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747 results on '"Heiland M"'

3. Effect of a synthetic hydroxyapatite-based bone grafting material compared to established bone substitute materials on regeneration of critical-size bone defects in the ovine scapula

Author

Wüster, J, primary, Neckel, N, additional, Sterzik, F, additional, Xiang-Tischhauser, L, additional, Barnewitz, D, additional, Genzel, A, additional, Koerdt, S, additional, Rendenbach, C, additional, Müller-Mai, C, additional, Heiland, M, additional, Nahles, S, additional, and Knabe, C, additional

Published
2024
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18. Spontan perirenale Blutungen ��� Ursachenabkl��rung anhand eines case reports

Author

Podbiel, S, Heiland, M, and Ubrig, B

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Die spontan perirenale Blutung ist eine seltene Komplikation verschiedener Nierenerkrankungen. In der Literatur wurden bisher erst ca. 600 F��lle publiziert. In der Mehrzahl der F��lle geht sie von Tumoren der Nieren, insbesondere Nierenzellkarzinomen oder Angiomyolipomen aus. Weiterhin [zum vollst��ndigen Text gelangen Sie ��ber die oben angegebene URL]

Published
2022
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24. 6- und 12-Monats-Ergebnisse des Vergleichs zwischen PEO-oberflächenmodifizierten und WE43-basierten Magnesiumimplantaten ohne Oberflächenmodifikation im Schweinemodell

Author

Fischer, H, Schmidt-Bleek, K, Jung, O, Smeets, R, Duda, GN, Kopp, A, Heiland, M, and Rendenbach, DC

Subjects
Minipigmodell, Schrauben, ddc: 610, Medicine and health, Platten, Magnesium, resorbierbare Implantate
Abstract

Fragestellung: Magnesium zeigt durch die Ähnlichkeit seines E-Moduls zum kortikalen Knochen und seiner Biokompatibilität vielversprechende Eigenschaften für die Verwendung als resorbierbares Osteosynthesematerial. Jedoch kommt es bei der Degradation von Magnesiumimplantaten zur Freisetzung [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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25. Detection of spontaneous seizures in EEGs in multiple experimental mouse models of epilepsy

Author

Wei L, Boutouil H, Gerbatin RR, Mamad O, Heiland M, Reschke CR, Del Gallo F, Fabene PF, Henshall DC, Lowery M, Morris G, and Mooney C

Abstract

Objective.Electroencephalography (EEG) is a key tool for non-invasive recording of brain activity and the diagnosis of epilepsy. EEG monitoring is also widely employed in rodent models to track epilepsy development and evaluate experimental therapies and interventions. Whereas automated seizure detection algorithms have been developed for clinical EEG, preclinical versions face challenges of inter-model differences and lack of EEG standardization, leaving researchers relying on time-consuming visual annotation of signals.Approach.In this study, a machine learning-based seizure detection approach, 'Epi-AI', which can semi-automate EEG analysis in multiple mouse models of epilepsy was developed. Twenty-six mice with a total EEG recording duration of 6451 h were used to develop and test the Epi-AI approach. EEG recordings were obtained from two mouse models of kainic acid-induced epilepsy (Models I and III), a genetic model of Dravet syndrome (Model II) and a pilocarpine mouse model of epilepsy (Model IV). The Epi-AI algorithm was compared against two threshold-based approaches for seizure detection, a local Teager-Kaiser energy operator (TKEO) approach and a global Teager-Kaiser energy operator-discrete wavelet transform (TKEO-DWT) combination approach.Main results.Epi-AI demonstrated a superior sensitivity, 91.4%–98.8%, and specificity, 93.1%–98.8%, in Models I–III, to both of the threshold-based approaches which performed well on individual mouse models but did not generalise well across models. The performance of the TKEO approach in Models I–III ranged from 66.9%–91.3% sensitivity and 60.8%–97.5% specificity to detect spontaneous seizures when compared with expert annotations. The sensitivity and specificity of the TKEO-DWT approach were marginally better than the TKEO approach in Models I–III at 73.2%–80.1% and 75.8%–98.1%, respectively. When tested on EEG from Model IV which was not used in developing the Epi-AI approach, Epi-AI was able to identify seizures with 76.3% sensitivity and 98.1% specificity.Significance.Epi-AI has the potential to provide fast, objective and reproducible semi-automated analysis of multiple types of seizure in long-duration EEG recordings in rodents.

Published
2021

30. Real‐world evidence from over one million COVID‐19 vaccinations is consistent with reactivation of the varicella‐zoster virus.

Author

Hertel, M., Heiland, M., Nahles, S., von Laffert, M., Mura, C., Bourne, P.E., Preissner, R., and Preissner, S.

Subjects
*HERPES zoster, *VARICELLA-zoster virus, *COVID-19 vaccines, *VACCINATION complications, *DRUG side effects, *VIRUS reactivation
Abstract

Background: Reactivation of the varicella‐zoster virus (VZV), which causes herpes zoster (HZ, synonym: shingles) in humans, can be a rare adverse reaction to vaccines. Recently, reports of cases after COVID‐19 vaccination have arisen. Objectives: The aim of this study was to assess whether the frequency of HZ is found to increase after COVID‐19 vaccination in a large cohort, based on real‐world data. As a hypothesis, the incidence of HZ was assumed to be significantly higher in subjects who received a COVID‐19 vaccine (Cohort I) vs. unvaccinated individuals (Cohort II). Methods: The initial cohorts of 1 095 086 vaccinated and 16 966 018 unvaccinated patients were retrieved from the TriNetX database and were matched on age and gender in order to mitigate confounder bias. Results: After matching, each cohort accounted for 1 095 086 patients. For the vaccinated group (Cohort I), 2204 subjects developed HZ within 60 days of COVID‐19 vaccination, while among Cohort II, 1223 patients were diagnosed with HZ within 60 days after having visited the clinic for any other reason (i.e. not vaccination). The risk of developing shingles was calculated as 0.20% and 0.11% for cohort I and cohort II, respectively. The difference was statistically highly significant (P < 0.0001; log‐rank test). The risk ratio and odds ratio were 1.802 (95% confidence interval [CI] = 1.680; 1.932) and 1.804 (95% CI = 1.682; 1.934). Conclusions: Consistent with the hypothesis, a higher incidence of HZ was statistically detectable post‐COVID‐19 vaccine. Accordingly, the eruption of HZ may be a rare adverse drug reaction to COVID‐19 vaccines. Even though the molecular basis of VZV reactivation remains murky, temporary compromising of VZV‐specific T‐cell‐mediated immunity may play a mechanistic role in post‐vaccination pathogenesis of HZ. Note that VZV reactivation is a well‐established phenomenon both with infections and with other vaccines (i.e. this adverse event is not COVID‐19‐specific). [ABSTRACT FROM AUTHOR]

Published
2022
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34. Robotische Harnleiterneueinpflanzung in eine robotisch angelegte Neoblase

Author

Roosen, A, Heiland, M, and Ubrig, B

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Stenosierungen der Harnleiter-Darm-Anastomose(n) nach Anlage einer Neoblase sind eine bekannte Spätkomplikation in der Harnableitungschirurgie. Die Versorgung im Sinne einer Neuanlage der Anastomose ist wegen der tiefen Lage im kleinen Becken und der üblicherweise vorhandenen ausgeprägten[zum vollständigen Text gelangen Sie über die oben angegebene URL], 66. Kongress der Nordrhein-Westfälischen Gesellschaft für Urologie

Published
2020
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36. Learning by doing virtually

Author

von Sternberg, N., Bartsch, M.S., Petersik, A., Wiltfang, J., Sibbersen, W., Grindel, T., Tiede, U., Warnke, P.H., Heiland, M., Russo, P.A.J., Terheyden, H., Pohlenz, P., and Springer, I.N.

Published
2007
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