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1. Supplementary Figure S1 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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2. Supplementary Table S2 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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3. Data from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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4. Supplementary Appendix S1 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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5. Predictive factors for lymph node metastases in vulvar cancer. An analysis of the AGO-CaRE-1 multicenter study

Author

Klapdor, Rüdiger, Wölber, Linn, Hanker, Lars, Schmalfeldt, Barbara, Canzler, Ulrich, Fehm, Tanja, Luyten, Alexander, Hellriegel, Martin, Kosse, Jens, Heiss, Christoph, Hantschmann, Peer, Mallmann, Peter, Tanner, Berno, Pfisterer, Jacobus, Jückstock, Julia, Hilpert, Felix, de Gregorio, Nikolaus, Hillemanns, Peter, Fürst, Sophie Teresa, and Mahner, Sven

Published
2019
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7. Role of tumour-free margin distance for loco-regional control in vulvar cancer—a subset analysis of the Arbeitsgemeinschaft Gynäkologische Onkologie CaRE-1 multicenter study

Author

Woelber, Linn, Griebel, Lis-Femke, Eulenburg, Christine, Sehouli, Jalid, Jueckstock, Julia, Hilpert, Felix, de Gregorio, Nikolaus, Hasenburg, Annette, Ignatov, Atanas, Hillemanns, Peter, Fuerst, Sophie, Strauss, Hans-Georg, Baumann, Klaus H., Thiel, Falk C., Mustea, Alexander, Meier, Werner, Harter, Philipp, Wimberger, Pauline, Hanker, Lars Christian, Schmalfeldt, Barbara, Canzler, Ulrich, Fehm, Tanja, Luyten, Alexander, Hellriegel, Martin, Kosse, Jens, Heiss, Christoph, Hantschmann, Peer, Mallmann, Peter, Tanner, Berno, Pfisterer, Jacobus, Richter, Barbara, Neuser, Petra, and Mahner, Sven

Published
2016
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9. Outcome After Sentinel Lymph Node Dissection in Vulvar Cancer: A Subgroup Analysis of the AGO-CaRE-1 Study

Author

Klapdor, Rüdiger, Hillemanns, Peter, Wölber, Linn, Jückstock, Julia, Hilpert, Felix, de Gregorio, Nikolaus, Iborra, Severine, Sehouli, Jalid, Habermann, Anika, Fürst, Sophie Teresa, Strauß, Hans Georg, Baumann, Klaus, Thiel, Falk, Mustea, Alexander, Meier, Werner, Harter, Philipp, Wimberger, Pauline, Hanker, Lars, Schmalfeldt, Barbara, Canzler, Ulrich, Fehm, Tanja, Luyten, Alexander, Hellriegel, Martin, Kosse, Jens, Heiss, Christoph, Hantschmann, Peer, Mallmann, Peter, Tanner, Berno, Pfisterer, Jacobus, Richter, Barbara, Jäger, Martin, and Mahner, Sven

Published
2017
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10. p53 and p16 expression profiles in vulvar cancer: a translational analysis by the Arbeitsgemeinschaft Gynäkologische Onkologie Chemo and Radiotherapy in Epithelial Vulvar Cancer study group

Author

Woelber, Linn, primary, Prieske, Katharina, additional, Eulenburg, Christine, additional, Oliveira-Ferrer, Leticia, additional, de Gregorio, Nikolaus, additional, Klapdor, Ruediger, additional, Kalder, Matthias, additional, Braicu, Iona, additional, Fuerst, Sophie, additional, Klar, Maximilian, additional, Strauss, Hans-Georg, additional, Beckmann, Matthias, additional, Meier, Werner, additional, Ignatov, Atanas, additional, Mustea, Alexander, additional, Jueckstock, Julia, additional, Schmidt, Georg, additional, Bauerschlag, Dirk, additional, Hellriegel, Martin, additional, Canzler, Ulrich, additional, Petry, Karl Ulrich, additional, Kommoss, Stefan, additional, Hantschmann, Peer, additional, Heubner, Martin, additional, Mahner, Sven, additional, and Burandt, Eike, additional

Published
2021
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11. Pelvine Lymphonodektomie beim Vulvakarzinom - Wohl oder Übel?

Author

Woelber, Linn, Bommert, Mareike, Prieske, Katharina, Fischer, Inger, Zu Eulenburg, Christine, Vettorazzi, Eik, Harter, Philipp, Jueckstock, Julia, Hilpert, Felix, De Gregorio, Niko, Iborra, Severine, Sehouli, Jalid, Ignatov, Atanas, Hillemanns, Peter, Fuerst, Sophie, Strauss, Hans Georg, Baumann, Klaus, Beckmann, Matthias, Mustea, Alexander, Meier, Werner, Wimberger, Pauline, Hanker, Lars, Canzler, Ulrich, Fehm, Tanja, Luyten, Alexander, Hellriegel, Martin, Kosse, Jens, Heiss, Christoph, Hantschmann, Peer, Mallmann, Peter, Tanner, Berno, Pfisterer, Jacobus, Mahner, Sven, Schmalfeldt, Barbara, and Jaeger, Anna

Subjects
recurrence, vulvar cancer, lymph node metastasis, pelvic lymphadenectomy, prognosis
Abstract

Since the publication of the updated German guideline in 2015, the recommendations for performing pelvic lymphadenectomy (LAE) in patients with vulvar cancer (VSCC) have changed considerably. The guideline recommends surgical lymph node staging in all patients with a higher risk of pelvic lymph node involvement. However, the current data do not allow the population at risk to be clearly defined, therefore, the indication for pelvic lymphadenectomy is still not clear. There are currently two published German patient populations who had pelvic LAE which can be used to investigate both the prognostic effect of histologically verified pelvic lymph node metastasis and the relation between inguinal and pelvic lymph node involvement. A total of 1618 patients with primary FIGO stage ≥ IB VSCC were included in the multicenter AGO CaRE-1 study (1998-2008), 70 of whom underwent pelvic LAE. During a retrospective single-center evaluation carried out at the University Medical Center Hamburg-Eppendorf (UKE), a total of 514 patients with primary VSCC treated between 1996-2018 were evaluated, 21 of whom underwent pelvic LAE. In both cohorts, around 80% of the patients who underwent pelvic LAE were inguinally node-positive, with a median number of three affected groin lymph nodes. There were no cases of pelvic lymph node metastasis without inguinal lymph node metastasis in either of the two cohorts. Between 33-35% of the inguinal node-positive patients also had pelvic lymph node metastasis; the median number of affected groin lymph nodes in these patients was high (> 4), and the maximum median diameter of the largest inguinal metastasis was > 40 mm in both cohorts. Pelvic lymph node staging and pelvic radiotherapy is therefore probably not necessary for the majority of node-positive patients with VSCC, as the relevant risk of pelvic lymph node involvement was primarily found in node-positive patients with high-grade disease. More, ideally prospective data collections are necessary to validate the relation between inguinal and pelvic lymph node involvement.

Published
2020

13. Pelvic Lymphadenectomy in Vulvar Cancer – Does it make sense?

Author

Woelber, Linn, additional, Bommert, Mareike, additional, Prieske, Katharina, additional, Fischer, Inger, additional, zu Eulenburg, Christine, additional, Vettorazzi, Eik, additional, Harter, Philipp, additional, Jueckstock, Julia, additional, Hilpert, Felix, additional, de Gregorio, Niko, additional, Iborra, Severine, additional, Sehouli, Jalid, additional, Ignatov, Atanas, additional, Hillemanns, Peter, additional, Fuerst, Sophie, additional, Strauss, Hans-Georg, additional, Baumann, Klaus, additional, Beckmann, Matthias, additional, Mustea, Alexander, additional, Meier, Werner, additional, Wimberger, Pauline, additional, Hanker, Lars, additional, Canzler, Ulrich, additional, Fehm, Tanja, additional, Luyten, Alexander, additional, Hellriegel, Martin, additional, Kosse, Jens, additional, Heiss, Christoph, additional, Hantschmann, Peer, additional, Mallmann, Peter, additional, Tanner, Berno, additional, Pfisterer, Jacobus, additional, Mahner, Sven, additional, Schmalfeldt, Barbara, additional, and Jaeger, Anna, additional

Published
2020
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14. Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology

Author

Wienbeck, Susanne, Uhlig, Johannes, Fischer, Uwe, Hellriegel, Martin, von Fintel, Eva, Kulenkampff, Dietrich, Surov, Alexey, Lotz, Joachim, and Perske, Christina

Subjects
Breast lesion
Abstract

To compare the accuracy of breast lesion size measurement of cone-beam breast-CT (CBBCT), digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM).Patients scheduled for mastectomy due to at least 1 malignant breast lesion were included. Mastectomy specimens were examined by CBBCT, DBT, FFDM, and histopathology.A total of 94 lesions (40 patients) were included. Histopathological analyses revealed 47 malignant, 6 high-risk, and 41 benign lesions. Mean histopathological lesion size was 20.8 mm (range 2-100). Mean absolute size deviation from histopathology was largest for FFDM (5.3 ± 6.7 mm) and smallest for CBBCT 50 mA, high-resolution mode (4.3 ± 6.7 mm). Differences between imaging modalities did not reach statistical significance (P = .85).All imaging methods tend to overestimate breast lesion size compared to histopathological gold standard. No significant differences were found regarding size measurements, although in tendency CBBCT showed better lesion detection and cT classification over FFDM. peerReviewed

Published
2019

15. p53 and p16 expression profiles reveal three prognostically relevant subgroups in vulvar cancer: A TMA based study by the AGO-CaRE-translational study group.

Author

Woelber, Linn Lena, primary, Prieske, Katharina, additional, Eulenburg, Christine, additional, de Gregorio, Nikolaus, additional, Klapdor, Rüdiger, additional, Kalder, Matthias, additional, Braicu, Elena Ioana, additional, Fuerst, Sophie, additional, Klar, Maximillian, additional, Strauss, Hans-Georg, additional, Mehlhorn, Grit, additional, Meier, Werner, additional, Ignatov, Atanas, additional, Mustea, Alexander, additional, Jueckstock, Julia Kathrin, additional, Schmidt, Georg, additional, Bauerschlag, Dirk, additional, Hellriegel, Martin, additional, Mahner, Sven, additional, and Burandt, Eike, additional

Published
2019
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17. Corrigendum to 'Borderline tumours of the ovary: A cohort study of the Arbeitsgemeinschaft Gynäkologische Onkologie AGO Study Group'

Author

du Bois, Andreas, Ewald-Riegler, Nina, de Gregorio, Nikolaus, Reuss, Alexander, Mahner, Sven, Fotopoulou, Christina, Kommoss, Friedrich, Schmalfeldt, Barbara, Hilpert, Felix, Fehm, Tanja, Burges, Alexander, Meier, Werner, Hillemanns, Peter, Hanker, Lars, Hasenburg, Annette, Strauss, Hans-Georg, Hellriegel, Martin, Wimberger, Pauline, Keyver-Paik, Mignon-Denise, Baumann, Klaus, Canzler, Ulrich, Wollschlaeger, Kerstin, Forner, Dirk, Pfisterer, Jacobus, Schröder, Willibald, Münstedt, Karsten, Richter, Barbara, Kommoss, Stefan, and Hauptmann, Steffen

Subjects
Medizin
Published
2016

19. Outcome After Sentinel Lymph Node Dissection in Vulvar Cancer: A Subgroup Analysis of the AGO-CaRE-1 Study

Author

Klapdor, Rüdiger, primary, Hillemanns, Peter, additional, Wölber, Linn, additional, Jückstock, Julia, additional, Hilpert, Felix, additional, de Gregorio, Nikolaus, additional, Iborra, Severine, additional, Sehouli, Jalid, additional, Habermann, Anika, additional, Fürst, Sophie Teresa, additional, Strauß, Hans Georg, additional, Baumann, Klaus, additional, Thiel, Falk, additional, Mustea, Alexander, additional, Meier, Werner, additional, Harter, Philipp, additional, Wimberger, Pauline, additional, Hanker, Lars, additional, Schmalfeldt, Barbara, additional, Canzler, Ulrich, additional, Fehm, Tanja, additional, Luyten, Alexander, additional, Hellriegel, Martin, additional, Kosse, Jens, additional, Heiss, Christoph, additional, Hantschmann, Peer, additional, Mallmann, Peter, additional, Tanner, Berno, additional, Pfisterer, Jacobus, additional, Richter, Barbara, additional, Jäger, Martin, additional, and Mahner, Sven, additional

Published
2016
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21. Corrigendum to “Borderline tumours of the ovary: A cohort study of the Arbeitsgemeinschaft Gynäkologische Onkologie AGO Study Group” [Eur J Cancer 49 (2013) 1905–1914]

Author

du Bois, Andreas, primary, Ewald-Riegler, Nina, additional, de Gregorio, Nikolaus, additional, Reuss, Alexander, additional, Mahner, Sven, additional, Fotopoulou, Christina, additional, Kommoss, Friedrich, additional, Schmalfeldt, Barbara, additional, Hilpert, Felix, additional, Fehm, Tanja, additional, Burges, Alexander, additional, Meier, Werner, additional, Hillemanns, Peter, additional, Hanker, Lars, additional, Hasenburg, Annette, additional, Strauss, Hans-Georg, additional, Hellriegel, Martin, additional, Wimberger, Pauline, additional, Keyver-Paik, Mignon-Denise, additional, Baumann, Klaus, additional, Canzler, Ulrich, additional, Wollschlaeger, Kerstin, additional, Forner, Dirk, additional, Pfisterer, Jacobus, additional, Schröder, Willibald, additional, Münstedt, Karsten, additional, Richter, Barbara, additional, Kommoss, Stefan, additional, and Hauptmann, Steffen, additional

Published
2016
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22. The course of vulvar cancer: The utility of multistate models in the AGO-CaRE-1 study.

Author

zu Eulenburg, Christine, primary, Woelber, Linn Lena, additional, Baumann, Klaus H., additional, Neuser, Petra, additional, Thiel, Falk, additional, Mustea, Alexander, additional, Meier, Werner, additional, Harter, Philipp, additional, Wimberger, Pauline, additional, Hanker, Lars Christian, additional, Schmalfeldt, Barbara, additional, Canzler, Ulrich, additional, Fehm, Tanja N., additional, Luyten, Alexander, additional, Hellriegel, Martin, additional, Reuss, Alexander, additional, Suling, Anna, additional, and Mahner, Sven, additional

Published
2016
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23. Surgical staging and its prognostic impact on patients with borderline ovarian tumors (BOT): A subanalysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) ROBOT study.

Author

Trillsch, Fabian, primary, Mahner, Sven, additional, Woelber, Linn Lena, additional, Vettorazzi, Eik, additional, Reuss, Alexander, additional, Ewald-Riegler, Nina, additional, De Gregorio, Nikolaus, additional, Fotopoulou, Christina, additional, Schmalfeldt, Barbara, additional, Burges, Alexander, additional, Hilpert, Felix, additional, Fehm, Tanja N., additional, Meier, Werner, additional, Hillemanns, Peter, additional, Hanker, Lars Christian, additional, Hasenburg, Annette, additional, Strauss, Hans-Georg, additional, Hellriegel, Martin, additional, Wimberger, Pauline, additional, and Du Bois, Andreas, additional

Published
2014
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24. Resection margin and locoregional control in vulvar cancer: A subset analysis of the AGO CARE-1 multicenter study.

Author

Woelber, Linn Lena, primary, Sehouli, Jalid, additional, Habermann, Anika, additional, Hillemanns, Peter, additional, Neuser, Petra, additional, Fuerst, Sophie, additional, Strauss, Hans-Georg, additional, Baumann, Klaus H., additional, Thiel, Falk Clemens, additional, Mustea, Alexander, additional, Meier, Werner, additional, Harter, Philipp, additional, Wimberger, Pauline, additional, Hanker, Lars Christian, additional, Schmalfeldt, Barbara, additional, Canzler, Ulrich, additional, Fehm, Tanja N., additional, Luyten, Alexander, additional, Hellriegel, Martin, additional, and Mahner, Sven, additional

Published
2014
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30. Borderline tumours of the ovary: A cohort study of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Study Group

Author

du Bois, Andreas, primary, Ewald-Riegler, Nina, additional, de Gregorio, Nikolaus, additional, Reuss, Alexander, additional, Mahner, Sven, additional, Fotopoulou, Christina, additional, Kommoss, Friedrich, additional, Schmalfeldt, Barbara, additional, Hilpert, Felix, additional, Fehm, Tanja, additional, Burges, Alexander, additional, Meier, Werner, additional, Hillemanns, Peter, additional, Hanker, Lars, additional, Hasenburg, Annette, additional, Strauss, Hans-Georg, additional, Hellriegel, Martin, additional, Wimberger, Pauline, additional, Keyver-Paik, Mignon-Denise, additional, Baumann, Klaus, additional, Canzler, Ulrich, additional, Wollschlaeger, Kerstin, additional, Forner, Dirk, additional, Pfisterer, Jacobus, additional, Schröder, Willibald, additional, Münstedt, Karsten, additional, Richter, Barbara, additional, Kommoss, Stefan, additional, and Hauptmann, Steffen, additional

Published
2013
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31. A genome-wide survey of RAS transformation targets

Author

Zuber, Johannes, primary, Tchernitsa, Oleg I., additional, Hinzmann, Bernd, additional, Schmitz, Anne-Chantal, additional, Grips, Martin, additional, Hellriegel, Martin, additional, Sers, Christine, additional, Rosenthal, André, additional, and Schäfer, Reinhold, additional

Published
2000
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34. Targeted chemotherapy for triple-negative breast cancers via LHRH receptor.

Author

Föst C, Duwe F, Hellriegel M, Schweyer S, Emons G, and Gründker C

Subjects
Animals, Caspase 3 metabolism, Cell Line, Tumor, Cell Proliferation drug effects, Doxorubicin pharmacology, Enzyme Activation drug effects, Female, Humans, Membrane Potential, Mitochondrial drug effects, Mice, Mice, Nude, Xenograft Model Antitumor Assays, Antineoplastic Agents, Hormonal pharmacology, Breast Neoplasms pathology, Doxorubicin analogs & derivatives, Gonadotropin-Releasing Hormone analogs & derivatives, Gonadotropin-Releasing Hormone pharmacology, Receptors, LHRH metabolism
Abstract

Triple-negative breast cancer does not express estrogen and progesterone receptors and there is no overexpression/amplification of the HER2-neu gene. Therefore, this subtype of breast cancer lacks the benefits of specific therapies which target these receptors. About 60% of all human breast cancers express receptors for luteinizing hormone releasing hormone (LHRH, GnRH), which might be used as a target. The LHRH receptor can be used for targeted chemotherapy with cytotoxic luteinizing hormone releasing hormone agonists such as AEZS-108 (AN-152), in which doxorubicin is linked to [D-Lys6]LHRH. In the present study we have analyzed by in vitro and in vivo experiments whether the cytotoxic LHRH agonist AEZS-108 (AN-152) induces apoptosis in triple-negative human breast cancer cells that express LHRH receptors. LHRH receptor expression in tumor biopsy specimens of triple-negative breast cancers was tested using immunohistochemistry. Cell proliferation was analyzed using alamar blue proliferation assay. Induction of apoptosis was quantified by measurement of loss of mitochondrial membrane potential. In vivo experiments were performed using nude mice bearing xenografted human breast tumors.Thirty-one of 42 triple-negative breast cancers (73.8%) expressed LHRH receptors. We could show that treatment of triple-negative but LHRH-positive MDA-MB-231, HCC1806 and HCC1937 human breast cancer cells with AEZS-108 (AN-152) resulted in apoptotic cell death in vitro via activation of caspase-3. The antitumor effects were confirmed in nude mice. AEZS-108 (AN-152) inhibited the growth of xenotransplants of triple-negative human breast cancers in nude mice completely, without any apparent side effects. The cytotoxic LHRH agonist AEZS-108 (AN-152) seems to be a suitable drug for an efficacious therapy for triple-negative breast cancers with little toxicity.

Published
2011
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35. Gonadotropin-releasing hormone (GnRH) agonist triptorelin inhibits estradiol-induced serum response element (SRE) activation and c-fos expression in human endometrial, ovarian and breast cancer cells.

Author

Gründker C, Günthert AR, Hellriegel M, and Emons G

Subjects
Antineoplastic Agents, Hormonal administration & dosage, Breast Neoplasms pathology, Cell Division drug effects, Cell Line, Tumor, Dose-Response Relationship, Drug, Endometrial Neoplasms metabolism, Endometrial Neoplasms pathology, Estrogen Receptor alpha metabolism, Estrogen Receptor beta metabolism, Estrogens metabolism, Female, Gene Expression drug effects, Genes, fos, Genital Neoplasms, Female pathology, Gonadotropin-Releasing Hormone agonists, Humans, Ovarian Neoplasms metabolism, Ovarian Neoplasms pathology, Response Elements drug effects, Triptorelin Pamoate administration & dosage, Antineoplastic Agents, Hormonal pharmacology, Breast Neoplasms metabolism, Estradiol pharmacology, Genital Neoplasms, Female metabolism, Proto-Oncogene Proteins c-fos antagonists & inhibitors, Serum Response Element drug effects, Triptorelin Pamoate pharmacology
Abstract

Background and Methods: The majority of human endometrial (>80%), ovarian (>80%) and breast (>50%) cancers express GnRH receptors. Their spontaneous and epidermal growth-factor-induced proliferation is dose- and time-dependently reduced by treatment with GnRH and its agonists. In this study, we demonstrate that the GnRH agonist triptorelin inhibits estradiol (E2)-induced cancer cell proliferation., Results: The proliferation of quiescent estrogen receptor alpha (ER alpha)-/ER beta-positive, but not of ER alpha-negative/ER beta-positive endometrial, ovarian and breast cancer cell lines, was significantly stimulated (P<0.001) (ANOVA) after treatment with E2 (10(-8) M). This effect was time- and dose-dependently antagonized by simultaneous treatment with triptorelin. The inhibitory effect was maximal at 10(-5) M concentration of triptorelin (P<0.001). In addition, we could show that, in ER alpha-/ER beta-positive cell lines, E2 induces activation of serum response element (SRE) and expression of the immediate early-response gene c-fos. These effects were blocked by triptorelin (P<0.001). E2-induced activation of estrogen-response element (ERE) was not affected by triptorelin., Conclusions: The transcriptional activation of SRE by E2 is due to ER alpha activation of the mitogen-activated protein kinase (MAPK) pathway. This pathway is impeded by GnRH, resulting in a reduction of E2-induced SRE activation and, in consequence, a reduction of E2-induced c-fos expression. This causes downregulation of E2-induced cancer cell proliferation.

Published
2004
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