1. Evaluation of the mucoadhesive properties of chitosan nanoparticles prepared using different chitosan to tripolyphosphate (CS:TPP) ratios.
- Author
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Hejjaji EMA, Smith AM, and Morris GA
- Subjects
- Adhesiveness, Chitosan chemistry, Chitosan metabolism, Drug Carriers metabolism, Mucins metabolism, Mucous Membrane metabolism, Particle Size, Chitosan analogs & derivatives, Drug Carriers chemistry, Mucous Membrane chemistry, Nanoparticles
- Abstract
Mucoadhesive molecules such as chitosan, can allow targeting of a particular tissue to prolong residence time and subsequently improve bioavailability. The purpose of this study was to investigate chitosan-tripolyphosphate (CS:TPP) nanoparticles and to evaluate the interaction between nanoparticles of different CS:TPP ratios with mucin using viscosity, particle size analysis and ζ-potential. For all CS:TPP ratios examined, a minimum value of viscosity was reached for a 3:1 CS:TPP ratio, however chitosan nanoparticles at this ratio were not stable (<+30 mV), whereas a CS:TPP ratio of 4:1 displayed the strongest interaction. This suggests a minimum CS:TPP ratio of 4:1 is required to produce stable nanoparticles able to form strong interactions, which is consistent with a greater mucin binding efficiencies at CS:TPP ratios of 4:1 and higher, which were quantified using a colorimetric assay. Further analysis of similar systems could lead potentially to tuneable chitosan nanoparticles for specific applications., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
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