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7. Zodasiran, an RNAi Therapeutic Targeting ANGPTL3, for Mixed Hyperlipidemia

8. Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia

10. Reassessing Phase II Heart Failure Clinical Trials

19. A First-in-Human Study of AMG 986, a Novel Apelin Receptor Agonist, in Healthy Subjects and Heart Failure Patients

21. Contributors

27. Contributors

28. First‐in‐Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers

29. First‐in‐Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers

31. Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations.

37. Pharmacokinetic evaluation of treprostinil(oral) for the treatment of pulmonary arterial hypertension

48. Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk.

49. Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.

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