598 results on '"Heitman, Laura H."'
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2. Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors
3. The effect of cancer-associated mutations on ligand binding and receptor function – A case for the 5-HT2C receptor
4. CC chemokine receptor 2 is allosterically modulated by sodium ions and amiloride derivatives through a distinct sodium ion binding site
5. A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence
6. 3DDPDs: describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors
7. Structural basis of selective cannabinoid CB2 receptor activation
8. Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor
9. Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2
10. Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor
11. Cellular Assay to Study β-Arrestin Recruitment by the Cannabinoid Receptors 1 and 2
12. Oncological drug discovery: AI meets structure-based computational research
13. Kinetic profiling and functional characterization of 8-phenylxanthine derivatives as A2B adenosine receptor antagonists
14. Stereochemical optimization of N,2-substituted cycloalkylamines as norepinephrine reuptake inhibitors.
15. Targeting solute carriers to modulate receptor–ligand interactions
16. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists
17. Anticancer opportunities at every stage of chemokine function
18. Synthesis and SAR evaluation of coumarin derivatives as potent cannabinoid receptor agonists
19. G protein-coupled receptors expressed and studied in yeast. The adenosine receptor as a prime example
20. Inhibition of macrophage migration in zebrafish larvae demonstrates in vivo efficacy of human CCR2 inhibitors
21. Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe.
22. Pharmacological characterization of allosteric modulators: A case for chemokine receptors.
23. Design and pharmacological profile of a novel covalent partial agonist for the adenosine A1 receptor
24. Characterization of cancer-related somatic mutations in the adenosine A2B receptor
25. LUF7244 plus Dofetilide Rescues Aberrant Kv11.1 Trafficking and Produces Functional IKv11.1
26. Label-free detection of prostaglandin transporter (SLCO2A1) function and inhibition: insights by wound healing and TRACT assays
27. Computational Characterization of Membrane Proteins as Anticancer Targets: Current Challenges and Opportunities
28. Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays
29. Molecular probes for the human adenosine receptors
30. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
31. Chapter 26 - Immunobiology and pharmacology of neuropeptide substance P
32. Affinity, binding kinetics and functional characterization of draflazine analogues for human equilibrative nucleoside transporter 1 (SLC29A1)
33. A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery
34. Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors
35. Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition
36. Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes
37. Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2).
38. Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R).
39. N‑Acyl‑N‑Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2B Receptor as Case Study.
40. Fluorophore-Labeled Pyrrolones Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR1.
41. Discovery of a Cannabinoid CB2 Receptor Fluorescent Probe Based on a Pyridin-2-yl-benzyl-imidazolidine-2,4-dione Scaffold.
42. Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.
43. Impact of allosteric modulation: Exploring the binding kinetics of glutamate and other orthosteric ligands of the metabotropic glutamate receptor 2
44. A binding kinetics study of human adenosine A3 receptor agonists
45. Intracellular Receptor Modulation: Novel Approach to Target GPCRs
46. Constitutive activity of the metabotropic glutamate receptor 2 explored with a whole-cell label-free biosensor
47. Structure-kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent-specific lipophilic effects on residence time
48. Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism
49. A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor
50. Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB2) ligand designed for PET studies
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