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26 results on '"Hemmatian, Haniyeh"'

12. Osteocyte apoptosis and cellular micropetrosis signify skeletal aging in type 1 diabetes

Author

Kolibová, Sofie Dragoun, primary, Wölfel, Eva Maria, additional, Hemmatian, Haniyeh, additional, Milovanovic, Petar, additional, Mushumba, Herbert, additional, Wulff, Birgit, additional, Neidhardt, Maximilian, additional, Püschel, Klaus, additional, Failla, Antonio Virgilio, additional, Vlug, Annegreet, additional, Schlaefer, Alexander, additional, Ondruschka, Benjamin, additional, Amling, Michael, additional, Hofbauer, Lorenz C., additional, Rauner, Martina, additional, Busse, Björn, additional, and Jähn-Rickert, Katharina, additional

Published
2023
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14. Reduced Bone Mass and Increased Osteocyte Tartrate‐Resistant Acid Phosphatase (TRAP) Activity, But Not Low Mineralized Matrix Around Osteocyte Lacunae, Are Restored After Recovery From Exogenous Hyperthyroidism in Male Mice

Author

Wölfel, Eva Maria, primary, Lademann, Franziska, additional, Hemmatian, Haniyeh, additional, Blouin, Stéphane, additional, Messmer, Phaedra, additional, Hofbauer, Lorenz C., additional, Busse, Björn, additional, Rauner, Martina, additional, Jähn‐Rickert, Katharina, additional, and Tsourdi, Elena, additional

Published
2022
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17. Reduced Bone Mass and Increased Osteocyte Tartrate‐Resistant Acid Phosphatase (TRAP) Activity, But Not Low Mineralized Matrix Around Osteocyte Lacunae, Are Restored After Recovery From Exogenous Hyperthyroidism in Male Mice.

Author

Wölfel, Eva Maria, Lademann, Franziska, Hemmatian, Haniyeh, Blouin, Stéphane, Messmer, Phaedra, Hofbauer, Lorenz C., Busse, Björn, Rauner, Martina, Jähn‐Rickert, Katharina, and Tsourdi, Elena

Abstract

Hyperthyroidism causes secondary osteoporosis through favoring bone resorption over bone formation, leading to bone loss with elevated bone fragility. Osteocytes that reside within lacunae inside the mineralized bone matrix orchestrate the process of bone remodeling and can themselves actively resorb bone upon certain stimuli. Nevertheless, the interaction between thyroid hormones and osteocytes and the impact of hyperthyroidism on osteocyte cell function are still unknown. In a preliminary study, we analyzed bones from male C57BL/6 mice with drug‐induced hyperthyroidism, which led to mild osteocytic osteolysis with 1.14‐fold larger osteocyte lacunae and by 108.33% higher tartrate‐resistant acid phosphatase (TRAP) activity in osteocytes of hyperthyroid mice compared to euthyroid mice. To test whether hyperthyroidism‐induced bone changes are reversible, we rendered male mice hyperthyroid by adding levothyroxine into their drinking water for 4 weeks, followed by a weaning period of 4 weeks with access to normal drinking water. Hyperthyroid mice displayed cortical and trabecular bone loss due to high bone turnover, which recovered with weaning. Although canalicular number and osteocyte lacunar area were similar in euthyroid, hyperthyroid and weaned mice, the number of terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL)‐positive osteocytes was 100% lower in the weaning group compared to euthyroid mice and the osteocytic TRAP activity was eightfold higher in hyperthyroid animals. The latter, along with a 3.75% lower average mineralization around the osteocyte lacunae in trabecular bone, suggests osteocytic osteolysis activity that, however, did not result in significantly enlarged osteocyte lacunae. In conclusion, we show a recovery of bone microarchitecture and turnover after reversal of hyperthyroidism to a euthyroid state. In contrast, osteocytic osteolysis was initiated in hyperthyroidism, but its effects were not reversed after 4 weeks of weaning. Due to the vast number of osteocytes in bone, we speculate that even minor individual cell functions might contribute to altered bone quality and mineral homeostasis in the setting of hyperthyroidism‐induced bone disease. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). [ABSTRACT FROM AUTHOR]

Published
2023
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20. Collagen Fiber Orientation Is Coupled with Specific Nano-Compositional Patterns in Dark and Bright Osteons Modulating Their Biomechanical Properties

Author

Stockhausen, Kilian E., primary, Qwamizadeh, Mahan, additional, Wölfel, Eva M., additional, Hemmatian, Haniyeh, additional, Fiedler, Imke A. K., additional, Flenner, Silja, additional, Longo, Elena, additional, Amling, Michael, additional, Greving, Imke, additional, Ritchie, Robert O., additional, Schmidt, Felix N., additional, and Busse, Björn, additional

Published
2021
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24. Collagen Fiber Orientation Is Coupled with Specific Nano-Compositional Patterns in Darkand BrightOsteons Modulating Their Biomechanical Properties

Author

Stockhausen, Kilian E., Qwamizadeh, Mahan, Wölfel, Eva M., Hemmatian, Haniyeh, Fiedler, Imke A. K., Flenner, Silja, Longo, Elena, Amling, Michael, Greving, Imke, Ritchie, Robert O., Schmidt, Felix N., and Busse, Björn

Abstract

Bone continuously adapts to its mechanical environment by structural reorganization to maintain mechanical strength. As the adaptive capabilities of bone are portrayed in its nano- and microstructure, the existence of darkand brightosteons with contrasting preferential collagen fiber orientation (longitudinal and oblique-angled, respectively) points at a required tissue heterogeneity that contributes to the excellent fracture resistance mechanisms in bone. Darkand brightosteons provide an exceptional opportunity to deepen our understanding of how nanoscale tissue properties influence and guide fracture mechanisms at larger length scales. To this end, a comprehensive structural, compositional, and mechanical assessment is performed using circularly polarized light microscopy, synchrotron nanocomputed tomography, focused ion beam/scanning electron microscopy, quantitative backscattered electron imaging, Fourier transform infrared spectroscopy, and nanoindentation testing. To predict how the mechanical behavior of osteons is affected by shifts in collagen fiber orientation, finite element models are generated. Fundamental disparities between both osteon types are observed: darkosteons are characterized by a higher degree of mineralization along with a higher ratio of inorganic to organic matrix components that lead to higher stiffness and the ability to resist plastic deformation under compression. On the contrary, brightosteons contain a higher fraction of collagen and provide enhanced ductility and energy dissipation due to lower stiffness and hardness.

Published
2021
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26. Reply Letter to the Editor: Clinical in Vivo Assessment of Bone Microarchitecture With CT Scanners: An Enduring Challenge.

Author

Mys, Karen, Varga, Peter, Gueorguiev, Boyko, Hemmatian, Haniyeh, Stockmans, Filip, and Lenthe, G Harry

Abstract

This protocol would have allowed us to scan an object of 6 cm in height and would have required 6 to 7 stacks when using the XtremeCT or XtremeCT II; this would have resulted in long scanning times of 20 and 12 minutes for the XtremeCT and XtremeCT II, respectively, as nicely illustrated in Table 1 of Tran and colleagues.[1] 1 Tran D, Vilayphiou N, Koller B. Clinical in vivo assessment of bone microarchitecture with CT scanners: an enduring challenge. 4 Koivisto J, Kiljunen T, Kadesjö N, Shi X-Q, Wolff J. Effective radiation dose of a MSCT, two CBCT and one conventional radiography device in the ankle region. [Extracted from the article]

Published
2020
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