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The objective of this work was to analyze the in vitro and in vivo tests of a novel Mg-based biodegradable alloy—Mg-0.5%Ca—with various amounts of Zn (0.5, 1, 1.5, 2.0, and 3.0 wt.%). In terms of in vitro biocompatibility, MTT and Calcein-AM cell viability assays, performed on the MG-63 cell line through the extract method, revealed that all five alloy extracts are non-cytotoxic at an extraction ratio of 0.025 g alloy per mL of cell culture medium. In the in vivo histological analysis, Mg-0.5Ca-1.5Zn demonstrated exceptional potential for stimulating bone remodeling and showed excellent biocompatibility. It was observed that Mg-0.5Ca-0.5Zn, Mg-0.5Ca-1.5Zn, and Mg-0.5Ca-3Zn displayed good biocompatibility. Furthermore, the histological examination highlighted the differentiation of periosteal cells into chondrocytes and subsequent bone tissue replacement through endochondral ossification. This process highlighted the importance of the initial implant's integrity and the role of the periosteum. In summary, Mg-0.5Ca-1.5Zn stands out as a promising candidate for bone regeneration and osseointegration, supported by both in vitro and in vivo findings. [ABSTRACT FROM AUTHOR]

Paralyzed patients have always been ideal candidates for physiotherapy. Regardless of the cause that led to the onset of paralysis (whether localized or generalized), physiotherapy helps these patients with devices and methods designed to restore their proper functioning of the body, as well as the quality of life. Obtaining the standing position is the main stage in the therapeutic process, being the indispensable element for the entire protocol. The present study focused on the devices we developed over time, adapting them for each patient, depending on the degree of damage they presented and the possible associated pathologies. At the same time, we wanted these devices to be available for any therapist or even owner, being made of common materials, easy to find, but also affordable. [ABSTRACT FROM AUTHOR]

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This study assessed seasonal incidence, economic losses, the efficacy of therapeutic protocols, the recovery time of affected animals and specific prophylactic measures applied to sheep with acute infectious pododermatitis. The studies were conducted over a period of 12 months in 3 different sheep farms from private units in the same area. The results of the study showed an increased incidence of the disease in all 3 farms, with an average of 26.94% of the sheep flock. The incidence of the disease was increased in the months of April-May- June-July and September-October (30%), when there were heavy rains. The high morbidity led to economic losses through the decrease in milk production by approximately 30% and the decrease in the weight of the sheep by 10.58% (4.2 kg) of their normal weight. The therapeutic protocol applied locally as well as parenterally, combined with a foot bath with 10% zinc sulphate solution, were effective in treating acute infectious pododermatitis of sheep. The average recovery time (days) was approximately the same in the three groups of sheep (5.25 ± 0.68 days for cases with moderate diseases and 10.2 ± 0.22 for cases with severe diseases). [ABSTRACT FROM AUTHOR]

Pain and inflammation management in the medical field are necessary in every pathology regardless of the origin. When it comes to the veterinary field, pain and inflammation reduction is the key to full recovery, considering the animal patient's behavior in such cases. Also, because the medication may in some cases be inaccessible or hard to be administered, veterinarians and owners should take alternative medicine into account, as many literature researches had indicated high efficacy. This research aims to analyze the latest discoveries regarding the inflammation and pain management through curcumin treatment. [ABSTRACT FROM AUTHOR]

Allergy is an exaggerated reaction of the body, which occurs after the contact with various substances that the immune system considers foreign and acts against them. Like humans, dogs can be allergic to various substances which, when inhaled or absorbed through the skin, airways or gastrointestinal tract, stimulate the immune system by releasing histamine that induces inflammation, erythema, edema and itching. It is considered that all the cases of allergies, whether low, moderate or severe, are genetic in nature. Dogs that become allergic to drugs, vaccines, food, dust, pollen, fleas, various household substances, etc., are "genetically programmed" to have an immune system capable of producing an allergic reaction. The allergic reaction is not due to medication, biological products, food or the environment, but it is considered to be a genetic trait inherited from parents. Because there are different types of allergies and many conditions that can cause skin problems in dogs, the symptoms they present differ from one allergy to another, from one patient to another, requiring both diagnosis and treatment to be made differential for each type of allergy and for each individual. The symptoms of allergic reactions can be diagnosed through allergic tests (intradermal or blood tests), the individual removal of allergens from the dog's living environment (in case of parasitic allergy), or by reagent therapy. Fighting allergies involves the use of antihistamines, antiinflammatory corticosteroids, topical antipruritic substances, leukotrienes inhibitors, as well as various plant extracts with antiallergic effect. [ABSTRACT FROM AUTHOR]

The aim of this paper is to briefly present some aspects of Babesia spp. taxonomy, incidence, clinical signs of their infection, and possibilities of prevention, as an introduction to a case study of canine babesiosis presentation. A 7-yearold Malinois dog was presented in August 2020 with signs of generalized icterus, high body temperature and mustard urine, all of them indicating babesiosis. Cytological examination confirmed the large Babesia canis spp., and the biochemical investigations revealed renal and hepatic failure. Although the therapeutic protocol included the specific antidote, imidocarb dipropionate – Imizol® (0.5 ml/10 kg body weight, in a single dose), fluid therapy, vitamin therapy, an antiemetic drug, and supplements for renal and hepatic functions sustaining, the investigated dog died. The postmortem investigation revealed generalized icterus. We consider the delaying of dog presentation at vet an important factor of this outcome; although an infection with various subspecies of Babesia canis was not excluded, the therapeutic intervention would have been the same. [ABSTRACT FROM AUTHOR]