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220 results on '"Henderson, Charles M."'

1. Sustained increases in atmospheric oxygen and marine productivity in the Neoproterozoic and Palaeozoic eras

Author

Stockey, Richard G., Cole, Devon B., Farrell, Una C., Agić, Heda, Boag, Thomas H., Brocks, Jochen J., Canfield, Don E., Cheng, Meng, Crockford, Peter W., Cui, Huan, Dahl, Tais W., Del Mouro, Lucas, Dewing, Keith, Dornbos, Stephen Q., Emmings, Joseph F., Gaines, Robert R., Gibson, Timothy M., Gill, Benjamin C., Gilleaudeau, Geoffrey J., Goldberg, Karin, Guilbaud, Romain, Halverson, Galen, Hammarlund, Emma U., Hantsoo, Kalev, Henderson, Miles A., Henderson, Charles M., Hodgskiss, Malcolm S. W., Jarrett, Amber J. M., Johnston, David T., Kabanov, Pavel, Kimmig, Julien, Knoll, Andrew H., Kunzmann, Marcus, LeRoy, Matthew A., Li, Chao, Loydell, David K., Macdonald, Francis A., Magnall, Joseph M., Mills, N. Tanner, Och, Lawrence M., O’Connell, Brennan, Pagès, Anais, Peters, Shanan E., Porter, Susannah M., Poulton, Simon W., Ritzer, Samantha R., Rooney, Alan D., Schoepfer, Shane, Smith, Emily F., Strauss, Justin V., Uhlein, Gabriel Jubé, White, Tristan, Wood, Rachel A., Woltz, Christina R., Yurchenko, Inessa, Planavsky, Noah J., and Sperling, Erik A.

Published
2024
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11. Carbonate Sedimentology and Conodont Biostratigraphy of Late Pennsylvanian–Early Permian Stratigraphic Sequences, Carlin Canyon, Nevada: New Insights into the Tectonic and Oceanographic Significance of an Iconic Succession of the Basin and Range

Author

Beauchamp, Benoit, primary, Henderson, Charles M., additional, Dehari, Elinda, additional, Von Bassenheim, Daniela Waldbott, additional, Elliot, Sean, additional, and González, Daniel Calvo, additional

Published
2022
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14. Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice.

Author

Kumar, Ramiya, Mota, Linda C, Litoff, Elizabeth J, Rooney, John P, Boswell, W Tyler, Courter, Elliott, Henderson, Charles M, Hernandez, Juan P, Corton, J Christopher, Moore, David D, and Baldwin, William S

Subjects
Animals, Mice, Inbred C57BL, Mice, Knockout, Mice, Cytochrome P-450 Enzyme System, Aryl Hydrocarbon Hydroxylases, Steroid Hydroxylases, Receptors, Cytoplasmic and Nuclear, Gene Expression, Gene Deletion, Female, CRISPR-Cas Systems, Cytochrome P450 Family 2, Pharmacological and Toxicological Phenomena, Cytochrome P-450 CYP3A, Inbred C57BL, Knockout, Receptors, Cytoplasmic and Nuclear, General Science & Technology
Abstract

Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cytochrome P450s (CYP). Here we investigated changes in transcript levels, protein expression, and steroid hydroxylation of several xenobiotic detoxifying CYPs in constitutive androstane receptor (CAR)-null and two CYP-null mouse models that have subfamily members regulated by CAR; the Cyp3a-null and a newly described Cyp2b9/10/13-null mouse model. Compensatory changes in CYP expression that occur in these models may also occur in polymorphic humans, or may complicate interpretation of ADME studies performed using these models. The loss of CAR causes significant changes in several CYPs probably due to loss of CAR-mediated constitutive regulation of these CYPs. Expression and activity changes include significant repression of Cyp2a and Cyp2b members with corresponding drops in 6α- and 16β-testosterone hydroxylase activity. Further, the ratio of 6α-/15α-hydroxylase activity, a biomarker of sexual dimorphism in the liver, indicates masculinization of female CAR-null mice, suggesting a role for CAR in the regulation of sexually dimorphic liver CYP profiles. The loss of Cyp3a causes fewer changes than CAR. Nevertheless, there are compensatory changes including gender-specific increases in Cyp2a and Cyp2b. Cyp2a and Cyp2b were down-regulated in CAR-null mice, suggesting activation of CAR and potentially PXR following loss of the Cyp3a members. However, the loss of Cyp2b causes few changes in hepatic CYP transcript levels and almost no significant compensatory changes in protein expression or activity with the possible exception of 6α-hydroxylase activity. This lack of a compensatory response in the Cyp2b9/10/13-null mice is probably due to low CYP2B hepatic expression, especially in male mice. Overall, compensatory and regulatory CYP changes followed the order CAR-null > Cyp3a-null > Cyp2b-null mice.

Published
2017

20. Redefinition of the Global Stratotype Section and Point (GSSP) and new Standard Auxiliary Boundary Stratotype (SABS) for the base of Wuchiapingian Stage (Lopingian Series, Permian) in South China

Author

Shen, Shu-zhong, primary, Yuan, Dong-xun, additional, Zhang, Yi-chun, additional, Henderson, Charles, M., additional, Zheng, Quan-feng, additional, Zhang, Hua, additional, Zhang, Min, additional, Dai, Yu, additional, Xu, Hai-peng, additional, Wang, Wen-qian, additional, Li, Qian, additional, Wang, Yue, additional, Wang, Xiang-dong, additional, Mu, Lin, additional, Ramezani, Jahandar, additional, Erwin, Douglas H., additional, Angiolini, Lucia, additional, Zhang, Fei-fei, additional, Hou, Zhang-shuai, additional, Chen, Jun, additional, Zhang, Xi-yang, additional, Zhang, Shu-han, additional, Wu, Qiong, additional, Pan, Yong-xin, additional, Stephenson, Michael, additional, and Mei, Shi-long, additional

Published
2023
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24. Contributors

Author

Gradstein, Felix M., primary, Ogg, James G., additional, Schmitz, Mark D., additional, Ogg, Gabi M., additional, Agterberg, Frits P., additional, Aretz, Markus, additional, Becker, Thomas R., additional, Butcher, Anthony, additional, Cramer, Bradley D., additional, Ernst, Richard E., additional, Esmeray-Senlet, Selen, additional, Fensome, Rob A., additional, Gale, Andrew S., additional, Gibbard, Philip L., additional, Goldman, Daniel, additional, Grossman, Ethan L., additional, Halverson, Galen P., additional, Henderson, Charles M., additional, Hesselbo, Stephen P., additional, Hiesinger, Harald, additional, Kerp, Hans, additional, Laskar, Jacques, additional, McArthur, John M., additional, Melchin, Michael J., additional, Paytan, Adina, additional, Peng, Shanchi, additional, Petrizzo, Maria Rose, additional, Peucker-Ehrenbrink, Bernhard, additional, Raffi, Isabella, additional, Sadler, Peter M., additional, Saltzman, Matthew R., additional, Shields, Graham A., additional, Simmons, Michael D., additional, Speijer, Robert P., additional, Strachan, Rob, additional, Watkins, David K., additional, Xiao, Shuhai, additional, Zalasiewicz, Jan, additional, Ahlberg, Per, additional, Babcock, Loren E., additional, Batenburg, Sietske J., additional, Bond, David P.G., additional, Chen, Zhong-Qiang, additional, Cope, John, additional, Da Silva, Anne-Christine, additional, Darling, James, additional, Davies, Andrew, additional, Faul, Kristina L., additional, Gradstein, Stephan R., additional, Gray, Ellen T., additional, Gréselle, Benjamin, additional, Head, Martin J., additional, Herbig, Hans-Georg, additional, Hill, Andrew C., additional, Hollis, Christopher J., additional, Hooker, Jerry J., additional, Howarth, Richard J., additional, Ifrim, Christina, additional, Jarvis, Ian, additional, Joachimski, Michael M., additional, Johnson, Clark M., additional, Korn, Dieter, additional, Leslie, Stephen A., additional, MacGabhann, Breandán A., additional, Mangerud, Gunn, additional, Marshall, John E., additional, McGowan, Alistair J., additional, Miller, Ken G., additional, Munsterman, Dirk K., additional, Murphy, Brendan J., additional, Mutterlose, Joerg, additional, Narbonne, Guy M., additional, Pälike, Heiko, additional, Porter, Susannah M., additional, Ravizza, Gregory E., additional, Ray, David C., additional, Rooney, Alan D., additional, Ruhl, Micha, additional, Rushton, Adrian, additional, Shen, Shu-Zhong, additional, Singer, Brad S., additional, Storey, Craig, additional, Tanaka, Ken, additional, Van Buchem, Frans S., additional, Wade, Bridget S., additional, Wang, Xiangdong, additional, Waters, Colin N., additional, Williams, Mark, additional, Yao, Weiqi, additional, Zhang, Shuan-Hong, additional, Zhou, Ying, additional, Beu, Alan G., additional, Crundwell, Martin, additional, Hinnov, Linda A., additional, Huang, Chunju, additional, Jiang, Haishui, additional, Krijgsman, Wouter, additional, Moore, Theodore, additional, Orchard, Michael, additional, Raine, J. Ian, additional, Sardella, Raffaele, additional, and Vernyhorova, Yuliia, additional

Published
2020
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27. Global Stratotype Section and Point (GSSP) for the base-Artinskian Stage (Lower Permian)

Author

Chernykh, Valery V., primary, Henderson, Charles M., additional, Kutygin, Ruslan V., additional, Filimonova, Tatiana V., additional, Sungatullina, Guzal M., additional, Afanasieva, Marina S., additional, Isakova, Tatiana N., additional, Sungatullin, Rafael Kh., additional, Stephenson, Michael H., additional, Angiolini, Lucia, additional, and Chuvashov, Boris I., additional

Published
2023
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29. REPLY : PERMIAN–TRIASSIC MICROBIALITE AND DISSOLUTION SURFACE ENVIRONMENTAL CONTROLS ON THE GENESIS OF MARINE MICROBIALITES AND DISSOLUTION SURFACE ASSOCIATED WITH THE END-PERMIAN MASS EXTINCTION: NEW SECTIONS AND OBSERVATIONS FROM THE NANPANJIANG BASIN, SOUTH CHINA

Author

LEHRMANN, DANIEL J., BENTZ, JOHN M., WOOD, TANNER, GOERS, ALEXA, DHILLON, RYAN, AKIN, SARA, LI, XIAOWEI, PAYNE, JONATHAN L., KELLEY, BRIAN M., MEYER, KATJA M., SCHAAL, ELLEN K., SUAREZ, MARINA B., YU, MEIYI, QIN, YANJIAO, LI, RONGXI, MINZONI, MARCELLO, and HENDERSON, CHARLES M.

Published
2016

32. Sr/Ca and Ba/Ca ratios support trophic partitioning within a Silurian conodont community from Gotland, Sweden

Author

Terrill, David F., Jarochowska, Emilia, Henderson, Charles M., Shirley, Bryan, Bremer, Oskar, Stratigraphy and paleontology, Stratigraphy & paleontology, Stratigraphy and paleontology, and Stratigraphy & paleontology

Subjects
fossil, Ecology, trophic network, Paleontology, Geology, Palaeozoic, trophic niche, marine ecosystem, apatite, conodonts, vertebrate, Geologi, strontium, diet, dietary niche, Paleozoic, General Agricultural and Biological Sciences, Silurian, Ecology, Evolution, Behavior and Systematics, geochemistry
Abstract

Conodonts were a highly diverse and abundant vertebrate group whose fossils are found in marine Paleozoic and Triassic strata around the world. They inhabited environments ranging from lagoons to open oceans and are represented by a wide variety of dental morphologies. Conodonts may have filled many different ecological niches and represent a significant proportion of nekton before the Devonian. Despite this, very little is known about trophic ecology of conodonts. While morphological diversity suggests a complex trophic structure within conodont communities, there is little evidence to support dietary niche partitioning among conodonts.We tested the hypothesis that individual conodont taxa occupied different trophic niches, using Sr/Ca and Ba/Ca ratios preserved in the dental elements of assemblages from Silurian strata of Gotland, Sweden. Sr/Ca and Ba/Ca have been shown to vary in vertebrate skeletal tissues depending on trophic positioning, although biological and environmental conditions can affect these ratios. Environmental influences were minimized by examining entire conodont communities from a tropical epeiric sea and by measuring strontium isotope ratios using thermal ionization mass spectrometry in the most metropolitan taxon (Ozarkodina confluens). Composition of white matter, a tissue unique to conodonts, was also analyzed using microprobe analysis, revealing significantly lower Sr concentrations than in surrounding lamellar tissue, suggesting taxon-specific histology should be considered when analyzing conodonts for geochemical data. Excluding taxa with highly variable quantities of white matter, the results show that each taxon preserves different Sr/Ca and Ba/Ca ratios with limited overlap, indicating variation in trophic positioning.

Published
2022

33. ENVIRONMENTAL CONTROLS ON THE GENESIS OF MARINE MICROBIALITES AND DISSOLUTION SURFACE ASSOCIATED WITH THE END-PERMIAN MASS EXTINCTION: NEW SECTIONS AND OBSERVATIONS FROM THE NANPANJIANG BASIN, SOUTH CHINA

Author

LEHRMANN, DANIEL J., BENTZ, JOHN M., WOOD, TANNER, GOERS, ALEXA, DHILLON, RYAN, AKIN, SARA, LI, XIAOWEI, PAYNE, JONATHAN L., KELLEY, BRIAN M., MEYER, KATJA M., SCHAAL, ELLEN K., SUAREZ, MARINA B., YU, MEIYI, QIN, YANJIAO, LI, RONGXI, MINZONI, MARCELLO, and HENDERSON, CHARLES M.

Published
2015

34. The Global Stratotype Section and Point (GSSP) for the base of the Capitanian Stage (Guadalupian, Middle Permian)

Author

Shen, Shu-zhong, primary, Yuan, Dong-xun, additional, Henderson, Charles M., additional, Lambert, Lance L., additional, Zhang, Yi-chun, additional, Erwin, Douglas H., additional, Ramezani, Jahandar, additional, Wang, Xiang-dong, additional, Zhang, Hua, additional, Wu, Qiong, additional, Wang, Wen-qian, additional, Hearst, Jonena M., additional, Chen, Jun, additional, Wang, Yue, additional, Qie, Wen-kun, additional, Qi, Yu-ping, additional, and Wardlaw, Bruce R., additional

Published
2022
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46. Calibrating the End-Permian Mass Extinction

Author

Shen, Shu-zhong, Crowley, James L., Wang, Yue, Bowring, Samuel A., Erwin, Douglas H., Sadler, Peter M., Cao, Chang-qun, Rothman, Daniel H., Henderson, Charles M., Ramezani, Jahandar, Zhang, Hua, Shen, Yanan, Wang, Xiang-dong, Wang, Wei, Mu, Lin, Li, Wen-zhong, Tang, Yue-gang, Liu, Xiao-lei, Liu, Lu-jun, Zeng, Yong, Jiang, Yao-fa, and Jin, Yu-gan

Published
2011

49. Reinvestigation of the Wordian-base GSSP section, West Texas, USA

Author

Yuan, Dong-xun, primary, Shen, Shu-zhong, additional, Henderson, Charles M., additional, Lambert, Lance L., additional, Hearst, Jonena M., additional, Zhang, Yi-chun, additional, Chen, Jun, additional, Qie, Wen-kun, additional, Zhang, Hua, additional, Wang, Xiang-dong, additional, Qi, Yu-ping, additional, and Wu, Qiong, additional

Published
2021
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50. High-precision U-Pb age constraints on the Permian floral turnovers, paleoclimate change, and tectonics of the North China block

Author

Wu, Qiong, primary, Ramezani, Jahandar, additional, Zhang, Hua, additional, Wang, Jun, additional, Zeng, Fangui, additional, Zhang, Yichun, additional, Liu, Feng, additional, Chen, Jun, additional, Cai, Yaofeng, additional, Hou, Zhangshuai, additional, Liu, Chao, additional, Yang, Wan, additional, Henderson, Charles M., additional, and Shen, Shu-zhong, additional

Published
2021
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