Search

Your search keyword '"Helthuis, Marinka"' showing total 18 results
Start Over Author "Helthuis, Marinka"
18 results on '"Helthuis, Marinka"'

4. Mediation and Longitudinal Analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Author

Lock, Siobhan K., primary, Legge, Sophie E., additional, Kappel, Djenifer B., additional, Willcocks, Isabella R., additional, Helthuis, Marinka, additional, Jansen, John, additional, Walters, James T. R., additional, Owen, Michael J., additional, O’Donovan, Michael C., additional, and Pardiñas, Antonio F., additional

Published
2023
Full Text
View/download PDF

7. Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

Author

Kappel, Djenifer B., primary, Legge, Sophie E., additional, Hubbard, Leon, additional, Willcocks, Isabella R., additional, O’Connell, Kevin S., additional, Smith, Robert L., additional, Molden, Espen, additional, Andreassen, Ole A., additional, King, Adrian, additional, Jansen, John, additional, Helthuis, Marinka, additional, Owen, Michael J., additional, O’Donovan, Michael C., additional, Walters, James T.R., additional, and Pardiñas, Antonio F., additional

Published
2023
Full Text
View/download PDF

9. Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: A longitudinal analysis and GWAS using clinical monitoring data from the UK

Author

Pardiñas, Antonio F., primary, Kappel, Djenifer B., additional, Roberts, Milly, additional, Tipple, Francesca, additional, Shitomi-Jones, Lisa M., additional, King, Adrian, additional, Jansen, John, additional, Helthuis, Marinka, additional, Owen, Michael J., additional, O’Donovan, Michael C., additional, and Walters, James T.R., additional

Published
2022
Full Text
View/download PDF

11. Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia

Author

Willcocks, Isabella R., primary, Legge, Sophie E., additional, Nalmpanti, Mariana, additional, Mazzeo, Lucy, additional, King, Adrian, additional, Jansen, John, additional, Helthuis, Marinka, additional, Owen, Michael J., additional, O’Donovan, Michael C., additional, Walters, James T. R., additional, and Pardiñas, Antonio F., additional

Published
2021
Full Text
View/download PDF

12. There Is Life After the UK Clozapine Central Non-Rechallenge Database

Author

Oloyede, Ebenezer, primary, Casetta, Cecilia, additional, Dzahini, Olubanke, additional, Segev, Aviv, additional, Gaughran, Fiona, additional, Shergill, Sukhi, additional, Mijovic, Alek, additional, Helthuis, Marinka, additional, Whiskey, Eromona, additional, MacCabe, James Hunter, additional, and Taylor, David, additional

Published
2021
Full Text
View/download PDF

13. Clozapine metabolism is associated with Absolute Neutrophil Count in individuals with treatment-resistant schizophrenia

Author

Willcocks, Isabella, primary, Legge, Sophie E., additional, Nalmpanti, Mariana, additional, Mazzeo, Lucy, additional, King, Adrian, additional, Jansen, John, additional, Helthuis, Marinka, additional, Owen, Michael J., additional, O’Donovan, Michael C., additional, Walters, James T.R., additional, and Pardiñas, Antonio F., additional

Published
2021
Full Text
View/download PDF

14. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Author

Pardiñas, Antonio F, Holmans, Peter, Han, Jun, Nothen, Markus, Goate, Alison, Cruchaga, Carlos, Nowotny, Petra, Morris, John C, Mayo, Kevin, O'Donovan, Michael, Owen, Michael, Williams, Julie, Hubbard, Leon, Achilla, Evanthia, Agerbo, Esben, Barr, Cathy L, Böttger, Theresa Wimberly, Breen, Gerome, Cohen, Dan, Collier, David A, Curran, Sarah, Dempster, Emma, Dima, Danai, Lynham, Amy, Sabes-Figuera, Ramon, Flanagan, Robert J, Frangou, Sophia, Frank, Josef, Gasse, Christiane, Gaughran, Fiona, Giegling, Ina, Grove, Jakob, Hannon, Eilis, Hartmann, Annette M, Mantripragada, Kiran, Heißerer, Barbara, Helthuis, Marinka, Horsdal, Henriette Thisted, Ingimarsson, Oddur, Jollie, Karel, Kennedy, James L, Köhler, Ole, Konte, Bettina, Lang, Maren, Legge, Sophie E, Rees, Elliott, Lewis, Cathryn, MacCabe, James, Malhotra, Anil K, McCrone, Paul, Meier, Sandra M, Mill, Jonathan, Mors, Ole, Mortensen, Preben Bo, Nöthen, Markus M, O'Donovan, Michael C, MacCabe, James H, Owen, Michael J, Pedersen, Carsten B, Rietschel, Marcella, Rujescu, Dan, Schwalber, Ameli, Sigurdsson, Engilbert, Sørensen, Holger J, Spencer, Benjamin, Stefansson, Hreinn, McCarroll, Steven A, Støvring, Henrik, Strohmaier, Jana, Sullivan, Patrick, Vassos, Evangelos, Verbelen, Moira, Walters, James T R, Werge, Thomas, Baune, Bernhard T, Byrne, Enda M, Pocklington, Andrew J, Dannlowski, Udo, Eley, Thalia C, Hayward, Caroline, Martin, Nicholas G, McIntosh, Andrew M, Plomin, Robert, Porteous, David J, Wray, Naomi R, Caballero, Armando, Geschwind, Daniel H, Escott-Price, Valentina, Huckins, Laura M, Ruderfer, Douglas M, Santiago, Enrique, Sklar, Pamela, Stahl, Eli A, Won, Hyejung, Als, Thomas D, Andreassen, Ole A, Bækvad-Hansen, Marie, Ripke, Stephan, Pedersen, Carsten Bøcker, Børglum, Anders D, Bybjerg-Grauholm, Jonas, Djurovic, Srdjan, Durmishi, Naser, Pedersen, Marianne Giørtz, Golimbet, Vera, Hougaard, David M, Carrera, Noa, Mattheisen, Manuel, Molden, Espen, Nordentoft, Merete, Pejovic-Milovancevic, Milica, Silagadze, Teimuraz, Hansen, Christine Søholm, Stefansson, Kari, Steinberg, Stacy, Tosato, Sarah, Consortium, GERAD1, Consortium, CRESTAR, Kirov, George, Bishop, Sophie, Harold, Denise, Sims, Rebecca, Gerrish, Amy, Chapman, Jade, Abraham, Richard, Hollingworth, Paul, Pahwa, Jaspreet, Denning, Nicola, Cameron, Darren, Thomas, Charlene, Taylor, Sarah, Powell, John, Proitsi, Petroula, Lupton, Michelle, Lovestone, Simon, Passmore, Peter, Craig, David, McGuinness, Bernadette, Johnston, Janet, Hamshere, Marian L, Todd, Stephen, Maier, Wolfgang, Jessen, Frank, Heun, Reiner, Schurmann, Britta, Ramirez, Alfredo, Becker, Tim, Herold, Christine, Lacour, André, and Drichel, Dmitriy

Subjects
0301 basic medicine, POSITIVE SELECTION, REGULATORY ELEMENTS, LD SCORE REGRESSION, Schizophrenia (object-oriented programming), Population, LOCI, Inheritance Patterns, Genome-wide association study, VARIANTS, Biology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, ddc:570, Genetics, Journal Article, Humans, Genetic Predisposition to Disease, genetics [Schizophrenia], GENOME-WIDE ASSOCIATION, Selection, Genetic, MENTAL-ILLNESS, education, Allele frequency, Alleles, education.field_of_study, HUMAN ADAPTATION, Mechanism (biology), Background selection, Genetic architecture, genome-wide association studies, schizophrenia, genetics [Genes, Lethal], NATURAL-SELECTION, 030104 developmental biology, DE-NOVO MUTATIONS, Genetic Loci, Case-Control Studies, Schizophrenia, Genes, Lethal, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life and decreased life expectancy. Lack of progress in improving treatment outcomes has been attributed to limited knowledge of the underlying biology, although large-scale genomic studies have begun to provide insights. We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls), and through meta-analysis with existing data we identify 50 novel associated loci and 145 loci in total. Through integrating genomic fine-mapping with brain expression and chromosome conformation data, we identify candidate causal genes within 33 loci. We also show for the first time that the common variant association signal is highly enriched among genes that are under strong selective pressures. These findings provide new insights into the biology and genetic architecture of schizophrenia, highlight the importance of mutation-intolerant genes and suggest a mechanism by which common risk variants persist in the population.

Published
2018

15. Pharmacogenomic Variants and Drug Interactions Identified Through the Genetic Analysis of Clozapine Metabolism

Author

Pardiñas, Antonio F., primary, Nalmpanti, Mariana, additional, Pocklington, Andrew J., additional, Legge, Sophie E., additional, Medway, Christopher, additional, King, Adrian, additional, Jansen, John, additional, Helthuis, Marinka, additional, Zammit, Stanley, additional, MacCabe, James, additional, Owen, Michael J., additional, O’Donovan, Michael C., additional, and Walters, James T.R., additional

Published
2019
Full Text
View/download PDF

16. PHARMACOGENOMIC ARCHITECTURE OF CLOZAPINE PLASMA CONCENTRATIONS

Author

Pardiñas, Antonio, primary, Nalmpanti, Mariana, additional, Pocklington, Andrew, additional, Sophie, Sophie, additional, Medway, Christopher, additional, King, Adrian, additional, Jansen, John, additional, Helthuis, Marinka, additional, Owen, Michael, additional, O'Donovan, Michael, additional, and Walters, James, additional

Published
2019
Full Text
View/download PDF

17. THE IMPACT OF THE DUFFY-NULL GENOTYPE IN CLOZAPINE-ASSOCIATED NEUTROPENIA: A GENOME-WIDE ASSOCIATION STUDY IN INDIVIDUALS OF AFRICAN ANCESTRY

Author

Legge, Sophie, primary, F. Pardiñas, Antonio, additional, Helthuis, Marinka, additional, A. Jansen, John, additional, Jollie, Karel, additional, Knapper, Steven, additional, H. MacCabe, James, additional, Rujescu, Dan, additional, A. Collier, David, additional, C. O'Donovan, Michael, additional, J. Owen, Michael, additional, and T. R. Walters, James, additional

Published
2019
Full Text
View/download PDF

18. Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Author

Pardiñas, Antonio F, Holmans, Peter, Han, Jun, Nothen, Markus, Goate, Alison, Cruchaga, Carlos, Nowotny, Petra, Morris, John C, Mayo, Kevin, Williams, Julie, Achilla, Evanthia, Agerbo, Esben, Hubbard, Leon, Barr, Cathy L, Böttger, Theresa Wimberly, Breen, Gerome, Cohen, Dan, Collier, David A, Curran, Sarah, Dempster, Emma, Dima, Danai, Sabes-Figuera, Ramon, Flanagan, Robert J, Lynham, Amy, Frangou, Sophia, Frank, Josef, Gasse, Christiane, Gaughran, Fiona, Giegling, Ina, Grove, Jakob, Hannon, Eilis, Hartmann, Annette M, Heißerer, Barbara, Helthuis, Marinka, Mantripragada, Kiran, Horsdal, Henriette Thisted, Ingimarsson, Oddur, Jollie, Karel, Kennedy, James L, Köhler, Ole, Konte, Bettina, Lang, Maren, Legge, Sophie E, Lewis, Cathryn, MacCabe, James, Rees, Elliott, Malhotra, Anil K, McCrone, Paul, Meier, Sandra M, Mill, Jonathan, Mors, Ole, Mortensen, Preben Bo, O'Donovan, Michael C, Owen, Michael J, Pedersen, Carsten B, MacCabe, James H, Rietschel, Marcella, Rujescu, Dan, Schwalber, Ameli, Sigurdsson, Engilbert, Sørensen, Holger J, Spencer, Benjamin, Stefansson, Hreinn, Støvring, Henrik, Strohmaier, Jana, Sullivan, Patrick, McCarroll, Steven A, Vassos, Evangelos, Verbelen, Moira, Walters, James T R, Werge, Thomas, Baune, Bernhard T, Byrne, Enda M, Pocklington, Andrew J, Dannlowski, Udo, Eley, Thalia C, Hayward, Caroline, Martin, Nicholas G, McIntosh, Andrew M, Plomin, Robert, Porteous, David J, Wray, Naomi R, Caballero, Armando, Geschwind, Daniel H, Escott-Price, Valentina, Huckins, Laura M, Ruderfer, Douglas M, Santiago, Enrique, Sklar, Pamela, Stahl, Eli A, Won, Hyejung, Als, Thomas D, Andreassen, Ole A, Bækvad-Hansen, Marie, Ripke, Stephan, Pedersen, Carsten Bøcker, Børglum, Anders D, Bybjerg-Grauholm, Jonas, Djurovic, Srdjan, Durmishi, Naser, Pedersen, Marianne Giørtz, Golimbet, Vera, Hougaard, David M, Carrera, Noa, Mattheisen, Manuel, Molden, Espen, Nordentoft, Merete, Pejovic-Milovancevic, Milica, Silagadze, Teimuraz, Hansen, Christine Søholm, Stefansson, Kari, Steinberg, Stacy, Tosato, Sarah, Consortium, GERAD1, Consortium, CRESTAR, Kirov, George, Bishop, Sophie, Harold, Denise, Sims, Rebecca, Gerrish, Amy, Chapman, Jade, Abraham, Richard, Hollingworth, Paul, Pahwa, Jaspreet, Denning, Nicola, Cameron, Darren, Thomas, Charlene, Taylor, Sarah, Powell, John, Proitsi, Petroula, Lupton, Michelle, Lovestone, Simon, Passmore, Peter, Craig, David, McGuinness, Bernadette, Johnston, Janet, Hamshere, Marian L, Todd, Stephen, Maier, Wolfgang, Jessen, Frank, Heun, Reiner, Schurmann, Britta, Ramirez, Alfredo, Becker, Tim, Herold, Christine, Lacour, Andre, and Drichel, Dmitriy

Subjects
0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, ddc:570, Genetics, Biology, Humanities, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract

Author(s): Pardinas, Antonio F; Holmans, Peter; Pocklington, Andrew J; Escott-Price, Valentina; Ripke, Stephan; Carrera, Noa; Legge, Sophie E; Bishop, Sophie; Cameron, Darren; Hamshere, Marian L; Han, Jun; Hubbard, Leon; Lynham, Amy; Mantripragada, Kiran; Rees, Elliott; MacCabe, James H; McCarroll, Steven A; Baune, Bernhard T; Breen, Gerome; Byrne, Enda M; Dannlowski, Udo; Eley, Thalia C; Hayward, Caroline; Martin, Nicholas G; McIntosh, Andrew M; Plomin, Robert; Porteous, David J; Wray, Naomi R; Caballero, Armando; Geschwind, Daniel H; Huckins, Laura M; Ruderfer, Douglas M; Santiago, Enrique; Sklar, Pamela; Stahl, Eli A; Won, Hyejung; Agerbo, Esben; Als, Thomas D; Andreassen, Ole A; Baekvad-Hansen, Marie; Mortensen, Preben Bo; Pedersen, Carsten Bocker; Borglum, Anders D; Bybjerg-Grauholm, Jonas; Djurovic, Srdjan; Durmishi, Naser; Pedersen, Marianne Giortz; Golimbet, Vera; Grove, Jakob; Hougaard, David M; Mattheisen, Manuel; Molden, Espen; Mors, Ole; Nordentoft, Merete; Pejovic-Milovancevic, Milica; Sigurdsson, Engilbert; Silagadze, Teimuraz; Hansen, Christine Soholm; Stefansson, Kari; Stefansson, Hreinn; Steinberg, Stacy; Tosato, Sarah; Werge, Thomas; GERAD1 Consortium; CRESTAR Consortium; Collier, David A; Rujescu, Dan; Kirov, George; Owen, Michael J; O'Donovan, Michael C; Walters, James TR | Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results