salo, P., Rugulies, R., Pentti, J., Pejtersen, J. H., Oksanen, T., Nordin, M., Nielsen, M. L., Kouvonen, A., Koskinen, A., Koskenvuo, M., Knutsson, A., Ferrie, J. E., Dragano, N., Burr, H., Borritz, M., Bjorner, J. B., Alfredsson, L., Batty, G. D., Singh-Manoux, A., Kivimaki, M., Heikkila, K., Madsen, I. E. H., Nyberg, S. T., Fransson, E. I., Westerlund, H., Westerholm, Peter J. M., Virtanen, M., Vahtera, J., Vaananen, A., Theorell, T., Suominen, S. B., Shipley, M. J., Salo, P., Rugulies, R., Pentti, J., Pejtersen, J. H., Oksanen, T., Nordin, M., Nielsen, M. L., Kouvonen, A., Koskinen, A., Koskenvuo, M., Knutsson, A., Ferrie, J. E., Dragano, N., Burr, H., Borritz, M., Bjorner, J. B., Alfredsson, L., Batty, G. D., Singh-Manoux, A., and Kivimaki, M.
- Abstract
BackgroundMany patients and healthcare professionals believe that work-related psychosocial stress, such as job strain, can make asthma worse, but this is not corroborated by empirical evidence. We investigated the associations between job strain and the incidence of severe asthma exacerbations in working-age European men and women. MethodsWe analysed individual-level data, collected between 1985 and 2010, from 102 175 working-age men and women in 11 prospective European studies. Job strain (a combination of high demands and low control at work) was self-reported at baseline. Incident severe asthma exacerbations were ascertained from national hospitalization and death registries. Associations between job strain and asthma exacerbations were modelled using Cox regression and the study-specific findings combined using random-effects meta-analyses. ResultsDuring a median follow-up of 10years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic code). In the age- and sex-adjusted analyses, job strain was associated with an increased risk of severe asthma exacerbations defined using the primary diagnostic code (hazard ratio, HR: 1.27, 95% confidence interval, CI: 1.00, 1.61). This association attenuated towards the null after adjustment for potential confounders (HR: 1.22, 95% CI: 0.96, 1.55). No association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19). ConclusionsOur findings suggest that job strain is probably not an important risk factor for severe asthma exacerbations leading to hospitalization or death.
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- 2014
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41. Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory
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Berg, S.M. van den, Moor, M.H. de, McGue, M., Pettersson, E., Terracciano, A., Verweij, K.J., Amin, N., Derringer, J., Esko, T., Grootheest, G. van, Hansell, N.K., Huffman, J., Konte, B., Lahti, J., Luciano, M., Matteson, L.K., Viktorin, A., Wouda, J., Agrawal, A., Allik, J., Bierut, L.J., Broms, U., Campbell, H., Smith, G.D., Eriksson, J.G., Ferrucci, L., Franke, B., Fox, J.P., Geus, E.J. de, Giegling, I., Gow, A.J., Grucza, R.A., Hartmann, A.M., Heath, A.C., Heikkila, K., Iacono, W.G., Janzing, J.G., Jokela, M., Kiemeney, B., Lehtimaki, T., Madden, P.A.F., Magnusson, P.K., Northstone, K., Nutile, T., Ouwens, K.G., Palotie, A., Pattie, A., Pesonen, A.K., Polasek, O., Pulkkinen, L., Pulkki-Raback, L., Raitakari, O.T., Realo, A., Rose, R.J., Ruggiero, D., Seppala, I., Slutske, W.S., Smyth, D.C., Sorice, R., Starr, J.M., Sutin, A.R., Tanaka, T., Verhagen, J., Vermeulen, S., Vuoksimaa, E., Widen, E., Willemsen, G., Wright, M.J., Zgaga, L., Rujescu, D., Metspalu, A., Wilson, J.F., Ciullo, M., Hayward, C., Rudan, I., Deary, I.J., Raikkonen, K., Arias Vasquez, A., Costa, P.T., Keltikangas-Jarvinen, L., Duijn, C.M. van, Penninx, B.W.J.H., Krueger, R.F., Evans, D.M., Kaprio, J., Pedersen, N.L., Martin, N.G., Boomsma, D.I., Berg, S.M. van den, Moor, M.H. de, McGue, M., Pettersson, E., Terracciano, A., Verweij, K.J., Amin, N., Derringer, J., Esko, T., Grootheest, G. van, Hansell, N.K., Huffman, J., Konte, B., Lahti, J., Luciano, M., Matteson, L.K., Viktorin, A., Wouda, J., Agrawal, A., Allik, J., Bierut, L.J., Broms, U., Campbell, H., Smith, G.D., Eriksson, J.G., Ferrucci, L., Franke, B., Fox, J.P., Geus, E.J. de, Giegling, I., Gow, A.J., Grucza, R.A., Hartmann, A.M., Heath, A.C., Heikkila, K., Iacono, W.G., Janzing, J.G., Jokela, M., Kiemeney, B., Lehtimaki, T., Madden, P.A.F., Magnusson, P.K., Northstone, K., Nutile, T., Ouwens, K.G., Palotie, A., Pattie, A., Pesonen, A.K., Polasek, O., Pulkkinen, L., Pulkki-Raback, L., Raitakari, O.T., Realo, A., Rose, R.J., Ruggiero, D., Seppala, I., Slutske, W.S., Smyth, D.C., Sorice, R., Starr, J.M., Sutin, A.R., Tanaka, T., Verhagen, J., Vermeulen, S., Vuoksimaa, E., Widen, E., Willemsen, G., Wright, M.J., Zgaga, L., Rujescu, D., Metspalu, A., Wilson, J.F., Ciullo, M., Hayward, C., Rudan, I., Deary, I.J., Raikkonen, K., Arias Vasquez, A., Costa, P.T., Keltikangas-Jarvinen, L., Duijn, C.M. van, Penninx, B.W.J.H., Krueger, R.F., Evans, D.M., Kaprio, J., Pedersen, N.L., Martin, N.G., and Boomsma, D.I.
- Abstract
Contains fulltext : 135909.pdf (publisher's version ) (Open Access), Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized.
- Published
- 2014
42. Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory
- Author
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van den Berg, SM, de Moor, MHM, McGue, M, Pettersson, E, Terracciano, A, Verweij, KJH, Amin, Najaf, Derringer, J, Esko, T, Van Grootheest, G, Hansell, NK, Huffman, J, Konte, B, Lahti, J, Luciano, M, Matteson, LK, Viktorin, A, Wouda, J, Agrawal, A, Allik, J, Bierut, L, Broms, U, Campbell, H, Smith, GD, Eriksson, JG, Ferrucci, L, Franke, B, Fox, JP, de Geus, EJC, Giegling, I, Gow, AJ, Grucza, R, Hartmann, AM, Heath, AC, Heikkila, K, Iacono, W, Janzing, J, Jokela, M, Kiemeney, L, Lehtimaki, T, Madden, PAF, Magnusson, PKE, Northstone, K, Nutile, T, Ouwens, KG, Palotie, A, Pattie, A, Pesonen, AK, Polasek, O, Pulkkinen, L, Pulkki-Raback, L, Raitakari, OT, Realo, A, Rose, RJ, Ruggiero, D, Seppala, I, Slutske, WS, Smyth, DC, Sorice, R, Starr, JM, Sutin, AR, Tanaka, T, Verhagen, J, Vermeulen, Shanna, Vuoksimaa, E, Widen, E, Willemsen, G, Wright, M, Zgaga, L, Rujescu, D, Metspalu, A, Wilson, JF, Ciullo, M, Hayward, C, Rudan, I, Deary, IJ, Raikkonen, K, Vasquez, AA, Costa, PT, Keltikangas-Jarvinen, L, Duijn, Cornelia, Penninx, BWJH, Krueger, RF, Evans, DM, Kaprio, J, Pedersen, NL, Martin, NG, Boomsma, DI, van den Berg, SM, de Moor, MHM, McGue, M, Pettersson, E, Terracciano, A, Verweij, KJH, Amin, Najaf, Derringer, J, Esko, T, Van Grootheest, G, Hansell, NK, Huffman, J, Konte, B, Lahti, J, Luciano, M, Matteson, LK, Viktorin, A, Wouda, J, Agrawal, A, Allik, J, Bierut, L, Broms, U, Campbell, H, Smith, GD, Eriksson, JG, Ferrucci, L, Franke, B, Fox, JP, de Geus, EJC, Giegling, I, Gow, AJ, Grucza, R, Hartmann, AM, Heath, AC, Heikkila, K, Iacono, W, Janzing, J, Jokela, M, Kiemeney, L, Lehtimaki, T, Madden, PAF, Magnusson, PKE, Northstone, K, Nutile, T, Ouwens, KG, Palotie, A, Pattie, A, Pesonen, AK, Polasek, O, Pulkkinen, L, Pulkki-Raback, L, Raitakari, OT, Realo, A, Rose, RJ, Ruggiero, D, Seppala, I, Slutske, WS, Smyth, DC, Sorice, R, Starr, JM, Sutin, AR, Tanaka, T, Verhagen, J, Vermeulen, Shanna, Vuoksimaa, E, Widen, E, Willemsen, G, Wright, M, Zgaga, L, Rujescu, D, Metspalu, A, Wilson, JF, Ciullo, M, Hayward, C, Rudan, I, Deary, IJ, Raikkonen, K, Vasquez, AA, Costa, PT, Keltikangas-Jarvinen, L, Duijn, Cornelia, Penninx, BWJH, Krueger, RF, Evans, DM, Kaprio, J, Pedersen, NL, Martin, NG, and Boomsma, DI
- Abstract
Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in > 160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized.
- Published
- 2014
43. The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
- Author
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Fall, T, Hagg, S, Magi, R, Ploner, A, Fischer, K (Kirsten), Horikoshi, M, Sarin, AP, Thorleifsson, G, Ladenvall, C, Kals, M, Kuningas, Maris, Draisma, HHM, Ried, JS, van Zuydam, NR, Huikari, V, Mangino, M, Sonestedt, E, Benyamin, B, Nelson, CP, Rivera, NV, Kristiansson, K, Shen, HY, Havulinna, AS, Dehghan, Abbas, Donnelly, LA, Kaakinen, M, Nuotio, ML, Robertson, N, Bruijn, Renee, Ikram, Arfan, Amin, Najaf, Balmforth, AJ, Braund, PS, Doney, ASF, Doring, A, Elliott, P, Esko, T, Franco Duran, OH, Gretarsdottir, S, Hartikainen, AL, Heikkila, K, Herzig, KH, Holm, H, Hottenga, JJ (Jouke Jan), Hypponen, E, Illig, T, Isaacs, Aaron, Isomaa, B, Karssen, Lennart, Kettunen, J, Koenig, W, Kuulasmaa, K, Laatikainen, T, Laitinen, J, Lindgren, C, Lyssenko, V, Laara, E, Rayner, NW, Mannisto, S, Pouta, A, Rathmann, W, Rivadeneira, Fernando, Ruokonen, A, Savolainen, MJ, Sijbrands, E.J.G., Small, KS, Smit, JH, Steinthorsdottir, V, Syvanen, AC, Taanila, A, Tobin, MD, Uitterlinden, André, Willems, SM, Willemsen, G, Witteman, JCM, Perola, M, Evans, A, Ferrieres, J, Virtamo, J, Kee, F, Tregouet, DA, Arveiler, D, Amouyel, P, Ferrario, MM, Brambilla, P, Hall, AS, Heath, A, Madden, PAF, Martin, NG, Montgomery, GW, Whitfield, JB, Jula, A, Knekt, P, Oostra, Ben, Duijn, Cornelia, Penninx, BWJH, Smith, GD, Kaprio, J, Samani, NJ, Gieger, C, Peters, A, Wichmann, HE, Boomsma, DI, de Geus, EJC, Tuomi, T, Power, C, Hammond, CJ, Spector, TD, Lind, L, Orho-Melander, M, Palmer, CNA, Morris, AD, Groop, L, Jarvelin, MR, Salomaa, V, Vartiainen, E, Hofman, Bert, Ripatti, S, Metspalu, A, Thorsteinsdottir, U, Stefansson, K, Pedersen, NL, McCarthy, MI, Ingelsson, E, Prokopenko, I, Fall, T, Hagg, S, Magi, R, Ploner, A, Fischer, K (Kirsten), Horikoshi, M, Sarin, AP, Thorleifsson, G, Ladenvall, C, Kals, M, Kuningas, Maris, Draisma, HHM, Ried, JS, van Zuydam, NR, Huikari, V, Mangino, M, Sonestedt, E, Benyamin, B, Nelson, CP, Rivera, NV, Kristiansson, K, Shen, HY, Havulinna, AS, Dehghan, Abbas, Donnelly, LA, Kaakinen, M, Nuotio, ML, Robertson, N, Bruijn, Renee, Ikram, Arfan, Amin, Najaf, Balmforth, AJ, Braund, PS, Doney, ASF, Doring, A, Elliott, P, Esko, T, Franco Duran, OH, Gretarsdottir, S, Hartikainen, AL, Heikkila, K, Herzig, KH, Holm, H, Hottenga, JJ (Jouke Jan), Hypponen, E, Illig, T, Isaacs, Aaron, Isomaa, B, Karssen, Lennart, Kettunen, J, Koenig, W, Kuulasmaa, K, Laatikainen, T, Laitinen, J, Lindgren, C, Lyssenko, V, Laara, E, Rayner, NW, Mannisto, S, Pouta, A, Rathmann, W, Rivadeneira, Fernando, Ruokonen, A, Savolainen, MJ, Sijbrands, E.J.G., Small, KS, Smit, JH, Steinthorsdottir, V, Syvanen, AC, Taanila, A, Tobin, MD, Uitterlinden, André, Willems, SM, Willemsen, G, Witteman, JCM, Perola, M, Evans, A, Ferrieres, J, Virtamo, J, Kee, F, Tregouet, DA, Arveiler, D, Amouyel, P, Ferrario, MM, Brambilla, P, Hall, AS, Heath, A, Madden, PAF, Martin, NG, Montgomery, GW, Whitfield, JB, Jula, A, Knekt, P, Oostra, Ben, Duijn, Cornelia, Penninx, BWJH, Smith, GD, Kaprio, J, Samani, NJ, Gieger, C, Peters, A, Wichmann, HE, Boomsma, DI, de Geus, EJC, Tuomi, T, Power, C, Hammond, CJ, Spector, TD, Lind, L, Orho-Melander, M, Palmer, CNA, Morris, AD, Groop, L, Jarvelin, MR, Salomaa, V, Vartiainen, E, Hofman, Bert, Ripatti, S, Metspalu, A, Thorsteinsdottir, U, Stefansson, K, Pedersen, NL, McCarthy, MI, Ingelsson, E, and Prokopenko, I
- Published
- 2013
44. Job Strain as a Risk Factor for Leisure-Time Physical Inactivity: An Individual-Participant Meta-Analysis of Up to 170,000 Men and Women: The IPD-Work Consortium
- Author
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Fransson, E. I., primary, Heikkila, K., additional, Nyberg, S. T., additional, Zins, M., additional, Westerlund, H., additional, Westerholm, P., additional, Vaananen, A., additional, Virtanen, M., additional, Vahtera, J., additional, Theorell, T., additional, Suominen, S., additional, Singh-Manoux, A., additional, Siegrist, J., additional, Sabia, S., additional, Rugulies, R., additional, Pentti, J., additional, Oksanen, T., additional, Nordin, M., additional, Nielsen, M. L., additional, Marmot, M. G., additional, Magnusson Hanson, L. L., additional, Madsen, I. E. H., additional, Lunau, T., additional, Leineweber, C., additional, Kumari, M., additional, Kouvonen, A., additional, Koskinen, A., additional, Koskenvuo, M., additional, Knutsson, A., additional, Kittel, F., additional, Jockel, K.-H., additional, Joensuu, M., additional, Houtman, I. L., additional, Hooftman, W. E., additional, Goldberg, M., additional, Geuskens, G. A., additional, Ferrie, J. E., additional, Erbel, R., additional, Dragano, N., additional, De Bacquer, D., additional, Clays, E., additional, Casini, A., additional, Burr, H., additional, Borritz, M., additional, Bonenfant, S., additional, Bjorner, J. B., additional, Alfredsson, L., additional, Hamer, M., additional, Batty, G. D., additional, and Kivimaki, M., additional
- Published
- 2012
- Full Text
- View/download PDF
45. Long Working Hours and Coronary Heart Disease: A Systematic Review and Meta-Analysis
- Author
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Virtanen, M., primary, Heikkila, K., additional, Jokela, M., additional, Ferrie, J. E., additional, Batty, G. D., additional, Vahtera, J., additional, and Kivimaki, M., additional
- Published
- 2012
- Full Text
- View/download PDF
46. Work stress, tobacco smoking and alcohol intake: a collaborative meta-analysis of individual-participant data from 15 European studies
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Heikkila, K., primary
- Published
- 2011
- Full Text
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47. Breast feeding and child behaviour in the Millennium Cohort Study
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Heikkila, K., primary, Sacker, A., additional, Kelly, Y., additional, Renfrew, M. J., additional, and Quigley, M. A., additional
- Published
- 2011
- Full Text
- View/download PDF
48. Elderly care for ethnic minorities : Wishes and expectations among elderly Finns in Sweden
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Heikkila, K, Ekman, Sirkka-Liisa, Heikkila, K, and Ekman, Sirkka-Liisa
- Abstract
Objectives. Although elderly people from immigrant and minority groups utilise elderly care facilities to a lesser extent than elderly people from majority groups, there is a lack of research on how elderly people with different ethnic backgrounds wish and expect to be cared,for when they are in need of institutional elderly care. This study aims to illuminate the role that culturally appropriate care plays in elderly Finnish immigrants' wishes and expectations of institutional elderly care in Sweden. Design. Thirty-nine elderly Finnish immigrants in Sweden, aged 75 years or more, were interviewed in their homes. The data were analysed with latent qualitative content analysis. Results. The elderly Finnish immigrants in Sweden wished to be able to continue living in their current homes for as long as possible. Later on, when entering institutional elderly care, they wanted to feel continuity, familiarity, security and companionship with others. As immigrants, they had to choose to be cared for either in well-known physical environments close to their current homes, or in a culturally appropriate care setting with familiar socio-cultural conditions. Conclusions. To be able to provide institutional elderly care for minority groups it is important to ease the access to elderly care amenities by providing care that results in maintaining as much continuity and familiarity as possible in the lives of the elderly people. This includes the care providers and other residents who share the familiar aspects of their lives. This involves providing culturally appropriate elderly care close to the elderly people's current homes.
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- 2003
- Full Text
- View/download PDF
49. 012 Breast feeding and behavioural development in children: findings from the Millennium Cohort Study
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Heikkila, K., primary, Sacker, A., additional, Kelly, Y., additional, Renfrew, M. J., additional, and Quigley, M. A., additional
- Published
- 2010
- Full Text
- View/download PDF
50. Geographical structure and differential natural selection among North European populations
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McEvoy, B. P., primary, Montgomery, G. W., additional, McRae, A. F., additional, Ripatti, S., additional, Perola, M., additional, Spector, T. D., additional, Cherkas, L., additional, Ahmadi, K. R., additional, Boomsma, D., additional, Willemsen, G., additional, Hottenga, J. J., additional, Pedersen, N. L., additional, Magnusson, P. K.E., additional, Kyvik, K. O., additional, Christensen, K., additional, Kaprio, J., additional, Heikkila, K., additional, Palotie, A., additional, Widen, E., additional, Muilu, J., additional, Syvanen, A.-C., additional, Liljedahl, U., additional, Hardiman, O., additional, Cronin, S., additional, Peltonen, L., additional, Martin, N. G., additional, and Visscher, P. M., additional
- Published
- 2009
- Full Text
- View/download PDF
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