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1. Minimal residual disease–driven treatment intensification with sequential addition of ibrutinib to venetoclax in R/R CLL

Author

Scarfò, Lydia, Heltai, Silvia, Albi, Elisa, Scarano, Eloise, Schiattone, Luana, Farina, Lucia, Moia, Riccardo, Deodato, Marina, Ferrario, Andrea, Motta, Marina, Reda, Gianluigi, Sancetta, Rosaria, Coscia, Marta, Rivela, Paolo, Laurenti, Luca, Varettoni, Marzia, Perotta, Eleonora, Capasso, Antonella, Ranghetti, Pamela, Colia, Maria, and Ghia, Paolo

Published
2022
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3. P646: VENETOCLAX RETREATMENT AFTER MRD-GUIDED VENETOCLAX +/- IBRUTINIB: THE IMPROVE STUDY COHORT

Author

Scarfò, Lydia, primary, Heltai, Silvia, additional, Albi, Elisa, additional, Scarano, Eloise, additional, Schiattone, Luana, additional, Farina, Lucia, additional, Moia, Riccardo, additional, Deodato, Marina, additional, Ferrario, Andrea, additional, Motta, Marina, additional, Noto, Alessandro, additional, Sancetta, Rosaria, additional, Coscia, Marta, additional, Rivela, Paolo, additional, Laurenti, Luca, additional, Varettoni, Marzia, additional, Perotta, Eleonora, additional, Capasso, Antonella, additional, Ranghetti, Pamela, additional, Martini, Francesca, additional, Sant’antonio, Emanuela, additional, Combi, Catalina, additional, Colia, Maria, additional, and Ghia, Paolo, additional

Published
2023
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4. P1517: HUMORAL AND CELLULAR IMMUNE RESPONSES TO SARS-COV-2 NATURAL INFECTION OR VACCINATION IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL): A STUDY BY ERIC, THE EUROPEAN RESEARCH INITIATIVE ON CLL

Author

Campanella, Alessandro, primary, Capasso, Antonella, additional, Taccetti, Caterina, additional, Heltai, Silvia, additional, Albi, Elisa, additional, Herishanu, Yair, additional, Haggenburg, Sabine, additional, Chatzikonstantinou, Thomas, additional, Doubek, Michael, additional, Kättström, Magdalena, additional, Giannopoulos, Krzysztof, additional, Simkovic, Martin, additional, Moreno, Carol, additional, Massaia, Massimo, additional, Bumbea, Horia, additional, Shimmari, Salem Al, additional, Ranghetti, Pamela, additional, Perotta, Eleonora, additional, Martini, Francesca, additional, Sant’antonio, Emanuela, additional, Colia, Maria, additional, Combi, Catalina, additional, Levi, Shai, additional, Kater, Arnon, additional, Hazenberg, Mette, additional, Nijhof, Inger, additional, Hofsink, Quincy, additional, Demosthenous, Christos, additional, Kotaskova, Jana, additional, Zaleska, Joanna, additional, Vrbacky, Filip, additional, Mora, Alba, additional, Bisogno, Davide, additional, Tripoli, Ignazio Ezio, additional, Popov, Viola Maria, additional, Roman, Viviana, additional, Scarano, Eloise, additional, Frenquelli, Michela, additional, Scarfò, Lydia, additional, Stamatopoulos, Kostas, additional, and Ghia, Paolo, additional

Published
2023
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5. Data from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients

Author

De Monte, Lucia, primary, Wörmann, Sonja, primary, Brunetto, Emanuela, primary, Heltai, Silvia, primary, Magliacane, Gilda, primary, Reni, Michele, primary, Paganoni, Anna Maria, primary, Recalde, Helios, primary, Mondino, Anna, primary, Falconi, Massimo, primary, Aleotti, Francesca, primary, Balzano, Gianpaolo, primary, Algül, Hana, primary, Doglioni, Claudio, primary, and Protti, Maria Pia, primary

Published
2023
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6. Supplementary Figure 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients

Author

De Monte, Lucia, primary, Wörmann, Sonja, primary, Brunetto, Emanuela, primary, Heltai, Silvia, primary, Magliacane, Gilda, primary, Reni, Michele, primary, Paganoni, Anna Maria, primary, Recalde, Helios, primary, Mondino, Anna, primary, Falconi, Massimo, primary, Aleotti, Francesca, primary, Balzano, Gianpaolo, primary, Algül, Hana, primary, Doglioni, Claudio, primary, and Protti, Maria Pia, primary

Published
2023
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7. Supplementary Table 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients

Author

De Monte, Lucia, primary, Wörmann, Sonja, primary, Brunetto, Emanuela, primary, Heltai, Silvia, primary, Magliacane, Gilda, primary, Reni, Michele, primary, Paganoni, Anna Maria, primary, Recalde, Helios, primary, Mondino, Anna, primary, Falconi, Massimo, primary, Aleotti, Francesca, primary, Balzano, Gianpaolo, primary, Algül, Hana, primary, Doglioni, Claudio, primary, and Protti, Maria Pia, primary

Published
2023
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10. Poster: CLL-461 Humoral Response to COVID-19 Vaccine: A Challenge in CLL

Author

Capasso, Antonella, primary, Albi, Elisa, additional, Schiattone, Luana, additional, Martini, Francesca, additional, Sant'Antonio, Emanuela, additional, Scarfò, Lydia, additional, Ranghetti, Pamela, additional, Frenquelli, Michela, additional, Campanella, Alessandro, additional, Perotta, Eleonora, additional, Heltai, Silvia, additional, Colia, Maria, additional, and Ghia, Paolo, additional

Published
2022
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11. Minimal Residual Disease-Driven Treatment Intensification By Sequential Addition of Ibrutinib to Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia: Results of the Monotherapy and Combination Phases of the Improve Study

Author

Scarfo, Lydia, primary, Heltai, Silvia, additional, Albi, Elisa, additional, Scarano, Eloise, additional, Schiattone, Luana, additional, Farina, Lucia, additional, Gaidano, Gianluca, additional, Deodato, Marina, additional, Ferrario, Andrea, additional, Motta, Marina, additional, Reda, Gianluigi, additional, Sancetta, Rosaria, additional, Coscia, Marta, additional, Ladetto, Marco, additional, Laurenti, Luca, additional, Varettoni, Marzia, additional, Perotta, Eleonora, additional, Capasso, Antonella, additional, Ranghetti, Pamela, additional, Colia, Maria, additional, and Ghia, Paolo, additional

Published
2020
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12. Additional file 2: of The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Author

Brunetto, Emanuela, Monte, Lucia De, Balzano, Gianpaolo, Camisa, Barbara, Laino, Vincenzo, Riba, Michela, Heltai, Silvia, Bianchi, Marco, Bordignon, Claudio, Falconi, Massimo, Bondanza, Attilio, Doglioni, Claudio, and Protti, Maria

Subjects
endocrine system, animal structures, animal diseases, hemic and immune systems, eye diseases
Abstract

Figure S2. Validation of knockdown of ASC/PYCARD expression in BxPC-3 and A8184 cells after siRNA transfections. Cells transfected with ASC siRNA showed significant reduction in both ASC mRNA expression. Significance was determined using Student’s t test. Values significantly different were indicated as: *p

Published
2019
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13. Additional file 5: of The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Author

Brunetto, Emanuela, Monte, Lucia De, Balzano, Gianpaolo, Camisa, Barbara, Laino, Vincenzo, Riba, Michela, Heltai, Silvia, Bianchi, Marco, Bordignon, Claudio, Falconi, Massimo, Bondanza, Attilio, Doglioni, Claudio, and Protti, Maria

Subjects
stomatognathic system, skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists
Abstract

Figure S5. IL-1β expression in the stroma is mainly supported by TAMs. Immunofluorescence staining was performed to identify IL-1β secreting cells in the tumor stroma. TAM are stained in red (i.e., CD163), IL-1β in green. (DOCX 248 kb)

Published
2019
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14. Additional file 7: of The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Author

Brunetto, Emanuela, Monte, Lucia De, Balzano, Gianpaolo, Camisa, Barbara, Laino, Vincenzo, Riba, Michela, Heltai, Silvia, Bianchi, Marco, Bordignon, Claudio, Falconi, Massimo, Bondanza, Attilio, Doglioni, Claudio, and Protti, Maria

Abstract

Figure S7. Proposed model of crosstalk within the tumor microenvironment leading to TSLP secretion by CAFs and Th2 inflammation. a Inflammatory cytokines are released from dying/dead tumor cells. b Tumor cells release ASC that activates TAMs to secrete IL-1β (c). d Tumor cell- and TAM-derived IL-1ι and IL-1β, respectively, induce TSLP secretion by CAFs. e TSLP activates resident DCs with Th2 polarizing capability. Pharmacological molecules able to interfere with these mechanisms are indicated in red. (DOCX 2538 kb)

Published
2019
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15. Additional file 3: of The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Author

Brunetto, Emanuela, Monte, Lucia De, Balzano, Gianpaolo, Camisa, Barbara, Laino, Vincenzo, Riba, Michela, Heltai, Silvia, Bianchi, Marco, Bordignon, Claudio, Falconi, Massimo, Bondanza, Attilio, Doglioni, Claudio, and Protti, Maria

Abstract

Figure S3. TSLP mRNA isoform expression in CAFs in steady state conditions or after activation. For activation CAFs (n = 5) were treated with recombinant cytokines (IL-1α, IL-1β and TNF-α), which were used either alone or in combinations at the concentration of 20 ng/ml/each cytokine. a Expression of short and long TSLP forms by CAF untreated (basal) or activated by cytokine treatment (activated). b Fold (DOCX 191 kb) increase in TSLP mRNA expression after activation for the long and short TSLP isoforms. Significance was determined by the Wilcoxon matched-pairs signed rank test (a) and Mann Whitney test (b). Values significantly different were indicated as: p

Published
2019
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16. Additional file 6: of The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Author

Brunetto, Emanuela, Monte, Lucia De, Balzano, Gianpaolo, Camisa, Barbara, Laino, Vincenzo, Riba, Michela, Heltai, Silvia, Bianchi, Marco, Bordignon, Claudio, Falconi, Massimo, Bondanza, Attilio, Doglioni, Claudio, and Protti, Maria

Subjects
endocrine system diseases, chemical and pharmacologic phenomena, digestive system diseases
Abstract

Figure S6. Levels of HMGB1 measured by ELISA in the supernatant of the indicated PDAC cell lines. (DOCX 86 kb)

Published
2019
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17. Additional file 1: of The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Author

Brunetto, Emanuela, Monte, Lucia De, Balzano, Gianpaolo, Camisa, Barbara, Laino, Vincenzo, Riba, Michela, Heltai, Silvia, Bianchi, Marco, Bordignon, Claudio, Falconi, Massimo, Bondanza, Attilio, Doglioni, Claudio, and Protti, Maria

Abstract

Figure S1. Validation of knockdown of IL-1α and IL-1β expression in Hs766T cells after siRNA transfections. Cells transfected with IL-1α + IL-1β siRNA showed significant reduction in both IL-1α and IL-1β mRNA expression. Significance was determined using Student’s t test. Values significantly different were indicated as: *p

Published
2019
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18. Additional file 4: of The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer

Author

Brunetto, Emanuela, Monte, Lucia De, Balzano, Gianpaolo, Camisa, Barbara, Laino, Vincenzo, Riba, Michela, Heltai, Silvia, Bianchi, Marco, Bordignon, Claudio, Falconi, Massimo, Bondanza, Attilio, Doglioni, Claudio, and Protti, Maria

Subjects
endocrine system diseases
Abstract

Figure S4. Inflammatory cytokine expression and secretion by PDAC cell lines. PDAC cell lines either commercially available or established from primary surgical samples were tested for mRNA expression of IL-1ι, IL-1β, IL-18 and TNF-ι by real time PCR (a), and protein expression in lysates (b) or in the supernatants (c) detected by ELISA. (DOCX 395 kb)

Published
2019
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22. Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection

Author

Goebel Frank D, Vollbrecht Thomas, Santagostino Elena, Stellbrink Hans-J, Lusso Paolo, Bogner Johannes R, Tambussi Giuseppe, Reitmeir Peter, Hoffmann Dieter, Vicenzi Elisa, Ghezzi Silvia, Biswas Priscilla, Allgayer Simone, Heltai Silvia, Kutscher Sarah, Dembek Claudia J, Protzer Ulrike, Draenert Rika, Tinelli Marco, Poli Guido, Erfle Volker, Malnati Mauro, and Cosma Antonio

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Long-term survival of HIV-1 infected individuals is usually achieved by continuous administration of combination antiretroviral therapy (ART). An exception to this scenario is represented by HIV-1 infected nonprogressors (NP) which maintain relatively high circulating CD4+ T cells without clinical symptoms for several years in the absence of ART. Several lines of evidence indicate an important role of the T-cell response in the modulation of HIV-1 infection during the acute and chronic phase of the disease. Results We analyzed the functional and the differentiation phenotype of Nef- and Tat-specific CD8+ T cells in a cohort of HIV-1 infected NP in comparison to progressors, ART-treated seropositive individuals and individuals undergoing a single cycle of ART interruption. We observed that a distinctive feature of NP is the presence of Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma. This population was present in 7 out of 11 NP. CD45RA+ IFN-gammaneg MIP-1beta+ CD8+ T cells were not detected in HIV-1 infected individuals under ART or withdrawing from ART and experiencing a rebounding viral replication. In addition, we detected Nef-specific CD45RA+ IFN-gammaneg MIP-1beta+ CD8+ T cells in only 1 out of 10 HIV-1 infected individuals with untreated progressive disease. Conclusion The novel antigen-specific CD45RA+ IFN-gammaneg MIP-1beta+ CD8+ T cell population represents a new candidate marker of long-term natural control of HIV-1 disease progression and a relevant functional T-cell subset in the evaluation of the immune responses induced by candidate HIV-1 vaccines.

Published
2010
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25. The intracellular detection of MIP-1beta enhances the capacity to detect IFN-gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT

Author

Goebel Frank D, Stellbrink Hans J, Bogner Johannes R, Tambussi Giuseppe, Nozza Silvia, Biswas Priscilla, Stadlbauer Birgit, Heltai Silvia, Allgayer Simone, Dembek Claudia J, Kutscher Sarah, Lusso Paolo, Tinelli Marco, Poli Guido, Erfle Volker, Pohla Heike, Malnati Mauro, and Cosma Antonio

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background T-cell mediated immunity likely plays an important role in controlling HIV-1 infection and progression to AIDS. Several candidate vaccines against HIV-1 aim at stimulating cellular immune responses, either alone or together with the induction of neutralizing antibodies, and assays able to measure CD8 and CD4 T-cell responses need to be implemented. At present, the IFN-γ-based ELISPOT assay is considered the gold standard and it is broadly preferred as primary assay for detection of antigen-specific T-cell responses in vaccine trials. However, in spite of its high sensitivity, the measurement of the sole IFN-γ production provides limited information on the quality of the immune response. On the other hand, the introduction of polychromatic flow-cytometry-based assays such as the intracellular cytokine staining (ICS) strongly improved the capacity to detect several markers on a single cell level. Results The cumulative analysis of 275 samples from 31 different HIV-1 infected individuals using an ICS staining procedure optimized by our laboratories revealed that, following antigenic stimulation, IFN-γ producing T-cells were also producing MIP-1β whereas T-cells characterized by the sole production of IFN-γ were rare. Since the analysis of the combination of two functions decreases the background and the measurement of the IFN-γ+ MIP-1β+ T-cells was equivalent to the measurement of the total IFN-γ+ T-cells, we adopted the IFN-γ+ MIP-1β+ data analysis system to evaluate IFN-γ-based, antigen-specific T-cell responses. Comparison of our ICS assay with ELISPOT assays performed in two different experienced laboratories demonstrated that the IFN-γ+ MIP-1β+ data analysis system increased the sensitivity of the ICS up to levels comparable to the sensitivity of the ELISPOT assay. Conclusion The IFN-γ+ MIP-1β+ data evaluation system provides a clear advantage for the detection of low magnitude HIV-1-specific responses. These results are important to guide the choice for suitable highly sensitive immune assays and to build reagent panels able to accurately characterize the phenotype and function of responding T-cells. More importantly, the ICS assay can be used as primary assay to evaluate HIV-1-specific responses without losing sensitivity in comparison to the ELISPOT assay.

Published
2008
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26. Killing of laminin receptor-positive human lung cancers by tumor-infiltrating lymphocytes bearing gamma-delta+ T-cell receptors

Author

Ferrarini, Marina, Heltai, Silvia, Pupa, Serenella M., Menard, Sylvie, and Zocchi, M. Raffaella

Subjects
T cells -- Receptors, Lung cancer, Tumor-infiltrating lymphocytes -- Health aspects, Health
Abstract

Background. The monomeric laminin receptor, a 67-kd high-affinity laminin-binding protein, is expressed by a variety of normal cell types. Overexpression and abnormal surface distribution of this receptor have been demonstrated in tumor cells, where it appears to promote tumor invasion and metastasis. Previously, we reported the existence of an association between laminin receptor overexpression by lung c-ancer cells and the presence of tumor-infiltrating lymphocytes (TILs) bearing [gamma][zeta] T-cell receptors. [gamma][zeta]+ lymphocytes represent a sizable fraction of the TILs in approximately one fourth of lung cancers analyzed thus far. Purpose: The aim of this study was to determine whether [gamma][zeta]+ TILs might participate in the immune response against lung cancer through recognition of monomeric laminin receptors expressed by tumor cells. Methods: Tumor cells from 11 lung cancer specimens exhibiting sizable [gamma][zeta]+ T-cell infiltrates and from 11 other specimens infiltrated predominantly by lymphocytes bearing [alpha][beta] T-cell receptors were analyzed for expression of the monomeric laminin receptor by use of the monoclonal antibody (MAb) MLuC5. [gamma][zeta]+ TILs and [alpha][beta]+ TILs derived from four tumors were each examined for cytotoxic activity toward lung cancer target cells by use of a standard 51Cr-release assay and lung tumor cell lines expressing different levels of surface monomeric laminin receptor. The ability of MAbs directed against the laminin receptor (i.e., MLUC5) or against [gamma][zeta] T-cell receptors (i.e., Ti[gamma]A and A13) as well as laminin peptides known to bind to the laminin receptor to inhibit TIL-mediated target cell lysis was also determined. Results: We confirmed that the association between overexpression of the monomeric laminin receptor by lung tumor cells and the presence of [gamma][zeta]+ TILs is statistically significant (two-sided P = .003; Fisher's exact test). We also observed a relationship between the levels of laminin receptor expression on cultured lung cancer cells and their susceptibility to specific lysis by [gamma][zeta]+, but not [alpha][beta]+, TILs. This specific cell killing was not T-cell receptor mediated, but it was inhibited by addition of the anti-monomeric laminin receptor MAb MLUC5 and by a synthetic peptide corresponding to amino acids 2091-2108 of the laminin A chain. Conclusions and Implications: Our results indicate that [gamma][zeta]+ TILs localized at human lung cancer sites can kill tumor cells in a process that involves interaction with the monomeric laminin receptor. The infiltration of [gamma][zeta]+ TILs at lung tumor sites may represent a first line of defense against cells undergoing malignant transformation. [J Natl Cancer Inst 1996;88:436-411

Published
1996

27. Modeling multiple myeloma-bone marrow interactions and response to drugs in a 3D surrogate microenvironment

Author

Belloni, Daniela, primary, Heltai, Silvia, additional, Ponzoni, Maurilio, additional, Villa, Antonello, additional, Vergani, Barbara, additional, Pecciarini, Lorenza, additional, Marcatti, Magda, additional, Girlanda, Stefania, additional, Tonon, Giovanni, additional, Ciceri, Fabio, additional, Caligaris-Cappio, Federico, additional, Ferrarini, Marina, additional, and Ferrero, Elisabetta, additional

Published
2018
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28. Outcomes of Venetoclax Retreatment after MRD-Guided Venetoclax +/- Ibrutinib: Results of the Improve Study

Author

Albi, Elisa, Scarfo, Lydia, Heltai, Silvia, Scarano, Eloise, Schiattone, Luana, Farina, Lucia, Moia, Riccardo, Deodato, Marina, Ferrario, Andrea, Motta, Marina, Noto, Alessandro, Sancetta, Rosaria, Coscia, Marta, Rivela, Paolo, Laurenti, Luca, Varettoni, Marzia, Perotta, Eleonora, Capasso, Antonella, Ranghetti, Pamela, Martini, Francesca, Sant'Antonio, Emanuela, Combi, Catalina, Colia, Maria, and Ghia, Paolo

Abstract

Data from small cohorts of patients (pts) with chronic lymphocytic leukemia (CLL) relapsing after venetoclax-based fixed-duration regimens suggest that venetoclax retreatment may be a feasible option. Information on the efficacy and tolerability of venetoclax retreatment in this setting is still scanty, making it worth exploring venetoclax retreatment in prospective cohorts of well-characterized pts with CLL. We analyzed the efficacy and safety of venetoclax retreatment in pts with relapsed/refractory CLL enrolled in our clinical trial IMPROVE (NCT04754035).

Published
2023
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29. Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients

Author

De Monte, Lucia, primary, Wörmann, Sonja, additional, Brunetto, Emanuela, additional, Heltai, Silvia, additional, Magliacane, Gilda, additional, Reni, Michele, additional, Paganoni, Anna Maria, additional, Recalde, Helios, additional, Mondino, Anna, additional, Falconi, Massimo, additional, Aleotti, Francesca, additional, Balzano, Gianpaolo, additional, Algül, Hana, additional, Doglioni, Claudio, additional, and Protti, Maria Pia, additional

Published
2016
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31. Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival

Author

Di Lullo, Giulia, primary, Marcatti, Magda, additional, Heltai, Silvia, additional, Brunetto, Emanuela, additional, Tresoldi, Cristina, additional, Bondanza, Attilio, additional, Bonini, Chiara, additional, Ponzoni, Maurilio, additional, Tonon, Giovanni, additional, Ciceri, Fabio, additional, Bordignon, Claudio, additional, and Protti, Maria Pia, additional

Published
2015
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32. Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms

Author

Moroni, Marco, primary, Ghezzi, Silvia, additional, Baroli, Paolo, additional, Heltai, Silvia, additional, De Battista, Davide, additional, Pensieroso, Simone, additional, Cavarelli, Mariangela, additional, Dispinseri, Stefania, additional, Vanni, Irene, additional, Pastori, Claudia, additional, Zerbi, Pietro, additional, Tosoni, Antonella, additional, Vicenzi, Elisa, additional, Nebuloni, Manuela, additional, Wong, Kim, additional, Zhao, Hong, additional, McHugh, Sarah, additional, Poli, Guido, additional, Lopalco, Lucia, additional, Scarlatti, Gabriella, additional, Biassoni, Roberto, additional, Mullins, James I, additional, Malnati, Mauro S, additional, and Alfano, Massimo, additional

Published
2014
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33. A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses

Author

Malnati, Mauro S., primary, Heltai, Silvia, additional, Cosma, Antonio, additional, Reitmeir, Peter, additional, Allgayer, Simone, additional, Glashoff, Richard H., additional, Liebrich, Walter, additional, Vardas, Eftyhia, additional, Imami, Nesrina, additional, Westrop, Samantha, additional, Nozza, Silvia, additional, Tambussi, Giuseppe, additional, Buttò, Stefano, additional, Fanales-Belasio, Emanuele, additional, Ensoli, Barbara, additional, Ensoli, Fabrizio, additional, Tripiciano, Antonella, additional, Fortis, Claudio, additional, Lusso, Paolo, additional, Poli, Guido, additional, Erfle, Volker, additional, and Holmes, Harvey, additional

Published
2012
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34. Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection

Author

Dembek, Claudia J, primary, Kutscher, Sarah, additional, Heltai, Silvia, additional, Allgayer, Simone, additional, Biswas, Priscilla, additional, Ghezzi, Silvia, additional, Vicenzi, Elisa, additional, Hoffmann, Dieter, additional, Reitmeir, Peter, additional, Tambussi, Giuseppe, additional, Bogner, Johannes R, additional, Lusso, Paolo, additional, Stellbrink, Hans-J, additional, Santagostino, Elena, additional, Vollbrecht, Thomas, additional, Goebel, Frank D, additional, Protzer, Ulrike, additional, Draenert, Rika, additional, Tinelli, Marco, additional, Poli, Guido, additional, Erfle, Volker, additional, Malnati, Mauro, additional, and Cosma, Antonio, additional

Published
2010
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35. The intracellular detection of MIP-1beta enhances the capacity to detect IFN-gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT

Author

Kutscher, Sarah, primary, Dembek, Claudia J, additional, Allgayer, Simone, additional, Heltai, Silvia, additional, Stadlbauer, Birgit, additional, Biswas, Priscilla, additional, Nozza, Silvia, additional, Tambussi, Giuseppe, additional, Bogner, Johannes R, additional, Stellbrink, Hans J, additional, Goebel, Frank D, additional, Lusso, Paolo, additional, Tinelli, Marco, additional, Poli, Guido, additional, Erfle, Volker, additional, Pohla, Heike, additional, Malnati, Mauro, additional, and Cosma, Antonio, additional

Published
2008
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36. Nef Alleles from Human Immunodeficiency Virus Type 1-InfectedLong-Term-Nonprogressor Hemophiliacs with or without Late Disease Progression Are Defective in Enhancing Virus Replication and CD4 Down-Regulation

Author

Crotti, Andrea, primary, Neri, Francesca, additional, Corti, Davide, additional, Ghezzi, Silvia, additional, Heltai, Silvia, additional, Baur, Andreas, additional, Poli, Guido, additional, Santagostino, Elena, additional, and Vicenzi, Elisa, additional

Published
2006
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